JP2014527831A5 - - Google Patents
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- Publication number
- JP2014527831A5 JP2014527831A5 JP2014532073A JP2014532073A JP2014527831A5 JP 2014527831 A5 JP2014527831 A5 JP 2014527831A5 JP 2014532073 A JP2014532073 A JP 2014532073A JP 2014532073 A JP2014532073 A JP 2014532073A JP 2014527831 A5 JP2014527831 A5 JP 2014527831A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- sequencing
- biological sample
- blood
- isotype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 47
- 108060003951 Immunoglobulin Proteins 0.000 claims description 18
- 102000018358 immunoglobulin Human genes 0.000 claims description 18
- 210000004369 blood Anatomy 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- 238000012163 sequencing technique Methods 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 10
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 5
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 4
- 238000003786 synthesis reaction Methods 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims 4
- 108091093088 Amplicon Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 208000037765 diseases and disorders Diseases 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 4
- 201000006417 multiple sclerosis Diseases 0.000 description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537878P | 2011-09-22 | 2011-09-22 | |
| US61/537,878 | 2011-09-22 | ||
| PCT/US2012/056911 WO2013044234A1 (en) | 2011-09-22 | 2012-09-24 | Detection of isotype profiles as signatures for disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017159019A Division JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527831A JP2014527831A (ja) | 2014-10-23 |
| JP2014527831A5 true JP2014527831A5 (https=) | 2015-11-12 |
| JP6198736B2 JP6198736B2 (ja) | 2017-09-20 |
Family
ID=47080791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532073A Active JP6198736B2 (ja) | 2011-09-22 | 2012-09-24 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
| JP2017159019A Pending JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017159019A Pending JP2018007689A (ja) | 2011-09-22 | 2017-08-22 | 疾患のシグネチャとしてのアイソタイププロファイルの検出 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130078633A1 (https=) |
| EP (1) | EP2758550B1 (https=) |
| JP (2) | JP6198736B2 (https=) |
| CN (1) | CN104271759B (https=) |
| AU (1) | AU2012312028A1 (https=) |
| CA (1) | CA2848516C (https=) |
| WO (1) | WO2013044234A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2525568B (en) | 2013-03-15 | 2020-10-14 | Abvitro Llc | Single cell barcoding for antibody discovery |
| EP3611262B1 (en) | 2013-03-15 | 2020-11-11 | Lineage Biosciences, Inc. | Methods of sequencing the immune repertoire |
| US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| US10941446B2 (en) | 2014-03-12 | 2021-03-09 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| CN113444783B (zh) | 2014-06-26 | 2024-04-09 | 西奈山伊坎医学院 | 通过分析预示性基因集诊断亚临床和临床的急性排异的方法 |
| EP3950944A1 (en) | 2014-09-15 | 2022-02-09 | AbVitro LLC | High-throughput nucleotide library sequencing |
| CN105040111B (zh) * | 2015-05-28 | 2017-07-14 | 眭维国 | 系统性红斑狼疮图谱模型的构建方法 |
| GB201612242D0 (en) * | 2016-07-14 | 2016-08-31 | Genome Res Ltd And Cambridge Entpr Ltd | Novel kit |
| CN107179288A (zh) * | 2017-07-03 | 2017-09-19 | 中国人民解放军第三军医大学 | 一种唾液中分泌型免疫球蛋白的检测方法 |
| CA3095198A1 (en) | 2018-04-16 | 2019-10-24 | Icahn School Of Medicine At Mount Sinai | Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood |
| CN110400600A (zh) * | 2019-08-01 | 2019-11-01 | 枣庄学院 | 一种基于旋转森林算法的miRNA-疾病相关性预测方法 |
| EP4093887A1 (en) * | 2020-01-22 | 2022-11-30 | Life Technologies Corporation | Immune repertoire biomarkers in autoimmune disease and immunodeficiency disorders |
| CN112485304B (zh) * | 2020-12-14 | 2022-08-09 | 河北工业大学 | 一种基于电导法的牛奶检测方法及系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5018067A (en) | 1987-01-12 | 1991-05-21 | Iameter Incorporated | Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators |
| US20020038227A1 (en) | 2000-02-25 | 2002-03-28 | Fey Christopher T. | Method for centralized health data management |
| US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
| US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
| CA2544708A1 (en) * | 2003-11-03 | 2005-05-12 | Genenews, Inc. | Liver cancer biomarkers |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| EP2364368B1 (en) | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| CN102918163B (zh) * | 2009-09-08 | 2016-10-05 | 美国控股实验室公司 | 用于诊断自闭症谱系障碍的组合物和方法 |
-
2012
- 2012-09-24 US US13/625,645 patent/US20130078633A1/en not_active Abandoned
- 2012-09-24 CN CN201280055957.5A patent/CN104271759B/zh active Active
- 2012-09-24 WO PCT/US2012/056911 patent/WO2013044234A1/en not_active Ceased
- 2012-09-24 EP EP12778840.4A patent/EP2758550B1/en active Active
- 2012-09-24 CA CA2848516A patent/CA2848516C/en active Active
- 2012-09-24 AU AU2012312028A patent/AU2012312028A1/en not_active Abandoned
- 2012-09-24 JP JP2014532073A patent/JP6198736B2/ja active Active
-
2017
- 2017-08-22 JP JP2017159019A patent/JP2018007689A/ja active Pending
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