JP2014079187A - 骨盤うっ血モデルラットおよびその作製方法 - Google Patents
骨盤うっ血モデルラットおよびその作製方法 Download PDFInfo
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Abstract
【解決手段】 メスラットの両側総腸骨静脈と子宮静脈を結紮し、4週以上飼育することを特徴とする骨盤うっ血モデルラットの作製方法、当該作製方法により得られる骨盤うっ血モデルラットおよびこのモデルラットを用いた頻尿治療薬のスクリーニング方法。
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Description
骨盤うっ血モデルラットの作製:
SD系メスラットを用い、吸入麻酔下に下腹部正中切開して両側総腸骨静脈を結紮し、子宮静脈も両側結紮して骨盤うっ血群とした。一方、何ら操作しないラットをコントロール群とし、上記静脈の剥離操作のみで静脈結紮しないラットをシャム群とした。
骨盤うっ血モデルラットの頻尿に対する薬剤の静脈内投与の影響:
実施例1で得たメスの骨盤うっ血モデルラット(1群6匹)に、ウレタン麻酔下、経尿道的にカテーテルを膀胱に挿入し、連続膀胱内圧測定を行なった。
骨盤うっ血モデルラットの頻尿に対する薬剤の経口投与の影響:
実施例1で得た骨盤うっ血モデルラットに対し、結紮処理1日目から飲料水に混合した試験薬剤を4週間、継続的に投与した。投与した薬剤は、公知の血管透過性亢進抑制剤のカルバゾクロムスルホン酸ナトリウム(0.25mg/ml)であった。
Claims (3)
- メスラットの両側総腸骨静脈と子宮静脈を結紮し、4週以上飼育することを特徴とする骨盤うっ血モデルラットの作製方法。
- 請求項1記載の作製方法により作製される骨盤うっ血モデルラット。
- 請求項2記載の骨盤うっ血モデルラットに被験薬剤を投与し、その頻尿抑制程度を評価することを特徴とする頻尿治療薬のスクリーニング方法。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014079188A (ja) * | 2012-10-16 | 2014-05-08 | Kimio Sugaya | 無菌性慢性前立腺炎非ヒトモデル動物、頻尿非ヒトモデル動物およびこれらを用いた被験物質の評価方法 |
WO2019009354A1 (ja) * | 2017-07-05 | 2019-01-10 | 株式会社沖縄リサーチセンター | 排尿障害改善用組成物 |
Citations (3)
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WO2009088054A1 (ja) * | 2008-01-11 | 2009-07-16 | Astellas Pharma Inc. | 精巣の疼痛又は不快感行動及び頻尿併発モデル動物 |
JP2009273396A (ja) * | 2008-05-14 | 2009-11-26 | Mitsubishi Chemical Medience Corp | 腹圧性尿失禁症モデル動物の作製方法 |
JP2014079188A (ja) * | 2012-10-16 | 2014-05-08 | Kimio Sugaya | 無菌性慢性前立腺炎非ヒトモデル動物、頻尿非ヒトモデル動物およびこれらを用いた被験物質の評価方法 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2009088054A1 (ja) * | 2008-01-11 | 2009-07-16 | Astellas Pharma Inc. | 精巣の疼痛又は不快感行動及び頻尿併発モデル動物 |
JP2009273396A (ja) * | 2008-05-14 | 2009-11-26 | Mitsubishi Chemical Medience Corp | 腹圧性尿失禁症モデル動物の作製方法 |
JP2014079188A (ja) * | 2012-10-16 | 2014-05-08 | Kimio Sugaya | 無菌性慢性前立腺炎非ヒトモデル動物、頻尿非ヒトモデル動物およびこれらを用いた被験物質の評価方法 |
Non-Patent Citations (2)
Title |
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JPN6015022437; Journal of orthopaedic science 3, 1998, 264-271 * |
JPN6015022439; 漢方の臨床 54, 6, 2007, 978-981 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014079188A (ja) * | 2012-10-16 | 2014-05-08 | Kimio Sugaya | 無菌性慢性前立腺炎非ヒトモデル動物、頻尿非ヒトモデル動物およびこれらを用いた被験物質の評価方法 |
WO2019009354A1 (ja) * | 2017-07-05 | 2019-01-10 | 株式会社沖縄リサーチセンター | 排尿障害改善用組成物 |
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