JP2014507450A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014507450A5 JP2014507450A5 JP2013557032A JP2013557032A JP2014507450A5 JP 2014507450 A5 JP2014507450 A5 JP 2014507450A5 JP 2013557032 A JP2013557032 A JP 2013557032A JP 2013557032 A JP2013557032 A JP 2013557032A JP 2014507450 A5 JP2014507450 A5 JP 2014507450A5
- Authority
- JP
- Japan
- Prior art keywords
- lta
- infections
- pharmaceutical composition
- mimetic
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 7
- 229960005486 vaccine Drugs 0.000 claims 3
- 208000031729 Bacteremia Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 2
- 206010014889 Enterococcal infections Diseases 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 206010062255 Soft tissue infection Diseases 0.000 claims 2
- 241000295644 Staphylococcaceae Species 0.000 claims 2
- 206010048038 Wound infection Diseases 0.000 claims 2
- 208000009361 bacterial endocarditis Diseases 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 201000007119 infective endocarditis Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010034674 peritonitis Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 208000019206 urinary tract infection Diseases 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- OKPQBUWBBBNTOV-UHFFFAOYSA-N Kojibiose Natural products COC1OC(O)C(OC2OC(OC)C(O)C(O)C2O)C(O)C1O OKPQBUWBBBNTOV-UHFFFAOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 1
- AYRXSINWFIIFAE-UHFFFAOYSA-N O6-alpha-D-Galactopyranosyl-D-galactose Natural products OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 claims 1
- 206010034133 Pathogen resistance Diseases 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000600 disaccharide group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 229960003082 galactose Drugs 0.000 claims 1
- DLRVVLDZNNYCBX-CQUJWQHSSA-N gentiobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-CQUJWQHSSA-N 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- PZDOWFGHCNHPQD-OQPGPFOOSA-N kojibiose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PZDOWFGHCNHPQD-OQPGPFOOSA-N 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical group 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451304P | 2011-03-10 | 2011-03-10 | |
| US61/451,304 | 2011-03-10 | ||
| EP20110157947 EP2500349B1 (en) | 2011-03-11 | 2011-03-11 | Synthetic LTA mimetics and use thereof as vaccine component for therapy and/or prophylaxis against gram-positive infections |
| EP11157947.0 | 2011-03-11 | ||
| PCT/EP2012/052801 WO2012119846A1 (en) | 2011-03-10 | 2012-02-17 | Synthetic lta mimetics and use thereof as vaccine component for therapy and/or pro-phylaxis against gram-positive infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507450A JP2014507450A (ja) | 2014-03-27 |
| JP2014507450A5 true JP2014507450A5 (OSRAM) | 2015-03-12 |
| JP6154751B2 JP6154751B2 (ja) | 2017-06-28 |
Family
ID=43828266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557032A Expired - Fee Related JP6154751B2 (ja) | 2011-03-10 | 2012-02-17 | 合成ｌｔａ模倣物、並びにグラム陽性感染症の治療及び／又は予防のためのワクチン成分としてのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9290531B2 (OSRAM) |
| EP (1) | EP2500349B1 (OSRAM) |
| JP (1) | JP6154751B2 (OSRAM) |
| CA (1) | CA2829126A1 (OSRAM) |
| ES (1) | ES2544808T3 (OSRAM) |
| WO (1) | WO2012119846A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10364298B2 (en) | 2011-11-18 | 2019-07-30 | National Research Council Of Canada | Clostridium difficile lipoteichoic acid and uses thereof |
| US10781175B2 (en) | 2016-07-15 | 2020-09-22 | Am Chemicals Llc | Solid supports and phosphoramidite building blocks for oligonucleotide conjugates |
| KR101950881B1 (ko) * | 2017-08-10 | 2019-02-22 | 서울대학교산학협력단 | 리포테이코익산(Lipoteichoic acid(LTA))을 함유하는 피부 재생 및 창상 치유용 약학 조성물 |
| CA3074703A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4714196A (en) * | 1995-01-30 | 1996-08-21 | Peter Truog | Antitumor and anticholesterol preparations containing a lipoteichoic acid from steptococcus |
| AUPQ137699A0 (en) | 1999-07-02 | 1999-07-22 | University Of New England, The | Control of acidosis |
| CA2474709A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
-
2011
- 2011-03-11 EP EP20110157947 patent/EP2500349B1/en not_active Not-in-force
- 2011-03-11 ES ES11157947.0T patent/ES2544808T3/es active Active
-
2012
- 2012-02-17 JP JP2013557032A patent/JP6154751B2/ja not_active Expired - Fee Related
- 2012-02-17 US US14/002,459 patent/US9290531B2/en not_active Expired - Fee Related
- 2012-02-17 WO PCT/EP2012/052801 patent/WO2012119846A1/en not_active Ceased
- 2012-02-17 CA CA2829126A patent/CA2829126A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Amyes | Enterococci and streptococci | |
| US9901592B2 (en) | Methods for treating resistant diseases using triazole containing macrolides | |
| Yang et al. | A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate | |
| Zhao et al. | Epidemiology of Haemophilus parasuis isolates from pigs in China using serotyping, antimicrobial susceptibility, biofilm formation and ERIC-PCR genotyping | |
| JP2014507450A5 (OSRAM) | ||
| Theilacker et al. | Serodiversity of opsonic antibodies against Enterococcus faecalis—glycans of the cell wall revisited | |
| Ghosh et al. | Synthesis of an aminooxy derivative of the tetrasaccharide repeating unit of Streptococcus dysgalactiae 2023 polysaccharide for a PS A1 conjugate vaccine | |
| Liang et al. | Structure–activity relationships of novel alkylides: 3-O-Arylalkyl clarithromycin derivatives with improved antibacterial activities | |
| JP6154751B2 (ja) | 合成ｌｔａ模倣物、並びにグラム陽性感染症の治療及び／又は予防のためのワクチン成分としてのその使用 | |
| JP2017537941A5 (OSRAM) | ||
| Lonks | What is the clinical impact of macrolide resistance? | |
| JP6230991B2 (ja) | エンテロコッカス・フェシウムクローナルコンプレックス１７に由来するラムノ多糖及びその使用 | |
| Ball | The future role and importance of macrolides | |
| WO2012105562A1 (ja) | 新規マクロライド誘導体 | |
| EP2450053B1 (en) | Novel antigen of enterococcal pathogens and use thereof as vaccine component for therapy and/or prophylaxis | |
| Adam | Clinical use of the new macrolides, azalides, and streptogramins in pediatrics | |
| Shadbad et al. | Filament genes and biofilm formation in Streptococcus agalactiae | |
| Tran | Telithromycin: a novel agent for the treatment of community-acquired upper respiratory infections | |
| WO2012105563A1 (ja) | マクロライド誘導体からなる動物用医薬品 | |
| HK1173393B (en) | Rhamno-polysaccharide from enterococcus faecium clonal complex 17 and uses thereof | |
| CA2789164A1 (en) | Lantibiotic salts | |
| Xu et al. | A new series of macrolide derivatives with 4 ″-O-saccharide substituents | |
| Paukner et al. | In vitro activity of lefamulin against bacterial pathogens causing community-acquired bacterial pneumonia: SENTRY surveillance 2017–2018 results from the United States [abstract no 703 plus poster] | |
| Vansarla | Role of HAMLET and metabolism in treatment and pathogenesis of pneumococci | |
| Gronthoud | Invasive Group A Streptococcal Infections |