JP2014515599A - 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 - Google Patents

炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 Download PDF

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JP2014515599A
JP2014515599A JP2014501305A JP2014501305A JP2014515599A JP 2014515599 A JP2014515599 A JP 2014515599A JP 2014501305 A JP2014501305 A JP 2014501305A JP 2014501305 A JP2014501305 A JP 2014501305A JP 2014515599 A JP2014515599 A JP 2014515599A
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デルモット ピー． マクゴバーン，
マーラ シー． ダビンスキー，
ケント ディー． テイラー，
ステファン アール． ターガン，
ジェロム アイ． ロッター
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

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JP2014501305A 2011-03-25 2012-03-26 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 Pending JP2014515599A (ja)

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US201161467881P 2011-03-25 2011-03-25
US201161467779P 2011-03-25 2011-03-25
US61/467,779 2011-03-25
US61/467,881 2011-03-25
PCT/US2012/030614 WO2012135144A2 (en) 2011-03-25 2012-03-26 Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease

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JP2016165692A Division JP2016198116A (ja) 2011-03-25 2016-08-26 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法

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JP2014515599A true JP2014515599A (ja) 2014-07-03
JP2014515599A5 JP2014515599A5 (enExample) 2015-05-14

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JP2016165692A Ceased JP2016198116A (ja) 2011-03-25 2016-08-26 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法

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US (1) US20140018447A1 (enExample)
EP (2) EP3330711A1 (enExample)
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CA (1) CA2830362A1 (enExample)
WO (1) WO2012135144A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016198116A (ja) * 2011-03-25 2016-12-01 セダーズ−シナイ メディカル センター 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法
US10633449B2 (en) 2013-03-27 2020-04-28 Cedars-Sinai Medical Center Treatment and reversal of fibrosis and inflammation by inhibition of the TL1A-DR3 signaling pathway
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
US11236393B2 (en) 2008-11-26 2022-02-01 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-TNFα therapy in inflammatory bowel disease
US11312768B2 (en) 2013-07-19 2022-04-26 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12402960B2 (en) 2010-10-11 2025-09-02 Ecole Polytechnique Federale De Lausanne (Epfl) Mechanical manipulator for surgical instruments
EP2627278B1 (en) 2010-10-11 2015-03-25 Ecole Polytechnique Fédérale de Lausanne (EPFL) Mechanical manipulator for surgical instruments
WO2013014621A2 (en) 2011-07-27 2013-01-31 Ecole Polytechnique Federale De Lausanne (Epfl) Mechanical teleoperated device for remote manipulation
US10265129B2 (en) 2014-02-03 2019-04-23 Distalmotion Sa Mechanical teleoperated device comprising an interchangeable distal instrument
EP3185808B1 (en) 2014-08-27 2022-02-23 DistalMotion SA Surgical system for microsurgical techniques
EP3653145B1 (en) 2014-12-19 2024-01-24 DistalMotion SA Reusable surgical instrument for minimally invasive procedures
WO2016097861A1 (en) 2014-12-19 2016-06-23 Distalmotion Sa Sterile interface for articulated surgical instruments
DK3232951T3 (da) 2014-12-19 2024-01-15 Distalmotion Sa Kirurgisk instrument med leddelt ende-effektor
WO2016097871A1 (en) 2014-12-19 2016-06-23 Distalmotion Sa Docking system for mechanical telemanipulator
WO2016097873A2 (en) 2014-12-19 2016-06-23 Distalmotion Sa Articulated handle for mechanical telemanipulator
EP3280337B1 (en) 2015-04-09 2019-11-13 DistalMotion SA Articulated hand-held instrument
EP4484082A3 (en) 2015-04-09 2025-03-12 Distalmotion SA Mechanical teleoperated device for remote manipulation
EP3340897B1 (en) 2015-08-28 2024-10-09 DistalMotion SA Surgical instrument with increased actuation force
US11058503B2 (en) 2017-05-11 2021-07-13 Distalmotion Sa Translational instrument interface for surgical robot and surgical robot systems comprising the same
US10477105B2 (en) * 2017-06-08 2019-11-12 Futurewei Technologies, Inc. Method and system for transmitting virtual reality (VR) content
US12376927B2 (en) 2018-02-07 2025-08-05 Distalmotion Sa Surgical robot systems comprising robotic telemanipulators and integrated laparoscopy
EP3749243A1 (en) 2018-02-07 2020-12-16 Distalmotion SA Surgical robot systems comprising robotic telemanipulators and integrated laparoscopy
WO2023037273A1 (en) 2021-09-13 2023-03-16 Distalmotion Sa Instruments for surgical robotic system and interfaces for the same
US11844585B1 (en) 2023-02-10 2023-12-19 Distalmotion Sa Surgical robotics systems and devices having a sterile restart, and methods thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100015156A1 (en) * 2007-03-06 2010-01-21 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children
US20100240077A1 (en) * 2003-04-11 2010-09-23 Cedars-Sinai Medical Center Methods of assessing crohn's disease patient phenotype by i2 serologic response

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916748A (en) * 1996-04-12 1999-06-29 Cedars-Sinai Medical Center Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20040053263A1 (en) * 2002-08-30 2004-03-18 Abreu Maria T. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
EP1613960B1 (en) * 2003-04-11 2009-06-03 Cedars-Sinai Medical Center Methods of assessing crohn's disease patient phenotype by i2, ompc and asca serologic response
US20100129838A1 (en) * 2008-11-11 2010-05-27 Prometheus Laboratories Inc. Methods for prediction of inflammatory bowel disease (ibd) using serologic markers
CA2830362A1 (en) * 2011-03-25 2012-10-04 Dermot P. Mcgovern Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100240077A1 (en) * 2003-04-11 2010-09-23 Cedars-Sinai Medical Center Methods of assessing crohn's disease patient phenotype by i2 serologic response
US20100015156A1 (en) * 2007-03-06 2010-01-21 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN5014005339; ＦＲＡＮＫＥ　ＡＮＤＲＥ: 'ＧＥＮＯＭＥ-ＷＩＤＥ　ＭＥＴＡ-ＡＮＡＬＹＳＩＳ　ＩＮＣＲＥＡＳＥＳ　ＴＯ　７１　ＴＨＥ　ＮＵＭＢＥＲ　以下備考' ＮＡＴＵＲＥ　ＧＥＮＥＴＩＣＳ Ｖ４２　Ｎ１２, 201012, Ｐ１１１８-１１２５ *
JPN6016007472; 'Ｊｏｕｒｎａｌ　ｏｆ　Ｃｒｏｈｎ'ｓ　ａｎｄ　Ｃｏｌｉｔｉｓ' ２００９，　Ｖｏｌ．３，　Ｎｏ．１，　ｐ．Ｓ９６．　＃Ｐ２１７ *
JPN6016007474; 'Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ　＆　Ｈｅｐａｔｏｌｏｇｙ' ２００８，　Ｖｏｌ．２０，　ｐｐ．３７-４５ *
JPN6016007477; 'Ｇｕｔ' １９９８，　Ｖｏｌ．４２，　ｐｐ．７８８-７９１ *
JPN6016007478; 'Ｇｕｔ' ２００４，　Ｖｏｌ．５３，　ｐｐ．１１１７-１１２２ *
JPN6016007480; 'Ｊｏｕｒｎａｌ　ｏｆ　Ｐａｔｈｏｌｏｇｙ' ２００３，　Ｖｏｌ．１９９，　ｐｐ．３６１-３６７ *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236393B2 (en) 2008-11-26 2022-02-01 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-TNFα therapy in inflammatory bowel disease
US12084722B2 (en) 2008-11-26 2024-09-10 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-TNFα therapy in inflammatory bowel disease
JP2016198116A (ja) * 2011-03-25 2016-12-01 セダーズ−シナイ メディカル センター 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法
US10633449B2 (en) 2013-03-27 2020-04-28 Cedars-Sinai Medical Center Treatment and reversal of fibrosis and inflammation by inhibition of the TL1A-DR3 signaling pathway
US11312768B2 (en) 2013-07-19 2022-04-26 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
US12269873B2 (en) 2013-07-19 2025-04-08 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2

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WO2012135144A3 (en) 2013-12-27
CA2830362A1 (en) 2012-10-04
WO2012135144A2 (en) 2012-10-04
EP3330711A1 (en) 2018-06-06
JP2016198116A (ja) 2016-12-01
US20140018447A1 (en) 2014-01-16
EP2689036A4 (en) 2015-04-15
EP2689036B1 (en) 2017-12-20
EP2689036A2 (en) 2014-01-29

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