JP2014012907A - Binder containing food product or food additive - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a binder that has a sufficient antibacterial property by uniformly developing a food product or a food additive having antibacterial and antiviral properties on a surface of a nanofiber and is further capable of discharging coated fine particles by coated with the fine particles and then sandwiched with a nonwoven fabric.SOLUTION: The binder containing a food product or a food additive includes a base polymer and a food product or a food additive, and is obtained by providing nano/micro particles of a food product or a food additive to a nanofiber having a diameter of 1 nm to 2000 nm.

Description

  The present invention relates to a food or a food additive-containing binder used for collecting fine particles.

  A technique for producing polymer fibers having an average fiber diameter of nanometer size by an electrospinning method is known (Patent Document 1). While the polymer solution moves from the nozzle to the target electrode by discharging the polymer solution from the nozzle provided at the tip of the container storing the raw polymer solution to the target electrode to which a high voltage is applied In addition, it is a technique in which a fibrous fiber is formed along the lines of electric force, and a polymer fiber is produced on the target electrode. By this method, fibers having an average fiber diameter of the order of 10 nm to several hundred nm and sheets or mats (nanofiber aggregates) in which the fibers are integrated can be produced.

  Polymer nanofibers produced by electrospinning have a smooth surface, and it is not always easy to decorate the surface and add functions. For this reason, if another substance different from the polymer is mixed in the polymer, the other substance may be embedded in the polymer of the nanofiber, and the original function may not be exhibited.

  On the other hand, from fibers produced using an electrospinning method, pollen prevention masks (Patent Document 2), water-soluble sheets (Patent Document 3), nanofibers containing foods or food additives (Patent Document 4), etc. The technology to be provided is being developed.

US Pat. No. 6,656,394 JP 2010-274102 A No. 2009/031620 JP 2008-38271 A

However, in the conventional technique (for example, Patent Document 4), the food or food additive may not be sufficiently uniformly dispersed or dissolved in the nanofibers. The effects of things could not be fully exhibited.
The present invention has been made in view of the above circumstances, and the purpose thereof is, for example, to allow food or food additives having antibacterial and antiviral properties to be uniformly expressed on the surface of the nanofiber, and By binding food additive particles, it is possible to fly particles to the outside, and to provide foods or food additive nano / micro binders that can give sufficient antibacterial and functional properties, etc. And

As a result of intensive studies to solve the above problems, the present inventors have completed the present invention.
Thus, the invention for solving the above-described problems is as follows.
(1) A nanofiber sheet to which food or food additive material particles having an average particle diameter of nano to micro are adhered, and both surfaces or one surface thereof are bonded with a nonwoven fabric having an average fiber diameter of nano to micro. A binder for nano / micro particles.
(2) The nano / microparticle binder according to (1), wherein the particles are released from the binder to the outside when passing through the atmosphere.

(3) Food or food additive material particles are catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, lysozyme, neem, sodium chloride, dextrin, The binder for nano / micro particles according to (1), comprising at least one food or food additive material particle selected from the group consisting of calcium, coenzyme Q10, iron pyrophosphate, theanine, amla, and emulsifier.
(4) The catechin polyphenol contains 20 to 80% as the total content of catechin in the catechin polyphenol, and further contains 20 to 95% as epigallocatechin gallate in the catechin, (3) The binder for nano-micro particles as described.

(5) Any of (1) to (5) above, wherein the nonwoven fabric contains at least one selected from the group consisting of polyolefin, polypropylene, polystyrene, polyamide, polyimide, polyester, polyvinyl alcohol, and polyurethane. The binder for nano-micro particles as described.
(6) The nano / microparticle binder according to any one of (1) to (5), wherein the nonwoven fabric is a nonwoven fabric produced by a wet method.

(7) The nanofiber sheet is PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinyl chloride, polyurethane, polyester, At least one base polymer selected from the group consisting of polypropylene, zein, collagen, methoxymethylated nylon, and catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid And at least one food or food additive selected from the group consisting of coumarin, lysozyme, and neem, and having a diameter of 1 nm to 2000 nm The binder for nano / microparticles according to any one of (1) to (6) above, comprising the nanofiber provided.
(8) In addition to the nanofiber sheet, PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinyl chloride, polyester (1) to (1), comprising at least one reinforcing polymer selected from the group consisting of polypropylene, zein, collagen, and polyurethane, and reinforcing nanofibers having a diameter of 1 nm to 2000 nm. (7) The binder for nano / micro particles according to any one of the above.

(9) The binder for nano / microparticles according to (7) or (8) above, wherein the food or food additive is uniformly dispersed or dissolved in the base polymer.
(10) The binder for nano / microparticles according to any one of (1) to (9) above, comprising only a base polymer and a food or food additive.

(11) The nano-microparticle binder according to any one of (1) to (10) above, wherein the mass per unit area of the nanofiber is 0.005 g / m ^{2 to} 10 g / m ² .
(12) air ^{permeability, 1cc / cm 2 · sec~1000cc /} cm 2 · said, which is a sec (1) ~ (11) nano-microparticles binder according to any one.

(13) The resin constituting the resin composition binder has negative or positive static electricity, and attracts the surrounding positively or negatively electrostatically charged substance, according to any one of (1) to (12) above Nano / micro particle binder.
(14) A nano-material according to any one of (1) to (13), wherein the binder is a food or food additive-containing binder, and the resin composition binder is composed of a nonwoven fabric and is used for air cleaning. Microparticle binder.

(15) The surgical nano / microparticle binder according to (14), wherein the fine particle capturing force of 0.1 μm or more is 99% or more.
(16) The surgical nano / microparticle binder according to the above (14), wherein the fine particle capturing force of 3 μm or more is 99% or more.

(17) The binder for nano / microparticles according to (14) above, which has a bacteriostatic activity value of 4.0 or more against Staphylococcus aureus and Escherichia coli.
(18) The binder for nano / microparticles according to (14), wherein the pressure loss (mmH ₂ O / cm ² ) is 3.0 or less.

(19) PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinylidene chloride, polyester, polypropylene, zein, collagen, At least one base polymer selected from the group consisting of polyvinyl chloride, methoxymethylated nylon and polyurethane is water, acetone, methanol, ethanol, propanol, toluene, benzene, cyclohexane, cyclohexanenon, tetrahydrofuran, dimethyl sulfoxide, 1, 4 -Dioxane, carbon tetrachloride, methylene chloride, pyridine, N-methyl-2-pyrrolidone, ethylene carbonate, diethyl carbonate, propylene car A polymer-containing solution dissolved in at least one solvent selected from the solvent group consisting of bonate, acetonitrile, lactic acid, acetic acid, dimethylacetamide, dimethylformamide, dichloromethane, trichloromethane, hexafluoroisopropanol, formic acid, chloroform, formaldehyde, and acetaldehyde At least one food selected from the group consisting of catechin polyphenols, persimmon astringent polyphenols, grape seed polyphenols, soybean polyphenols, lemon peel polyphenols, coffee polyphenols, phenylcarboxylic acid, ellagic acid, coumarin, or A food additive or a food additive-containing solution is prepared by dissolving the food additive in at least one solvent selected from the solvent group, and the polymer-containing solution and the food or food additive are prepared. The nano-microparticle according to any one of (1) to (18) above, wherein a mixed solution is prepared by mixing with an additive-containing solution, and the mixed solution is produced from fibers spun by an electrospinning method. Method for manufacturing binder.
(20) The solvent for preparing the base polymer solution and the food or food additive-containing solution is any one selected from the group consisting of formic acid, hexafluoroisopropanol, water, dimethylformamide, ethanol and dichloromethane. The method for producing a binder for nano / microparticles according to (19), which is characterized in that it exists.

(21) The method for producing a binder for nano / microparticles according to the above (19) or (20), wherein the food or the food additive-containing solution contains sodium chloride.
(22) The method for producing a binder for nano / microparticles according to any one of (19) to (21), wherein the mixed solution is uniformly transparent.
In producing the binder, when spinning the nanofiber nonwoven fabric, a nonwoven fabric having a diameter of 1 nm to 10 cm is used as a collector and spinning onto the nonwoven fabric, or after spinning the nanofiber nonwoven fabric alone A method of adhering to a non-woven fabric having a diameter of 1 nm to 10 cm by an adhesion component such as thermocompression bonding or a solvent can be employed.

  ADVANTAGE OF THE INVENTION According to this invention, the nonwoven fabric which contains a foodstuff or a food additive uniformly on the surface of a nanofiber can be provided. This nanofiber nonwoven fabric has both the function of nanofiber and the function of catechins that are foods or food additives, so it has antioxidant, antibacterial, antiviral, deodorant, harmful substance adsorption, Has mold action. For this reason, it can use conveniently about the binder for nano / micro particles containing a foodstuff or a food additive, especially the binder for surgical nano / micro particles.

FIG. 1 is a drawing-substitute electron micrograph (magnification: × 1000) of nanofibers. Example 1 FIG. 2 is a drawing-substitute electron micrograph (magnification: × 4000) of the nanofiber. Example 1 FIG. 3 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 2) FIG. 4 is a drawing-substitute electron micrograph (magnification: × 4000) of the nanofiber. (Example 2) FIG. 5 is a drawing-substituting electron micrograph (magnification: × 500) of the nanofiber. (Example 3) FIG. 6 is a drawing-substitute electron micrograph (magnification: × 3000) of the nanofiber. (Example 3) FIG. 7 is a drawing-substitute electron micrograph (magnification: × 10000) of the nanofiber. Example 4 FIG. 8 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 5) FIG. 9 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 5)

FIG. 10 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 6) FIG. 11 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 6) FIG. 12 is a drawing-substitute electron micrograph (magnification: × 10000) of the nanofiber. (Example 7) FIG. 13 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 8) FIG. 14 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 8) FIG. 15 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. Example 9 FIG. 16 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. Example 9 FIG. 17 is a drawing-substitute electron micrograph (magnification: × 5000) of the nanofiber. (Example 10) FIG. 18 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 10) FIG. 19 is a drawing-substitute electron micrograph (magnification: 500) of the nanofiber. (Example 11)

FIG. 20 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 11) FIG. 21 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 12) FIG. 22 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 12) FIG. 23 is a drawing-substitute electron micrograph (magnification: × 4000) of the nanofiber. (Example 13) FIG. 24 is a drawing-substitute electron micrograph (magnification: × 5000) of the nanofiber. (Example 14) FIG. 25 is a drawing-substitute electron micrograph (magnification: × 5000) of fiber. (Example 15) FIG. 26 is a drawing-substitute electron micrograph of the nanofiber (magnification: × 5000). (Example 16) FIG. 27 is a drawing-substitute electron micrograph (magnification: 5000) of the nanofiber. (Example 17) FIG. 28 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 18) FIG. 29 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 19)

FIG. 30 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 20) FIG. 31 is a drawing-substitute electron micrograph (magnification: × 5000) of nanofibers. (Example 20) FIG. 32 is a drawing-substitute electron micrograph of the nanofiber (magnification: × 5000). (Example 21) FIG. 33 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 21) FIG. 34 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 22) FIG. 35 is a drawing-substitute electron micrograph (magnification: × 500) of the nanofiber. (Example 23) FIG. 36 is a drawing-substitute electron micrograph (magnification: × 5000) of the nanofiber. (Example 24) FIG. 37 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 24) FIG. 38 is a drawing-substitute electron micrograph (magnification: × 5000) of the nanofiber. (Example 25) FIG. 39 is a drawing-substitute electron micrograph (magnification: × 20000) of the nanofiber. (Example 25)

FIG. 40 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 26) FIG. 41 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 26) FIG. 42 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 27) FIG. 43 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 28) FIG. 44 is a drawing-substitute electron micrograph (magnification: × 1000) of the nanofiber. (Example 29) FIG. 45 is a drawing-substitute electron micrograph (magnification: x100) of the nanofiber. (Example 30)

Next, embodiments of the present invention will be described in detail. The technical scope of the present invention is not limited by the following embodiments, and various modifications can be made without changing the gist of the invention. Further, the technical scope of the present invention extends to an equivalent range.
The binder used in the present invention may be electrospinning, melt spinning, or melt electrospinning. Preferably, the material spun onto the nonwoven fabric using the electrospinning method and sandwiching the particles using the micro nonwoven fabric. Or stuck on the nonwoven fabric.
For the particles, after dissolving or turbidizing the food or food additive in the liquid, use an electrospinning device as described in the electrostatic coating method (described as electrolytic coating below), or fine particles by spray drying. Is generated.
This electrostatic coating method is similar to the electrospinning method, and can be applied evenly as fine particles by placing the paint in a container such as a syringe, applying charge from the outside, and spraying the paint in a charged state. Technology.

PVA used in the present invention is a kind of synthetic resin represented by the formula (—CH ₂ CH (OH) —) _n , and since it contains many hydroxyl groups, its hydrophilicity is very strong, It is soluble.
Polylactic acid is a type of biodegradable plastic that has lactic acid (CH ₃ CH (OH) COOH) as a unit and a plurality of lactic acids are linked to have a high molecular weight. Lactic acid as a material for producing polylactic acid can be produced from plants (for example, corn, bonito, sugar cane, beet, sweet potato, etc.). In order to produce polylactic acid, lactic acid is generally cyclized into lactide, which is ring-opened and polymerized to form polylactic acid. However, in the present invention, the method for producing polylactic acid is not particularly limited.

Two types of optical isomers, L-type and D-type, are known for lactic acid as a simple substance constituting polylactic acid. The present invention can also be used for polylactic acid produced using either L-type or D-type lactic acid as a unit (or for polylactic acid containing L-type and D-type in any ratio).
Fibroin means a kind of fibrous protein that is the main component of silkworm silk.
Chitosan mainly means β-1,4-polyglucosamine and is a deacetylated product of chitin. Although a β-1,4-polyglucosamine structure is main, it is produced by melting chitin with concentrated alkali, so there may be some structural changes.

Chitin means a linear nitrogen-containing polysaccharide polymer composed of poly-β1-4-N acetylglucosamine. Known as the main component of the exoskeleton of arthropods and crustaceans.
Nylon 6, nylon 66, nylon 9T, and nylon 610 mean types of polyamide synthetic fibers.
Polyamide means a polymer composed of a large number of monomers bonded by amide bonds.

Polystyrene means a polymer in which a large number of styrenes are bonded.
Polyacrylonitrile means one kind of organic polymer obtained by polymerizing acrylonitrile.
Polyethylene terephthalate means a kind of polyester formed by dehydration condensation of ethylene glycol and terephthalic acid.
Polyvinyl chloride is a kind of polymer compound obtained by homopolymerization of vinyl chloride or copolymerization with vinyl acetate or the like.
Polyvinylidene chloride means a synthetic resin obtained by polymerizing vinylidene groups containing chlorine.

Polyester means a polycondensate of polyvalent carboxylic acid and polyalcohol.
Polyolefin is a general term for polymers (polymers) synthesized using simple olefins and alkenes as monomers (unit molecules). For example, polyethylene is a polyolefin obtained by polymerizing ethylene. Polypropylene is another well-known polyolefin and is made from propylene.
Zein is a major protein of corn seed and belongs to prolamin. Prolamin is a generic term for proteins belonging to simple proteins, soluble in 60% to 90% ethanol, and insoluble in 90% or more ethanol, water, and neutral salt solutions. In addition, wheat gliadin, barley hordein and so on. Zein is composed of various molecular species, and main components include those having a molecular weight of 22,000 and a molecular weight of 19000.
Collagen means the main protein component that constitutes the connective tissue of animals. Mammals account for nearly 30% of the body's total protein. Collagen consists of 10 or more protein super families such as type I and type II, and has a high content of glycine and proline. In the present invention, any type of collagen or mixture can be used.

  In the present invention, the food or food additive material is not particularly limited, but preferably catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid , Coumarin, lysozyme, neem, sodium chloride, dextrin, calcium, coenzyme Q10, iron pyrophosphate, theanine, amla, at least one food additive material, more preferably catechin polyphenol,柿 Astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, lysozyme, Over arm is a food or food additive material having a functionality such.

  Catechin polyphenol is a water-soluble polyhydric phenol that is abundant in plants such as tea. There are two types of catechin: non-polymerized catechin and polymerized catechin. The non-polymerized catechin includes a gallate body containing catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate, and a non-gallate body containing catechin, epicatechin, gallocatechin and epigallocatechin. Furthermore, catechin has a classification method of epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate, and a non-epi form including catechin, gallocatechin, catechin gallate, and gallocatechin gallate.

The content of typical catechin contained in catechin polyphenol is not particularly limited, but epigallocatechin ghat: EGCg represents 20 to 95% in catechin, and catechin total content is 20 to 80%. The thing containing is preferable.
The catechin oligomer means a product in which 3 to 10 catechins are bonded. Catechin includes a plurality of types as described above. In the present invention, a catechin oligomer to which any of these molecules (including the same type or different types) is bound can be used.

The persimmon astringent polyphenol means polyphenols obtained from the juice obtained from the fruit of astringent persimmon. Persimmon astringent polyphenol contains tannin, catechin, flavonoid and the like.
The grape seed polyphenol means a polyphenol obtained from a juice obtained from grape seeds. Grape seed polyphenol contains anthocyanins and the like.
The soy polyphenol means a polyphenol obtained from a juice obtained from soybean. Soy polyphenol contains isoflavones, anthocyanins and the like.

Lemon peel polyphenol means polyphenol obtained from juice obtained from lemon peel. Lemon peel polyphenol contains hesperidin and the like.
Coffee polyphenol means a polyphenol obtained from the juice of coffee beans. Coffee polyphenol contains bitter components such as chlorogenic acid.
In the present specification, “the catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin” are collectively referred to as “polyphenol compound”. The polyphenol compound is included in the food or food additive of the present invention.

  Next, lysozyme used in the present invention is an enzyme that hydrolyzes polysaccharides that constitute the cell walls of eubacteria. This action is also called a lytic enzyme because it appears to dissolve bacteria. In humans, it is contained in tears, nasal discharge and breast milk. Industrially, lysozyme extracted from egg white is applied to food and medicine. Used as a food additive to improve shelf life. In particular, since the effect is enhanced by using in combination with glycine or adjusting the pH with an organic acid, it is distributed to food manufacturers in the form of a combination of egg white lysozyme-glycine-organic acid.

  The neem is a name of a medicinal tree (Indosendan) mainly cultivated in India and Southeast Asia, and the neem in the present invention means an oil squeezed from the medicinal tree. The neem and lysozyme are included in the food or food additive of the present invention.

Next, the emulsifier used in the present invention is a general term for drugs used for the purpose of emulsification, foaming and defoaming. As synthetic additives, glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, and sucrose fatty acid ester are approved, and among these, glycerin fatty acid ester has the highest consumption. Other natural and existing additives include lecithin from soybeans and egg yolk, saponin from Kiraya, sodium casein made from milk. For limited use, oxyethylene fatty acid alcohol, sodium oleate and morpholine fatty acid salts, and polyoxyethylene higher fatty acid alcohol for skin removal during canned citrus cans are approved as coating agents for fruit and vegetable skins. Yes. Outside Japan, calcium stearoyl lactate is used for bread making, and ammonium monoglyceride phosphate is used as a viscosity reducing agent for chocolate.
The glycerin fatty acid ester is a typical food emulsifier in which a fatty acid is ester-bonded to one or two of the three hydroxy groups of glycerin. A combination of one fatty acid is a monoglyceride and a combination of two fatty acids is a diglyceride, which are commonly called monoglycerides.

Sucrose fatty acid ester is comprised with the fatty acid obtained from sucrose of a hydrophilic group and edible fats and oils of a lipophilic group.
Iron pyrophosphate is obtained by reacting ferric chloride or ferrous iron with sodium pyrophosphate as a raw material, and is designated as a food additive.
Coenzyme Q10 is called CoQ-10 and is a benzoquinone structurally similar to fat-soluble quinone and vitamin K, and is generally known as ubiquinone. CoQ-10 is found in most organisms and is essential for the production of cellular energy. CoQ-10 (2,3 dimethyl-5 methyl-6-decaprenylbenzoquinone) is an endogenous antioxidant found in small amounts in meat and seafood. CoQ-10 is found in all human cells, but the highest concentration of CoQ-10 is found in the heart, liver, kidney and pancreas. This is usually found in organs of many mammalian species.

Sodium chloride is a sodium chloride represented by the chemical formula NaCl. Often referred to simply as salt or salt, the term “salt” is a term that refers to a sodium chloride product originally prepared for food and medical use.
For most living organisms on earth, including mammals including humans (living bodies), it is an important substance that is essential for sustaining life as a source of sodium, an essential mineral.
Calcium is a metal element having an atomic number of 20. The element symbol is Ca. It is a kind of periodic earth group 2 alkaline earth metal element and is a representative mineral (essential element) of animals and plants including humans. In Japan (mainly in the health field), there are times when it turns to “calcium” after a specific trademark. Various forms of calcium exist as food additives such as calcium chloride, calcium sulfate, calcium hydroxide, calcium carbonate, calcium phosphate, calcium lactate, and whey calcium.

  In the present specification, “the above-mentioned soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, neem, lysozyme, sodium chloride, dextrin, calcium, coenzyme Q10, iron pyrophosphate, theanine, amla, The “particles made of emulsifier” are collectively referred to as “food or food additive material particles”. The polyphenol compound is included in the food or food additive of the present invention.

The nanofiber of the present invention means a fiber having a single yarn diameter of about 1 nm to about 2000 nm, and when it is produced by an electrospinning method, a collection of nanofibers becomes a nonwoven fabric. The nanofiber obtained as a nonwoven fabric is useful as a binder and a binder for fine particles.
For fine particles, food or food additive material particles are catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, sodium chloride, dextrin, calcium, coenzyme Q10, at least one food or food additive material particle selected from the group consisting of iron pyrophosphate, theanine, amla, and emulsifier, and is a particle of nano to micro size.
For this reason, although it does not specifically limit, an average particle diameter is 0.01 nm-1000 micrometers, Preferably, an average particle diameter is 0.5 nm-100 micrometers, More preferably, an average particle diameter is 1 nm-10 micrometers.

If the air permeability of the binder is too small, the resistance is large, which is not preferable. Moreover, although the larger one is preferable about the air permeability of a binder, technical difficulty becomes large. For this reason, the numerical value of air permeability is not particularly limited, but the upper limit is 1000 cc / cm ² · sec or less, preferably 500 cc / cm ² · sec or less, more preferably 300 cc / cm ² · sec or less. The lower limit is 1 cc / cm ² · sec or more, preferably 10 cc / cm ² · sec or more, more preferably 40 cc / cm ² · sec or more.

  In order to produce a non-woven fabric, the base polymer is mixed with an appropriate solvent (inorganic solvent such as water, acid amide solvent (including protic polar solvent and aprotic polar solvent), organic acid solvent (particularly carboxylic acid or sulfonic acid). In a solvent containing a). Apart from this, among foods or food additives, polyphenol compounds called functional substances having antibacterial and antiviral effects are used as organic acid solvents (particularly including solvents containing carboxylic acids or sulfonic acids). Dissolve.

  In order to prepare a biodegradable polyester-containing solution (or a polymer-containing solution), 1 part by mass to 50 parts by mass of the base polymer (preferably 3 parts by mass to 20 parts by mass, more preferably 3 parts by mass to 10 parts by mass). Part) is dissolved in 50 to 99 parts by mass of the solvent (preferably 80 to 97 parts by mass, more preferably 90 to 99 parts by mass). Moreover, in order to prepare a food or food additive-containing solution, 0.001 to 70 parts by mass of the food or food additive (preferably 0.1 to 60 parts by mass, more preferably 1 to 4 parts by mass). 50 parts by mass) is dissolved in 30 parts by mass to 99.999 parts by mass of solvent (preferably 40 parts by mass to 99.999 parts by mass, more preferably 50 parts by mass to 99.999 parts by mass). The biodegradable polyester-containing solution (or polymer-containing solution) and the food or food additive-containing solution are 50 parts by mass to 99.999 parts by mass: 0.0001 parts by mass to 50 parts by mass (preferably 60 parts by mass). Parts by mass to 99.999 parts by mass: 0.0001 parts by mass to 40 parts by mass, and more preferably 75 parts by mass to 99 parts by mass: 1 part by mass to 25 parts by mass). In the nanofibers thus produced, the ratio of polymer to food or food additive is 50 parts by mass to 99.9999 parts by mass: 50 parts by mass to 0.0001 parts by mass (preferably 60 parts by mass to 99.9999 parts by mass: 40 parts by mass to 0.0001 parts by mass).

Next, both solutions are mixed to prepare a mixed solution. In the present invention, since the mixed solution is transparent, the polyphenol compound is also dissolved (not suspended). For this reason, even when the electrospinning method is performed, the polyphenol compound is uniformly distributed in the nanofibers.
Sodium chloride (NaCl) can be contained in the food or food additive-containing solution. This is preferable because the fiber diameter can be stably produced with a minimum size. Moreover, as a density | concentration of sodium chloride, 0.001 mass%-1 mass% are preferable, and 0.01 mass%-0.1 mass% are still more preferable.

An electrospinning method is performed using the mixed solution. The electrospinning method can be influenced by factors such as the concentration of the spinning substrate, the type of solvent, the diameter of the needle, the injection distance, the rotation speed, the voltage, and the injection speed. In order to actually manufacture a nanofiber nonwoven fabric, the above factors can be combined appropriately.
As a test for evaluating the capturing ability of fine particles of 0.1 μm or more, it can be evaluated by a PFE test (Particulate Filtration Efficiency).
In addition, as a test for evaluating the fine particle capturing ability of 3 μm or more, it can be evaluated by a BFE test (Bacterial Filtration Efficiency).

The bacteriostatic activity value refers to the difference in the number of live bacteria in the processed product relative to the raw product, after inoculating the fiber product and the processed product with antibacterial deodorization and antibacterial treatment, and inoculating bacteria. Indicates. The bacteriostatic activity value can be evaluated by using a quantitative test (bacterial solution absorption method) described in JIS L1902.
Further, the air permeability of the binder can be evaluated by using a Frazier type air permeability test described in JIS L 1096.
EXAMPLES Next, although an Example and a test example demonstrate this invention in detail, this invention is not limited by these Examples and a test example.

Example 1. Polylactic acid + catechin polyphenol + NaCl
Polylactic acid (made by Mitsui Chemicals, Inc.) is used as the base polymer, and catechin polyphenol (made by Taiyo Chemical Co., Ltd., Sunphenon BG-3: polyphenol content 80% or more, catechin content 70% or more, average as food or food additive The particle size is 100 μm.) Hereinafter, a nonwoven fabric was produced using “catechin (denoted as Sanphenon BG-3)”.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, ethanol was added to catechin polyphenol (Sunphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution), and 0.01 wt% NaCl was further dissolved. The above two kinds of solutions were mixed with 7.5 g of a biodegradable polyester-containing solution and 2.5 g of a polyphenol compound-containing solution to obtain a colorless and transparent mixed solution. This mixed solution (polylactic acid and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.1 and FIG.2. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 2 Polylactic acid + catechin polyphenol As a base polymer, polylactic acid (manufactured by Mitsui Chemicals) is used, and as a food or food additive, catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon EGCg: EGCg content of 90% or more, average particle size is 100 μm). Hereinafter, a nonwoven fabric was produced using “catechin (Sanphenon EGCg)”.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added to catechin (Sanphenon EGCg) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a transparent mixed solution. This mixed solution (polylactic acid and catechin EGCg-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.3 and FIG.4. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . In addition, about the fabric weight, it was able to design freely according to a use by changing conditions suitably in the range similar to Example 1. FIG.

Example 3 Non-woven fabric was prepared using polylactic acid (made by Mitsui Chemicals, Inc.) as a polylactic acid + astringent astringent polyphenol base, and using astringent astringent polyphenol (odorless astringent astringent: manufactured by Osugi-type Paper Industries Co., Ltd.) as a food or food additive.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added and dissolved in persimmon astringent polyphenol to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a transparent mixed solution. This mixed solution (polylactic acid and persimmon astringent polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.5 and FIG.6. The average fiber diameter of the nonwoven fabric was 2 μm. The basis weight was 0.5 g / m ² . In addition, about the fabric weight, it was able to design freely according to a use by changing conditions suitably in the range similar to Example 1. FIG.

Example 4 Polyvinyl alcohol + catechin polyphenol Polyvinyl alcohol (manufactured by Wako Pure Chemical Industries, Ltd .; hereinafter referred to as “PVA”) is used as a base polymer, and catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sanphenon BG-) as a food or food additive. 3. An average particle size of 100 μm (hereinafter referred to as “catechin (Sanphenon BG-3)”) was used to prepare a nonwoven fabric.

  PVA 10g and ion exchange water 90g were mixed, PVA was melt | dissolved by heating (40-60 degreeC), and the biodegradable polyester containing solution (polymer containing solution) was prepared. Further, ethanol was added to catechin polyphenol (Sunphenon BG-3) and mixed to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Among the two types of solutions, 7.5 g of the polyvinyl alcohol-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a reddish brown transparent mixed solution. This mixed solution (PVA and catechin (Sunphenon BG-3) -containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

An electron micrograph of the obtained nonwoven fabric is shown in FIG. The average fiber diameter of the nonwoven fabric was 250 to 500 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.01 g / m ² . In addition, about the fabric weight, it was able to design freely according to a use by changing conditions suitably in the range similar to Example 1. FIG.

Example 5 FIG. Polyvinyl chloride + catechin polyphenol Polyvinyl chloride (manufactured by Wako Pure Chemical Industries, Ltd.) is used as a base polymer, and catechin polyphenol (manufactured by Taiyo Chemical Co., Ltd., Sunphenon BG-3, average particle size is 100 μm) as a food or food additive. Hereinafter, a nonwoven fabric was produced using “catechin (denoted as Sanphenon BG-3)”.

  10 g of polyvinyl chloride and 90 g of dimethylformamide solution were mixed, and the polyvinyl chloride was dissolved at room temperature (about 25 ° C.) to prepare a polyvinyl chloride-containing solution (polymer-containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types, 7.5 g of the polyvinyl chloride-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (polyvinyl chloride and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.8 and FIG.9. The average fiber diameter of the nonwoven fabric was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 6 Polyethylene terephthalate + catechin polyphenol Polyethylene terephthalate is used as a base polymer, and catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon BG-3, hereinafter referred to as “catechin (Sunphenon BG-3)”) as a food or food additive. A nonwoven fabric was prepared.
10 g of polyethylene terephthalate and 90 g of a 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution are mixed, and the polyethylene terephthalate is dissolved at room temperature (about 25 ° C.). Containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Among the two kinds of solutions, 7.5 g of a polyethylene terephthalate-containing solution and 2.5 g of a polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (polyethylene terephthalate-containing solution and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.10 and FIG.11. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.7 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 7 Polyurethane + catechin polyphenol Polyurethane is used as the base polymer, and catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon BG-3, hereinafter referred to as “catechin (Sunphenon BG-3)”) is used as the food or food additive. A nonwoven fabric was prepared.

  10 g of polyurethane and 90 g of dimethylformamide solution were mixed, and the polyurethane was dissolved at room temperature (about 25 ° C.) to prepare a polyurethane-containing solution (polymer-containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the polyurethane-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (polyurethane and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nonwoven fabric was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 8 FIG. Soluble nylon (methoxymethylated nylon) + catechin polyphenol Soluble nylon (methoxymethylated nylon) is used as a base polymer, and catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon BG-3) as a food or food additive. A non-woven fabric was produced using catechin (referred to as “Sanphenon BG-3”).

  Soluble nylon 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. . Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. Among the above two types of solutions, 7.5 g of a soluble nylon-containing solution and 2.5 g of a catechin (Sunphenon BG-3) -containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial nonwoven fabric is used as a collector at a distance of 10-200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of room temperature (about 25 ° C.) under atmospheric pressure and an applied voltage of 20-50 KV. Electrospinning was performed to obtain a nanofiber nonwoven fabric.

Electron micrographs of the resulting nanofiber nonwoven fabric are shown in FIGS. In the figure, a nanofiber nonwoven fabric was spun into a commercially available nonwoven fabric having a large diameter, and the average fiber diameter of the nanofiber nonwoven fabric was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.3 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 9 Polylactic acid + Phenylcarboxylic acid A non-woven fabric was produced using polylactic acid (manufactured by Mitsui Chemicals, Inc.) as the base polymer and phenylcarboxylic acid (gallic acid) as the food or food additive.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added to phenylcarboxylic acid (gallic acid) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a colorless and transparent mixed solution. This mixed solution (polylactic acid and phenylcarboxylic acid-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.15 and FIG.16. The average fiber diameter of the nonwoven fabric was 1000 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 10 Polylactic acid + Elagic acid Polylactic acid (manufactured by Mitsui Chemicals, Inc.) was used as the base polymer, and non-woven fabric was prepared using ellagic acid as the food or food additive.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added to ellagic acid and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). After the two kinds of solutions, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a colorless and transparent mixed solution. This mixed solution (polylactic acid and ellagic acid-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.17 and FIG.18. The average fiber diameter of the nonwoven fabric was 1500 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 11 Polylactic acid + coumarin A non-woven fabric was produced using polylactic acid (manufactured by Mitsui Chemicals, Inc.) as a base polymer and coumarin as a food or food additive.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added to and dissolved in coumarin to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a colorless and transparent mixed solution. This mixed solution (polylactic acid and coumarin-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.19 and FIG.20. The average fiber diameter of the nonwoven fabric was 1500 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 12 FIG. Polylactic acid + coffee polyphenol (chlorogenic acid)
A non-woven fabric was prepared using polylactic acid (manufactured by Mitsui Chemicals, Inc.) as the base polymer and coffee polyphenol (chlorogenic acid) as the food or food additive.

  10 g of polylactic acid and 90 g of dichloromethane were mixed and the polylactic acid resin was dissolved at room temperature (about 25 ° C.) to prepare a biodegradable polyester-containing solution (polymer-containing solution). Further, dimethylformamide was added to coffee polyphenol (chlorogenic acid) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the biodegradable polyester-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a colorless and transparent mixed solution. This mixed solution (polylactic acid and coffee polyphenol (chlorogenic acid) -containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG.21 and FIG.22. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 2 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 13 Polyvinyl alcohol + coumarin A nonwoven fabric was produced using polyvinyl alcohol (manufactured by Wako Pure Chemical Industries) as a base polymer and coumarin (manufactured by Wako Pure Chemical Industries) as a food or food additive.

  Polyvinyl alcohol and 50 wt% ethanol / water solution were mixed, and the polyvinyl alcohol was dissolved by heating (40 to 60 ° C.) to prepare a polyvinyl alcohol-containing solution. Further, ethanol was added to coumarin and dissolved to prepare a 20 wt% polyphenol compound-containing solution. The above two types of solutions were mixed with a polyvinyl alcohol-containing solution 7.5 g and a polyphenol compound-containing solution 2.5 g to obtain a transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

An electron micrograph of the obtained nonwoven fabric is shown in FIG. The average fiber diameter of the nonwoven fabric was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 14 Soluble Nylon (Methoxymethylated Nylon) + Ground Tea Leaf Product As a base polymer, soluble nylon (methoxymethylated nylon) is used, and a commercially available tea leaf is ground as a food or food additive. Description) was used to produce a nonwoven fabric.

  1 to 20 g of soluble nylon and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution are mixed to make 100 g, soluble nylon is dissolved at room temperature (about 25 ° C.), and contains soluble nylon A solution was prepared. Further, 10 g of the crushed tea leaf was mixed with the above prepared solution to prepare a crushed tea leaf mixed solution. Next, this mixed solution was put into a syringe. As a syringe needle, an 18G needle (outer diameter 1.3 mm, inner diameter 1.1 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG. The average fiber diameter of the nonwoven fabric was 250 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 15. Soluble Nylon (Methoxymethylated Nylon) + Extracted Tea Leaf Milled Material As base polymer, soluble nylon (methoxymethylated nylon) was used as a food or food additive. After extraction, tea leaf ground material, average particle size 100 μm (at 80 ° C. A non-woven fabric was prepared using tea leaves extracted by hot water extraction three times and dried.

  1 to 20 g of soluble nylon and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution are mixed to make 100 g, soluble nylon is dissolved at room temperature (about 25 ° C.), and contains soluble nylon A solution was prepared. Furthermore, 7 g of the tea leaf pulverized product having an average particle size of 100 μm after extraction (tea leaf extracted by hot water extraction at 80 ° C. three times at 80 ° C.) was mixed with the above-mentioned adjusted solution, and mixed with the tea leaf pulverized product after extraction. A solution was prepared. Next, this mixed solution was put into a syringe. As a syringe needle, an 18G needle (outer diameter 1.3 mm, inner diameter 1.1 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIG. The average fiber diameter of the nonwoven fabric was 450 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.2 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 16 Polyvinyl alcohol + ground tea leaf product Polyvinyl alcohol (manufactured by Wako Pure Chemical Industries, Ltd.) is used as the base polymer, and commercially available tea leaves are ground as a food or food additive, using an average particle size of 150 μm (hereinafter referred to as tea leaf ground product). A nonwoven fabric was prepared.

  Polyvinyl alcohol and 50 wt% ethanol / water solution were mixed, and the polyvinyl alcohol was dissolved by heating (about 40 to 60 ° C.) to prepare a polyvinyl alcohol-containing solution. Further, 10 g of the tea leaf pulverized product having an average particle size of 150 μm was mixed with the above-mentioned adjustment solution to prepare a tea leaf pulverized product mixed solution. Next, this mixed solution was put into a syringe. As a syringe needle, an 18G needle (outer diameter 1.3 mm, inner diameter 1.1 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric is shown in FIG. The average fiber diameter of the nonwoven fabric was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.3 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 17. Polyvinyl alcohol + extracted tea leaf pulverized product As a base polymer, polyvinyl alcohol (manufactured by Wako Pure Chemical Industries, Ltd.) was used, and as a food or food additive, extracted tea leaf pulverized product with an average particle size of 100 μm (extracted three times at 80 ° C. with hot water) Non-woven fabric was prepared using dried and crushed tea leaves).

  Polyvinyl alcohol and 50 wt% ethanol / water solution were mixed, and the polyvinyl alcohol was dissolved by heating (about 40 to 60 ° C.) to prepare a polyvinyl alcohol-containing solution. Furthermore, 0.01-10 g of tea leaf pulverized product after extraction (dried and pulverized tea leaf extracted three times at 80 ° C.) was mixed with the above prepared solution, and mixed solution with tea leaf pulverized product after extraction Was prepared. Next, this mixed solution was put into a syringe. As a syringe needle, an 18G needle (outer diameter 1.3 mm, inner diameter 1.1 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

An electron micrograph of the obtained nonwoven fabric is shown in FIG. The average fiber diameter of the nonwoven fabric was 450 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.3 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 18 PGA (polyglutamic acid) + catechin polyphenol PGA (polyglutamic acid) is used as the base polymer, and catechin polyphenol (Sunphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd.) as the food or food additive. The average particle size is 100 μm. (Referred to as “Sanphenon BG-3”)) to prepare a nonwoven fabric.

  PGA (polyglutamic acid) and 50 wt% ethanol / water solution were mixed, and PGA was dissolved by heating (40 to 60 ° C.) to prepare a PGA-containing solution. Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. The above two types of solutions were mixed with PGA (7.5 g of a polyglutamic acid-containing solution and 2.5 g of a polyphenol compound-containing solution, and then this mixed solution was put into a syringe. 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd. Applied pressure 20-50 KV under atmospheric pressure and room temperature (about 25 ° C.), inside the tip of the syringe needle Electrospinning was performed at a distance of 10 to 200 cm from the aperture to the fibrous material collecting electrode to obtain a nanofiber sheet.

An electron micrograph of the obtained nonwoven fabric is shown in FIG. The average fiber diameter of the nonwoven fabric was 1000 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.2 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 19. Zein + catechin polyphenol Using zein as the base polymer, catechin polyphenol as a food or food additive (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon BG-3, average particle size of 100 μm, hereinafter referred to as “catechin (Sunphenon BG-3)” A non-woven fabric was prepared using

  Zein was mixed with 70 wt% ethanol / water solution, and the zein was dissolved by heating (40-60 ° C.) to prepare a zein-containing solution. Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. The above two kinds of solutions were mixed with 7.5 g of a zein-containing solution and 2.5 g of a polyphenol-containing solution, and then this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

An electron micrograph of the obtained nonwoven fabric is shown in FIG. The nanofiber sheet was placed on a commercially available non-woven fabric having a large diameter, and the average fiber diameter of the nanofiber sheet was 500 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.15 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 20. Fibroin + catechin polyphenol Fibroin is used as a base polymer, and catechin polyphenol (Sanphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as a food or food additive. Hereinafter, “catechin (Sunphenon BG-3)” Was used to prepare a nonwoven fabric.

  Mix fibroin 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g, dissolve fibroin at room temperature (about 25 ° C), and fibroin-containing solution (polymer-containing solution) Was prepared. Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the fibroin-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (fibroin and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

Electron micrographs of the obtained nonwoven fabric are shown in FIGS. The average fiber diameter of the nonwoven fabric was 500 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.5 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 21. Nylon 6,6 + catechin polyphenol Nylon 6,6 is used as a base polymer, and catechin polyphenol (Sanphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as a food or food additive. BG-3) ") was used to prepare a nonwoven fabric.

  Nylon 6,610 g and formic acid 90 g were mixed, and nylon 6,6 was dissolved at room temperature (about 25 ° C.) to prepare a nylon 6,6 containing solution (polymer containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the nylon 6,6 containing solution and 2.5 g of the polyphenol compound containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (nylon 6, 6 and catechin polyphenol-containing transparent solution) was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A sheet was obtained.

The electron micrograph of the obtained nonwoven fabric was shown in FIGS. The average fiber diameter of the nonwoven fabric was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 22. Soluble Nylon (Methoxymethylated Nylon) + Lysozyme Fabricate non-woven fabric using soluble nylon (methoxymethylated nylon) as the base polymer and lysozyme (Taiyo Chemical Co., Ltd., lysozyme Taiyo) as the food or food additive. did.

  Soluble nylon 10g and formic acid 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. Further, ethanol was added to lysozyme (manufactured by Taiyo Kagaku Co., Ltd., lysozyme sun) and dissolved to prepare a 20 wt% lysozyme compound-containing solution. Of the two types of solutions described above, 7.5 g of a soluble nylon-containing solution and 2.5 g of a lysozyme (manufactured by Taiyo Chemical Co., Ltd., lysozyme sun) -containing solution were mixed to obtain a brown mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial non-woven fabric (polyolefin) is applied as a collector at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of atmospheric pressure and room temperature (about 25 ° C.). ) Was used to obtain a nanofiber sheet.

An electron micrograph of the obtained nanofiber sheet is shown in FIG. In the figure, a nanofiber sheet was spun into a commercially available nonwoven fabric having a large diameter, and the average fiber diameter of the nanofiber sheet was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.3 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 23. Soluble nylon (methoxymethylated nylon) + neem A nonwoven fabric was produced using soluble nylon (methoxymethylated nylon) as a base polymer and neem as a food or food additive.

  10 g of soluble nylon and 90 g of methanol were mixed, and soluble nylon was dissolved at room temperature (about 25 ° C.) to prepare a soluble nylon-containing solution. Further, dimethylformamide was added to the neem and dissolved to prepare a 20 wt% neem compound-containing solution. Among the above two types of solutions, 7.5 g of the soluble nylon-containing solution and 2.5 g of the neem-containing solution were mixed to obtain a brown mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial non-woven fabric (polyolefin) is applied as a collector at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of atmospheric pressure and room temperature (about 25 ° C.). ) Was used to obtain a nanofiber sheet.

An electron micrograph of the obtained nanofiber sheet is shown in FIG. In the figure, a nanofiber sheet was spun into a commercially available nonwoven fabric having a large diameter, and the average fiber diameter of the nanofiber sheet was 150 nm. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.3 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 24. Three-layer reinforced nanofiber sheet (nonwoven fabric + polyurethane nanofiber sheet + (soluble nylon + catechin) nanofiber sheet)
Commercial nonwoven fabric (polyolefin) 10-50 μm as a collector, polyurethane as a reinforcing nanofiber sheet, soluble nylon as a base polymer, catechin polyphenol (Sanphenon BG, manufactured by Taiyo Kagaku Co., Ltd.) as a food or food additive 3. The average particle size was 100 μm, and a nonwoven fabric was prepared using “catechin (Sanphenon BG-3)”).

  10 g of polyurethane and 90 g of dimethylformamide solution were mixed, and the polyurethane was dissolved at room temperature (about 25 ° C.) to prepare a polyurethane-containing solution (polymer-containing solution). This solution was then placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nanofiber sheet was obtained on (commercially available nonwoven fabric (polyolefin)).

  Next, 10 g of soluble nylon and 90 g of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution are mixed, soluble nylon is dissolved at room temperature (about 25 ° C.), and soluble nylon-containing solution (Polymer-containing solution) was prepared. Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the soluble nylon-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (soluble nylon and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under the conditions of atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV was applied, and the commercially available nonwoven fabric (polyolefin) + polyurethane nanofiber sheet prepared above was used as a collector, and the tip of a syringe needle was placed thereon. Electrospinning was performed at a distance of 10 to 200 cm from the inner diameter to the fibrous material collecting electrode to obtain a three-layer reinforced nanofiber sheet.

Electron micrographs of the obtained nonwoven fabric are shown in FIGS. The average fiber diameter of the obtained catechin-containing nanofiber sheet was 500 nm for polyurethane nanofibers and 150 nm for catechin + soluble nylon nanofibers. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 25. Three-layer reinforced nanofiber sheet (nonwoven fabric + polyurethane nanofiber sheet + (polyvinyl alcohol + catechin) nanofiber sheet)
Commercial nonwoven fabric (polyolefin) 10-50 μm as collector, polyurethane as reinforcing nanofiber, polyvinyl alcohol as base polymer, catechin polyphenol (Sanphenon BG-3 manufactured by Taiyo Chemical Co., Ltd.) as food or food additive The average particle size was 100 μm, and a nonwoven fabric was prepared using “catechin (Sanphenon BG-3)”).

  10 g of a polyurethane solution and 90 g of a dimethylformamide solution were mixed and the polyurethane was dissolved at room temperature (about 25 ° C.) to prepare a polyurethane-containing solution (polymer-containing solution). This solution was then placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Under an atmospheric pressure and room temperature (about 25 ° C.), an applied voltage of 20 to 50 KV is applied, and electrospinning is performed at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode. A nanofiber sheet was obtained on (commercially available nonwoven fabric (polyolefin)).

  Next, 10 g of polyvinyl alcohol and 90 g of water were mixed, and the polyvinyl alcohol was dissolved at room temperature (about 25 ° C.) to prepare a polyvinyl alcohol-containing solution (polymer-containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the two types of solutions, 7.5 g of the polyvinyl alcohol-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (polyvinyl alcohol and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Applying an applied voltage of 20-50 KV under atmospheric pressure and room temperature (about 25 ° C.), using the commercially available non-woven fabric (polyolefin) + polyurethane nanofiber prepared above as a collector, on top of the tip of the syringe needle Electrospinning was performed at a distance of 10 to 200 cm from the aperture to the fibrous material collecting electrode to obtain a three-layer reinforced nanofiber sheet.

The electron micrograph of the obtained nonwoven fabric was shown in FIGS. The average fiber diameter of the obtained catechin-containing nanofiber sheet was 500 to 1000 nm for polyurethane nanofibers and 250 nm for catechin + polyvinyl alcohol nanofibers. Further, fibers having a fiber diameter of 1 μm or more were not observed. The basis weight was 0.1 g / m ² . Note that the basis weight, by suitably changing conditions, could be freely designed by applications in the range of ^{0.005g / m 2 ~10g / m 2} .

Example 26. 1. Adhere catechin particles onto nanofiber sheet made of soluble nylon (methoxymethylated nylon) + catechin polyphenol. Soluble nylon (methoxymethylated nylon) is used as the base polymer, and catechin polyphenol (Sunphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as food or food additive. Hereinafter, “catechin (Sunphenon BG- 3) ”) was used to prepare a nonwoven fabric.

  Soluble nylon 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. . Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. Among the above two types of solutions, 7.5 g of a soluble nylon-containing solution and 2.5 g of a catechin (Sunphenon BG-3) -containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial nonwoven fabric (polyester) is used as a collector at a distance of 10-200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of room temperature (about 25 ° C.) under atmospheric pressure and an applied voltage of 20-50 KV. Electrospinning was performed using a non-woven fabric to obtain a nanofiber sheet.

2. The nanofiber sheet prepared above was put in an electrospinning apparatus, and the liquid prepared next was electrolytically applied from above by applying electricity in the same manner as described above.
20 wt% of catechin polyphenol was dissolved in ethanol, the solution was put into a syringe, and electrocoated on the nanofiber sheet using the electrospinning apparatus as described above, and dried. The electron micrograph of the obtained nonwoven fabric is shown in FIG. The average particle size of the attached catechin polyphenol was 700 nm.

3. The produced catechin polyphenol-attached nanofiber sheet is allowed to pass through the atmosphere at a flow rate of 3 m ³ / s and the catechin polyphenol on the nanofiber is desorbed, leaving only the nanofiber, so that the catechin polyphenol is released to the outside of the binder. It was confirmed. The electron micrograph of the obtained nonwoven fabric is shown in FIG.

Example 27. 1. Adhering NaCl + food emulsifier: glycerin fatty acid ester particles on nanofiber sheet made of polyurethane + catechin polyphenol Polyurethane is used as a base polymer, and catechin polyphenol (manufactured by Taiyo Kagaku Co., Ltd., Sunphenon BG-3, average particle size is 100 μm. Hereinafter, referred to as “catechin (Sunphenon BG-3)”) is used as a base polymer. A nonwoven fabric was prepared.

  20 g of 45% polyurethane solution and 80 g of dimethylformamide solution were mixed and the polyurethane was dissolved at room temperature (about 25 ° C.) to prepare a polyurethane-containing solution (polymer-containing solution). Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution (food or food additive-containing solution). Of the above two types of solutions, 7.5 g of the polyurethane-containing solution and 2.5 g of the polyphenol compound-containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution (polyurethane and catechin polyphenol-containing transparent solution) was placed in a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. Commercially available non-woven fabric (polyamide non-woven fabric) at a distance of 10-200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the conditions of atmospheric pressure and room temperature (about 25 ° C.) Electrospinning was performed using as a support to obtain a nanofiber sheet on the nonwoven fabric.

2. The non-woven fabric + nanofiber sheet prepared above was put into a nanofiber collector part of an electrospinning apparatus, and the next prepared liquid was electrolytically applied from above.
After dissolving 35 wt% of NaCL with respect to the water content in an 80 wt% ethanol solution and adding 0.01 to 10% of an emulsifier for food: glycerin fatty acid ester (manufactured by Taiyo Kagaku Co., Ltd .: glycerin dicaprylate), it is put in a syringe. In the same manner as above, using an electrospinning apparatus, the nanofiber sheet was electrolytically coated and dried. The electron micrograph of the obtained nonwoven fabric is shown in FIG. The average particle size of the adhered particles was 44.1 μm.

3. The prepared NaCl + glycerin fatty acid ester-attached nanofiber sheet is allowed to pass through the atmosphere at a flow rate of 3 m ³ / s, and the NaCl + glycerin fatty acid ester on the nanofiber is desorbed, and only nanofibers remain as in Example 24. confirmed.

Example 28. 1. Adhering particles of iron pyrophosphate coated with emulsifier for food: sucrose fatty acid ester on nanofiber sheet made of soluble nylon (methoxymethylated nylon) + catechin polyphenol Soluble nylon (methoxymethylated nylon) is used as the base polymer, and catechin polyphenol (Sunphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as food or food additive. Hereinafter, “catechin (Sunphenon BG- 3) ”) was used to prepare a nonwoven fabric.

  Soluble nylon 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. . Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. Among the above two types of solutions, 7.5 g of a soluble nylon-containing solution and 2.5 g of a catechin (Sunphenon BG-3) -containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial nonwoven fabric (polyvinyl chloride) is used as a collector at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of room temperature (about 25 ° C.) under atmospheric pressure and an applied voltage of 20 to 50 KV. Electrospinning was performed using an alcohol non-woven fabric to obtain a nanofiber sheet.

2. The nanofiber sheet prepared above was put into an electrospinning apparatus, and the next prepared liquid was electrolytically applied from above.
Put 10g in 50wt% ethanol, 1.0g iron pyrophosphate (Sun Active Fe, manufactured by Taiyo Kagaku Co., Ltd.) and 0.4g food emulsifier: 0.4g sucrose fatty acid ester (manufactured by Taiyo Kagaku Co., Ltd.) After mixing, the mixture was put into a syringe, electrolytically coated on the nanofiber sheet using the electrospinning apparatus as described above, and dried. An electron micrograph of the obtained nonwoven fabric is shown in FIG. The average particle size of the adhered particles was 33.5 μm.

3. When air was passed through the produced catechin polyphenol-attached nanofiber sheet at a flow rate of 3 m ³ / s, it was confirmed that the particles on the nanofibers were detached and only the nanofibers remained as in the above example.

Example 29. An emulsifier: decaglycerin monooleate + theanine particles is attached on a nanofiber sheet made of soluble nylon (methoxymethylated nylon) + catechin polyphenol. Soluble nylon (methoxymethylated nylon) is used as the base polymer, and catechin polyphenol (Sunphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as food or food additive. Hereinafter, “catechin (Sunphenon BG- 3) ”) was used to prepare a nonwoven fabric.

  Soluble nylon 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. . Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. Among the above two types of solutions, 7.5 g of a soluble nylon-containing solution and 2.5 g of a catechin (Sunphenon BG-3) -containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial nonwoven fabric (polypropylene) is used as a collector at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under an atmospheric pressure at room temperature (about 25 ° C.) and an applied voltage of 20 to 50 KV. Electrospinning was performed using a non-woven fabric to obtain a nanofiber sheet.

2. The nanofiber sheet prepared above was put into an electrospinning apparatus, and the next prepared liquid was electrolytically applied from above.
In 50 wt% ethanol, 0.4 g of theanine (Suntheanine manufactured by Taiyo Kagaku Co., Ltd.) and emulsifier for food monooleic acid decaglycerin (manufactured by Taiyo Kagaku Co., Ltd.) is placed in a container and heated at 40 ° C. In the same manner as above, using an electrospinning apparatus, the nanofiber sheet was electrolytically coated and dried. The electron micrograph of the obtained nonwoven fabric is shown in FIG. The average particle size of the adhered particles was 25 μm.

3. When air was passed through the produced catechin polyphenol-attached nanofiber sheet at a flow rate of 3 m ³ / s, it was confirmed that the particles on the nanofibers were detached and only the nanofibers remained as in the above example.

Example 30. FIG. Emulsifier: Glycerin fatty acid ester + dextrin particles are attached on a nanofiber sheet made of soluble nylon (methoxymethylated nylon) + catechin polyphenol. Soluble nylon (methoxymethylated nylon) is used as the base polymer, and catechin polyphenol (Sunphenon BG-3, manufactured by Taiyo Kagaku Co., Ltd., average particle size is 100 μm as food or food additive. Hereinafter, “catechin (Sunphenon BG- 3) ”) was used to prepare a nonwoven fabric.

  Soluble nylon 10g and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) solution 90g were mixed, soluble nylon was melt | dissolved at normal temperature (about 25 degreeC), and the soluble nylon containing solution was prepared. . Further, ethanol was added to catechin (Sanphenon BG-3) and dissolved to prepare a 20 wt% polyphenol compound-containing solution. Among the above two types of solutions, 7.5 g of a soluble nylon-containing solution and 2.5 g of a catechin (Sunphenon BG-3) -containing solution were mixed to obtain a brown transparent mixed solution. Next, this mixed solution was put into a syringe. A syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.) was used. A commercial non-woven fabric (polyolefin) is applied as a collector at a distance of 10 to 200 cm from the inner diameter of the tip of the syringe needle to the fibrous material collecting electrode under the condition of atmospheric pressure and room temperature (about 25 ° C.). Electrospinning was performed using a non-woven fabric to obtain a nanofiber sheet.

2. The nanofiber sheet prepared above was put into an electrospinning apparatus, and the next prepared liquid was electrolytically applied from above.
In 50 wt% ethanol, 0.4 g of dextrin and food emulsifier: glycerin fatty acid ester (manufactured by Taiyo Kagaku Co., Ltd .: glycerin dicaprylate ester) are placed in a container, heated at 40 ° C. and mixed well, then placed in a syringe and electrospun as described above. It was electrolytically coated on the nanofiber sheet using an apparatus and dried. The electron micrograph of the obtained nonwoven fabric is shown in FIG. The average particle size of the adhered particles was 140 μm.

3. When air was passed through the produced catechin polyphenol-attached nanofiber sheet at a flow rate of 3 m ³ / s, it was confirmed that the particles on the nanofibers were detached and only the nanofibers remained as in the above example.

Comparative Example 1
As Comparative Example 1, the nanofiber of Example 1 described in Patent Document 4 was produced as follows.
90 mg of polylactic acid (weight average molecular weight (Mw) = 13,000, number average molecular weight (Mn) = 61,000, trade name Lacia (registered trademark) H-900 (manufactured by Mitsui Chemicals), 819 mg of 1, Add 1,1,3,3,3-hexafluoroisopropanol (HFIP) to the sample bottle and stir overnight (about 10 hours or more) at room temperature (20 ° C.-25 ° C.) using a magnetic stirrer. However, the polylactic acid was completely dissolved.

To another sample bottle, add 4.5 mg of epigallocatechin gallate (EGCg: Sanphenon EGCg manufactured by Taiyo Kagaku Co., Ltd.) and 86.5 mg of dimethylformamide (DMF), and use a magnetic stirrer at room temperature for 1 While stirring for 2 hours, EGCg was completely dissolved.
909 mg of the polylactic acid solution and 91 mg of the EGCg solution were further mixed in another sample bottle, and the mixture was vibrated and stirred using a vortex mixer until they were mixed. After stirring, the solution became cloudy.

After injecting the mixed solution of polylactic acid and EGCg into the syringe, the bubbles in the syringe were expelled. This syringe was set in the syringe pump of the electrospinning apparatus. Using a syringe needle of 25G (outer diameter 0.5 mm, inner diameter 0.32 mm: manufactured by Hoshiseido Medical Equipment Co., Ltd.), injection distance 10 cm, rotation speed 100 rpm, voltage 10 kv, injection speed 3 mL / hr, Electrospinning was performed.
A nanofiber sheet having an outer diameter of about 100 nm to 500 nm was produced by electrospinning.

  However, insolubles of EGCg were found to be almost spherical at some nanofibers. This was thought to be because the EGCg solution once dissolved returned to the insoluble state in the mixed solution in the syringe by being mixed with the polylactic acid solution.

Test Example 1 Absorbance measurement of electrospinning solution The absorbance of the electrospinning solution used in Example 1, Example 2 and Comparative Example 1 was measured at 660 nm. The results are shown in Table 1.

  Since the absorbances of the solutions of Example 1 and Example 2 were almost equal to the absorbance of the control, it was considered that the food or food additive was uniformly dissolved in these solutions. On the other hand, the liquid of Comparative Example 1 is also cloudy in appearance, and its absorbance is as high as 3 or more, indicating that the food or food additive is not uniformly dissolved.

Test Example 2 Comparison of nanofiber diameters The diameters of the nanofibers produced in Example 1, Example 2, and Comparative Example 1 were measured. As a result, the average diameter of the nanofibers of Example 1 and Example 2 was 0.5 μm, and the average diameter of the nanofibers of Comparative Example 1 was 20 μm. Thus, in this example, it was found that a nanofiber having a smaller diameter can be provided.

Test Example 3 Polyphenol Elution Test from Nanofiber Sheet Using the nanofibers produced in Example 1, Example 2 and Comparative Example 1, it was evaluated whether polyphenol elution was observed.
Test method: 0.292 g of each electrospun composition was weighed, put into a beaker containing 50 ml of ion-exchanged water, and stirred for 24 hours at a rotational speed of 8 rpm using a magnetic stirrer. Thereafter, the total polyphenol content in this solution was measured by the iron tartrate method.

The iron tartrate method used ethyl gallate as a standard solution, and was calculated as a converted amount of gallic acid (reference document: “Green tea polyphenol” food or food additive effective utilization technology series No. 10). 5 mL of a sample was developed with 5 mL of iron tartrate standard solution, dissolved in 25 mL with a phosphate buffer, the absorbance was measured at 540 nm, and the total amount of polyphenols was determined from a calibration curve with ethyl gallate.
Preparation of iron tartrate standard solution: 100 mg of ferrous sulfate heptahydrate and 500 mg of sodium / potassium tartrate (Rochelle salt) were made up to 100 mL with distilled water.

Preparation of phosphate buffer: 1/15 M disodium hydrogen phosphate solution and 1/15 M sodium dihydrogen phosphate solution were mixed and adjusted to pH 7.5.
The results are shown in Table 2.

  In Comparative Example 1, an elution of 92.86 ppm was observed. On the other hand, in Example 1 and Example 2, since it was about 1/4 of the elution amount, in the nanofibers of the examples, polyphenols may be contained in the nanofibers in a form that is more difficult to elute. I understood.

Test Example 4 Antibacterial test Based on JIS L1902, a quantitative test (bacterial solution absorption method) was performed. In the method, 0.4 g of the sample prepared in Examples 1 to 30 was placed in a vial, inoculated with 0.2 ml of the test bacterial solution, and cultured at 37 ± 1 ° C. for 18 ± 1 hour. 20 ml of physiological saline containing 0.2% nonionic surfactant was added to wash out the bacteria from the sample, and the number of bacteria in the washed out solution was measured by the colony method or the ATP method.
Bacteriostatic activity value = log (viable cell count after standard cloth culture)-(log processed cell culture viable cell count)
Antibacterial effect: Antibacterial and deodorant finish Bacteriostatic activity value ≧ 2.0
As a result, in the examples described in Examples 1 to 30, the bacteriostatic activity value was larger than 5.7 in Staphylococcus aureus, and strong antibacterial activity was recognized. In addition, strong antibacterial activity of 4.0 or more was also observed in Escherichia coli.

  Moreover, when the antibacterial property was also confirmed in Comparative Example 1 described in Test Example 1, the bacteriostatic activity value was smaller than 1.4 and 2.0 in Staphylococcus aureus, and no antibacterial activity was observed. In addition, antibacterial activity was not recognized in Escherichia coli because it was 1.0 or less.

Test Example 5 Deodorization test (1) Deodorization test Using the nanofibers produced in Example 1, a nanofiber sheet was prepared. A deodorization test was performed using this nanofiber sheet. First, 2.7 L of 100 ppm various odor component atmospheres were prepared in an odor bag, a 4 × 4 cm nanofiber sheet was put therein, and the odor component concentrations after 0, 1, 2, 3, and 24 hours were measured. For the measurement, a detector tube dedicated to various odor components (manufactured by Gastec Co., Ltd.) was used. The results are shown in Table 3. The concentration (ppm / g) indicates the deodorizing amount.

(2) Warm desorption test Since acetaldehyde and formaldehyde are easily desorbed from the adsorbate during heating, a warm desorption test was performed.
The nanofiber sheet adsorbed by acetaldehyde and formaldehyde used in the (1) deodorization test above is put in a smell bag containing 3 L of air, and a heating test is performed in an atmosphere of a constant temperature machine at 80 ° C. The gas concentration after a few hours was measured with a gas detector tube.
The results are shown in Table 4. The concentration (ppm / g) indicates the amount of desorption.

Test Example 6.3 Particle Collection Test of 3 μm or more: Bacterial Filtration Efficiency (BFE) Test Food or food additive-containing binder (surgical binder) using the nanofiber sheet produced in Examples 1-30 above A BFE test was conducted using this binder.
The details of the test method were performed in accordance with the procedure specified in ASTM-F2101-07. Specifically, it is as follows.
Staphylococcus aureus ATCC 6538 (Staphylococcus aureus) was used, and when the bacteria were collected with an undersensor sampler, a bacterial turbid solution was prepared so that the total number of colonies was 2200 ± 500. A petri dish was poured with 27 ml of agar medium and solidified.

  Petri dishes containing agar media were set on the first to sixth stages of the undersampler. Next, a sample (15 cm × 15 cm) was sandwiched and set between the undersensor mbler and the aerosol chamber. The bacterial turbid solution supplied to the nebulizer from the bacterial suspension supply device is aerosolized to a size of about 3 μm using a compressor, and the air flow rate in the aerosol chamber and the undersampler is sucked at a rate of 28.3 L / min. After performing this for a certain time, the petri dish taken out from the undersampler was cultured at 37 ± 2 ° C. for 48 hours. After the culture, the number of colonies of 1 to 6 petri dishes was determined. BFE (%) was calculated by the following formula.

Here, A: the total number of colonies of the control, B: the total number of colonies when the sample is set.
As a result of the above test, for any of the binders of Examples 1 to 30, a fine particle capturing force of 3 μm or more showed a filtration efficiency of 99% or more.

Test Example 7. Particle Collection Test of 0.1 μm or more: Particulate Filtration Efficiency Test (Particulate Filtration Efficiency)
A food or food additive-containing binder (surgical binder) was prepared using the nanofiber sheet produced in Examples 1 to 30 above, and a PFE test was performed using this binder.

The details of the test method were performed in accordance with the procedure specified in ASTM F2299. Specifically, the neutralization of the particles is not performed.
Test particles (0.1 μm polystyrene latex particles (manufactured by JSR)) are continuously and stably supplied into a test chamber maintained in a clean environment by a HEPA binder, and before and after the binder material as a test piece while sucking at a constant flow rate ( The number of particles on the upstream and downstream sides is measured with two particle counters, and the collection efficiency (%) is calculated.
The collection efficiency was calculated by the following formula.

PFE (%) = (1−the number of downstream particles / the number of upstream particles) × 100
As a result of the above test, for any binder, the fine particle capturing power of 0.1 μm or more showed a filtration efficiency of 99% or more.

Test Example 9 Antifungal Test A food or food additive-containing binder (surgical binder) was prepared using the nanofiber sheet produced in Examples 1 to 30 above, and an antifungal test was performed using this binder.

The details of the test method were performed according to the procedure defined in JIS Z 2911. Specifically, it is as follows.
As test mold, dry-sterilized test pieces of Aspergillus niger ATCC 6275, Penicillium citrinum ATCC 9849, Chaetmium globosum ATCC 6205, Mycothelium verrucaria ATCC 9095 in each test piece 5 The ceramic porcelain plate was placed, placed on a glass plate, covered, and cultured at 28 ± 2 ° C. for 4 weeks to evaluate the mycelial growth.
As a result of the above test, no hyphal growth was observed for any of the binders.

Test Example 10 Breathability test The specimens of the nanofiber sheets obtained in Examples 1 to 30 were measured by the method A of the general textile test method (Fragile method: defined by JIS-L-1096). In the measurement, the surface on which the nanofibers were not attached was brought into contact with the side on which air was inhaled.
The details of the test method were carried out according to the procedure defined in JIS L 1096.

Specifically, it is as follows.
For the test, a 200 mm × 200 mm sample is prepared and prepared from 5 different locations of the sample using a Fragil type tester. Attach the specimen to the cylindrical clamp (air inlet) of the Frazier tester. The suction fan is adjusted so that the inclined barometer has a pressure of 125 Pa, and the pressure (cm) indicated by the vertical barometer when adjusted is read. From the pressure indicated by the vertical barometer when adjusted and the type of air hole (air orifice) used, the amount of air (cm3 / cm2 / sec) that the test piece passes through the conversion table attached to the tester Obtained and converted to the following air permeability (cc / cm 2 · sec).
As a result of the above test, all binders exhibited high air permeability of 40 (cc / cm 2 · sec) or more, and in Examples 5, 8, 21, 22, and 23, the air permeability was 120 ( cc / cm 2 · sec), 228 (cc / cm 2 · sec), 157 (cc / cm 2 · sec), 108 (cc / cm 2 · sec), 118 (cc / cm 2 · sec), and air permeability 100 (cc / Cm 2 · sec) or more.

Test Example 11 Thickness / Weight / Pressure Loss First, the thickness and weight (mass per unit area) were measured using the general nonwoven fabric test method described in JIS L1913. Moreover, about the pressure loss test, it implemented according to MIL-M-36954C.
As an evaluation sample, the above-mentioned Examples 5, 8, 12, 22, and 24 are used as comparative examples, and a commercial manufacturer's N95 standard product is used as Comparative Example 1, and two commercially available hepa filters for air purifiers are used. It was set as Comparative Examples 2 and 3. The results are shown in Table 5 below.

  The present invention can provide a non-woven fabric containing a food or food additive uniformly on the surface of the nanofiber. This nanofiber nonwoven fabric has an antioxidant action, an antibacterial action, an antiviral action, a deodorizing action, a harmful substance adsorbing action, an antifungal action and the like. For this reason, binders, particularly binders for surgical nano / micro particles, can be suitably used, and contribute greatly to the industry.

Claims (22)

  It is a nanofiber sheet to which food or food additive material particles having an average particle size of nano to micro are attached, and both surfaces or one surface thereof are bonded to a non-woven fabric having an average fiber size of nano to micro. Nano / micro particle binder.   2. The nano / micro particle binder according to claim 1, wherein the particles are released from the binder to the outside when passing through the atmosphere.   Food or food additive material particles are catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, lysozyme, neem, sodium chloride, dextrin, calcium, coenzyme The binder for nano / micro particles according to claim 1, comprising at least one food or food additive material particle selected from the group consisting of Q10, iron pyrophosphate, theanine, amla and emulsifier.   The catechin polyphenol contains 20 to 80% as a total catechin content in the catechin polyphenol, and further contains 20 to 95% as epigallocatechin gallate in the catechin. Microparticle binder.   The nano-microparticle according to any one of claims 1 to 5, wherein the nonwoven fabric contains at least one selected from the group consisting of polyolefin, polypropylene, polystyrene, polyamide, polyimide, polyester, polyvinyl alcohol, and polyurethane. Binder.   The binder for nano / micro particles according to any one of claims 1 to 5, wherein the nonwoven fabric is a nonwoven fabric produced by a wet method.   Nanofiber sheet is PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinyl chloride, polyurethane, polyester, polypropylene, zein At least one base polymer selected from the group consisting of collagen, methoxymethylated nylon, catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, Including at least one food or food additive selected from the group consisting of lysozyme and neem and having a diameter of 1 nm to 2000 nm Claims 1-6 or nano-microparticles binder according to characterized in that it comprises a Bruno fibers.   In addition to nanofiber sheets, PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinyl chloride, polyester, polypropylene, 8. A reinforcing nanofiber comprising at least one reinforcing polymer selected from the group consisting of zein, collagen, and polyurethane, and having a diameter of 1 nm to 2000 nm. Nano / micro particle binder.   The binder for nano / micro particles according to claim 7 or 8, wherein the food or food additive is uniformly dispersed or dissolved in the base polymer.   The binder for nano / microparticles according to any one of claims 1 to 9, comprising only a base polymer and a food or food additive. Mass per unit area of the ^{nanofibers, 0.005g / m 2 ~10g / m} 2 in claims 1 to 10 nano-microparticles binder according to any one, characterized in that. ^{Breathable, 1cc / cm 2 · sec~1000cc /} cm 2 · sec in claim 1 to 11 or nano-microparticles binder according to characterized in that.   The binder for nano / micro particles according to any one of claims 1 to 12, wherein the resin constituting the resin composition binder is negatively or positively charged and attracts a surrounding positively or negatively charged substance. .   14. The binder for nano / micro particles according to any one of claims 1 to 13, wherein the binder is a food or food additive-containing binder, and the resin composition binder is composed of a nonwoven fabric and is used for air cleaning.   The nano-microparticle binder according to claim 14, wherein the fine particle capturing force of 0.1 µm or more is 99% or more.   The nano-microparticle binder according to claim 14, wherein a fine particle capturing force of 3 μm or more is 99% or more.   The binder for nano / micro particles according to claim 14, wherein the bacteriostatic activity value is 4.0 or more against S. aureus and E. coli. 15. The nano-microparticle binder according to claim 14, wherein the pressure loss (mmH ₂ O / cm ² ) is 3.0 or less.   PVA, polylactic acid, fibroin, chitosan, chitin, nylon 6, nylon 6,6, nylon 9T, nylon 610, polyamide, polystyrene, polyacrylonitrile, polyethylene terephthalate, polyvinylidene chloride, polyester, polypropylene, zein, collagen, polyvinyl chloride , Methoxymethylated nylon, at least one base polymer selected from the group consisting of polyurethane, water, acetone, methanol, ethanol, propanol, toluene, benzene, cyclohexane, cyclohexanenon, tetrahydrofuran, dimethyl sulfoxide, 1,4-dioxane, Carbon tetrachloride, methylene chloride, pyridine, N-methyl-2-pyrrolidone, ethylene carbonate, diethyl carbonate, propylene carbonate A base polymer solution is prepared by dissolving in at least one solvent selected from the solvent group consisting of acetonitrile, lactic acid, acetic acid, dimethylacetamide, dimethylformamide, dichloromethane, trichloromethane, hexafluoroisopropanol, formic acid, chloroform, formaldehyde, and acetaldehyde. At least one food or food additive selected from the group consisting of catechin polyphenol, persimmon astringent polyphenol, grape seed polyphenol, soybean polyphenol, lemon peel polyphenol, coffee polyphenol, phenylcarboxylic acid, ellagic acid, coumarin, neem, lysozyme Prepare a food or food additive-containing solution by dissolving in at least one solvent selected from the solvent group. The nano-microparticle binder according to any one of claims 1 to 18, wherein a mixed solution is prepared by mixing with a food additive-containing solution, and the mixed solution is produced from fibers spun by an electrospinning method. Production method.   The solvent for preparing the base polymer solution and the food or food additive-containing solution is any one selected from the group consisting of formic acid, hexafluoroisopropanol, water, dimethylformamide, ethanol and dichloromethane. 20. The method for producing a binder according to claim 19, wherein the binder is produced.   The method for producing a binder according to claim 19 or 20, wherein the food or food additive-containing solution contains sodium chloride.   The method for producing a binder according to any one of claims 19 to 21, wherein the mixed solution is uniformly transparent.