JP2014521737A5 - - Google Patents
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- Publication number
- JP2014521737A5 JP2014521737A5 JP2014525462A JP2014525462A JP2014521737A5 JP 2014521737 A5 JP2014521737 A5 JP 2014521737A5 JP 2014525462 A JP2014525462 A JP 2014525462A JP 2014525462 A JP2014525462 A JP 2014525462A JP 2014521737 A5 JP2014521737 A5 JP 2014521737A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- lower alkyl
- halogens
- halogen
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11177742.1 | 2011-08-17 | ||
| EP11177742 | 2011-08-17 | ||
| PCT/EP2012/066136 WO2013024168A1 (en) | 2011-08-17 | 2012-08-17 | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521737A JP2014521737A (ja) | 2014-08-28 |
| JP2014521737A5 true JP2014521737A5 (https=) | 2015-05-28 |
| JP6051218B2 JP6051218B2 (ja) | 2016-12-27 |
Family
ID=46826450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014525462A Expired - Fee Related JP6051218B2 (ja) | 2011-08-17 | 2012-08-17 | アルツハイマー病等のタウオパチーの治療に有用なピペラジンチアジアゾール誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9187440B2 (https=) |
| EP (1) | EP2744798B1 (https=) |
| JP (1) | JP6051218B2 (https=) |
| CN (1) | CN103649062B (https=) |
| AU (1) | AU2012296804B2 (https=) |
| CA (1) | CA2841037C (https=) |
| ES (1) | ES2573299T3 (https=) |
| PL (1) | PL2744798T3 (https=) |
| WO (1) | WO2013024168A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2744798T3 (pl) * | 2011-08-17 | 2016-08-31 | Remynd Nv | Pochodne tiazolu piperazyny użyteczne w leczeniu tauopatii, takich jak choroba alzheimera |
| WO2015140130A1 (en) * | 2014-03-17 | 2015-09-24 | Remynd Nv | Oxadiazole compounds |
| WO2025104092A1 (en) * | 2023-11-13 | 2025-05-22 | Remynd N.V. | Modulators of septin 6 for use in the prevention and/or treatment of neurodegenerative disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004032567A1 (de) | 2004-07-05 | 2006-03-02 | Grünenthal GmbH | Substituierte 1-Propiolyl-piperazine |
| AU2005324024B2 (en) * | 2005-01-07 | 2011-02-17 | F. Hoffmann-La Roche Ag | [4-(Heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (GlyT-1) inhibitors for the treatment of neurological and neuropsychiatric disorders |
| EP1705474B1 (en) | 2005-03-21 | 2010-04-28 | F.Hoffmann-La Roche Ag | Method for determining lipophilicity |
| PE20070099A1 (es) * | 2005-06-30 | 2007-02-06 | Janssen Pharmaceutica Nv | N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso |
| GB0602335D0 (en) * | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
| CA2676715A1 (en) * | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| EP2726470B1 (en) * | 2011-07-01 | 2015-04-29 | reMynd NV | 1,2,4-thiadiazol-5-ylpiperazine derivatives useful in the treatment of neurodegenerative diseases |
| PL2744798T3 (pl) | 2011-08-17 | 2016-08-31 | Remynd Nv | Pochodne tiazolu piperazyny użyteczne w leczeniu tauopatii, takich jak choroba alzheimera |
-
2012
- 2012-08-17 PL PL12756402T patent/PL2744798T3/pl unknown
- 2012-08-17 ES ES12756402.9T patent/ES2573299T3/es active Active
- 2012-08-17 JP JP2014525462A patent/JP6051218B2/ja not_active Expired - Fee Related
- 2012-08-17 US US14/238,905 patent/US9187440B2/en active Active
- 2012-08-17 CN CN201280034129.3A patent/CN103649062B/zh not_active Expired - Fee Related
- 2012-08-17 EP EP12756402.9A patent/EP2744798B1/en active Active
- 2012-08-17 WO PCT/EP2012/066136 patent/WO2013024168A1/en not_active Ceased
- 2012-08-17 CA CA2841037A patent/CA2841037C/en active Active
- 2012-08-17 AU AU2012296804A patent/AU2012296804B2/en not_active Ceased
-
2015
- 2015-10-15 US US14/884,689 patent/US9808456B2/en not_active Expired - Fee Related
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