JP2014507164A - ハプロタイプ決定のための方法およびシステム - Google Patents

ハプロタイプ決定のための方法およびシステム Download PDF

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JP2014507164A
JP2014507164A JP2013555620A JP2013555620A JP2014507164A JP 2014507164 A JP2014507164 A JP 2014507164A JP 2013555620 A JP2013555620 A JP 2013555620A JP 2013555620 A JP2013555620 A JP 2013555620A JP 2014507164 A JP2014507164 A JP 2014507164A
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nucleic acid
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ファン,ジャン−ビン
エス. フィッシャー,ジェフリー
ケイパー,フィオナ
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イルミナ,インコーポレイテッド
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
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    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

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JP2013555620A 2011-02-25 2012-02-24 ハプロタイプ決定のための方法およびシステム Pending JP2014507164A (ja)

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US201161446890P 2011-02-25 2011-02-25
US61/446,890 2011-02-25
US201161509960P 2011-07-20 2011-07-20
US61/509,960 2011-07-20
PCT/US2012/026623 WO2012116331A2 (en) 2011-02-25 2012-02-24 Methods and systems for haplotype determination

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017533722A (ja) * 2014-11-14 2017-11-16 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2673380B1 (en) 2011-02-09 2018-12-12 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP6367196B2 (ja) 2012-08-14 2018-08-01 テンエックス・ジェノミクス・インコーポレイテッド マイクロカプセル組成物および方法
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9411930B2 (en) * 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
KR102190198B1 (ko) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
JP2016539343A (ja) 2013-08-30 2016-12-15 イルミナ インコーポレイテッド 親水性または斑状親水性表面上の液滴の操作
US10172916B2 (en) 2013-11-15 2019-01-08 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating heart failure with agonists of hypocretin receptor 2
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
WO2015200869A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
JP2017526046A (ja) 2014-06-26 2017-09-07 10エックス ゲノミクス,インコーポレイテッド 核酸配列アセンブルのプロセス及びシステム
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
EP4219710A3 (en) 2014-08-01 2023-08-16 Dovetail Genomics, LLC Tagging nucleic acids for sequence assembly
AU2015311866B2 (en) 2014-09-03 2018-06-07 Nant Holdings Ip, Llc Synthetic genomic variant-based secure transaction devices, systems and methods
CN107427808B (zh) 2015-01-12 2020-10-23 10X基因组学有限公司 用于制备核酸测序文库的方法和系统以及用其制备的文库
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的系统和方法
US20160298114A1 (en) * 2015-03-18 2016-10-13 The Board Of Trustees Of The Leland Stanford Junior University Haplotype Based Generalizable Allele Specific Silencing for Therapy of Cardiovascular Disease
WO2016154540A1 (en) 2015-03-26 2016-09-29 Dovetail Genomics Llc Physical linkage preservation in dna storage
CN105046105B (zh) * 2015-07-09 2018-02-02 天津诺禾医学检验所有限公司 染色体跨度的单体型图及其构建方法
CN105385755A (zh) * 2015-11-05 2016-03-09 上海序康医疗科技有限公司 一种利用多重pcr技术进行snp-单体型分析的方法
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
SG11201806757XA (en) 2016-02-11 2018-09-27 10X Genomics Inc Systems, methods, and media for de novo assembly of whole genome sequence data
CA3014911A1 (en) 2016-02-23 2017-08-31 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
JP7497976B2 (ja) 2016-05-13 2024-06-11 ダブテイル ゲノミクス エルエルシー 保存されたサンプルからの長距離連鎖情報の回復
KR101815529B1 (ko) 2016-07-29 2018-01-30 (주)신테카바이오 휴먼 하플로타이핑 시스템 및 방법
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
CN110870018B (zh) 2017-05-19 2024-11-22 10X基因组学有限公司 用于分析数据集的系统和方法
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
CN111479631B (zh) 2017-10-27 2022-02-22 10X基因组学有限公司 用于样品制备和分析的方法和系统
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
CN111699388B (zh) 2017-12-12 2024-08-02 10X基因组学有限公司 用于单细胞处理的系统和方法
CN111712579B (zh) 2017-12-22 2024-10-15 10X基因组学有限公司 用于处理来自一个或多个细胞的核酸分子的系统和方法
CA3090102A1 (en) 2018-01-31 2019-08-08 Dovetail Genomics, Llc Sample prep for dna linkage recovery
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
WO2019169028A1 (en) 2018-02-28 2019-09-06 10X Genomics, Inc. Transcriptome sequencing through random ligation
WO2019195166A1 (en) 2018-04-06 2019-10-10 10X Genomics, Inc. Systems and methods for quality control in single cell processing
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US12188014B1 (en) 2018-07-25 2025-01-07 10X Genomics, Inc. Compositions and methods for nucleic acid processing using blocking agents
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
SG11202101164TA (en) 2018-08-03 2021-03-30 10X Genomics Inc Methods and systems to minimize barcode exchange
WO2020041148A1 (en) 2018-08-20 2020-02-27 10X Genomics, Inc. Methods and systems for detection of protein-dna interactions using proximity ligation
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US12169198B2 (en) 2019-01-08 2024-12-17 10X Genomics, Inc. Systems and methods for sample analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
EP3924505B1 (en) 2019-02-12 2025-12-17 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US12275993B2 (en) 2019-02-12 2025-04-15 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2020167862A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transfer of reagents between droplets
US12305239B2 (en) 2019-02-12 2025-05-20 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2020167866A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transposon loading
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
US11920183B2 (en) 2019-03-11 2024-03-05 10X Genomics, Inc. Systems and methods for processing optically tagged beads
EP3947722A1 (en) 2019-03-27 2022-02-09 10X Genomics, Inc. Systems and methods for processing rna from cells
US12235262B1 (en) 2019-09-09 2025-02-25 10X Genomics, Inc. Methods and systems for single cell protein analysis
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
US12421558B2 (en) 2020-02-13 2025-09-23 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
US12480158B1 (en) 2020-11-05 2025-11-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12084715B1 (en) 2020-11-05 2024-09-10 10X Genomics, Inc. Methods and systems for reducing artifactual antisense products
US12398262B1 (en) 2021-01-22 2025-08-26 10X Genomics, Inc. Triblock copolymer-based cell stabilization and fixation system and methods of use thereof
CN120158497A (zh) 2021-02-23 2025-06-17 10X基因组学有限公司 基于探针的核酸和蛋白质分析
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KR20250008056A (ko) 2022-05-11 2025-01-14 프로빈셜 헬스 서비시즈 오쏘리티 유전성 질환의 진단 및 관리를 위한 부모 기원 질환 대립유전자 검출 방법 및 장치
CN115992261B (zh) * 2022-12-13 2025-06-24 中国科学院海洋研究所 一种构建牡蛎单倍型基因组的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065617A2 (en) * 2003-01-17 2004-08-05 The Trustees Of Boston University Haplotype analysis
WO2004081191A2 (en) * 2003-03-12 2004-09-23 Cleveland State University Molecular haplotyping of genomic dna
US20040185453A1 (en) * 2003-03-21 2004-09-23 Joel Myerson Affinity based methods for separating homologous parental genetic material and uses thereof
WO2010148039A2 (en) * 2009-06-15 2010-12-23 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146870A1 (en) * 2003-01-27 2004-07-29 Guochun Liao Systems and methods for predicting specific genetic loci that affect phenotypic traits
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
GB0523276D0 (en) * 2005-11-15 2005-12-21 London Bridge Fertility Chromosomal analysis by molecular karyotyping
US8592150B2 (en) * 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
CN102203285B (zh) * 2008-10-21 2014-12-31 宋清 利用单倍切割确定单倍型的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065617A2 (en) * 2003-01-17 2004-08-05 The Trustees Of Boston University Haplotype analysis
WO2004081191A2 (en) * 2003-03-12 2004-09-23 Cleveland State University Molecular haplotyping of genomic dna
US20040185453A1 (en) * 2003-03-21 2004-09-23 Joel Myerson Affinity based methods for separating homologous parental genetic material and uses thereof
WO2010148039A2 (en) * 2009-06-15 2010-12-23 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6016002093; Bio Techniques Vol.38, 2005, p.553-559 *
JPN6016002096; PNAS Vol.100, No.13, 2003, p.7449-7453 *
JPN6016002098; PNAS Vol.87, 1990, p.6296-6300 *
JPN6016002101; Nature Biotechnology Vol.29, No.1, 201101, p.59-63 *
JPN6016002102; Nucleic Acids Research Vol.35, No.1, 2007, e6, p.1-8 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017533722A (ja) * 2014-11-14 2017-11-16 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法
JP2020141707A (ja) * 2014-11-14 2020-09-10 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法
JP7108658B2 (ja) 2014-11-14 2022-07-28 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法
JP2024112825A (ja) * 2014-11-14 2024-08-21 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法
JP7723792B2 (ja) 2014-11-14 2025-08-14 アテナ ダイアグナスティクス,インコーポレイテッド サイレントキャリア遺伝子型を検出する方法

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AU2012222108A1 (en) 2013-07-18
EP2678449A4 (en) 2015-06-24
WO2012116331A3 (en) 2013-03-07
EP2678449A2 (en) 2014-01-01
US20140045706A1 (en) 2014-02-13
CN103492588A (zh) 2014-01-01
CA2824431A1 (en) 2012-08-30
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