JP2014515354A5 - - Google Patents
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- JP2014515354A5 JP2014515354A5 JP2014511580A JP2014511580A JP2014515354A5 JP 2014515354 A5 JP2014515354 A5 JP 2014515354A5 JP 2014511580 A JP2014511580 A JP 2014511580A JP 2014511580 A JP2014511580 A JP 2014511580A JP 2014515354 A5 JP2014515354 A5 JP 2014515354A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- hydrogen
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- -1 amino, Fmoc Chemical class 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000638 benzylaminocarbonyl group Chemical group C(C1=CC=CC=C1)NC(=O)* 0.000 claims 2
- 229960002173 citrulline Drugs 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 2
- AUDYZXNUHIIGRB-UHFFFAOYSA-N 3-thiophen-2-ylpyrrole-2,5-dione Chemical compound O=C1NC(=O)C(C=2SC=CC=2)=C1 AUDYZXNUHIIGRB-UHFFFAOYSA-N 0.000 claims 1
- 238000006845 Michael addition reaction Methods 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488023P | 2011-05-19 | 2011-05-19 | |
| US61/488,023 | 2011-05-19 | ||
| PCT/US2012/038562 WO2012159027A2 (en) | 2011-05-19 | 2012-05-18 | Osw-1 analogs and conjugates, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515354A JP2014515354A (ja) | 2014-06-30 |
| JP2014515354A5 true JP2014515354A5 (enExample) | 2015-07-09 |
Family
ID=47177654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511580A Pending JP2014515354A (ja) | 2011-05-19 | 2012-05-18 | Ｏｓｗ−１類似体および抱合体、ならびにそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9790253B2 (enExample) |
| EP (1) | EP2710024A4 (enExample) |
| JP (1) | JP2014515354A (enExample) |
| CN (1) | CN103857689A (enExample) |
| WO (1) | WO2012159027A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056236A (zh) * | 2015-08-13 | 2015-11-18 | 暨南大学 | Orp4l在制备治疗急性髓性白血病产品中的应用 |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| CN111159770B (zh) * | 2019-12-31 | 2022-12-13 | 医渡云（北京）技术有限公司 | 文本数据脱敏方法、装置、介质及电子设备 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| FR3125047B1 (fr) * | 2021-07-06 | 2024-03-15 | Centre Nat Rech Scient | Composé de type 7a,8,9,10,11,11a-hexahydro-1H,7H-pyrano[2,3-c]xanthene, leur procédé de préparation, leurs intermédiaires et leurs applications thérapeutiques. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318924A1 (de) | 1993-06-03 | 1994-12-08 | Schering Ag | Cephalostatin-Analoga |
| JPH0948794A (ja) * | 1995-06-02 | 1997-02-18 | Yutaka Sashita | ステロイド配糖体及びこれを有効成分とする医薬 |
| US7321050B2 (en) | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
| US6753414B2 (en) * | 2001-08-07 | 2004-06-22 | University Of Iowa Research Foundation, Inc. | Process for preparing saponin compounds |
| JP4741838B2 (ja) | 2002-07-31 | 2011-08-10 | シアトル ジェネティクス，インコーポレーテッド | 癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用 |
| US20050004044A1 (en) | 2003-04-07 | 2005-01-06 | Board Of Regents | Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en-22-one 16-0-(2-0-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1->3)-(2-0-acetyl-alpha-L-arabinopyranoside)] or OSW-1 and its derivatives for cancer therapeutics |
| CN104998273A (zh) | 2003-11-06 | 2015-10-28 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| AU2005227328A1 (en) | 2004-03-29 | 2005-10-06 | John A. Beutler | Schweinfurthin analogues |
| CN1844138A (zh) * | 2006-05-12 | 2006-10-11 | 中国科学院上海有机化学研究所 | 一种合成虎眼万年青皂甙的脱除保护基的方法 |
| US20110319352A1 (en) * | 2008-12-11 | 2011-12-29 | President And Fellows Of Harvard College | Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof |
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2012
- 2012-05-18 WO PCT/US2012/038562 patent/WO2012159027A2/en not_active Ceased
- 2012-05-18 CN CN201280035918.9A patent/CN103857689A/zh active Pending
- 2012-05-18 EP EP12786278.7A patent/EP2710024A4/en not_active Withdrawn
- 2012-05-18 JP JP2014511580A patent/JP2014515354A/ja active Pending
- 2012-05-18 US US14/118,589 patent/US9790253B2/en not_active Expired - Fee Related