JP2014515599A5 - - Google Patents
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- JP2014515599A5 JP2014515599A5 JP2014501305A JP2014501305A JP2014515599A5 JP 2014515599 A5 JP2014515599 A5 JP 2014515599A5 JP 2014501305 A JP2014501305 A JP 2014501305A JP 2014501305 A JP2014501305 A JP 2014501305A JP 2014515599 A5 JP2014515599 A5 JP 2014515599A5
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- JP
- Japan
- Prior art keywords
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- genetic variant
- serological marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000002068 genetic effect Effects 0.000 claims description 46
- 230000000405 serological effect Effects 0.000 claims description 32
- 239000003550 marker Substances 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 17
- 208000029725 Metabolic bone disease Diseases 0.000 claims description 16
- 241001408449 Asca Species 0.000 claims description 12
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 10
- 208000011231 Crohn disease Diseases 0.000 claims description 8
- 206010018691 Granuloma Diseases 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims description 4
- 102100030461 Alpha-ketoglutarate-dependent dioxygenase FTO Human genes 0.000 claims description 4
- 102100021597 Endoplasmic reticulum aminopeptidase 2 Human genes 0.000 claims description 4
- 101001062620 Homo sapiens Alpha-ketoglutarate-dependent dioxygenase FTO Proteins 0.000 claims description 4
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 4
- 101000634537 Homo sapiens Neuronal PAS domain-containing protein 2 Proteins 0.000 claims description 4
- 101000830596 Homo sapiens Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 4
- 108090000174 Interleukin-10 Proteins 0.000 claims description 4
- 102000003814 Interleukin-10 Human genes 0.000 claims description 4
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 claims description 4
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 claims description 4
- 102100034256 Mucin-1 Human genes 0.000 claims description 4
- 102100029045 Neuronal PAS domain-containing protein 2 Human genes 0.000 claims description 4
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims description 4
- 108010080821 leucine-rich amelogenin peptide Proteins 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 230000002966 stenotic effect Effects 0.000 claims description 4
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims description 3
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims description 3
- 206010049088 Osteopenia Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108050009312 plexin Proteins 0.000 claims description 2
- 102000002022 plexin Human genes 0.000 claims description 2
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 208000037804 stenosis Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 4
- 101710151318 Cytochrome P450 10 Proteins 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467881P | 2011-03-25 | 2011-03-25 | |
| US201161467779P | 2011-03-25 | 2011-03-25 | |
| US61/467,779 | 2011-03-25 | ||
| US61/467,881 | 2011-03-25 | ||
| PCT/US2012/030614 WO2012135144A2 (en) | 2011-03-25 | 2012-03-26 | Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016165692A Division JP2016198116A (ja) | 2011-03-25 | 2016-08-26 | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515599A JP2014515599A (ja) | 2014-07-03 |
| JP2014515599A5 true JP2014515599A5 (enExample) | 2015-05-14 |
Family
ID=46932277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501305A Pending JP2014515599A (ja) | 2011-03-25 | 2012-03-26 | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
| JP2016165692A Ceased JP2016198116A (ja) | 2011-03-25 | 2016-08-26 | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016165692A Ceased JP2016198116A (ja) | 2011-03-25 | 2016-08-26 | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140018447A1 (enExample) |
| EP (2) | EP3330711A1 (enExample) |
| JP (2) | JP2014515599A (enExample) |
| CA (1) | CA2830362A1 (enExample) |
| WO (1) | WO2012135144A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US12402960B2 (en) | 2010-10-11 | 2025-09-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Mechanical manipulator for surgical instruments |
| EP2627278B1 (en) | 2010-10-11 | 2015-03-25 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Mechanical manipulator for surgical instruments |
| WO2013014621A2 (en) | 2011-07-27 | 2013-01-31 | Ecole Polytechnique Federale De Lausanne (Epfl) | Mechanical teleoperated device for remote manipulation |
| CA2830362A1 (en) * | 2011-03-25 | 2012-10-04 | Dermot P. Mcgovern | Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease |
| EP3639841B1 (en) | 2013-03-27 | 2023-09-06 | Cedars-Sinai Medical Center | Treating fibrosis by inhibiting tl1a |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| US10265129B2 (en) | 2014-02-03 | 2019-04-23 | Distalmotion Sa | Mechanical teleoperated device comprising an interchangeable distal instrument |
| EP3185808B1 (en) | 2014-08-27 | 2022-02-23 | DistalMotion SA | Surgical system for microsurgical techniques |
| EP3653145B1 (en) | 2014-12-19 | 2024-01-24 | DistalMotion SA | Reusable surgical instrument for minimally invasive procedures |
| WO2016097861A1 (en) | 2014-12-19 | 2016-06-23 | Distalmotion Sa | Sterile interface for articulated surgical instruments |
| DK3232951T3 (da) | 2014-12-19 | 2024-01-15 | Distalmotion Sa | Kirurgisk instrument med leddelt ende-effektor |
| WO2016097871A1 (en) | 2014-12-19 | 2016-06-23 | Distalmotion Sa | Docking system for mechanical telemanipulator |
| WO2016097873A2 (en) | 2014-12-19 | 2016-06-23 | Distalmotion Sa | Articulated handle for mechanical telemanipulator |
| EP3280337B1 (en) | 2015-04-09 | 2019-11-13 | DistalMotion SA | Articulated hand-held instrument |
| EP4484082A3 (en) | 2015-04-09 | 2025-03-12 | Distalmotion SA | Mechanical teleoperated device for remote manipulation |
| EP3340897B1 (en) | 2015-08-28 | 2024-10-09 | DistalMotion SA | Surgical instrument with increased actuation force |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| US11058503B2 (en) | 2017-05-11 | 2021-07-13 | Distalmotion Sa | Translational instrument interface for surgical robot and surgical robot systems comprising the same |
| US10477105B2 (en) * | 2017-06-08 | 2019-11-12 | Futurewei Technologies, Inc. | Method and system for transmitting virtual reality (VR) content |
| US12376927B2 (en) | 2018-02-07 | 2025-08-05 | Distalmotion Sa | Surgical robot systems comprising robotic telemanipulators and integrated laparoscopy |
| EP3749243A1 (en) | 2018-02-07 | 2020-12-16 | Distalmotion SA | Surgical robot systems comprising robotic telemanipulators and integrated laparoscopy |
| WO2023037273A1 (en) | 2021-09-13 | 2023-03-16 | Distalmotion Sa | Instruments for surgical robotic system and interfaces for the same |
| US11844585B1 (en) | 2023-02-10 | 2023-12-19 | Distalmotion Sa | Surgical robotics systems and devices having a sterile restart, and methods thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916748A (en) * | 1996-04-12 | 1999-06-29 | Cedars-Sinai Medical Center | Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis |
| USH2191H1 (en) * | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| EP1613960B1 (en) * | 2003-04-11 | 2009-06-03 | Cedars-Sinai Medical Center | Methods of assessing crohn's disease patient phenotype by i2, ompc and asca serologic response |
| US7662569B2 (en) * | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| US20100129838A1 (en) * | 2008-11-11 | 2010-05-27 | Prometheus Laboratories Inc. | Methods for prediction of inflammatory bowel disease (ibd) using serologic markers |
| CA2830362A1 (en) * | 2011-03-25 | 2012-10-04 | Dermot P. Mcgovern | Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease |
-
2012
- 2012-03-26 CA CA2830362A patent/CA2830362A1/en not_active Abandoned
- 2012-03-26 EP EP17208382.6A patent/EP3330711A1/en not_active Withdrawn
- 2012-03-26 US US14/007,391 patent/US20140018447A1/en not_active Abandoned
- 2012-03-26 WO PCT/US2012/030614 patent/WO2012135144A2/en not_active Ceased
- 2012-03-26 EP EP12765854.0A patent/EP2689036B1/en not_active Not-in-force
- 2012-03-26 JP JP2014501305A patent/JP2014515599A/ja active Pending
-
2016
- 2016-08-26 JP JP2016165692A patent/JP2016198116A/ja not_active Ceased
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