JP2014501242A - 歯科疾患、障害、および損傷の治療方法 - Google Patents
歯科疾患、障害、および損傷の治療方法 Download PDFInfo
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Abstract
Description
本出願は、2010年12月20日出願の米国仮出願No. 61/459,859の35 USC§119(e)に基づく優先権を主張する。該仮出願の全体は参照によりここに組み入れられる。
本発明の分野は、歯科疾患、障害および損傷を予防し、回復させ、改善し、または治療するための方法に関する。特に、本発明の分野は、歯肉(gingival (gums))および骨の歯科疾患、障害または損傷を予防し、回復させ、改善し、または治療することに関する。該歯科疾患、障害および損傷を予防し、回復させ、改善し、および治療するためのそのような方法は、胚外サイトカイン分泌細胞(extraembryonic cytokine-secreting cells)(本明細書において、ECS細胞と称する)およびそれに由来するならし培地、例えば羊膜由来多能性前駆(AMP)細胞、それに由来するならし培地(本明細書において、羊膜由来細胞性サイトカイン溶液またはACCS、プールされたACCSと称する)、および/またはそれに由来する細胞産物、ならびに生理的サイトカイン溶液(本明細書において、PCSと称する)を、それぞれ単独でかつ/または互いに組み合わせてかつ/または、活性および/もしくは不活性物質を含む他の物質と組み合わせて含む新規組成物を利用する。
歯肉炎(歯肉の炎症)は、通常、歯周炎(歯肉疾患)に先立つ。初期の歯肉炎では、プラーク(歯の表面に形成される細菌の粘着性で無色のフィルム)中の細菌が歯肉の炎症を引き起こし、しばしば出血させる。この段階では、歯は依然としてその槽にしっかりと埋め込まれており、不可逆的な骨または他の組織の損傷は生じていない。しかし、未治療のままにすると、歯肉炎は歯周炎に進行しうる。歯周炎では、歯肉の内側の層および骨が歯から離れ、ポケットと称される空間を形成する。これらのポケットは残渣を溜め、しばしば感染を受ける。プラーク中の細菌によって生産される毒素、および感染と闘う時に身体によって生産される酵素は、歯を固定する骨および結合組織の破壊を引き起こす。疾患が進行するにつれて、ポケットは深くなり、より多くの骨および結合組織が破壊される。最終的に歯はもはや適所に固定されず、ゆるくなり、歯の喪失に至ることがよくある。実際、歯周炎は成人の歯の喪失の主因である。
本発明の目的は、歯科疾患、障害および損傷、特に、歯周病(歯肉疾患)を予防し、回復させ、改善し、または治療するための新規方法を提供することである。該歯科疾患、障害および損傷を予防し、回復させ、改善し、および治療するためのそのような方法は、胚外サイトカイン分泌細胞(本明細書において、ECS細胞と称する)およびそれに由来するならし培地、例えば羊膜由来多能性前駆(AMP)細胞、それに由来するならし培地(本明細書において、羊膜由来細胞性サイトカイン溶液またはACCS、プールされたACCSと称する)、および/またはそれに由来する細胞産物、ならびに生理的サイトカイン溶液(本明細書において、PCSと称する)を、それぞれ単独でかつ/または互いに組み合わせてかつ/または、活性および/もしくは不活性物質を含む他の物質と組み合わせて含む新規組成物を利用する。
本明細書中で定義される「単離された」とは、その元の環境から取り出され、したがってその天然状態から「ヒトの手によって」改変された物質を表す。
本発明では、当技術分野の技術の範囲内の慣用の分子生物学、微生物学、および組み換えDNA技術を用いてよい。そのような技術は文献で完全に説明される。例えば、Sambrook et al, 2001, "Molecular Cloning: A Laboratory Manual"; Ausubel, ed., 1994, "Current Protocols in Molecular Biology" Volumes I-III; Celis, ed., 1994, "Cell Biology: A Laboratory Handbook" Volumes I-III; Coligan, ed., 1994, "Current Protocols in Immunology" Volumes I-III; Gait ed., 1984, "Oligonucleotide Synthesis"; Hames & Higgins eds., 1985, "Nucleic Acid Hybridization"; Hames & Higgins, eds., 1984,"Transcription And Translation"; Freshney, ed., 1986, "Animal Cell Culture"; IRL Press, 1986, "Immobilized Cells And Enzymes"; Perbal, 1984, "A Practical Guide To Molecular Cloning"を参照のこと。
ECS細胞 - 本発明のECS細胞の生産に後に使用することができる細胞を胚外組織から単離するための種々の方法が当技術分野で報告されている(例えば、US2003/0235563, US2004/0161419, US2005/0124003, 米国仮出願Nos. 60/666,949, 60/699,257, 60/742,067, 60/813,759, 米国出願No. 11/333,849, 米国出願No. 11/392,892, PCTUS06/011392, US2006/0078993, PCT/US00/40052, 米国特許No. 7,045,148, US2004/0048372, およびUS2003/0032179を参照のこと)。
ECS細胞のならし培地 - ECS細胞を使用することを除き、ACCSに関して以下に記載されるようにしてECS細胞のならし培地を得る。
ECS細胞、例えばAMP細胞および/またはACCS、プールされたACCSまたはPCSを含む組成物を被験体に投与して、種々の細胞または組織の機能を提供し、例えば、歯科疾患、障害または損傷を予防し、回復させ、改善し、または治療することができる。本明細書中で使用される「被験体」とは、ヒトまたは非ヒト動物を意味する。
ACCS、プールされたACCSまたはPCSを持続放出組成物として製剤化することができる。当業者は、ACCS、プールされたACCSまたはPCSなどのタンパク質ベースの治療物質などの治療物質の持続放出組成物を作製するための方法論に精通している。
以下の実施例は、本発明の方法および組成物の製造方法および使用方法についての完全な開示および説明を当業者に提供するために記載され、発明者らが自らの発明とみなすものの範囲を限定することは意図されていない。使用される数字(例えば、量、温度、など)に関する精度を保証するよう努めたが、いくらかの実験誤差および偏差が考慮されるべきである。特に指定しない限り、割合は重量に基づく割合であり、分子量は平均分子量であり、温度は摂氏温度であり、圧力は大気圧であるか、またはほぼ大気圧である。
解離剤PXXIIIを使用して羊膜上皮細胞を出発羊膜から解離させた。羊膜の平均重量範囲は18〜27 gであった。PXXIIIで解離させた場合、羊膜1gあたりの回収された細胞数は約10〜15 x 106であった。
本発明のAMP細胞を使用して、プールされたACCSなどのACCSを作製することができる。上記のようにAMP細胞を単離し、ほぼ10mLの上記培地を含むT75フラスコ中にほぼ1 x 106細胞/mLを播種した。細胞を集密まで培養し、培地を交換し、集密化の3日後にACCSを回収した。場合により3日後に再びACCSを回収し、場合により3日後に再び回収する。当業者は、集密培養からACCSを回収するための他の実施形態、例えば他の組織培養容器、例えば、非限定的に、セルファクトリー、フラスコ、ホローファイバー、または懸濁培養装置、などを使用する実施形態もまた、本発明の方法によって想定されることを認識する(上記「詳細な説明」を参照のこと)。ACCSを、回収後に、冷凍保存し、凍結乾燥し、放射線照射し、かつ/または持続放出用に製剤化することもまた、本発明によって想定される。異なる時点でACCSを回収することもまた、想定される(詳細に関しては「詳細な説明」を参照のこと)。
担体中で生理的レベルの指定サイトカインまたは因子を組み合わせることによって以下のPCS組成物を製造する。
ACCS、例えばプールされたACCS、またはPCSの組成物を、本明細書中に記載されている(「詳細な説明」を参照のこと)かまたはそうでなければ当業者によく知られている持続放出製剤技術のいずれかと組み合わせることによって、ACCS、例えばプールされたACCS、またはPCSの持続放出組成物を製造する。
モデル: P. gingivalis誘発性歯周炎のウサギモデルでACCSを試験した。該モデルは、6週間にわたる結紮+ P. gingivalis適用を利用したが、これは、疾患モデルの確認時にかなりの量の歯肉の炎症および歯周病に関連する骨減少を誘発する。ACCSを、P. gingivalis適用の前に適用し、その後、次の6週にわたって週に3回適用した。
モデル: P. gingivalis誘発性歯周炎のウサギモデルでACCSを試験する。該モデルは、6週間にわたる結紮+ P. gingivalis適用を利用するが、これは、疾患モデルの確認時にかなりの量の歯肉の炎症および歯周病に関連する骨減少を誘発する。ACCSを、結紮+ P. gingivalis適用の6週間後に適用し、その後、追加の6週にわたって週に3回適用した。
モデル: P. gingivalis誘発性歯周炎のウサギモデルでAMP細胞を試験した。該モデルは、6週間にわたる結紮+ P. gingivalis適用を利用するが、これは、疾患モデルの確認時にかなりの量の歯肉の炎症および歯周病に関連する骨減少を誘発する。AMP細胞はACCSと同じ肯定的な効果(疾患を予防するか、または回復させるか、またはその進行を停止させる)を有することが予測される。その理由は、AMP細胞が、ACCS中に存在する活性因子を分泌するからである。
Claims (12)
- その必要がある患者の歯科疾患、障害または損傷を予防し、回復させ、改善し、または治療するための方法であって、胚外サイトカイン分泌(ECS)細胞、それに由来するならし培地、それに由来する細胞溶解物、それに由来する細胞産物、および生理的サイトカイン溶液(PCS)からなる群から選択される1種以上の組成物の治療上有効量を患者に投与するステップを含む方法。
- 歯科疾患が歯肉炎および歯周炎からなる群から選択される、請求項1の方法。
- ECS細胞が羊膜由来多能性前駆(AMP)細胞である、請求項1の方法。
- ならし培地が羊膜由来細胞性サイトカイン溶液(ACCS)またはプールされたACCSである、請求項1の方法。
- PCSが持続放出用に製剤化されている、請求項1の方法。
- ACCSまたはプールされたACCSが持続放出用に製剤化されている、請求項4の方法。
- ECS細胞、それに由来するならし培地、それに由来する細胞溶解物、またはそれに由来する細胞産物を他の物質または治療法と組み合わせて投与する、請求項1の方法。
- 他の物質が活性物質である、請求項7の方法。
- 活性物質が、成長因子、サイトカイン、インヒビター、免疫抑制剤、ステロイド、ケモカイン、抗体、抗生物質、抗真菌剤、抗ウイルス剤、マイトマイシンC、および他の細胞タイプからなる群から選択される、請求項8の方法。
- 他の治療法が非外科的および外科的治療法からなる群から選択される、請求項7の方法。
- 非外科的治療法が、専門的歯科クリーニング、スケーリングおよびルートプレーニングからなる群から選択される、請求項10の方法。
- 外科的治療法が、フラップ手術/ポケット縮小手術、骨移植、組織工学、軟組織移植、組織再生誘導法、および骨の外科手術からなる群から選択される、請求項10の方法。
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