JP2014522817A5 - - Google Patents
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- JP2014522817A5 JP2014522817A5 JP2014517211A JP2014517211A JP2014522817A5 JP 2014522817 A5 JP2014522817 A5 JP 2014522817A5 JP 2014517211 A JP2014517211 A JP 2014517211A JP 2014517211 A JP2014517211 A JP 2014517211A JP 2014522817 A5 JP2014522817 A5 JP 2014522817A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- day
- administered
- composition
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 12
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 10
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 8
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 6
- 229960004308 acetylcysteine Drugs 0.000 claims 6
- 235000019136 lipoic acid Nutrition 0.000 claims 6
- 229960002663 thioctic acid Drugs 0.000 claims 6
- 229960004441 tyrosine Drugs 0.000 claims 6
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 5
- 239000002269 analeptic agent Substances 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 206010016256 fatigue Diseases 0.000 claims 4
- 229940011671 vitamin b6 Drugs 0.000 claims 4
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 2
- 229930003779 Vitamin B12 Natural products 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 2
- 229940025084 amphetamine Drugs 0.000 claims 2
- 229960004823 armodafinil Drugs 0.000 claims 2
- YFGHCGITMMYXAQ-LJQANCHMSA-N armodafinil Chemical compound C=1C=CC=CC=1C([S@](=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-LJQANCHMSA-N 0.000 claims 2
- LUCXVPAZUDVVBT-UNTBIKODSA-N atomoxetine hydrochloride Chemical compound Cl.O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C LUCXVPAZUDVVBT-UNTBIKODSA-N 0.000 claims 2
- 235000013734 beta-carotene Nutrition 0.000 claims 2
- 239000011648 beta-carotene Substances 0.000 claims 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 2
- 229960002747 betacarotene Drugs 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 229960001344 methylphenidate Drugs 0.000 claims 2
- 239000011785 micronutrient Substances 0.000 claims 2
- 235000013369 micronutrients Nutrition 0.000 claims 2
- 229960001165 modafinil Drugs 0.000 claims 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
- 235000008160 pyridoxine Nutrition 0.000 claims 2
- 239000011677 pyridoxine Substances 0.000 claims 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 2
- 235000019163 vitamin B12 Nutrition 0.000 claims 2
- 239000011715 vitamin B12 Substances 0.000 claims 2
- 235000019158 vitamin B6 Nutrition 0.000 claims 2
- 239000011726 vitamin B6 Substances 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 claims 1
- 208000006154 Chronic hepatitis C Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 229960002430 atomoxetine Drugs 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960001042 dexmethylphenidate Drugs 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- JUMYIBMBTDDLNG-OJERSXHUSA-N hydron;methyl (2r)-2-phenyl-2-[(2r)-piperidin-2-yl]acetate;chloride Chemical compound Cl.C([C@@H]1[C@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 JUMYIBMBTDDLNG-OJERSXHUSA-N 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 235000011649 selenium Nutrition 0.000 claims 1
- 229940091258 selenium supplement Drugs 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 235000016804 zinc Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500869P | 2011-06-24 | 2011-06-24 | |
| US61/500,869 | 2011-06-24 | ||
| PCT/US2012/043756 WO2012178014A1 (en) | 2011-06-24 | 2012-06-22 | Compositions and methods for treatment of chronic fatigue |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017084218A Division JP6574809B2 (ja) | 2011-06-24 | 2017-04-21 | 慢性疲労の治療用の組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014522817A JP2014522817A (ja) | 2014-09-08 |
| JP2014522817A5 true JP2014522817A5 (enExample) | 2015-07-30 |
Family
ID=47362061
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517211A Pending JP2014522817A (ja) | 2011-06-24 | 2012-06-22 | 慢性疲労の治療用の組成物および方法 |
| JP2017084218A Expired - Fee Related JP6574809B2 (ja) | 2011-06-24 | 2017-04-21 | 慢性疲労の治療用の組成物および方法 |
| JP2019091840A Pending JP2019147826A (ja) | 2011-06-24 | 2019-05-15 | 慢性疲労の治療用の組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017084218A Expired - Fee Related JP6574809B2 (ja) | 2011-06-24 | 2017-04-21 | 慢性疲労の治療用の組成物および方法 |
| JP2019091840A Pending JP2019147826A (ja) | 2011-06-24 | 2019-05-15 | 慢性疲労の治療用の組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2723448B1 (enExample) |
| JP (3) | JP2014522817A (enExample) |
| AU (3) | AU2012272731A1 (enExample) |
| CA (1) | CA2840363A1 (enExample) |
| ES (1) | ES2626651T3 (enExample) |
| WO (1) | WO2012178014A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2840363A1 (en) * | 2011-06-24 | 2012-12-27 | K-Pax Pharmaceuticals, Inc. | Compositions comprising a central nervous system stimulant and select micronutrients useful in the treatment of chronic fatigue |
| CN104055759B (zh) * | 2014-06-16 | 2016-08-31 | 重庆工商大学 | 一种药物组合物及其应用 |
| BR112017002911A2 (pt) * | 2015-10-13 | 2017-12-12 | Asan Found | composição para prevenção ou tratamento de obesidade contendo ácido alfa-lipóico e n-acetilcisteína como ingredientes ativos |
| GB201811312D0 (en) * | 2018-07-10 | 2018-08-29 | Nuchido Ltd | Compositions |
| WO2020176807A1 (en) | 2019-02-27 | 2020-09-03 | Vanderbilt University | Methods of treating trigeminal nerve pain |
| RU2709501C1 (ru) * | 2019-10-15 | 2019-12-18 | Виктор Александрович Сисев | Фармацевтическая композиция для парентерального капельного введения |
| JP7627100B2 (ja) * | 2020-09-30 | 2025-02-05 | 森永乳業株式会社 | 貧血の予防又は治療用組成物、血中ヘモグロビン濃度の増加又は低下予防用組成物、及び血中赤血球数の増加又は低下予防用組成物 |
| JP2024163642A (ja) * | 2023-05-12 | 2024-11-22 | アピ株式会社 | 外用組成物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096712A (en) * | 1990-03-06 | 1992-03-17 | Interneuron Pharmaceuticals, Inc. | Method for enhancing performance so as to improve vigor and decrease fatigue, confusion, tension, and anxiety |
| GB2355191A (en) * | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
| WO2005000203A2 (en) * | 2001-10-31 | 2005-01-06 | Sention, Inc. | Methods for treating cognitive impairment and improving cognition |
| GB2381451A (en) * | 2001-11-01 | 2003-05-07 | New Technology Res Ltd | Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect |
| US7585523B2 (en) * | 2002-08-27 | 2009-09-08 | Targeted Medical Pharma | Composition and method to augment and sustain neurotransmitter production |
| CA2550625C (en) * | 2003-12-31 | 2013-05-28 | Integrative Health Consulting, Inc. | Nutrient compositions and methods for enhanced effectiveness of the immune system |
| ITRM20040606A1 (it) * | 2004-12-13 | 2005-03-13 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per il trattamento della sindrome fibromialgica. |
| US20060257502A1 (en) * | 2005-05-11 | 2006-11-16 | Jiankang Liu | A combination of mitochondrial nutrients for relieving stress, preventing and improving stress-related disorders |
| EP2153831A4 (en) * | 2007-05-31 | 2010-12-15 | Suntory Holdings Ltd | ANTIERMÜDUNGSMITTEL AND ORAL COMPOSITION, BOTH WITH ANDROGRAPHOLIDE AS ACTIVE INGREDIENTS |
| CA2840363A1 (en) * | 2011-06-24 | 2012-12-27 | K-Pax Pharmaceuticals, Inc. | Compositions comprising a central nervous system stimulant and select micronutrients useful in the treatment of chronic fatigue |
-
2012
- 2012-06-22 CA CA2840363A patent/CA2840363A1/en not_active Abandoned
- 2012-06-22 EP EP12803463.4A patent/EP2723448B1/en not_active Not-in-force
- 2012-06-22 ES ES12803463.4T patent/ES2626651T3/es active Active
- 2012-06-22 AU AU2012272731A patent/AU2012272731A1/en not_active Abandoned
- 2012-06-22 JP JP2014517211A patent/JP2014522817A/ja active Pending
- 2012-06-22 EP EP17166089.7A patent/EP3248653A1/en not_active Withdrawn
- 2012-06-22 WO PCT/US2012/043756 patent/WO2012178014A1/en not_active Ceased
-
2017
- 2017-04-21 JP JP2017084218A patent/JP6574809B2/ja not_active Expired - Fee Related
- 2017-07-13 AU AU2017204833A patent/AU2017204833A1/en not_active Abandoned
-
2019
- 2019-03-07 AU AU2019201575A patent/AU2019201575A1/en not_active Abandoned
- 2019-05-15 JP JP2019091840A patent/JP2019147826A/ja active Pending
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