JP2014520147A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014520147A5 JP2014520147A5 JP2014517091A JP2014517091A JP2014520147A5 JP 2014520147 A5 JP2014520147 A5 JP 2014520147A5 JP 2014517091 A JP2014517091 A JP 2014517091A JP 2014517091 A JP2014517091 A JP 2014517091A JP 2014520147 A5 JP2014520147 A5 JP 2014520147A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- benzo
- dihydroisoxazol
- methylcarbamoyl
- quinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 11
- 229940079593 drug Drugs 0.000 claims 9
- 108060008539 Transglutaminase Proteins 0.000 claims 7
- 102000003601 transglutaminase Human genes 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 5
- -1 sec-butyldisulfanyl Chemical group 0.000 claims 5
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- SEBPGRSSPNLOGD-UHFFFAOYSA-N 2-(butan-2-yldisulfanyl)-1,3-benzothiazole Chemical compound C1=CC=C2SC(SSC(C)CC)=NC2=C1 SEBPGRSSPNLOGD-UHFFFAOYSA-N 0.000 claims 2
- GKOFVQMAKBQPDS-UHFFFAOYSA-N 2-(butan-2-yldisulfanyl)-6-nitro-1h-benzimidazole Chemical compound C1=C([N+]([O-])=O)C=C2NC(SSC(C)CC)=NC2=C1 GKOFVQMAKBQPDS-UHFFFAOYSA-N 0.000 claims 2
- XXLFTWNQPCRCES-UHFFFAOYSA-N 2-(cyclohexyldisulfanyl)-1h-benzimidazole Chemical compound C1CCCCC1SSC1=NC2=CC=CC=C2N1 XXLFTWNQPCRCES-UHFFFAOYSA-N 0.000 claims 2
- XSOKDCYWAQPFME-UHFFFAOYSA-N 2-(cyclopentyldisulfanyl)-1h-benzimidazole Chemical compound C1CCCC1SSC1=NC2=CC=CC=C2N1 XSOKDCYWAQPFME-UHFFFAOYSA-N 0.000 claims 2
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 claims 2
- 102000002933 Thioredoxin Human genes 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 claims 2
- 108060008226 thioredoxin Proteins 0.000 claims 2
- 229940094937 thioredoxin Drugs 0.000 claims 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 108700039882 Protein Glutamine gamma Glutamyltransferase 2 Proteins 0.000 claims 1
- 102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000107 disulfanyl group Chemical group [*]SS[H] 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161499044P | 2011-06-20 | 2011-06-20 | |
| US61/499,044 | 2011-06-20 | ||
| PCT/US2012/043150 WO2012177640A2 (en) | 2011-06-20 | 2012-06-19 | Modulation of tissue transglutaminase activation in disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014520147A JP2014520147A (ja) | 2014-08-21 |
| JP2014520147A5 true JP2014520147A5 (enExample) | 2015-08-13 |
Family
ID=47423169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517091A Pending JP2014520147A (ja) | 2011-06-20 | 2012-06-19 | 疾患における組織トランスグルタミナーゼ活性化の調節 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20140322278A1 (enExample) |
| EP (1) | EP2721169A4 (enExample) |
| JP (1) | JP2014520147A (enExample) |
| AU (1) | AU2012273105A1 (enExample) |
| CA (1) | CA2839549A1 (enExample) |
| WO (1) | WO2012177640A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015116846A1 (en) * | 2014-01-30 | 2015-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of tissue transglutaminase activation in disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040116496A1 (en) * | 1996-12-06 | 2004-06-17 | Lynn Kirkpatrick | Asymmetric Disulfides and methods of using same |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| AU2003234597A1 (en) * | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US20040259176A1 (en) * | 2003-02-25 | 2004-12-23 | Cerione Richard A. | Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity |
| US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
-
2012
- 2012-06-19 AU AU2012273105A patent/AU2012273105A1/en not_active Abandoned
- 2012-06-19 EP EP12801941.1A patent/EP2721169A4/en not_active Withdrawn
- 2012-06-19 JP JP2014517091A patent/JP2014520147A/ja active Pending
- 2012-06-19 CA CA2839549A patent/CA2839549A1/en not_active Abandoned
- 2012-06-19 WO PCT/US2012/043150 patent/WO2012177640A2/en not_active Ceased
- 2012-06-19 US US14/126,629 patent/US20140322278A1/en not_active Abandoned
-
2017
- 2017-04-12 US US15/485,958 patent/US20170266198A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010529118A5 (enExample) | ||
| EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
| JP2011522816A5 (enExample) | ||
| JP2010536849A5 (enExample) | ||
| FI3811943T3 (fi) | Yhdiste käytettäväksi silmäsairauksien hoidossa | |
| BR112013032122A2 (pt) | liberação modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)fenil] benzamida solubilizada usando ácidos orgânicos | |
| JP2011516477A5 (enExample) | ||
| RU2014120792A (ru) | Способ лечения стромальных опухолей желудочно-кишечного тракта | |
| JP2010222367A5 (enExample) | ||
| IL223783B (en) | Compound 1-converted indole for use in the treatment of a disease or condition, a pharmaceutical preparation containing the compound and use of the compound to prepare a medicine | |
| IL199152A (en) | Annals 2 - (piperidine-4-ram) -4-phenoxy or phenylamino-pyrimidine, containing and containing pharmaceutical preparations for the preparation of viral infections | |
| HRP20151000T1 (hr) | Antivirusni spojevi | |
| IL216741A (en) | History of imidazolidine-2-van 1,3-imaging modalities as 17-cyp inhibitors, pharmaceutical preparations containing them, and their use in the preparation of drugs for the treatment of diseases | |
| EA021275B9 (ru) | Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение для лечения pask-опосредованного заболевания | |
| MX377802B (es) | Metodos y composiciones para trastornos del sueño y otros trastornos. | |
| CL2007002347A1 (es) | Compuestos derivados de fenilo, piridina y quinolina; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto en el tratamiento de diabetes mellitus, trastornos en la tolerancia de la glucosa, obesidad, enfermedad de crohn, enferm | |
| JP2009500443A5 (enExample) | ||
| JP2012136529A5 (enExample) | ||
| WO2008078424A1 (ja) | ベンゾキサゾール誘導体 | |
| WO2009099553A3 (en) | Use of kinase inhibitor in treatment of atherosclerosis | |
| JP2020529995A5 (enExample) | ||
| HRP20241716T1 (hr) | Postupci liječenja promjena u ponašanju | |
| CL2007002195A1 (es) | Compuesto n-((1r,2s,5r)-5-(isopropil(metil)amino)-2-((s)-2-oxo-3-(6-(trifluorometil)quinazolin-4-ilamino)pirrolidin-1-il)ciclohexil)acetamida; forma cristalina del compuesto; composicion farmaceutica; y uso en el tratamiento de enfermedades tales com | |
| JP2015518007A5 (enExample) | ||
| FR2918282B1 (fr) | Medicament pour le traitement de la maladie de parkinson |