JP2014510130A5 - - Google Patents
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- Publication number
- JP2014510130A5 JP2014510130A5 JP2014503177A JP2014503177A JP2014510130A5 JP 2014510130 A5 JP2014510130 A5 JP 2014510130A5 JP 2014503177 A JP2014503177 A JP 2014503177A JP 2014503177 A JP2014503177 A JP 2014503177A JP 2014510130 A5 JP2014510130 A5 JP 2014510130A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- influenza
- mesylate
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 2
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- FQCPPVRJPILDIK-UHFFFAOYSA-N chembl126077 Chemical compound N1C2=CC=CC=C2C(N=O)=C1C1=C(O)NC2=CC=CC=C21 FQCPPVRJPILDIK-UHFFFAOYSA-N 0.000 claims 2
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 claims 2
- 229960000928 clofarabine Drugs 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- YAEMHJKFIIIULI-UHFFFAOYSA-N n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea Chemical compound C1=CC(OC)=CC=C1CNC(=O)NC1=NC=C([N+]([O-])=O)S1 YAEMHJKFIIIULI-UHFFFAOYSA-N 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 claims 2
- 229960003425 tirofiban Drugs 0.000 claims 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
- 229960002190 topotecan hydrochloride Drugs 0.000 claims 2
- 229960003048 vinblastine Drugs 0.000 claims 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
- 235000012711 vitamin K3 Nutrition 0.000 claims 2
- 239000011652 vitamin K3 Substances 0.000 claims 2
- 229940041603 vitamin k 3 Drugs 0.000 claims 2
- ZVAGBRFUYHSUHA-LZOXOEDVSA-N (2z)-2-[(5z)-5-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole;methanesulfonic acid Chemical compound CS(O)(=O)=O.COC1=C\C(=C/2N=C3C=CC=CC3=C\2)N\C1=C/C=1NC(C)=CC=1C ZVAGBRFUYHSUHA-LZOXOEDVSA-N 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 238000011374 additional therapy Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940043075 fluocinolone Drugs 0.000 claims 1
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 1
- 229960003971 influenza vaccine Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229960005554 obatoclax mesylate Drugs 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 239000002911 sialidase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305410.0 | 2011-04-08 | ||
| EP11305410 | 2011-04-08 | ||
| PCT/EP2012/056467 WO2012136851A1 (en) | 2011-04-08 | 2012-04-10 | Methods and pharmaceutical compositions for inhibiting influenza viruses replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510130A JP2014510130A (ja) | 2014-04-24 |
| JP2014510130A5 true JP2014510130A5 (https=) | 2015-05-21 |
| JP6006292B2 JP6006292B2 (ja) | 2016-10-12 |
Family
ID=44318127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014503177A Expired - Fee Related JP6006292B2 (ja) | 2011-04-08 | 2012-04-10 | インフルエンザウイルス複製を阻害するための方法および医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9168236B2 (https=) |
| EP (1) | EP2694046A1 (https=) |
| JP (1) | JP6006292B2 (https=) |
| KR (1) | KR20140027987A (https=) |
| CN (1) | CN103648491B (https=) |
| WO (1) | WO2012136851A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR200469630Y1 (ko) | 2012-10-29 | 2013-10-28 | 태영주식회사 | 폐합성수지의 재활용을 위한 세척장치 |
| WO2015124570A1 (en) * | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
| WO2016201581A1 (en) | 2015-06-18 | 2016-12-22 | The Hospital For Sick Children | Method of treating medulloblastoma |
| EP3427743B1 (en) * | 2016-03-11 | 2021-02-24 | Kagoshima University | Anti-hepatoma-virus agent |
| CN113197894B (zh) * | 2020-02-02 | 2022-08-05 | 武汉大学 | 奥巴托克在制备广谱抗冠状病毒药物中的应用 |
| KR102251682B1 (ko) * | 2020-09-08 | 2021-05-17 | 주식회사 알엠 | 폐플라스틱 페트류 및 페트 플레이크의 세정 및 살균 방법 |
| CN114796215B (zh) * | 2022-05-27 | 2023-07-07 | 贵州医科大学 | 替罗非班在用于制备治疗人呼吸道合胞病毒感染的药物中的应用 |
| WO2024054941A1 (en) * | 2022-09-08 | 2024-03-14 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for inhibiting viral methyltransferases |
| CN116549460A (zh) * | 2023-03-23 | 2023-08-08 | 大连大学 | 糖类皮质激素在制备预防和治疗病毒性上呼吸道疾病药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258585B1 (en) | 1992-05-14 | 2001-07-10 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting influenza virus replication |
| WO1998030228A1 (en) * | 1997-01-13 | 1998-07-16 | Emory University | Compounds and their combinations for the treatment of influenza infection |
| US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
| WO2002009699A2 (en) * | 2000-07-28 | 2002-02-07 | Immupharm Aps | Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract |
| US20050170334A1 (en) | 2002-03-13 | 2005-08-04 | Toshifumi Mikayama | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
| CN1832939B (zh) | 2003-05-30 | 2010-04-28 | 杰明X医药品加拿大公司 | 用于治疗癌症或病毒病的三杂环化合物、组合物和方法 |
| WO2006029081A2 (en) * | 2004-09-02 | 2006-03-16 | Neopharm, Inc. | Nucleoside-lipid conjugates, their method of preparation and uses thereof |
| US20070270362A1 (en) * | 2006-05-18 | 2007-11-22 | The University Of Washington | Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders |
| US9289462B2 (en) * | 2008-09-17 | 2016-03-22 | Terry Gage | Method for medical treatment utilizing glutathione |
| JP5809560B2 (ja) * | 2008-10-08 | 2015-11-11 | アビヴァックス | インフルエンザに対して使用するためのワクチン組成物 |
| US9079970B2 (en) * | 2008-12-09 | 2015-07-14 | Dana Farber Cancer Institute, Inc. | Methods and compositions for specific modulation of MCL-1 |
| US8883995B2 (en) * | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
| CA2775720A1 (en) * | 2009-09-30 | 2011-04-07 | Saint Louis University | Peptides for inducing heterosubtypic influenza t cell responses |
-
2012
- 2012-04-10 CN CN201280023188.0A patent/CN103648491B/zh not_active Expired - Fee Related
- 2012-04-10 EP EP12713153.0A patent/EP2694046A1/en not_active Withdrawn
- 2012-04-10 US US14/110,214 patent/US9168236B2/en not_active Expired - Fee Related
- 2012-04-10 WO PCT/EP2012/056467 patent/WO2012136851A1/en not_active Ceased
- 2012-04-10 JP JP2014503177A patent/JP6006292B2/ja not_active Expired - Fee Related
- 2012-04-10 KR KR1020137029788A patent/KR20140027987A/ko not_active Withdrawn
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