JP2014237599A - 局所作用型の抗炎症組成物 - Google Patents
局所作用型の抗炎症組成物 Download PDFInfo
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- JP2014237599A JP2014237599A JP2013119904A JP2013119904A JP2014237599A JP 2014237599 A JP2014237599 A JP 2014237599A JP 2013119904 A JP2013119904 A JP 2013119904A JP 2013119904 A JP2013119904 A JP 2013119904A JP 2014237599 A JP2014237599 A JP 2014237599A
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Abstract
Description
刺激接触性皮膚炎(ICD)を誘導するために、2%クロトン油10μL(アセトン/オリーブ油)(シグマ社)を、マウス耳の両側面及び背中に適用した。一方、マウスの耳両側面及び背中に、組換えヒトチオレドキシンタンパク質の20μg/mL PBS溶液(レドックスバイオサイエンス社)、又は対照としてBSA20μg/mL溶液を、ナノスプレー機(ミスト量1mL/分)で、10cmの間隔から5秒間に亘り、局所的に投与した。組換えヒトチオレドキシンタンパク質の投与タイミングは、マウスごとに、クロトン油の投与の前又は後のいずれかとした。
Claims (6)
- Cys−Gly−Pro−Cysを含むアミノ酸配列からなるポリペプチドを有効成分として含有し、上皮又は粘膜に投与される局所作用型の抗炎症組成物。
- 紫外線もしくは放射線による火傷、又は医薬品による副作用に起因する炎症性疾患患者に投与される請求項1記載の組成物。
- サイトカイン生産又は分泌を局所的に抑制する請求項1又は2記載の組成物。
- 全身性免疫抑制剤ではない請求項1から3いずれか記載の組成物。
- 感染症、自己免疫疾患、肺がん、及び皮膚がんからなる群より選ばれる1種以上に罹患し、又は非ステロイド性抗炎症薬の投与が禁忌である炎症性疾患患者に投与される請求項1から4いずれか記載の組成物。
- 前記ポリペプチドは、配列番号1のアミノ酸配列、又は配列番号1と80%以上の相同性(ただし、Cys−Gly−Pro−Cysは保存されている)を有するアミノ酸配列を含む請求項1から5いずれか記載の組成物。
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JP2013119904A JP2014237599A (ja) | 2013-06-06 | 2013-06-06 | 局所作用型の抗炎症組成物 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008501772A (ja) * | 2004-06-11 | 2008-01-24 | シンジェンタ リミテッド | 炎症性皮膚状態を寛解するための方法 |
JP2011001269A (ja) * | 2009-06-16 | 2011-01-06 | Chikako Nishigori | 紫外線誘発皮膚炎又は一次刺激性皮膚炎の予防又は治療用外用剤 |
JP2012167121A (ja) * | 2005-02-25 | 2012-09-06 | Redox Bioscience Inc | 炎症性眼表面疾患の予防ないし治療剤 |
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- 2013-06-06 JP JP2013119904A patent/JP2014237599A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008501772A (ja) * | 2004-06-11 | 2008-01-24 | シンジェンタ リミテッド | 炎症性皮膚状態を寛解するための方法 |
JP2012167121A (ja) * | 2005-02-25 | 2012-09-06 | Redox Bioscience Inc | 炎症性眼表面疾患の予防ないし治療剤 |
JP2011001269A (ja) * | 2009-06-16 | 2011-01-06 | Chikako Nishigori | 紫外線誘発皮膚炎又は一次刺激性皮膚炎の予防又は治療用外用剤 |
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