JP2014520876A5 - - Google Patents
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- JP2014520876A5 JP2014520876A5 JP2014520667A JP2014520667A JP2014520876A5 JP 2014520876 A5 JP2014520876 A5 JP 2014520876A5 JP 2014520667 A JP2014520667 A JP 2014520667A JP 2014520667 A JP2014520667 A JP 2014520667A JP 2014520876 A5 JP2014520876 A5 JP 2014520876A5
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- JP
- Japan
- Prior art keywords
- group
- compound
- formula
- compound represented
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 31
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 3
- 125000006241 alcohol protecting group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- -1 ethyloxy Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- 125000006242 amine protecting group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004185 ester group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000002560 nitrile group Chemical group 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305942 | 2011-07-20 | ||
| EP11305942.2 | 2011-07-20 | ||
| PCT/EP2012/064212 WO2013011098A1 (en) | 2011-07-20 | 2012-07-19 | Imino-sugar c-glycosides, preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014520876A JP2014520876A (ja) | 2014-08-25 |
| JP2014520876A5 true JP2014520876A5 (cg-RX-API-DMAC7.html) | 2015-08-13 |
Family
ID=46551544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520667A Pending JP2014520876A (ja) | 2011-07-20 | 2012-07-19 | イミノ糖ｃ−グリコシド、その製造および使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140296288A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2734534A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014520876A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2842015A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013011098A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3105235B1 (en) * | 2014-02-12 | 2019-11-06 | Amicus Therapeutics, Inc. | Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of mps iiic |
| PL3984994T3 (pl) | 2016-02-04 | 2024-11-04 | Takeda Pharmaceutical Company Limited | Podstawiony związek piperydyny jako agonista oreksyny typu 2 do leczenia narkolepsji |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62155291A (ja) * | 1985-12-20 | 1987-07-10 | バイエル・アクチエンゲゼルシヤフト | ３−アミノ−４，５−ジヒドロキシピペリジン類、それらの製造方法及びそれらの使用 |
| DE3620645A1 (de) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
| GB0622702D0 (en) * | 2006-11-15 | 2006-12-27 | Univ Dundee | Selective glycosidase inhibitors |
| EP2323652A2 (en) * | 2008-08-06 | 2011-05-25 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
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2012
- 2012-07-19 US US14/233,713 patent/US20140296288A1/en not_active Abandoned
- 2012-07-19 WO PCT/EP2012/064212 patent/WO2013011098A1/en not_active Ceased
- 2012-07-19 CA CA 2842015 patent/CA2842015A1/en not_active Abandoned
- 2012-07-19 EP EP12738107.7A patent/EP2734534A1/en not_active Withdrawn
- 2012-07-19 JP JP2014520667A patent/JP2014520876A/ja active Pending