JP2014517037A5 - - Google Patents
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- Publication number
- JP2014517037A5 JP2014517037A5 JP2014515915A JP2014515915A JP2014517037A5 JP 2014517037 A5 JP2014517037 A5 JP 2014517037A5 JP 2014515915 A JP2014515915 A JP 2014515915A JP 2014515915 A JP2014515915 A JP 2014515915A JP 2014517037 A5 JP2014517037 A5 JP 2014517037A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- group
- composition according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102100026437 Branched-chain-amino-acid aminotransferase, cytosolic Human genes 0.000 claims 3
- 101000766268 Homo sapiens Branched-chain-amino-acid aminotransferase, cytosolic Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- IEHMHYAHHVRZIF-UHFFFAOYSA-N 4-methyl-5-oxohexanoic acid Chemical group CC(=O)C(C)CCC(O)=O IEHMHYAHHVRZIF-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161520645P | 2011-06-13 | 2011-06-13 | |
| US61/520,645 | 2011-06-13 | ||
| PCT/US2012/042046 WO2012173987A2 (en) | 2011-06-13 | 2012-06-12 | Methods of treatment using a bcat1 inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016228528A Division JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517037A JP2014517037A (ja) | 2014-07-17 |
| JP2014517037A5 true JP2014517037A5 (cg-RX-API-DMAC7.html) | 2015-07-23 |
| JP6053768B2 JP6053768B2 (ja) | 2016-12-27 |
Family
ID=47357689
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515915A Expired - Fee Related JP6053768B2 (ja) | 2011-06-13 | 2012-06-12 | Ｂｃａｔ１阻害剤を使用する治療方法 |
| JP2016228528A Expired - Fee Related JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016228528A Expired - Fee Related JP6243996B2 (ja) | 2011-06-13 | 2016-11-25 | Ｂｃａｔ１阻害剤を使用する治療方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9422224B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2717869B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6053768B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012173987A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10941109B2 (en) | 2011-06-13 | 2021-03-09 | Ergon Pharmaceuticals Llc | Compositions and methods of treatment using a BCAT1 inhibitor |
| KR101775761B1 (ko) | 2014-07-30 | 2017-09-19 | 주식회사 엘지화학 | 변성 공액 디엔계 중합체, 이를 포함하는 변성 고무 조성물 및 변성 공액 디엔계 중합체의 제조방법 |
| ITUB20151014A1 (it) * | 2015-05-27 | 2016-11-27 | Univ Degli Studi Del Piemonte Orientale Amedeo Avogadro | Ligandi del recettore b7h nel trattamento di osteopenia e osteoporosi |
| EP4446338A3 (en) * | 2015-09-23 | 2025-05-07 | Pfizer Inc. | Cells and method of cell culture |
| JP7256509B2 (ja) * | 2016-08-22 | 2023-04-12 | エルゴン ファーマシューティカルズ エルエルシー | Ｂｃａｔ１阻害剤を使用する組成物及び治療方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626069A (zh) * | 1999-12-08 | 2005-06-15 | 沃尼尔·朗伯公司 | 支链氨基酸依赖性氨基转移酶的抑制剂及其在治疗糖尿病性视网膜病中的应用 |
| DE60111639T2 (de) * | 2000-09-19 | 2006-04-27 | Warner-Lambert Co. Llc | Hemmer der verzweigten aminosäure-abhängigen aminotransferase und deren verwendung in der behandlung von neurodegenerativen erkrankungen |
| EP1756039B1 (en) * | 2004-05-14 | 2012-10-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US7842467B1 (en) | 2005-05-12 | 2010-11-30 | Celera Corporation | Breast disease targets and uses thereof |
| GB0705400D0 (en) * | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| EP2427430B1 (en) * | 2009-05-04 | 2014-09-10 | The Royal Institution for the Advancement of Learning/McGill University | 5-oxo-ete receptor antagonist compounds |
| EP2481801A1 (en) * | 2011-01-28 | 2012-08-01 | Deutsches Krebsforschungszentrum | Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia |
-
2012
- 2012-06-12 WO PCT/US2012/042046 patent/WO2012173987A2/en not_active Ceased
- 2012-06-12 EP EP12800655.8A patent/EP2717869B1/en not_active Not-in-force
- 2012-06-12 US US14/125,687 patent/US9422224B2/en not_active Expired - Fee Related
- 2012-06-12 JP JP2014515915A patent/JP6053768B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-25 JP JP2016228528A patent/JP6243996B2/ja not_active Expired - Fee Related
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