JP2014527396A5 - - Google Patents
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- Publication number
- JP2014527396A5 JP2014527396A5 JP2014509528A JP2014509528A JP2014527396A5 JP 2014527396 A5 JP2014527396 A5 JP 2014527396A5 JP 2014509528 A JP2014509528 A JP 2014509528A JP 2014509528 A JP2014509528 A JP 2014509528A JP 2014527396 A5 JP2014527396 A5 JP 2014527396A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence represented
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 34
- 230000000694 effects Effects 0.000 claims 3
- 101000804783 Homo sapiens Chemokine XC receptor 1 Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 102000045922 human XCR1 Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 101000804764 Homo sapiens Lymphotactin Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000056976 human XCL1 Human genes 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530194P | 2011-09-01 | 2011-09-01 | |
| US61/530,194 | 2011-09-01 | ||
| US201261659637P | 2012-06-14 | 2012-06-14 | |
| US61/659,637 | 2012-06-14 | ||
| PCT/JP2012/072667 WO2013032032A1 (en) | 2011-09-01 | 2012-08-30 | Anti-human xcr1 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527396A JP2014527396A (ja) | 2014-10-16 |
| JP2014527396A5 true JP2014527396A5 (enExample) | 2015-10-01 |
| JP5989096B2 JP5989096B2 (ja) | 2016-09-07 |
Family
ID=46881120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509528A Expired - Fee Related JP5989096B2 (ja) | 2011-09-01 | 2012-08-30 | 抗ヒトｘｃｒ１抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9371389B2 (enExample) |
| EP (1) | EP2751140B1 (enExample) |
| JP (1) | JP5989096B2 (enExample) |
| KR (1) | KR101767717B1 (enExample) |
| CN (1) | CN103764680B (enExample) |
| AR (1) | AR087749A1 (enExample) |
| AU (1) | AU2012302596B2 (enExample) |
| BR (1) | BR112014004352A2 (enExample) |
| CA (1) | CA2846370C (enExample) |
| ES (1) | ES2684173T3 (enExample) |
| HK (1) | HK1199038A1 (enExample) |
| IL (1) | IL231075A (enExample) |
| IN (1) | IN2014CN01466A (enExample) |
| MX (1) | MX346560B (enExample) |
| MY (1) | MY166152A (enExample) |
| PH (1) | PH12014500384A1 (enExample) |
| RU (1) | RU2619180C2 (enExample) |
| TW (1) | TWI563004B (enExample) |
| WO (1) | WO2013032032A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10071170B2 (en) | 2013-06-24 | 2018-09-11 | Ablbio | Antibody-drug conjugate having improved stability and use thereof |
| AU2016301969B2 (en) * | 2015-08-05 | 2022-10-06 | Acticor Biotech | Novel anti-human GPVI antibodies and uses thereof |
| SG11201906530TA (en) | 2017-02-03 | 2019-08-27 | Acticor Biotech | Inhibition of platelet aggregation using anti-human gpvi antibodies |
| US11246911B2 (en) | 2017-02-07 | 2022-02-15 | Vib Vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| CN107312092B (zh) * | 2017-05-04 | 2020-12-11 | 华南农业大学 | 一种斜带石斑鱼ccr12的多克隆抗体制备方法及其应用 |
| US20210130776A1 (en) * | 2017-09-29 | 2021-05-06 | The Broad Institute, Inc. | Methods and compositions for modulating suppression of lymphocyte activity |
| WO2019148089A1 (en) | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| US12410225B2 (en) | 2018-11-08 | 2025-09-09 | Orionis Biosciences, Inc | Modulation of dendritic cell lineages |
| US20220073630A1 (en) | 2018-12-28 | 2022-03-10 | Hoffmann-La Roche, Inc. | A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5786210A (en) | 1994-02-08 | 1998-07-28 | Schering Corporation | Mammalian thymokine genes |
| WO2001072830A2 (de) * | 2000-03-31 | 2001-10-04 | Ipf Pharmaceuticals Gmbh | Diagnostik- und arzneimittel zur untersuchung des zelloberflächenproteoms von tumor- und entzündungszellen sowie zur behandlung von tumorerkrankungen und entzündlichen erkrankungen vorzugsweise mit hilfe einer spezifischen chemokinrezeptor-analyse und der chemokinrezeptor-ligand-interaktion |
| AU2002246557A1 (en) | 2000-11-29 | 2002-08-06 | Lifespan Biosciences, Inc. | Compositions and methods related to chemokine (c motif) xc receptor 1 (ccxcr1) |
| US20050136033A9 (en) * | 2002-08-13 | 2005-06-23 | Matthias Mack | Method of treating allergen induced airway disease |
| WO2004072646A1 (en) * | 2003-02-13 | 2004-08-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 5 (gpr5) |
| EP1698902A1 (en) * | 2005-03-01 | 2006-09-06 | DKFZ Deutsches Krebsforschungszentrum | Use of XCR1 for diagnosing or monitoring of immune tolerance |
| CN101293924A (zh) * | 2007-04-24 | 2008-10-29 | 上海国健生物技术研究院 | 骨桥蛋白的功能表位、与其特异性结合的单克隆抗体及其在制备抗肿瘤转移药物中的用途 |
| EP2062592A1 (en) * | 2007-11-20 | 2009-05-27 | BUNDESREPUBLIK DEUTSCHLAND letztvertreten durch das Robert Koch-Institut vertreten durch seinen Präsidenten | System for delivery into a XCR1 positive cell and uses thereof |
| KR20110128876A (ko) | 2009-02-16 | 2011-11-30 | 바이오렉스 쎄라퓨틱스, 인코포레이티드 | 인간화된 항-ｃｄ20 항체 및 이용 방법 |
-
2012
- 2012-08-30 PH PH1/2014/500384A patent/PH12014500384A1/en unknown
- 2012-08-30 AR ARP120103217A patent/AR087749A1/es unknown
- 2012-08-30 US US14/240,090 patent/US9371389B2/en not_active Expired - Fee Related
- 2012-08-30 IN IN1466CHN2014 patent/IN2014CN01466A/en unknown
- 2012-08-30 JP JP2014509528A patent/JP5989096B2/ja not_active Expired - Fee Related
- 2012-08-30 BR BR112014004352A patent/BR112014004352A2/pt not_active Application Discontinuation
- 2012-08-30 ES ES12761822T patent/ES2684173T3/es active Active
- 2012-08-30 KR KR1020147004507A patent/KR101767717B1/ko not_active Expired - Fee Related
- 2012-08-30 CN CN201280041366.2A patent/CN103764680B/zh not_active Expired - Fee Related
- 2012-08-30 AU AU2012302596A patent/AU2012302596B2/en not_active Ceased
- 2012-08-30 EP EP12761822.1A patent/EP2751140B1/en not_active Not-in-force
- 2012-08-30 TW TW101131633A patent/TWI563004B/zh not_active IP Right Cessation
- 2012-08-30 MY MYPI2014700412A patent/MY166152A/en unknown
- 2012-08-30 RU RU2014106832A patent/RU2619180C2/ru not_active IP Right Cessation
- 2012-08-30 HK HK14112359.4A patent/HK1199038A1/xx unknown
- 2012-08-30 MX MX2014002078A patent/MX346560B/es active IP Right Grant
- 2012-08-30 WO PCT/JP2012/072667 patent/WO2013032032A1/en not_active Ceased
- 2012-08-30 CA CA2846370A patent/CA2846370C/en not_active Expired - Fee Related
-
2014
- 2014-02-20 IL IL231075A patent/IL231075A/en active IP Right Grant
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