JP2014511865A - 水溶液中で多量化できるシリル単量体、およびその使用法 - Google Patents

水溶液中で多量化できるシリル単量体、およびその使用法 Download PDF

Info

Publication number
JP2014511865A
JP2014511865A JP2014504080A JP2014504080A JP2014511865A JP 2014511865 A JP2014511865 A JP 2014511865A JP 2014504080 A JP2014504080 A JP 2014504080A JP 2014504080 A JP2014504080 A JP 2014504080A JP 2014511865 A JP2014511865 A JP 2014511865A
Authority
JP
Japan
Prior art keywords
alkyl
group
heteroaryl
phenyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014504080A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014511865A5 (enExample
Inventor
フランシス バラニー
マニッシュ ピングル
ドナルド イー． ベルイストローム
サラ エフ． ジャルディーナ
リー ダニエル アーノルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of JP2014511865A publication Critical patent/JP2014511865A/ja
Publication of JP2014511865A5 publication Critical patent/JP2014511865A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014504080A 2011-04-07 2012-04-09 水溶液中で多量化できるシリル単量体、およびその使用法 Pending JP2014511865A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473091P 2011-04-07 2011-04-07
US61/473,091 2011-04-07
PCT/US2012/032813 WO2013058825A1 (en) 2011-04-07 2012-04-09 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017212453A Division JP6757709B2 (ja) 2011-04-07 2017-11-02 水溶液中で多量化できるシリル単量体、およびその使用法

Publications (2)

Publication Number Publication Date
JP2014511865A true JP2014511865A (ja) 2014-05-19
JP2014511865A5 JP2014511865A5 (enExample) 2015-05-28

Family

ID=48141233

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014504080A Pending JP2014511865A (ja) 2011-04-07 2012-04-09 水溶液中で多量化できるシリル単量体、およびその使用法
JP2017212453A Active JP6757709B2 (ja) 2011-04-07 2017-11-02 水溶液中で多量化できるシリル単量体、およびその使用法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017212453A Active JP6757709B2 (ja) 2011-04-07 2017-11-02 水溶液中で多量化できるシリル単量体、およびその使用法

Country Status (4)

Country Link
US (2) US20140163229A1 (enExample)
EP (1) EP2693883B1 (enExample)
JP (2) JP2014511865A (enExample)
WO (1) WO2013058825A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018052952A (ja) * 2011-04-07 2018-04-05 コーネル ユニバーシティー 水溶液中で多量化できるシリル単量体、およびその使用法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140194383A1 (en) 2011-04-07 2014-07-10 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
EP3294810A4 (en) 2015-05-12 2019-01-02 Blinkbio Inc. Silicon based drug conjugates and methods of using same
AR106515A1 (es) 2015-10-29 2018-01-24 Bayer Cropscience Ag Sililfenoxiheterociclos trisustituidos y análogos
WO2017214491A1 (en) 2016-06-09 2017-12-14 Blinkbio, Inc. Silanol based therapeutic payloads
JP2020518592A (ja) 2017-05-03 2020-06-25 バイエル・アクチエンゲゼルシヤフト トリ置換シリルヘテロアリールオキシキノリン類及び類縁体
US20200115389A1 (en) 2018-09-18 2020-04-16 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118585A1 (en) * 2004-06-04 2005-12-15 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
DK8892D0 (da) * 1992-01-23 1992-01-23 Symbicom Ab Humant proteingen
JPH08302016A (ja) 1995-04-27 1996-11-19 Sumitomo Durez Co Ltd シロキサン変性ポリイミド樹脂組成物
CN1165577C (zh) 1997-05-30 2004-09-08 株式会社资生堂 含有反应性甲硅烷基的共聚物、配合有该共聚物的组合物及其处理方法
WO1999013332A1 (en) 1997-09-05 1999-03-18 Matsushita Electric Industrial Co., Ltd. Fluorescence polarization method
US6326478B1 (en) * 1998-07-08 2001-12-04 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
GB0111459D0 (en) 2001-05-10 2001-07-04 Isis Innovation Universal fluorescent sensors
US20100081792A1 (en) 2001-06-28 2010-04-01 Smithkline Beecham Corporation Ligand
WO2004071641A2 (en) 2003-02-10 2004-08-26 Pointilliste, Inc. Self-assembling arrays and uses thereof
CA2646186A1 (en) * 2006-03-21 2007-11-29 Joyant Pharmaceuticals, Inc. Small molecule apoptosis promoters
US20080255425A1 (en) 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle treated medical devices
AR066150A1 (es) 2007-04-27 2009-07-29 Isdin Sa Compuestos de benzotriazollilfenol sililados sustituidos
CA2730565A1 (en) * 2007-07-27 2009-02-05 Ensemble Discovery Corporation Detection assays and use thereof
US20110130361A1 (en) 2007-08-09 2011-06-02 Jonathan Grimm Silicon derivatives as histone deacetylase inhibitors
WO2009076373A1 (en) * 2007-12-10 2009-06-18 Concert Pharmaceuticals Inc. Heterocyclic kinase inhibitors
JP2011516547A (ja) * 2008-04-09 2011-05-26 コーネル ユニバーシティー コフェロンならびにその作製および使用方法
US9771345B2 (en) 2009-10-07 2017-09-26 Cornell University Coferons and methods of making and using them
US20140161729A1 (en) 2011-04-07 2014-06-12 Cornell University Cofluorons and methods of making and using them
US20140194383A1 (en) 2011-04-07 2014-07-10 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
WO2013058825A1 (en) * 2011-04-07 2013-04-25 Cornell University Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same
WO2015081280A1 (en) * 2013-11-26 2015-06-04 Coferon, Inc. Bromodomain ligands capable of dimerizing in an aqueous solution

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118585A1 (en) * 2004-06-04 2005-12-15 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018052952A (ja) * 2011-04-07 2018-04-05 コーネル ユニバーシティー 水溶液中で多量化できるシリル単量体、およびその使用法

Also Published As

Publication number Publication date
EP2693883B1 (en) 2018-12-26
JP2018052952A (ja) 2018-04-05
JP6757709B2 (ja) 2020-09-23
US20140163229A1 (en) 2014-06-12
EP2693883A1 (en) 2014-02-12
US20170080001A1 (en) 2017-03-23
EP2693883A4 (en) 2014-10-08
US10912786B2 (en) 2021-02-09
WO2013058825A1 (en) 2013-04-25

Similar Documents

Publication Publication Date Title
JP2018052952A (ja) 水溶液中で多量化できるシリル単量体、およびその使用法
US11970448B2 (en) Monomers capable of dimerizing in an aqueous solution, and methods of using same
JP6762299B2 (ja) 免疫調節剤
TWI352084B (en) Gsk-3 inhibitors
JP2023161027A (ja) 協同的結合に関与する化合物及びその使用
US20140243321A1 (en) Bioorthogonal monomers capable of dimerizing and targeting bromodomains, and methods of using same
US20140243286A1 (en) Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same
IL274355A (en) Aza-pyridone compounds and their uses
JP7440572B2 (ja) デュアルｍａｇｌ及びｆａａｈインヒビター
US9718782B2 (en) TrkA kinase inhibitors, compositions and methods thereof
WO2015106292A1 (en) Bcr-abl tyrosine-kinase ligands capable of dimerizing in an aqueous solution, and methods of using same
JP2022051738A (ja) 化合物
WO2016115360A1 (en) C-myc ligands capable of dimerizing in an aqueous solution, and methods of using same
JP6927548B2 (ja) ある種のタンパク質キナーゼ阻害剤
CN106831780A (zh) 具有cdk4/6和hdac抑制活性的新型杂环衍生物
US20230109505A1 (en) Small molecule inhibitors of scl15a4 with anti-inflammatory activity
US20150087043A1 (en) Monomers capable of multimerizing in an aqueous solution that employ bioorthogonal chemistries, and methods of using same
Herkommer et al. Design, synthesis, and biological evaluation of simplified side chain hybrids of the potent actin binding polyketides rhizopodin and bistramide
US20150080570A1 (en) Alpha,beta-unsaturated monomers capable of multimerization in an aqueous solution, and methods of using same
WO2013183718A1 (ja) スクリーニング方法、タンパク質の不安定性及び／又は安定性を誘導する物質、及び、タンパク質の活性評価
KR102647050B1 (ko) 면역프로테아좀 억제제
CN113825506A (zh) 结合细胞周期蛋白依赖性激酶抑制剂1b(p27kip1)的小分子
US20250250257A1 (en) Novel crystalline forms
JP2009514865A (ja) 有糸分裂キネシン阻害剤
US12503453B2 (en) USP7 inhibition

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150408

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150408

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150515

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20160520

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160520

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160720

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161018

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170120

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170705