JP2014185104A - 顎関節症用外用剤 - Google Patents
顎関節症用外用剤 Download PDFInfo
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- JP2014185104A JP2014185104A JP2013060985A JP2013060985A JP2014185104A JP 2014185104 A JP2014185104 A JP 2014185104A JP 2013060985 A JP2013060985 A JP 2013060985A JP 2013060985 A JP2013060985 A JP 2013060985A JP 2014185104 A JP2014185104 A JP 2014185104A
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- 239000010410 layer Substances 0.000 claims abstract description 33
- 229910052751 metal Inorganic materials 0.000 claims abstract description 26
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Abstract
【解決手段】顎関節用外用剤1は、支持体層3と、支持体層3の一面に設けられた粘着層5と、を備え、支持体層3及び粘着層5の少なくとも一方は、金属及びシリカの少なくとも一方を含む。
【選択図】図1
Description
図1は、一実施形態に係る顎関節症用外用剤を示す図である。図1では、顎関節症用外用剤として、剤形が貼付剤であるものを一例として示しており、貼付剤の断面構成を示している。図1に示すように、顎関節症用外用剤1は、支持体層3と、粘着層5と、を備えている。顎関節症用外用剤1は、透明性及び柔軟性を有している。
続いて、上述の顎関節症用外用剤1を用いて行った臨床試験について説明する。なお、臨床試験に用いた顎関節症用外用剤1は、略円形形状を呈しており、例えば直径が35mm程度のものである。
1. 小さな食物を口に入れる
2. 大きな食物を口に入れる
3. やわらかいものを噛む
4. かたいものを噛む
5. 食べ物をすりつぶす
6. 食いしばる
7. 奥歯の歯磨き
8. あくび
9. しゃべる
10.長時間しゃべる
11.食事をする
12.長時間食事をする
13.首を曲げる
0:この活動を行うのに全く困難(苦痛)はない。
1:この活動を行うのに少し困難(苦痛)を感じる。
2:この活動を行うのにかなり困難(苦痛)を感じる。
3:この活動は苦痛が強くて、私には行えない。
日常生活障害度は、各項目について上記4段階で評価を行い、評価した結果の値(0〜3)を合計して算出している。日常生活障害度は、数値が高いほど、日常生活において活動が困難なことを表す。以上の評価項目の試験結果について、表1に示す。なお、表1中の括弧内に示す数値は、標準偏差を示している。
・ステアリルアルコール 6.00重量%
・ステアリン酸 2.00重量%
・水添ラノリン 3.50重量%
・スクワラン 10.00重量%
・オクチルドデカノール 9.00重量%
・1,3−ブチレングリコール 8.00重量%
・PEG1500 3.50重量%
・POE(25)セチルアルコールエーテル 3.50重量%
・モノステアリン酸グリセリン 3.50重量%
・チタン微粒子 0.01重量%
・精製水 50.99重量%
・ジプロピレングリコール 8.00重量%
・PEG1500 7.50重量%
・カルボキシビニルポリマー 0.50重量%
・メチルセルロース 0.30重量%
・POE(15)オレイルアルコールエーテル 1.20重量%
・水酸化カリウム 0.10重量%
・チタン微粒子 0.005重量%
・精製水 82.395重量%
Claims (7)
- 金属及びシリカの少なくとも一方を含む、顎関節症用外用剤。
- 前記金属が微粒子である、請求項1記載の顎関節症用外用剤。
- 前記金属が遷移金属である、請求項1又は2項記載の顎関節症用外用剤。
- 剤形が、塗布剤、貼付剤及びエアゾール剤のいずれかである、請求項1〜3のいずれか一項記載の顎関節症用外用剤。
- 剤形が前記貼付剤であり、
支持体層と、
前記支持体層の一面に設けられた粘着層と、を備え、
前記支持体層及び前記粘着層の少なくとも一方は、前記金属及び前記シリカの少なくとも一方を含む、請求項4記載の顎関節症用外用剤。 - 前記金属及び前記シリカを含み、
前記金属が前記シリカに担持されている、請求項1〜5のいずれか一項記載の顎関節症用外用剤。 - 前記支持体層及び前記粘着層が透明性及び柔軟性を有する、請求項5又は6記載の顎関節症用外用剤。
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JP2013060985A JP6096021B2 (ja) | 2013-03-22 | 2013-03-22 | 顎関節症用外用剤 |
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JP2013060985A JP6096021B2 (ja) | 2013-03-22 | 2013-03-22 | 顎関節症用外用剤 |
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JP2014185104A true JP2014185104A (ja) | 2014-10-02 |
JP6096021B2 JP6096021B2 (ja) | 2017-03-15 |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997028793A1 (fr) * | 1996-02-07 | 1997-08-14 | Lead Chemical Co., Ltd. | Preparation a usage externe comprenant du tranilast et processus de production de cette preparation |
JP2003192580A (ja) * | 2001-12-26 | 2003-07-09 | Mitsubishi Chem Mkv Co | 貼付材用フィルム |
JP2003226656A (ja) * | 2002-01-30 | 2003-08-12 | Takamitsu:Kk | 膏体及びこれを用いた外用貼付剤 |
JP2006248832A (ja) * | 2005-03-10 | 2006-09-21 | Taiyo Kagaku Co Ltd | 物質担持多孔質シリカ |
US20080193559A1 (en) * | 2006-07-21 | 2008-08-14 | Nano Plasma Center Co., Ltd. | Pain relief composition comprising paramagnetic silver nanoparticles |
JP2009108001A (ja) * | 2007-10-31 | 2009-05-21 | Fuairudo Kk | 疼痛緩和用組成物とその利用 |
WO2012012509A1 (en) * | 2010-07-23 | 2012-01-26 | Johnson & Johnson Consumer Companies, Inc. | Corrosion current-generating metal particulates and use thereof |
-
2013
- 2013-03-22 JP JP2013060985A patent/JP6096021B2/ja active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997028793A1 (fr) * | 1996-02-07 | 1997-08-14 | Lead Chemical Co., Ltd. | Preparation a usage externe comprenant du tranilast et processus de production de cette preparation |
JP2003192580A (ja) * | 2001-12-26 | 2003-07-09 | Mitsubishi Chem Mkv Co | 貼付材用フィルム |
JP2003226656A (ja) * | 2002-01-30 | 2003-08-12 | Takamitsu:Kk | 膏体及びこれを用いた外用貼付剤 |
JP2006248832A (ja) * | 2005-03-10 | 2006-09-21 | Taiyo Kagaku Co Ltd | 物質担持多孔質シリカ |
US20080193559A1 (en) * | 2006-07-21 | 2008-08-14 | Nano Plasma Center Co., Ltd. | Pain relief composition comprising paramagnetic silver nanoparticles |
JP2009108001A (ja) * | 2007-10-31 | 2009-05-21 | Fuairudo Kk | 疼痛緩和用組成物とその利用 |
WO2012012509A1 (en) * | 2010-07-23 | 2012-01-26 | Johnson & Johnson Consumer Companies, Inc. | Corrosion current-generating metal particulates and use thereof |
Non-Patent Citations (3)
Title |
---|
MED. SCI. SPORTS EXERC., vol. 42, JPN6016036610, 2010, pages 2273 - 2281, ISSN: 0003496007 * |
慢性疼痛, vol. 21, no. 1, JPN6016036609, 2002, pages 79 - 82, ISSN: 0003496006 * |
歯学, vol. 68巻 1号, JPN6016036608, 1980, pages 100 - 108, ISSN: 0003404470 * |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |