JP2014505107A5 - - Google Patents
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- Publication number
- JP2014505107A5 JP2014505107A5 JP2013553557A JP2013553557A JP2014505107A5 JP 2014505107 A5 JP2014505107 A5 JP 2014505107A5 JP 2013553557 A JP2013553557 A JP 2013553557A JP 2013553557 A JP2013553557 A JP 2013553557A JP 2014505107 A5 JP2014505107 A5 JP 2014505107A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- halogen
- syndrome
- use according
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 201000010917 PTEN hamartoma tumor syndrome Diseases 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 208000002927 Hamartoma Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 208000012609 Cowden disease Diseases 0.000 claims 2
- 201000002847 Cowden syndrome Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical group 0.000 claims 2
- CWHUFRVAEUJCEF-UHFFFAOYSA-N BKM120 Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=CC(N2CCOCC2)=NC(N2CCOCC2)=N1 CWHUFRVAEUJCEF-UHFFFAOYSA-N 0.000 claims 1
- 208000007531 Proteus syndrome Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161441896P | 2011-02-11 | 2011-02-11 | |
US61/441,896 | 2011-02-11 | ||
PCT/US2012/024440 WO2012109423A1 (en) | 2011-02-11 | 2012-02-09 | Method of inhibiting hamartoma tumor cells |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014505107A JP2014505107A (ja) | 2014-02-27 |
JP2014505107A5 true JP2014505107A5 (US20080131398A1-20080605-C00009.png) | 2015-03-12 |
Family
ID=45809596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013553557A Withdrawn JP2014505107A (ja) | 2011-02-11 | 2012-02-09 | 過誤腫性腫瘍細胞を阻害する方法 |
Country Status (11)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
CA2849995A1 (en) | 2011-09-27 | 2013-04-04 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
KR20150131224A (ko) | 2013-03-14 | 2015-11-24 | 노파르티스 아게 | 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
CN106458968B (zh) * | 2014-04-22 | 2019-06-25 | 巴塞尔大学 | 三嗪、嘧啶和吡啶衍生物的新制备方法 |
CN105001151B (zh) * | 2015-08-28 | 2017-07-14 | 苏州明锐医药科技有限公司 | 布帕尼西中间体及其制备方法 |
CN109414415B (zh) * | 2016-05-18 | 2023-05-02 | 拓客股份有限公司 | 皮肤病变的治疗 |
SG11201809652PA (en) * | 2016-05-18 | 2018-12-28 | Piqur Therapeutics Ag | Treatment of skin lesions |
CN106905294A (zh) * | 2016-07-08 | 2017-06-30 | 苏州科睿思制药有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺的晶型及其制备方法 |
CN106632443B (zh) * | 2016-11-23 | 2022-06-17 | 山东友帮生化科技有限公司 | 一种2-氨基嘧啶-5-硼酸频哪酯硼酸盐的合成方法 |
KR20200090767A (ko) * | 2017-11-23 | 2020-07-29 | 피쿠르 테라퓨틱스 아게 | 피부 장애의 치료 |
CN114213340B (zh) | 2022-02-22 | 2022-06-07 | 北京蓝晶微生物科技有限公司 | 2,4-二氨基嘧啶氧化物的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
SG177469A1 (en) * | 2009-07-02 | 2012-02-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
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2012
- 2012-02-09 EP EP12707171.0A patent/EP2673268A1/en not_active Withdrawn
- 2012-02-09 CA CA2826387A patent/CA2826387A1/en not_active Abandoned
- 2012-02-09 RU RU2013141559/04A patent/RU2013141559A/ru not_active Application Discontinuation
- 2012-02-09 CN CN201280013673XA patent/CN103476765A/zh active Pending
- 2012-02-09 WO PCT/US2012/024440 patent/WO2012109423A1/en active Application Filing
- 2012-02-09 JP JP2013553557A patent/JP2014505107A/ja not_active Withdrawn
- 2012-02-09 BR BR112013020159A patent/BR112013020159A2/pt not_active IP Right Cessation
- 2012-02-09 US US13/984,422 patent/US20140309221A1/en not_active Abandoned
- 2012-02-09 AU AU2012214413A patent/AU2012214413A1/en not_active Abandoned
- 2012-02-09 KR KR1020137023617A patent/KR20140063509A/ko not_active Application Discontinuation
- 2012-02-09 MX MX2013009256A patent/MX2013009256A/es not_active Application Discontinuation