JP2014039570A - Liquid transfer method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid transfer method preventing liquid in a container from foaming to promptly transfer medicine in a medicine container to a syringe.SOLUTION: There is provided a method for transferring liquid in a container to a syringe through a needle tube of the syringe by using a container holder holding a container whose opening part is hermetically closed by an elastic packing section, and a syringe holder holding the syringe. The method comprises: a gas-involving process of involving gas in the syringe; a puncture process of puncturing the needle tube into the elastic packing section; a liquid-transferring process of placing the needle tip of the needle tube on the liquid phase portion of the container and pulling the pusher of the syringe after the puncture process to transfer part of the liquid in the container to the syringe; and a gas-transferring process of placing the needle tip on the gas phase portion of the container and pushing the pusher after the liquid-transferring process to transfer part of the gas in the syringe to the container.

Description

  The present invention relates to a method for transferring a liquid in a container sealed with a rubber stopper or the like to a syringe.

  In order to transfer a medicine sealed in a medicine container such as a vial with an elastic filler such as a rubber stopper to a syringe barrel of a syringe by the apparatus, the following steps are performed.

  First, the pusher is retracted to suck air of approximately the same volume as the volume of medicine to be sucked into the syringe barrel. Then, the needle tube and the rubber plug are made to face each other so that the syringe is positioned above the drug container, and the needle tube of the syringe is punctured into the rubber plug of the drug container. In this state, the syringe and the drug container are rotated 180 degrees while maintaining the positional relationship with each other so that the syringe is positioned below the drug container, the syringe pusher is retracted (pulled), and the necessary drug is Transfer part to syringe. Then, while maintaining the positional relationship between the syringe and the drug container, the pusher is advanced (pushed) to transfer a part of the air in the syringe to the drug container.

  Thereafter, the movement of the drug to the syringe barrel and the transfer of the air to the drug container are repeated, and finally the necessary drug transfer to the syringe barrel is completed (Patent Document 1).

International Publication No. 2010/113401

  However, in the prior art, it may take time to move all the medicines in the medicine container to the syringe barrel.

  That is, in the step of moving a part of the air in the syringe barrel to the drug container, the needle tip is located in the drug solution, and foaming occurs. Even if the drug solution is moved to the syringe in this state, it is necessary to wait for the bubbles to disappear because the drug solution for foaming remains in the drug container.

  Accordingly, an object of the present invention is to provide a liquid transfer method for quickly moving a medicine in a medicine container to a syringe by preventing foaming in the liquid in the medicine container.

  The present invention uses a container holder that holds a container whose opening is sealed with an elastic cuff, and a syringe holder that holds a syringe to transfer the liquid in the container from the needle tube of the syringe to the syringe. A gas containing step of containing gas in the syringe; a puncturing step of puncturing the needle tube into the elastic plug; and after the puncturing step, the needle tip of the needle tube into the liquid phase portion of the container A portion of the liquid in the container is transferred to the syringe by pulling the pusher of the syringe, and after the liquid transferring step and the liquid transferring step, the needle tip is placed in the gas phase portion of the container. And a gas transfer step of transferring a part of the gas of the syringe to the container by pushing the pusher.

  Thereby, the chemical | medical agent of a chemical | medical agent container can be rapidly moved to a syringe, without generating foaming in the liquid of a chemical | medical agent container.

  It is preferable that the method further includes a step of inclining the container in a direction in which the liquid in the container does not come into contact with the elastic plugging portion, and causing the needle tip of the needle tube to face the opening of the container at a constant interval.

  Thereby, since the upper part of the container is a gas phase part, even if the needle tube punctures the elastic plug part, the possibility that the liquid leaks from the container for some reason can be reduced. Further, by making the needle tip and the opening of the container face each other, in the subsequent puncturing step, puncture can be performed with the needle tube perpendicular to the elastic plugging portion.

  Moreover, it is preferable to replace the gas contained in the gas-containing step with the liquid in the container by repeating the liquid transfer step and the gas transfer step.

  Thereby, since the transfer of the liquid to the syringe is gradually completed, the transfer is completed, so that the foaming can be reduced without causing a sudden change in the pressure inside the container and the syringe.

  In the liquid transfer step, the needle tip of the needle tube is arranged in the liquid phase portion of the container by changing the inclination of the syringe holder so that the inclination of the syringe becomes a depression angle, and the gas transfer step includes the syringe It is preferable to place the needle tip in the gas phase portion of the container by changing the tilt of the holder so that the tilt of the syringe is at an elevation angle.

  Thereby, the liquid of a container can be transferred to a syringe, without changing the inclination of a syringe so much. Therefore, foaming of the liquid transferred to the syringe can be prevented.

  In the liquid transfer step, the tip of the needle tube is arranged in the liquid phase portion of the container by changing the inclination of the container holder so that the inclination of the container is a depression angle, and the gas transfer step is performed in the container It is preferable to place the needle tip in the gas phase portion of the container by changing the inclination of the holder so that the inclination of the container is an elevation angle.

  Thereby, the liquid of a container can be transferred to a syringe, without changing the inclination of a container so much. Therefore, the foaming of the liquid in the container can be prevented.

  Further, the liquid of the container is transferred from the needle tube of the syringe to the syringe by changing the inclination of the container holder holding the container whose opening is sealed by the elastic clogging portion and the inclination of the syringe holder holding the syringe. A gas containing step of containing gas in the syringe, a puncturing step of puncturing the needle tube in the elastic clogging portion by narrowing a distance between the container holder and the syringe holder, and the puncturing After the step, by changing the inclination of at least one of the container holder and the syringe holder, the needle tip of the needle tube is arranged in the liquid phase part of the container, and the pusher of the syringe is pulled to pull the pusher A part of the liquid in the container is transferred to the syringe, and after the liquid transfer step and after the liquid transfer step, the inclination of at least one of the container holder and the syringe holder is changed. The needle tip is disposed in the gas phase portion of said vessel, having a gas transfer step of transferring a portion of the syringe of the gas into the container by pushing the pushing element.

  Thereby, the chemical | medical agent of a chemical | medical agent container can be rapidly moved to a syringe, without generating foaming in the liquid of a chemical | medical agent container. In addition, since the liquid in the container can be transferred to the syringe without changing the inclination of the syringe or the container so much, foaming of the liquid transferred to the syringe or the liquid in the container can be prevented.

  ADVANTAGE OF THE INVENTION According to this invention, the chemical | medical agent of a chemical | medical agent container can be rapidly moved to a syringe, without generating foaming in the liquid of a chemical | medical agent container.

(A) is the front view of the chemical | medical agent transfer apparatus which concerns on embodiment of this invention, (b) is the top view. The perspective view of the liquid transfer machine which concerns on embodiment of this invention The flowchart which showed the one part step which implements the liquid transfer method which concerns on embodiment of this invention The front view of the liquid transfer machine explaining the initial process of the liquid transfer method concerning an embodiment of the invention The front view of the liquid transfer machine explaining the gas containing process of the liquid transfer method which concerns on embodiment of this invention The front view of the liquid transfer machine explaining the puncture process of the liquid transfer method which concerns on embodiment of this invention (A) is the front view of the liquid transfer machine explaining the liquid transfer process of the liquid transfer method which concerns on embodiment of this invention, (b) is the partially expanded view. The front view of the liquid transfer machine explaining the gas transfer process of the liquid transfer method which concerns on embodiment of this invention (A) is a front view of the liquid transfer machine explaining the final sampling step of the liquid transfer method according to the embodiment of the present invention, (b) is a partially enlarged view thereof The front view of the liquid transfer machine explaining the non-puncture process of the liquid transfer method which concerns on embodiment of this invention

  Below, the liquid transfer method of this invention is demonstrated in detail with drawing. FIG. 1 shows a drug transfer device 1 for implementing the liquid transfer method of the present invention.

  The medicine transfer device 1 is a storage shelf for storing a base 7 on which a plurality of vials 5 (corresponding to the container of the present invention) are mounted, and a syringe 9 in which no medicine has yet entered, inside a sealed box 3. 11. A syringe holder 13 for holding the syringe 9, a container holder 15 for holding the vial 5, a syringe holder 13 and a container holder 15 are movably mounted, and can rotate vertically on the side surface inside the box 3. The base 17 and the syringe 9 are rearranged from the storage shelf 11 to the syringe holder 13 and removed from the syringe holder 13, and the vial 5 is rearranged from the base 7 to the container holder 15 and removed from the container holder 15. 19 or the like.

  Such a drug transfer device 1 can safely handle dangerous drugs such as radiopharmaceuticals and anticancer drugs, and can reduce work burdens on humans such as mixed preparation and transfer of drug solutions.

  The vial 5 stores a liquid such as the chemical solution 21 and is sealed with a rubber plug 25 (corresponding to the elastic filling portion of the present invention) in the opening 23.

  In the syringe 9, a needle base 29 connected to one end of the needle tube 27 is connected to the opening at the tip of the syringe barrel 31. The pusher 33 is reciprocally movable in the syringe barrel 31. By operating the pusher 33, liquid or gas is taken in and out of the syringe barrel 31.

  FIG. 2 is a perspective view of the liquid transfer device 35 including the syringe holder 13, the container holder 15, and the rotating base 17 on which these are mounted. The liquid transfer machine 35 transfers the drug solution 21 in the vial 5 to the syringe 9 and transfers the gas in the syringe 9 to the vial 5 and directly executes the liquid transfer method of the present invention.

  The syringe holder 13 holds the syringe 9 and fixes it relative to the syringe holder 13, and a syringe barrel fixing portion 39 that fixes both ends in the longitudinal direction of the syringe barrel 31 on the base 37, and A pusher holding portion 43 is provided for receiving a flange at one end of the pusher 33 and reciprocatingly moving on the axis of the syringe 9 by the motor 41 to move the pusher 33 in the syringe barrel 31.

  The container holder 15 includes a container storage body 45 that stores the vial 5 and the like. One side surface of the container storage body 45 is open, and this is an inlet for storing the vial 5. Further, a notch 49 is provided on one surface of the container housing 45 facing the syringe holder 13 so that the opening 23 of the vial 5 can be received and fixed. The container holder 15 having such a configuration holds the vial 5 and fixes it relative to the container holder 15.

  The rotary base 17 has a circular plate 51 as a main component, and the syringe holder 13 and the container holder 15 are mounted on the surface of the circular plate 51 at positions facing each other. That is, the syringe holder 13 and the container holder 15 are mounted on the circular plate 51 so that the opening 23 of the vial 5 is disposed on the extension of the needle tube 27 of the syringe 9.

  The rotary base 17 is provided with a motor 53 that moves the syringe holder 13 on the axis of the syringe 9 and a roller 55 that is fixed to the rotary base 17 and guides the movement of the syringe holder 13 from four corners. With this configuration, the syringe holder 13 can move in the direction of the container holder 15 together with the base 37, and the needle tube 27 can be punctured into the rubber stopper 25 of the opening 23 of the vial 5.

  The rotation base 17 is provided with a shaft (not shown) that is connected to the container holder 15. More specifically, when the container holder 15 stores the vial 5, the shaft is configured to be provided in the container holder 15 near the opening 23 and driven by a motor 57 provided on the back surface of the rotation base 17. ing. For this reason, the container holder 15 has the vicinity of the opening 23 of the vial 5 as the central axis, that is, even if the opening 23 changes its direction, the opening 23 is always positioned on the extension of the needle tube 27. The inclination in a plane parallel to the surface of the circular plate 51 can be changed. Therefore, the container holder 15 is configured to change the inclination relative to the circular plate 51 and change the inclination by changing the angle of the rotation base 17.

  Such a rotation base 17 is connected to the inner side surface of the box 3 of the medicine transfer device 1 and is configured to rotate in the vertical plane by the motor 67 around the center of the circular plate 51. Therefore, the syringe holder 13 attached to the rotation base 17 changes the inclination according to the change in the angle in the vertical plane of the rotation base 17. In response to this, the drug solution 21 in the syringe 9 also moves in the syringe barrel 31. The chemical solution 21 in the vial 5 moves in the vial 5 in accordance with the rotation of the container holder 15 as well as the rotation of the rotation base 17.

  Next, based on the flowchart shown in FIG. 3, the liquid transfer method of the present invention will be described with reference to FIGS.

  The initial process of Step 1 includes a process of initializing the inclination of the syringe holder 13 and the container holder 15, a process of moving the pusher holding portion 43 of the syringe holder 13 toward the container holder 15, and a syringe holder. 13, the step of initializing the position of the base 37, the step of the arm 19 taking the syringe 9 from the storage shelf 11 and mounting it to the syringe holder 13, and the arm 19 taking the vial 5 from the base 7 and the container holder 15 is attached.

  First, the initial inclination of the syringe holder 13 and the container holder 15 in the first step may be arbitrary. In this embodiment, the inclination of the syringe holder 13 is set such that when the syringe 9 is mounted on the syringe holder 13, the direction of the needle tip 59 is vertically downward. Further, the inclination of the container holder 15 was set such that when the vial 5 was mounted on the container holder 15, the direction of the opening 23 was vertically upward (hereinafter, the upper direction in FIG. The circular plate 51 of the rotating base 17 is regarded as a clock board, and the inclination of the syringe holder 13 or the syringe 9 is represented by the clockwise direction in which the needle tip 59 of the needle tube 27 faces. (In the initial step, as shown in FIG. 4, for example, the syringe holder 13 is tilted at 6 o'clock and the container holder 15 is tilted at 12 o'clock). .

  Next is a step of moving the pusher holding portion 43 of the syringe holder 13 toward the container holder 15 side. The purpose of this step is to align the position of the pusher holding portion 43 with the pusher 33 of the syringe 9 introduced into the syringe holding machine 13. In this embodiment, since the pusher 33 of the syringe 9 in the storage shelf 11 is at the position where the tip is inserted to the innermost part of the syringe barrel 31, the pusher holding portion 43 is moved to the container holding machine 15 side. It was.

  In the step of setting the position of the base 37 of the syringe holder 13 to the initial value, the base 37 of the syringe holder 13 is set to the position farthest from the container holder 15.

  In the last step of the initial step, the arm 19 is operated according to an instruction from a control unit (not shown), and the syringe 9 and the vial 5 are attached to the syringe holder 13 and the container holder 15, respectively.

  FIG. 4 shows a state where the initial process is completed. A cap (not shown) that protects the needle tube 27 of the syringe 9 is removed by the arm 19 when the syringe 9 is stored in the storage shelf 11.

  Step 2 is a process of making the syringe 9 and the vial 5 face each other. In this step, the vial 5 is tilted so that the drug solution 21 in the vial 5 does not come into contact with the rubber stopper 25, and the needle tip 59 of the needle tube 27 is opposed to the opening 23 of the vial 5 at a constant interval.

  This step can be realized by adjusting the tilt of the syringe holder 13 and the container holder 15 and the position of the base 37 of the syringe holder 13, but in this embodiment, it has already been realized in the initial step of Step 1. Therefore, there is no new operation to be performed in this step.

  Step 3 is a gas-containing process for causing the syringe 9 to contain a gas. As shown in FIG. 5, this can be realized by moving the pusher holder 43 of the syringe holder 13 in a direction away from the container holder 15 (direction of 12 o'clock of the syringe holder 13) by a predetermined distance. . In this embodiment, since all of the drug solution 21 (for example, 15 ml) in the vial 5 is introduced into the syringe barrel 31, the gas content is the same volume as the drug solution 21 in the vial 5. In addition, the container holder 15 may be operated with the gas introduced into the syringe barrel 31 as a gas volume corresponding to the same mass as the drug solution 21.

  Step 4 is a puncturing process. As shown in FIG. 6, the syringe holder 13 moves the needle tube 27 of the syringe 9 by moving in the direction of the container holder 15 (6 o'clock direction) by the motor 53 and reducing the distance from the container holder 15. The rubber stopper 25 of the vial 5 is punctured. Here, the needle tip 59 of the needle tube 27 passes through the rubber stopper 25 and is then disposed in the gas phase portion 63 in the vial 5 without touching the drug solution 21. By doing so, even if the internal pressure of the vial 5 is higher than the internal pressure of the medicine transfer device 1 for some reason, the possibility that the liquid medicine 21 leaks from the vial 5 can be suppressed.

  Step 5 is a liquid transfer process. In this step, the needle tip 59 of the needle tube 27 is disposed in the liquid phase portion 21 (in the drug solution 21) in the vial 5, and a part of the drug solution 21 in the vial 5 is syringed by pulling the pusher 33 of the syringe 9. And a step of transferring to 9.

  First, the process of arranging the needle tip 59 of the needle tube 27 in the drug solution 21 in the vial 5 will be described. As shown in FIG. 7, the container holder 15 is set at 4 o'clock (2 o'clock with respect to the syringe holder 13), the syringe holder 13 is tilted at 8 o'clock, and the syringe 9 and the vial 5 are tilted. Make each one a corner. Since the drug solution 21 moves downward due to gravity, the needle tip 59 of the needle tube 27 of the syringe 9 can be placed in the drug solution 21 of the vial 5 by such an operation.

  More specifically, as shown in FIG. 7B, which is a partially enlarged view of FIG. 7A, the inclination of the syringe holder 13 and the container holder 15 is adjusted, and the needle tip 59 of the needle tube 27 is It is arranged in the vicinity of the shoulder 65 of the vial 5. By doing so, the needle tip 59 can be reliably arranged in the liquid phase portion 21 of the vial 5.

  Here, the inclination of either one of the syringe holder 13 and the container holder 15 may be changed to be a depression angle, but in this embodiment, the inclinations of both the syringe holder 13 and the container holder 15 are changed. Thus, by changing both inclinations, one inclination can be made small and generation | occurrence | production of the foaming of the chemical | medical solution 21 by the operation | movement for inclining can be suppressed.

  In the next step, the drug solution 21 is transferred to the syringe barrel 31. The drug solution 21 in the vial 5 can be moved to the syringe barrel 31 by pulling the pusher holding portion 43 of the syringe holding machine 13 by a certain distance with the inclination of the syringe 9 and the vial 5 kept at the depression angle.

  The fixed distance for pulling the pusher holding portion 43 is a distance that does not transfer all of the drug solution 21 in the vial 5 to the syringe barrel 31. In this embodiment, the distance that the drug solution 21 of about several ml can move to the syringe barrel 31 is used. . Thereby, the inside of the vial 5 becomes a reduced pressure environment with respect to the internal pressure of the box 3 of the medicine transfer device 1.

  Step 6 is a gas transfer process. In this step, the needle tip 59 of the needle tube 27 of the syringe 9 is disposed in the gas phase portion 63 (in gas) of the vial 5, and a portion of the gas in the syringe 9 is vialed by pushing the pusher 33 of the syringe 9. And the process of transferring to step 5.

  In the step of disposing the needle tip 59 of the needle tube 27 of the syringe 9 in the gas phase portion 63 of the vial 5, the syringe holder 13 and the container holder 15 are at an elevation angle. In this embodiment, the angle of the rotary base 17 is changed by the motor 67 (see FIG. 1B), and the inclination of the syringe holder 13 is set to 10:00, and the inclination of the container holder 15 is set to 2 o'clock by the motor 57. Thereby, as shown in FIG. 8, the needle tip 59 can be disposed in the gas phase portion 63 of the vial 5.

  More specifically, the inclinations of the syringe holder 13 and the container holder 15 are adjusted, and the needle tip 59 of the needle tube 27 is moved to the shoulder 65 of the vial 5 opposite to the position of the needle tip 59 during the liquid transfer process. It is arranged in the vicinity of. By doing so, the needle tip 59 can be reliably placed in the gas phase portion 63 of the vial 5.

  In this state, the pusher 33 of the syringe 9 is pushed by a certain distance by the pusher holding portion 43. Thereby, a part of gas of the syringe 9 is transferred to the vial 5. The pushing distance of the pusher 33 is the same distance as the distance by which the pusher 33 is pulled in the liquid transfer step, and several ml of gas from the syringe barrel 31 is introduced into the gas phase portion 63 of the vial 5. That is, the amount that the chemical solution 21 is transferred from the vial 5 to the syringe barrel 31 in the liquid transfer step is the same as the amount that the gas is transferred from the syringe barrel to the vial 5 in the gas transfer step. Thereby, the inside of the vial 5 becomes the same as the internal pressure of the box 3 of the medicine transfer device 1.

  Here, any one of the inclinations of the syringe holder 13 and the container holder 15 may be an elevation angle. In this embodiment, the inclinations of both the syringe holder 13 and the container holder 15 were changed. Thus, by changing both inclinations, one inclination can be made small and generation | occurrence | production of the foaming of the chemical | medical solution 21 can be suppressed.

  Step 7 determines whether or not the number of times that the liquid transfer step (Step 5) and the gas transfer step (Step 6) have been performed has reached a predetermined number. If the predetermined number is met, the process proceeds to the next step 8; otherwise, the process returns to the liquid transfer process of step 5.

  The predetermined number of steps 7 is set so that the remaining amount of the chemical solution 21 in the vial 5 becomes several ml by repeating the liquid transfer process and the gas transfer process. That is, the amount of the chemical solution in the vial 5 mounted on the liquid transfer device 35 is controlled in advance, and as described above, the liquid transfer step and the gas transfer step are each performed once and transferred to the syringe barrel 31. The amount of chemical is fixed. Therefore, the predetermined number of times of Step 7 can be determined by managing the number of times of performing the liquid transfer process and the gas transfer process and the amount of the chemical solution in the vial 5 mounted on the liquid transfer machine 35.

  In step 7, if the number of execution times of the liquid transfer process and the gas transfer process reaches a predetermined number, the process proceeds to the final sampling process in step 8.

  The final sampling step is a step of transferring all the remaining drug solution 21 (several ml) in the vial 5 to the syringe 9. The motors 57 and 67 that change the inclination of the container holder 15 and the syringe holder 13 are driven, the container holder 15 is set to the 6 o'clock direction, and the angle of the rotation base 17 is changed to change the inclination of the syringe holder 13 to 12 o'clock. In the direction. As a result, the remaining drug solution 21 in the vial 5 collects on the lower surface of the rubber stopper 25, so that the needle tip 59 of the needle tube 27 is positioned in the gas phase portion 63.

  In this state, as shown in FIG. 9, the base 37 of the syringe holder 13 is moved away from the vial 5 by the motor 53 so that the needle tip 59 is positioned at the liquid phase portion 21 of the vial 5. Then, the pusher holding portion 43 of the syringe holding machine 13 is pulled to transfer all the remaining drug solution 21 to the syringe barrel 31.

  Then, it progresses to the process of the non-puncture process of step 9. First, with the state where Step 8 is completed, the rotary base 17 is rotated 180 degrees, the syringe holder 13 is turned to 6 o'clock, and the container holder 15 is turned to 12 o'clock. Then, as shown in FIG. 10, the base 37 of the syringe holder 13 is moved away from the vial 5, and the needle tube 27 is pulled away from the rubber stopper 25.

  By carrying out the above steps, all of the drug solution in the vial 5 is transferred to the syringe 9. Such a drug transfer device 1 may be used as part of mixing preparation, and the syringe 9 containing the drug solution 21 is used for medication of a patient or the like.

  In the present embodiment, all the drug solution 21 in the vial 5 is transferred to the syringe 9, but a part (for example, half of the drug solution in the vial 5) may be transferred. In this case, the process proceeds from step 7 to the non-puncture process of step 9 without going through the final sampling process.

  Further, in the present embodiment, the syringe holder 13 and the syringe 9 are configured to change the inclination only by the rotation base 17 and the vial 5 is configured to change the inclination by the rotation base 17 and the container holder 15, but is not limited thereto. Never happen. For example, the syringe holder 13 may be configured not only to change the inclination by adjusting the angle of the rotation base 17 like the container holder 15 but also to change the inclination with respect to the rotation base 17 itself. Further, the container holding machine 15 may be configured such that the inclination with respect to the rotation base 17 cannot be changed.

  The syringe holder 13 holds the syringe 9 in order to cause the syringe 9 to perform some operation, and may be a partial configuration of a manipulator that holds the syringe 9. The same applies to the container holder 15. Therefore, the syringe holder 13 and the container holder 15 may be arm holding portions. In addition, the syringe holder 13 and the container holder 15 may be configured such that the inclination can be changed by themselves.

  As described above, in the present embodiment, since the process shown in the flowchart of FIG. 3 is performed, the drug solution 21 can be quickly moved to the syringe 9 without generating bubbles in the drug solution 21 of the vial 5.

  That is, when the air of the syringe 9 is transferred to the vial 5, the needle tip 59 of the needle tube 27 is arranged in the gas 63 of the vial 5 (not in the chemical solution), so that the chemical solution 21 is unlikely to foam.

  In addition, since the positional relationship between the syringe holder 13 and the container holder 15 is leveled, and the inclination in which the syringe 9 and the vial 5 face is repeated as the elevation angle and the depression angle based on this, foaming of the drug solution 21 is unlikely to occur. Further, in this repetition, the amount of insertion of the needle tube 27 inserted into the rubber stopper 25 of the vial 5 is not changed, so that the configuration is not complicated. That is, when the positional relationship between the syringe holder 13 and the container holder 15 is fixed vertically and the drug solution 21 is transferred, each time the drug solution 21 in the vial 5 is transferred to the syringe 9, the rubber plug 25 of the needle tube 27 is transferred to the rubber plug 25. It is necessary to reduce the amount of insertion. Therefore, in some cases, it is necessary to perform image processing with a camera or the like. In the present embodiment, since such a configuration is not required, the drug solution 21 can be transferred to the syringe 9 with a simple configuration.

  INDUSTRIAL APPLICATION This invention is useful for the apparatus which transfers a chemical | medical agent from the container by which the opening part was sealed by the elastic clogging part. In particular, it is useful for equipment such as a drug mixing apparatus that performs mixing preparation.

1 drug transfer device 3 box 5 vial (container)
7 Pedestal 9 Syringe 11 Storage shelf 13 Syringe holder 15 Container holder 17 Rotating base 19 Arm 21 Chemical liquid (liquid phase part)
23 Opening 25 Rubber plug (elastic plug)
27 Needle tube 29 Needle base 31 Injection cylinder 33 Pusher 35 Liquid transfer machine 37 Base 39 Injection cylinder fixing part 41 Motor 43 Pusher holding part 45 Container storage body 49 Notch 51 Circular plate 53 Motor 55 Roller 57 Motor 59 Needle tip 63 Air Phase 65 Shoulder 67 Motor

Claims (6)

A method of transferring a liquid in the container from a needle tube of the syringe to the syringe using a container holder that holds a container whose opening is sealed by an elastic clogging portion and a syringe holder that holds a syringe. ,
A gas containing step of containing a gas in the syringe;
A puncturing step of puncturing the needle tube into the elastic plugging portion;
After the puncturing step, the needle tip of the needle tube is disposed in the liquid phase portion of the container, and a liquid transfer step is performed by pulling a pusher of the syringe to transfer a part of the liquid in the container to the syringe.
A gas transfer step of placing the needle tip in the gas phase portion of the container after the liquid transfer step and transferring a part of the gas of the syringe to the container by pushing the pusher. A liquid transfer method. Tilting the container so that the liquid in the container does not come into contact with the elastic plug,
The liquid transfer method according to claim 1, further comprising a step of causing the needle tip of the needle tube to face the opening of the container at a constant interval.   The liquid transfer method according to claim 1, wherein the gas contained in the gas-containing step is exchanged with the liquid in the container by repeating the liquid transfer step and the gas transfer step. In the liquid transfer step, by changing the inclination of the syringe holder, the needle tip of the needle tube is arranged in the liquid phase portion of the container with the inclination of the syringe as a depression angle,
4. The gas transfer step according to claim 1, wherein the needle tip is arranged in a gas phase portion of the container with the inclination of the syringe as an elevation angle by changing the inclination of the syringe holder. The liquid transfer method according to item 1. In the liquid transfer step, by changing the inclination of the container holder, the needle tip of the needle tube is arranged in the liquid phase part of the container with the inclination of the container as a depression angle,
5. The gas transfer step according to claim 1, wherein the needle tip is arranged in a gas phase portion of the container with an inclination of the container as an elevation angle by changing an inclination of the container holder. The liquid transfer method according to item 1. A method of transferring the liquid in the container from the needle tube of the syringe to the syringe by changing the inclination of the container holder holding the container whose opening is sealed by the elastic filling portion and the inclination of the syringe holder holding the syringe Because
A gas containing step of containing a gas in the syringe;
A puncturing step of puncturing the needle tube into the elastic plugging portion by narrowing the distance between the container holder and the syringe holder;
After the puncturing step, by changing the inclination of at least one of the container holder and the syringe holder, the needle tip of the needle tube is placed in the liquid phase portion of the container and the pusher of the syringe is pulled. And transferring a part of the liquid in the container to the syringe, and a liquid transfer step,
After the liquid transfer step, by changing the inclination of at least one of the container holder and the syringe holder, the needle tip is arranged in the gas phase part of the container and the syringe is pushed by pushing the pusher. And a gas transfer step of transferring a part of the gas to the container.

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