JP2014043566A5 - - Google Patents

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JP2014043566A5
JP2014043566A5 JP2013154368A JP2013154368A JP2014043566A5 JP 2014043566 A5 JP2014043566 A5 JP 2014043566A5 JP 2013154368 A JP2013154368 A JP 2013154368A JP 2013154368 A JP2013154368 A JP 2013154368A JP 2014043566 A5 JP2014043566 A5 JP 2014043566A5
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Japan
Prior art keywords
polylactic acid
resin
acid resin
emulsion
fine particles
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JP2013154368A
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Japanese (ja)
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JP2014043566A (en
JP6168401B2 (en
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Publication of JP2014043566A5 publication Critical patent/JP2014043566A5/ja
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数平均粒子径が１０ｎｍ以上１μｍ未満であり、粒子径分布指数が１〜２であることを特徴とするポリ乳酸系樹脂微粒子。 The number average particle diameter of Ri 1μm less der than 10 nm, the polylactic acid resin particles, wherein 1-2 der Rukoto particle size distribution index. 真球度が９０以上である、請求項１に記載のポリ乳酸系樹脂微粒子。 Sphericity of 90 or more, the polylactic acid resin particles of claim 1. 請求項１または２に記載のポリ乳酸系樹脂微粒子を分散させてなる分散液。 Dispersion obtained by dispersing a polylactic acid-based resin particles according to claim 1 or 2. ポリ乳酸系樹脂（Ａ）およびポリ乳酸系樹脂とは異なるポリマー（Ｂ）をエーテル系有機溶媒（Ｃ）に溶解し、前記ポリ乳酸系樹脂（Ａ）を主成分とする溶液相と前記ポリ乳酸系樹脂とは異なるポリマー（Ｂ）を主成分とする溶液相の２相に相分離する系を形成する溶解工程と、前記相分離する系を撹拌してエマルションを形成するエマルション形成工程と、前記ポリ乳酸系樹脂（Ａ）の溶解度が前記エーテル系有機溶媒（Ｃ）よりも小さいポリ乳酸系樹脂の貧溶媒（α）を前記エマルションに接触させることによってポリ乳酸系樹脂微粒子を析出させる粒子析出工程とを有するポリ乳酸系樹脂微粒子の製造方法であって、前記粒子析出工程は、前記ポリ乳酸系樹脂の貧溶媒（α）の前記エマルションへの添加または前記エマルションの前記ポリ乳酸系樹脂の貧溶媒（α）への添加により前記ポリ乳酸系樹脂の貧溶媒（α）と前記エマルションとを接触させる添加工程と、前記ポリ乳酸系樹脂の貧溶媒（α）と前記エマルションの接触状態を維持することによりポリ乳酸系樹脂微粒子を析出させる接触工程とを含んでおり、前記ポリ乳酸系樹脂（Ａ）と前記ポリ乳酸系樹脂とは異なるポリマー（Ｂ）の質量比（Ａ／Ｂ）が０．８以下であり、前記エマルション形成時の撹拌動力が０．０１ｋＷ／ｍ３以上であり、前記添加工程の所要時間が１０分以上９０分以内であることを特徴とするポリ乳酸系樹脂微粒子の製造方法。 A polylactic acid-based resin (A) and a polymer (B) different from the polylactic acid-based resin are dissolved in an ether-based organic solvent (C), and a solution phase containing the polylactic acid-based resin (A) as a main component and the polylactic acid A dissolution step for forming a system for phase separation into two phases of a solution phase mainly composed of a polymer (B) different from the system resin, an emulsion formation step for stirring the phase separation system to form an emulsion, and Particle precipitation step for precipitating polylactic acid resin fine particles by bringing the poor solvent (α) of the polylactic acid resin having a solubility of the polylactic acid resin (A) smaller than that of the ether organic solvent (C) into contact with the emulsion The method for producing the polylactic acid-based resin fine particles comprises: adding the polylactic acid-based resin to a poor solvent (α) of the polylactic acid-based resin or adding the emulsion to the emulsion. An addition step of bringing the poor solvent (α) of the polylactic acid resin and the emulsion into contact with each other by addition of the relactic acid resin to the poor solvent (α), and the poor solvent (α) of the polylactic acid resin and the emulsion A contact step of precipitating polylactic acid resin fine particles by maintaining the contact state of the polylactic acid resin (A) and the mass ratio of the polymer (B) different from the polylactic acid resin (A) (A / B) is 0.8 or less, the stirring power at the time of forming the emulsion is 0.01 kW / m 3 or more, and the time required for the addition step is 10 minutes or more and 90 minutes or less. A method for producing lactic acid resin fine particles. 前記エーテル系有機溶媒（Ｃ）の沸点が１００℃以上である、請求項４に記載のポリ乳酸系樹脂微粒子の製造方法。 The manufacturing method of the polylactic acid-type resin microparticles | fine-particles of Claim 4 whose boiling point of the said ether type organic solvent (C) is 100 degreeC or more. 前記エーテル系有機溶媒（Ｃ）がジエチレングリコールジメチルエーテルである、請求項５に記載のポリ乳酸系樹脂微粒子の製造方法。 The method for producing polylactic acid-based resin fine particles according to claim 5 , wherein the ether-based organic solvent (C) is diethylene glycol dimethyl ether. 前記ポリ乳酸系樹脂とは異なるポリマー（Ｂ）がヒドロキシプロピルセルロースである、請求項４〜６のいずれかに記載のポリ乳酸系樹脂微粒子の製造方法。 The method for producing polylactic acid resin fine particles according to any one of claims 4 to 6 , wherein the polymer (B) different from the polylactic acid resin is hydroxypropylcellulose. 前記ポリ乳酸系樹脂の貧溶媒（α）が水である、請求項４〜７のいずれかに記載のポリ乳酸系樹脂微粒子の製造方法。 The method for producing polylactic acid resin fine particles according to any one of claims 4 to 7 , wherein the poor solvent (α) of the polylactic acid resin is water.
JP2013154368A 2012-07-31 2013-07-25 Polylactic acid resin fine particles, dispersion using the same, and method for producing polylactic acid resin fine particles Expired - Fee Related JP6168401B2 (en)

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JP2013154368A JP6168401B2 (en) 2012-07-31 2013-07-25 Polylactic acid resin fine particles, dispersion using the same, and method for producing polylactic acid resin fine particles

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JP2012169542 2012-07-31
JP2012169542 2012-07-31
JP2013154368A JP6168401B2 (en) 2012-07-31 2013-07-25 Polylactic acid resin fine particles, dispersion using the same, and method for producing polylactic acid resin fine particles

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JP2014043566A JP2014043566A (en) 2014-03-13
JP2014043566A5 true JP2014043566A5 (en) 2016-08-04
JP6168401B2 JP6168401B2 (en) 2017-07-26

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JP7058944B2 (en) 2017-03-31 2022-04-25 日揮触媒化成株式会社 Organic-inorganic composite particles and cosmetics

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JP6306917B2 (en) * 2014-03-25 2018-04-04 大東化成工業株式会社 Method for producing spherical biodegradable polymer powder
US9988501B2 (en) 2014-06-09 2018-06-05 Toray Industries, Inc. Method of producing polymer microparticles
CN111566130B (en) 2018-01-05 2023-01-24 凸版印刷株式会社 Composite particle, method for producing composite particle, dry powder, and resin composition for molding
JP6861453B2 (en) 2018-03-30 2021-04-21 日揮触媒化成株式会社 Organic-inorganic composite particles, their manufacturing methods, and cosmetics
WO2019208801A1 (en) 2018-04-27 2019-10-31 凸版印刷株式会社 Sustained-release composite particles, method for producing sustained-release composite particles, dry powder, and wallpaper
WO2019208802A1 (en) * 2018-04-27 2019-10-31 凸版印刷株式会社 Composite particles, method for producing composite particles, dry powder, composition for application to skin, and method for producing composition for application to skin
CN110841108A (en) * 2019-12-27 2020-02-28 南京思元医疗技术有限公司 Preparation method of polylactic acid microparticles and injectable soft tissue filler

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JP5133478B2 (en) * 2001-06-12 2013-01-30 ユニチカ株式会社 Method for producing biodegradable polyester resin fine particles
JP3998519B2 (en) * 2001-06-20 2007-10-31 ユニチカ株式会社 Cosmetics
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JP2013010704A (en) * 2011-06-28 2013-01-17 Tokyo Univ Of Science Nanoparticle for iontophoresis and method of manufacturing the same

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7058944B2 (en) 2017-03-31 2022-04-25 日揮触媒化成株式会社 Organic-inorganic composite particles and cosmetics

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