JP2014505891A - 測定チップ、マイクロ流体デバイス及び方法 - Google Patents
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Abstract
Description
のような大きさであるとき、好ましくは、マイクロ流体測定チャネル104及びマイクロ流体廃棄チャネル114は同じ寸法を持つ。ここで、dは、マイクロ流体チャネルの水力直径である。異なる寸法、すなわち異なる水力直径を持つマイクロ流体チャネルに関して、これらのチャネルの公差における異なる変動が発生する可能性があることが分かっている。これは、マイクロ流体デバイスをチューニングすること、特に接合部40を含むマイクロ流体抵抗ネットワーク20をチューニングすることをより困難にする。
Claims (14)
- マイクロ流体抵抗ネットワークと共に使用される測定チップであって、
前記ネットワークからサンプル・ストリームを受けるサンプル入口とサンプル出口との間に延在するサンプルチャネルであって、測定手段を含み、第1の流体抵抗を持つ、サンプルチャネルと、前記ネットワークから別々の廃棄ストリームを受ける廃棄入口と廃棄出口との間に延在する廃棄チャネルであって、第2の流体抵抗を持つ、廃棄チャネルとを有する、測定チップ。 - 前記サンプルチャネル及び前記廃棄チャネルの個別の寸法が同じである、請求項1に記載の測定チップ。
- 前記サンプル出口及び前記廃棄出口が同じである、請求項2に記載の測定チップ。
- 前記チップが、前記廃棄チャネルを複数有する、請求項1乃至3のいずれかに記載の測定チップ。
- 前記廃棄チャネルが、同じ廃棄入口及び/又は同じ廃棄出口を共有する、請求項4に記載の測定チップ。
- 前記チップが、ガラスチップである、請求項1乃至5のいずれかに記載の測定チップ。
- 前記測定手段が、第1の電極及び第1のカウンタ電極を含む第1の電極ペアと、前記第1の電極ペアの下流に第2の電極ペアとを有し、
前記第2の電極ペアは、追加的な電極及び追加的なカウンタ電極を有し、
前記第1の及び追加的な電極が、同じ電流信号に結合されるよう構成され、前記第1の及び追加的なカウンタ電極は、接地に結合されるよう構成される、請求項1乃至6のいずれかに記載の測定チップ。 - 前記電極が、プラチナ電極である、請求項7に記載の測定チップ。
- マイクロ流体デバイスであって、
マイクロ流体サンプル調整ステージ、並びに該調整ステージと流体連通するサンプル出力及び廃棄出力を含むマイクロ流体抵抗ネットワークと、
請求項1乃至8のいずれかに記載の測定チップとを有し、
前記マイクロ流体抵抗ネットワークが、前記測定チップとは分離しており、
前記サンプルチャネルは、前記サンプル出力と流体連通し、前記廃棄チャネルが、前記廃棄出力と流体連通する、マイクロ流体デバイス。 - 前記マイクロ流体抵抗ネットワークが、ポリマー物質から作られる、請求項9に記載のマイクロ流体デバイス。
- サンプルを受ける第1の入口と、
希釈剤を受ける第2の入口とを更に有し、
前記サンプル調整ステージが、前記希釈剤で前記サンプルを希釈する希釈ステージのチェーンを有し、下流の希釈ステージは、前記チェーンにおける以前の希釈ステージから受ける前記サンプルを更に希釈するよう構成され、
前記希釈ステージの第1のものが、前記第1の入口と流体連通し、
前記希釈ステージの各々は、前記第2の入口と流体連通し、
前記希釈ステージの少なくともいくつかが、前記受けたサンプルの部分を前記廃棄チャネルに供給する別々の出力を有する、請求項9又は10に記載のマイクロ流体デバイス。 - 前記サンプルが、血液サンプルであり、
前記マイクロ流体抵抗ネットワークは更に、
追加的なサンプル調整ステージと、
前記血液サンプルを受ける前記サンプル調整ステージ及び前記追加的なサンプル調整ステージの少なくとも1つと流体連通する第1の追加的な入口と、
前記追加的なサンプル調整ステージに対して溶解剤を提供する前記追加的なサンプル調整ステージと流体連通する第2の追加的な入口と、
前記追加的なサンプル調整ステージに対してクエンチ溶液を提供する前記サンプル調整ステージと流体連通する第3の追加的な入口と、
前記追加的なサンプル調整ステージと流体連通する追加的なサンプル出口とを有する、請求項11に記載のマイクロ流体デバイス。 - 前記マイクロ流体抵抗ネットワークが更に、前記サンプル調整ステージ、前記サンプル出口及び前記廃棄出口の間に接合部を有し、
前記接合部は、前記サンプル出口に関するサンプル部分及び前記廃棄出口に関する廃棄部分へと、前記希釈された全体の血液サンプルを分離するよう設計される、請求項12に記載のマイクロ流体デバイス。 - マイクロ流体抵抗ネットワークと共に用いる測定チップを製造する方法において、
ガラス基板を提供するステップと、
前記ガラス基板を通るサンプルチャネルを形成するステップであって、前記サンプルチャネルが、前記ネットワークからサンプルストリームを受けるサンプル入口とサンプル出口との間に延在する、ステップと、
前記ガラス基板を通る廃棄チャネルを形成するステップであって、前記廃棄チャネルが、前記ネットワークから別々の廃棄ストリームを受ける廃棄入口と廃棄出口との間に延在する、ステップと、
前記サンプルチャネルにおいて測定手段を形成するステップとを有する、方法。
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EP11155003.4 | 2011-02-18 | ||
EP11155003A EP2490020A1 (en) | 2011-02-18 | 2011-02-18 | Measurement chip, microfluidic device and method of measurement chip manufacture |
PCT/IB2012/050585 WO2012110922A1 (en) | 2011-02-18 | 2012-02-09 | Measurement chip, microfluidic device and method |
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JP2014505891A true JP2014505891A (ja) | 2014-03-06 |
JP5919302B2 JP5919302B2 (ja) | 2016-05-18 |
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US (2) | US9733238B2 (ja) |
EP (2) | EP2490020A1 (ja) |
JP (1) | JP5919302B2 (ja) |
CN (1) | CN103354903B (ja) |
BR (1) | BR112013020729B1 (ja) |
RU (1) | RU2604622C2 (ja) |
WO (1) | WO2012110922A1 (ja) |
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CN103055983A (zh) * | 2012-12-31 | 2013-04-24 | 苏州汶颢芯片科技有限公司 | 一种检测土壤中多环芳烃的离心式微流控芯片及其制备方法 |
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WO2012110922A1 (en) | 2012-08-23 |
CN103354903B (zh) | 2016-10-05 |
BR112013020729A2 (pt) | 2016-10-18 |
RU2013142350A (ru) | 2015-04-10 |
US20170307599A1 (en) | 2017-10-26 |
JP5919302B2 (ja) | 2016-05-18 |
EP2676135B1 (en) | 2020-05-13 |
CN103354903A (zh) | 2013-10-16 |
US20130323125A1 (en) | 2013-12-05 |
US9733238B2 (en) | 2017-08-15 |
RU2604622C2 (ru) | 2016-12-10 |
US10156563B2 (en) | 2018-12-18 |
EP2490020A1 (en) | 2012-08-22 |
EP2676135A1 (en) | 2013-12-25 |
BR112013020729B1 (pt) | 2020-10-27 |
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