JP2014205715A5 - - Google Patents

Info

Publication number

JP2014205715A5

JP2014205715A5 JP2014157319A JP2014157319A JP2014205715A5 JP 2014205715 A5 JP2014205715 A5 JP 2014205715A5 JP 2014157319 A JP2014157319 A JP 2014157319A JP 2014157319 A JP2014157319 A JP 2014157319A JP 2014205715 A5 JP2014205715 A5 JP 2014205715A5

Authority

JP

Japan

Prior art keywords

salts

group

ophthalmic composition

acid

pyridoxine

Prior art date

2014-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 235000002639 sodium chloride Nutrition 0.000 claims 15
• 239000000203 mixture Substances 0.000 claims 12
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 12
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
• XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 9
• 239000003795 chemical substances by application Substances 0.000 claims 8
• 239000000017 hydrogel Substances 0.000 claims 8
• 229920001296 polysiloxane Polymers 0.000 claims 8
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 6
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 6
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 6
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
• 235000003704 aspartic acid Nutrition 0.000 claims 6
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 6
• 229940059329 chondroitin sulfate Drugs 0.000 claims 6
• VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims 6
• 235000019162 flavin adenine dinucleotide Nutrition 0.000 claims 6
• 239000011714 flavin adenine dinucleotide Substances 0.000 claims 6
• 229940093632 flavin-adenine dinucleotide Drugs 0.000 claims 6
• 235000008160 pyridoxine Nutrition 0.000 claims 6
• 239000011677 pyridoxine Substances 0.000 claims 6
• 229940011671 vitamin b6 Drugs 0.000 claims 6
• ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
• 229910021538 borax Inorganic materials 0.000 claims 3
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 3
• 239000004327 boric acid Substances 0.000 claims 3
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 3
• YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 claims 3
• 239000008103 glucose Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 238000002156 mixing Methods 0.000 claims 3
• 229940054534 ophthalmic solution Drugs 0.000 claims 3
• 239000002997 ophthalmic solution Substances 0.000 claims 3
• 230000003204 osmotic effect Effects 0.000 claims 3
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 3
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
• 229920000053 polysorbate 80 Polymers 0.000 claims 3
• 229940068968 polysorbate 80 Drugs 0.000 claims 3
• 229940068988 potassium aspartate Drugs 0.000 claims 3
• 239000001103 potassium chloride Substances 0.000 claims 3
• 235000011164 potassium chloride Nutrition 0.000 claims 3
• 239000008213 purified water Substances 0.000 claims 3
• ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 3
• 229960004172 pyridoxine hydrochloride Drugs 0.000 claims 3
• 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims 3
• 239000011764 pyridoxine hydrochloride Substances 0.000 claims 3
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 3
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 3
• 239000011780 sodium chloride Substances 0.000 claims 3
• 229940037001 sodium edetate Drugs 0.000 claims 3
• 239000004328 sodium tetraborate Substances 0.000 claims 3
• 235000010339 sodium tetraborate Nutrition 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• 208000003464 asthenopia Diseases 0.000 claims 2
• 230000004888 barrier function Effects 0.000 claims 2
• 210000003560 epithelium corneal Anatomy 0.000 claims 2
• 238000009825 accumulation Methods 0.000 claims 1
• 210000002919 epithelial cell Anatomy 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 238000012423 maintenance Methods 0.000 claims 1
• 230000003449 preventive effect Effects 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000001179 sorption measurement Methods 0.000 claims 1