JP2014518255A5 - - Google Patents
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- Publication number
- JP2014518255A5 JP2014518255A5 JP2014518000A JP2014518000A JP2014518255A5 JP 2014518255 A5 JP2014518255 A5 JP 2014518255A5 JP 2014518000 A JP2014518000 A JP 2014518000A JP 2014518000 A JP2014518000 A JP 2014518000A JP 2014518255 A5 JP2014518255 A5 JP 2014518255A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- methoxyphenyl
- dihydro
- trifluoromethyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PRQZENXGVVLPIF-UHFFFAOYSA-N 1-chloro-3h-indol-2-one Chemical compound C1=CC=C2N(Cl)C(=O)CC2=C1 PRQZENXGVVLPIF-UHFFFAOYSA-N 0.000 claims 2
- SCRXASNUPJPFGP-UHFFFAOYSA-N 1-fluoro-3h-indol-2-one Chemical compound C1=CC=C2N(F)C(=O)CC2=C1 SCRXASNUPJPFGP-UHFFFAOYSA-N 0.000 claims 2
- HWSLMIXAPNOWGU-AWEZNQCLSA-N (3s)-1-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2[C@H](F)C1=O HWSLMIXAPNOWGU-AWEZNQCLSA-N 0.000 claims 1
- MJKHLWVXDGUTSW-AWEZNQCLSA-N (3s)-3-chloro-1-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2[C@H](Cl)C1=O MJKHLWVXDGUTSW-AWEZNQCLSA-N 0.000 claims 1
- HWSLMIXAPNOWGU-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2C(F)C1=O HWSLMIXAPNOWGU-UHFFFAOYSA-N 0.000 claims 1
- MJKHLWVXDGUTSW-UHFFFAOYSA-N 3-chloro-1-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-3h-indol-2-one Chemical compound COC1=CC=C(Cl)C=C1N1C2=CC(C(F)(F)F)=CC=C2C(Cl)C1=O MJKHLWVXDGUTSW-UHFFFAOYSA-N 0.000 claims 1
- 208000001914 Fragile X syndrome Diseases 0.000 claims 1
- 102000004257 Potassium Channel Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108020001213 potassium channel Proteins 0.000 claims 1
- 239000004036 potassium channel stimulating agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11171532.2 | 2011-06-27 | ||
| EP11171532A EP2540295A1 (en) | 2011-06-27 | 2011-06-27 | Compositions for the treatment of Fragile X syndrome |
| PCT/IB2012/053089 WO2013001412A1 (en) | 2011-06-27 | 2012-06-19 | Compositions for the treatment of fragile x syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518255A JP2014518255A (ja) | 2014-07-28 |
| JP2014518255A5 true JP2014518255A5 (https=) | 2015-07-16 |
| JP6012726B2 JP6012726B2 (ja) | 2016-10-25 |
Family
ID=44840530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518000A Active JP6012726B2 (ja) | 2011-06-27 | 2012-06-19 | 脆弱ｘ症候群の治療用組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10435366B2 (https=) |
| EP (2) | EP2540295A1 (https=) |
| JP (1) | JP6012726B2 (https=) |
| DK (1) | DK2723336T3 (https=) |
| ES (1) | ES2797395T3 (https=) |
| PL (1) | PL2723336T3 (https=) |
| PT (1) | PT2723336T (https=) |
| WO (1) | WO2013001412A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2540295A1 (en) * | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
| CA2907494C (en) * | 2013-03-15 | 2022-10-04 | The Children's Hospital Of Philadelphia | Magnetoencephalography biomarkers of gaba-b agonist drug activity in autism spectrum disorders |
| WO2016128771A1 (en) | 2015-02-13 | 2016-08-18 | Canbex Therapeutics Limited | Compounds for treating disorders associated with bk channel modulation |
| CN110545809A (zh) | 2017-02-24 | 2019-12-06 | 奥维德医疗公司 | 治疗发作性疾病的方法 |
| US11730769B2 (en) | 2017-12-22 | 2023-08-22 | Children's Medical Center Corporation | Compositions and methods for Williams Syndrome (WS) therapy |
| EP3912625A1 (en) * | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| WO2025233532A1 (en) | 2024-05-10 | 2025-11-13 | Les Laboratoires Servier | Maxi-k potassium channel openers and therapeutic applications thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| US20020045566A1 (en) * | 2000-10-13 | 2002-04-18 | Gribkoff Valentin K. | Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof |
| HUP0400063A2 (hu) * | 2001-02-20 | 2004-04-28 | Bristol-Myers Squibb Company | Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| CA2438868A1 (en) * | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| FR2857452B1 (fr) * | 2003-07-11 | 2005-09-30 | Univ Rabelais Francois | Test de depistage de l'autisme, methode de selection de patients repondant audit test et utilisation des medicaments activateurs de canaux bkca pour le traitement de ladite maladie |
| DE102004053673A1 (de) * | 2004-11-03 | 2006-05-04 | Endress + Hauser Flowtec Ag | Vorrichtung zur Bestimmung und/oder Überwachung des Volumen- und/oder Massendurchflusses eines Mediums |
| US20110294782A1 (en) | 2006-11-10 | 2011-12-01 | Massachusetts Institute Of Technology | Small molecule pak inhibitors |
| US20100316678A1 (en) * | 2007-06-28 | 2010-12-16 | Cnsbio Pty Ltd. | Combination methods and compositions for treatment of neuropathic pain |
| EP2540295A1 (en) * | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
-
2011
- 2011-06-27 EP EP11171532A patent/EP2540295A1/en not_active Withdrawn
-
2012
- 2012-06-19 PL PL12735048T patent/PL2723336T3/pl unknown
- 2012-06-19 ES ES12735048T patent/ES2797395T3/es active Active
- 2012-06-19 EP EP12735048.6A patent/EP2723336B1/en active Active
- 2012-06-19 US US14/128,154 patent/US10435366B2/en active Active
- 2012-06-19 WO PCT/IB2012/053089 patent/WO2013001412A1/en not_active Ceased
- 2012-06-19 JP JP2014518000A patent/JP6012726B2/ja active Active
- 2012-06-19 PT PT127350486T patent/PT2723336T/pt unknown
- 2012-06-19 DK DK12735048.6T patent/DK2723336T3/da active
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