JP2014000451A - Nebulizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To propose a nebulizer for a fluid, especially for a medical aerosol therapeutic agent.SOLUTION: To make operation easier and ensure increased operational reliability, a nebulizer has a closed vessel (3) containing a fluid preinstalled therein and the closed vessel (3) is opened before or during the first use of the nebulizer. The vessel cannot be replaced nor expressly removed from the nebulizer.

Description

  The present invention relates to a nebulizer as described in the preamble of claim 1.

  The starting point of the present invention is shown in principle in WO 91/14468, in particular in WO 97/12687 (FIGS. 6a and 6b) and in FIGS. 1 and 2 of the drawings of the present application. It is a nebulizer marketed under the trade name “Respimat” in the form of an inhaler. This nebulizer has, as a reservoir for the fluid to be nebulized, a pressure generator with an insertable rigid container with an inner bag containing the fluid and a drive spring for delivering and atomizing the fluid. doing.

  To complement the disclosure content of this application, please refer to the entire disclosure content of both WO 91/14468 and WO 97/12687. Generally, these patent documents disclose that the spring pressure applied to the fluid is preferably 5 MPa to 200 MPa, preferably 10 MPa to 100 MPa, and the amount of fluid delivered per stroke is 10 μl (microliter) to 50 μl (microliter). ), Preferably 10 μl (microliter) to 20 μl (microliter), most preferably about 15 μl (microliter) of nebulizer. The fluid is converted to an aerosol state, and the droplets have an aerodynamic diameter of up to 20 μm, preferably 3 μm to 10 μm. Further, the disclosures of these patent documents are preferably in the form of a cylinder with a length of about 9 cm to about 15 cm, a width of about 2 cm to about 5 cm, and a nozzle spray spread of 20 ° to 160 °, preferably Relates to a nebulizer of 80 ° to 100 °. These values also apply to the nebulizer according to the teachings of the present invention as particularly preferred values.

  Prior to use, the nebulizer is first opened by loosening the lower housing part and the sealed container is inserted into the nebulizer. When the container is stored, the container is opened by inserting the delivery tube into the inner bag. Next, the lower housing part is pushed on again.

  By rotating the lower housing part of the nebulizer, the drive spring can be placed under tension and fluid can be drawn into the compression chamber of the pressure generator. When the container is moved into the lower housing part with only one movement in the nebulizer while the container is under tensioning operation, the puncture element provided in the lower housing part when the container is first pulled The base of the container is punctured to allow air to flow in or out. After manual operation of the locking element, the fluid in the pressure chamber is placed under pressure by a drive spring and such fluid is delivered as an aerosol through the nozzle and into the mouthpiece without the use of a propellant gas.

  After opening the nebulizer, the empty container may be replaced with a full container so that the nebulizer can be used again.

  An object of the present invention is to provide a nebulizer that is easy to operate and has improved operational reliability.

International Publication No. 91/14468 Pamphlet International Publication No. 97/12687 Pamphlet

  This object is achieved by a nebulizer as described in claim 1. Another advantageous feature is the subject matter of the dependent claims.

  The basic technical idea of the present invention is that even when the nebulizer is delivered, a sealed container is accommodated in the nebulizer, and the nebulizer opens the container inside the nebulizer before or during the first use of the nebulizer. It is in the configuration. This basic technical idea is simplified and referred to as “preliminary storage container”. This facilitates operation because it is not necessary to open the nebulizer, insert the container, and close the nebulizer. Furthermore, unwanted contamination or damage of the nebulizer caused by inaccurate operation when inserting the container can be eliminated in this way. Therefore, good operational safety is obtained because it is impossible to insert or misuse the container during insertion.

  Another feature of the present invention that can be implemented independently is that the nebulizer is configured such that the container is not replaceable and in particular the container cannot be removed. This prevents the container from being replaced. This also facilitates the operation in this case, thus improving operational reliability. This also prevents the nebulizer from being used or reused in an undesirable or unauthorized manner.

  In particular, the nebulizer cannot be opened to replace an empty container with a full container in an undesirable manner, and the lower housing part cannot be removed.

  As a result of the combination of configurations that make it impossible to exchange the pre-container and the container, particularly easy operation and high operational reliability are obtained. This means that the user can only use the nebulizer as a single-use item until the container is empty, and the unnecessary or unauthorized use of the nebulizer cannot replace the container. It is because it is blocked by.

  Correspondingly, however, the ease of operation and improved operational reliability for the user is that the container is pre-stored in a pharmacy, for example, by trained staff, and optionally opened at the same time. Can be achieved. However, the container is made so that it cannot be exchanged, and in particular, provided that the user cannot open the nebulizer.

  Further advantages, features, properties and aspects of the present invention will become apparent upon reading the following description of some preferred embodiments with reference to the appended claims and drawings.

1 is a non-schematic cross-sectional view of a known nebulizer in a non-tensioning operation state. It is a schematic sectional drawing of the well-known nebulizer in the tension operation state of the state rotated 90 degrees compared with FIG. It is a schematic sectional drawing of the nebulizer proposed according to 1st Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 4 is a schematic cross-sectional view of the nebulizer of FIG. 3 in an activated state or with the container open. It is a schematic sectional drawing of the nebulizer proposed according to 2nd Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 6 is an enlarged detail view taken along the dashed line in FIG. 5. FIG. 6 is a schematic cross-sectional view of the nebulizer of FIG. 5 in an activated state or with the container open. It is a schematic sectional drawing of the nebulizer proposed according to 2nd Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 9 is an enlarged detail view taken along the dashed line in FIG. 8. FIG. 9 is a schematic cross-sectional view of the nebulizer of FIG. 8 in an actuated state or with the container open and the actuating member pushed on. FIG. 11 shows the nebulizer of FIG. 10 with the actuating member omitted. FIG. 6 is a schematic perspective view of a nebulizer proposed according to a fourth embodiment with an actuating member similar to the third embodiment but not pushed on. It is a schematic sectional drawing of the nebulizer proposed according to 5th Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 14 is a schematic cross-sectional view of the nebulizer of FIG. 13 in an activated state or with the container open. It is a schematic sectional drawing of the nebulizer proposed according to 6th Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 16 is a schematic cross-sectional view of the nebulizer of FIG. 15 in an activated state or with the container open. It is a schematic sectional drawing of the nebulizer proposed according to 7th Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 18 is a schematic cross-sectional view of the nebulizer of FIG. 17 in an activated state or with the container open. It is a schematic sectional drawing of the nebulizer proposed according to 8th Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 20 is a schematic cross-sectional view of the nebulizer of FIG. 19 in an activated state but in a non-tensioning operating state or with the container open. FIG. 21 is a diagram corresponding to FIG. 20 but showing the nebulizer in a pulling operation state. FIG. 22 is an enlarged detail view taken along the dashed line in FIG. 21. It is a schematic sectional drawing of the nebulizer proposed according to 9th Embodiment in the delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 24 is a schematic cross-sectional view of the nebulizer of FIG. 23 in an activated state but in a non-tensioned operating state or with the container open. FIG. 25 is a diagram corresponding to FIG. 24 but showing the nebulizer in a pulling operation state. It is a detailed perspective view of the transport lock for containers provided in the nebulizer of the nebulizer as the ninth embodiment in a fixed state. FIG. 27 is a partial cross-sectional side view of the transport lock of FIG. 26 in a fixed state. FIG. 28 is a view of the transport lock corresponding to FIG. 27 in an open state. FIG. 6 is a schematic axial view of a transport lock in an open state. It is a perspective view of the inner part of the nebulizer as a 9th embodiment. It is the schematic of the housing component of the nebulizer as 9th Embodiment. It is a partial cross section side view of the transport lock for nebulizers as a 10th embodiment in a fixed state. FIG. 33 is a view of the transport lock corresponding to FIG. 32 in an open state. FIG. 22 is a schematic cross-sectional view of the lower part of the nebulizer proposed according to the eleventh embodiment in an intermediate state. FIG. 35 is a schematic axial cross-sectional view of the nebulizer of FIG. 34 in the overlap region of the housing part and the inner part in the delivered state. FIG. 36 is a schematic axial sectional view showing the nebulizer of FIG. 34 corresponding to FIG. 35 in an intermediate state. FIG. 35 is a partial cross-sectional side view of a housing part with a container and a transport lock of the nebulizer of FIG. 34; FIG. 35 is a partial cross-sectional side view of the housing part of the nebulizer of FIG. 34, showing a state in which the inner part is partially pushed in. FIG. 35 is a partial cross-sectional side view of the housing part of the nebulizer of FIG. 34, showing the state where the inner part is fully pushed in. FIG. 35 is a partial cross-sectional side view of the housing component of the nebulizer of FIG. 34, showing a state in which the container is opened or the container base is punctured. It is a schematic sectional drawing of the nebulizer proposed according to 12th Embodiment in a delivery state, and is a figure which shows the state by which the airtight container is accommodated in the nebulizer. FIG. 42 is a schematic cross-sectional view of the nebulizer of FIG. 41 in an operational tensioning operation or with the container open.

  In the figures, the same reference signs are used for the same or similar parts, and corresponding or equivalent properties and advantages are achieved even without repeating the description.

  1 and 2 show a known nebulizer 1 for atomizing a fluid 2, in particular a high-efficiency pharmaceutical formulation, etc., which nebulizer is in a non-tensioning operation state (FIG. 1) and a tensioning operation (starting or It is schematically shown in the (priming) state (FIG. 2). The nebulizer is particularly configured as a portable inhaler and preferably operates without propellant gas.

  When nebulizing fluid 2, preferably a liquid, in particular a pharmaceutical formulation, an aerosol is formed that can be inhaled or inhaled by a user (not shown). Normally, inhalation takes place at least once a day, in particular several times a day, preferably at set intervals, depending on the patient's complaint.

  The known nebulizer 1 has an insertable, preferably replaceable container 3 containing a fluid 2. This container thus forms a reservoir of fluid 2 to be nebulized. Preferably, the container 3 contains a sufficient amount of fluid 2 or active substance to provide up to 200 doses, i.e. allow up to 200 sprays or applications. A typical container 3 as disclosed in WO 96/06011 contains a volume of about 2 ml (milliliter) to about 10 ml (milliliter).

  The container 3 has a substantially cylindrical or cartridge shape, and once the nebulizer 1 is opened, the container can be inserted into the nebulizer from below and can be replaced if desired. This container is preferably of rigid construction, and the fluid 2 is held in a folding bag 4 in particular in the container 3.

  The nebulizer 1 further comprises a pressure generator 5 which transports and atomizes the fluid 2 in a particularly preset and arbitrarily adjustable dosage. The pressure generator 5 comprises a holder 6 for the container 3, an associated drive spring 7 (only partly shown) with a locking element 8 that can be manually operated and released, and a transport tube 9 with a check valve 10. And a pressure chamber 11 and a discharge nozzle 12 provided in the vicinity of the mouthpiece 13. The container 3 is fixed in the nebulizer 1 by a holder 6, and a transport pipe 9 enters the container 3. The holder 6 may be configured so that the container 3 can be exchanged.

  When the drive spring 7 is pulled in the axial direction, the holder 6 moves downward in the drawing together with the container 3 and the transport tube 9, and the fluid 2 is sucked out of the container 3 and passes through the check valve 10 to pass through the pressure generator 5. Into the pressure chamber 11.

  During the next relaxation after the actuation of the locking element 8, the fluid 2 in the pressure chamber 11 is moved back upward by the relaxation of the drive spring 7, which now has a check valve 10 which is now closed, and is now applied. When working as a pressure ram, it is placed under pressure. Due to this pressure, the fluid 2 is pumped into the discharge nozzle 12 and then atomized to the state of the aerosol 14 as shown in FIG. The droplet size of Respimat type particles for instruments has already been described above.

  A user (not shown) can inhale the aerosol 14, during which time supply air can be drawn into the mouthpiece 13 through the at least one supply opening 15.

  The nebulizer 1 has an upper housing part 16 and an inner part 17 rotatable relative to the upper housing part (FIG. 2), the inner part has an upper part 17a and a lower part 17b (FIG. 1), On the other hand, in particular a manually operable housing part 18 is releasably fixed to this inner part, preferably by means of a holding element 19, and in particular is attached thereto. The housing part 18 can be removed from the nebulizer 1 in order to insert and / or replace the container 3.

  The housing part 18 can be rotated relative to the upper housing part 16, and this is accompanied by the rotation of the part 17 b of the inner part 17 located below in the drawing. As a result, the drive spring 7 is pulled in the axial direction by a gear (not shown) acting on the holder 6. During pulling, the container 3 is moved axially downward until the container 3 occupies the end position as shown in FIG. In this state, the drive spring 7 is under tension. During the atomization process, the container 3 is returned to its original position by the drive spring 7. Thus, the container 3 performs a lifting movement during the pulling operation and during the atomization process.

  The housing part 18 preferably forms a cap-shaped lower housing part and fits around the lower free end of the container 3 or on the lower free end of the container 3. When the drive spring 7 is pulled, the container 3 moves (further) into the housing part 18 with its end part or towards its end face, while acting in the axial direction provided in the housing part 18. When the spring 20 abuts the base (bottom) 21 of the container and the container first contacts the piercing element 19, the spring punctures the container 3 or the base seal provided thereon with the piercing element 22, Air can be taken in.

  The nebulizer 1 preferably has a monitoring device 23 that counts the operation of the nebulizer 1 by detecting the rotation of the inner part 17 relative to the upper part 16 of the housing. Reference will now be made to FIGS. 3 through 42, detailing the configuration and mode of operation of 12 embodiments of the nebulizer 1 of the present invention, highlighting only the essential differences from the nebulizer 1 of FIGS. explain. Thus, the description with respect to FIGS. 1 and 2 applies accordingly or supplementarily, whereas the features of FIGS. 1 and 2 and any of the nebulizer positions or mutual features as described above are optional. Desired combinations are possible.

  3 and 4 show, in schematic cross-section, a first embodiment of the proposed nebulizer 1. FIG. 3 shows a delivery state in which the container 3 is sealed. FIG. 4 shows the operating state, ie the state after opening the container 3.

  As suggested, the closed (still closed) container 3 is already stored in the nebulizer 1 in its delivered state as shown in FIG. In the closed state, in the illustrated embodiment, an outer seal 24 provided at the end of the container 3 on the head side, a diaphragm 25 provided inside the container 3, a membrane, a plastic seal, etc. (only partially shown) Not) is not yet open. Furthermore, in the closed state, in the illustrated embodiment, the vent opening 26 provided in the base of the container 3 is sealed, i.e. has not yet been punctured, and this vent opening has no puncture element 22. Can be opened. It should be noted that the container 3 may have a small number of openings and / or different numbers of openings, depending on the particular configuration.

  In all of the proposed embodiments, the nebulizer 1 is configured such that the container 3 can be opened or opened inside the nebulizer 1 at the beginning of the nebulizer 1 or during its use. The container 3 is already opened especially when the seal 24 and the diaphragm 25 are opened. Hereinafter, this is simplified and also referred to as an operating state. The piercing or opening of the vent opening 26 may be performed separately, in particular when the nebulizer 1 is subsequently pulled (first).

  It is proposed that the opening of the container 3 is carried out in particular by means of a delivery element, in particular a transport tube 9, etc., preferably by puncturing the container 3 or by insertion into the container 3. By a suitable relative movement, in particular in the longitudinal direction or in the lifting direction of the container 3 relative to the transport tube 9, the transport tube 9 punctures the seal 24, which transport tube passes through the diaphragm 25 and into the interior of the container 3, in particular the bag. 4, thereby opening the container 3, i.e. forming a fluid coupling for the fluid 2 to escape from the container 3. Thus, the container 3 is particularly opened at its head end.

  Next, during the normal pulling operation and atomization process, the container 3 is preferably moved together with the conveying element or conveying tube by the holder 6 so that the resulting fluid coupling is maintained, thus the container 3. However, it is preferably always open.

  By opening the vent opening 26, as described above, preferably, the ventilation obtained at the base is prior to the aforementioned opening of the container 3, during the opening of the container 3, depending on the particular embodiment or requirement. Or it is good to carry out in the head side edge part especially after the said container 3 open | release.

  In the first embodiment, the container 3 is stored in advance, and the delivered housing part 18 is not completely pushed on in the axial direction. In contrast, a fixing member 27 is provided between the housing part 18 and the upper housing part 16 so that the housing part or the lower part 18 is pushed far enough away from the upper housing part 16. The sealed (still sealed) container 3 can be held away from the transport tube 9 in the axial direction.

  In the remote non-actuated position, the housing part 18 is preferably secured by at least one latching arm 28 attached to the upper housing part 16 or the inner part 17 so that the housing part 18 is not lost. In particular, it will not come off. Preferably, the latching arm 28 operates by engaging the latching protrusion 29 in a latching recess 30 provided in the housing part 18, thereby causing the housing part 18 to be axially engaged by an interlock engagement method. It is fixed so that it is not completely removed. However, other structural solutions are possible.

  In particular, after the housing part or lower part 18 of the nebulizer 1 is first pushed on axially (partially in the axial direction), it can no longer be removed from the nebulizer 1, i.e. the nebulizer 1 is opened. As a result, the container 3 cannot be replaced, i.e. cannot be removed again.

  In the first embodiment, the fixing member 27 has at least a substantially hollow cylindrical shape, and this fixing member is provided between the housing part 18 and the upper housing part 16 in the axial direction. In order to operate the nebulizer 1, i.e. to push on the housing part 18 sufficiently in the axial direction and thereby open the container 3, the fixing member 27 must first be removed. In the first embodiment, the fixing member 27 is configured, for example, as a banderol made of plastic, and can be manually opened, removed, or Can be broken. As a variant or simultaneously, the fixing member 27 may form the original seal or may constitute the original seal. However, other embodiments of the fixing member 27, for example, a fixing member in the form of a security tag or the like, can be used.

  Once the fixing member 27 is removed, the user (not shown) can push on the housing part 18 completely in the axial direction, thereby causing the operating state of the nebulizer 1, i.e. the conveying element. Alternatively, the container 3 can be opened by inserting the transport tube 9. FIG. 4 shows this operating state in which the housing part 18 is fully pushed on. In this push-on state, the housing part 18 is preferably again in this case by means of an interlocking engagement, in particular a latching arm 28 or a latching projection 29 and another corresponding latching recess 31. Is fixed or held by a fitting or by some other mechanical fixing device.

  FIG. 4 shows the nebulizer 1 or container 3 in the activated state, where the container 3 has already been opened and the housing part 18 has been fully pushed on in the axial direction. In order to engage the holder 6 with the end of the container 3 on the head side and then move the container 3 along the holder 6 to perform the pulling operation and the pressurizing process, the nebulizer 1 is first pulled. Sometimes it is necessary. During this pulling operation, the holder 6 is brought axially closer to or moved into the housing part 18 together with the transport tube 9, thus the holder 6 engages the container 3 and preferably also holds the container 3. Pressing against the piercing element 22 near the base of the housing part 18 thereby piercing or opening the vent opening 26. FIG. 4 shows the nebulizer 1 in a relaxed state, i.e., in particular after the first atomization. The holder 6 engages the container 3 and the transport tube 9 is completely inserted into the container 3.

  In the delivery state shown in FIG. 3, that is, in a state where the container 3 is closed (still closed), the nebulizer 1 can be stored. In particular, the closed seal 24 prevents the solvent contained in the fluid 2 from escaping or in any case only very small amounts.

  In order to prevent undesired opening of the container 3, in particular the seal 24 or the vent opening 26, the nebulizer 1 preferably has a transport lock not shown in the first embodiment. The transport lock may be undesirably undesired, for example, if the container 3 is accidentally dropped during transport, for example by frictional engagement, forced engagement or interlock engagement. It moves axially in the nebulizer 1 and thereby prevents accidental opening. Several possible ways of securing the container 3 during transport will be described in detail with reference to other embodiments.

  It should be noted that the opening of the container 3 is preferably only possible by operation by mechanical means and / or only by manual operation. However, additionally or alternatively, the container 3 can be opened in other ways, for example by chemical means, electrical means, pneumatic means, hydraulic means, or similar means. .

  After removing the fixing member 27 and pushing the housing part 18 axially (fully), the nebulizer 1 proposed according to the invention is activated and this is similar to the nebulizer 1 shown in FIGS. Can be used. Conventionally, it has been necessary to open the nebulizer by removing the housing part 18 to accommodate the container 3 and then to close the nebulizer 1 by pushing on the housing part 18. It is easy to implement and has high operational reliability. Specifically, this process prevents improper containers 3 or used containers 3 from being inserted into the nebulizer 1 by the user. In addition, this process prevents the separately supplied container 3 from being accidentally opened before insertion into the nebulizer 1. In addition, the solution of the present invention eliminates the risk of contamination or damage to the nebulizer 1, such as the transport tube 9, even if the nebulizer 1 is opened and the container 3 is used improperly.

  Preferably, in this case, in particular, the nebulizer 1 cannot be opened and the housing part 18 cannot again be removed, so that the container 3 cannot be removed, and an undesirable replacement of the container by the user, in particular Unnecessary provisional or subsequent opening of the nebulizer 1 by the user can be prevented.

  Next, another embodiment will be described in detail with reference to FIGS. The related description is limited to the essential differences from the first embodiment described above and the known nebulizer 1 of FIGS. Thus, the observations and explanations given with respect to the first embodiment and the known nebulizer 1 apply directly or complementarily, even if they are not repeated for reasons of simplification.

  5 to 7 show a second embodiment of the nebulizer 1 of the present invention. FIG. 5 shows the nebulizer 1 in the delivered state, i.e. with the container 3 inserted into the nebulizer 1 but still sealed. FIG. 6 is an enlarged detailed view of FIG. FIG. 7 shows the nebulizer 1 in the actuated state, i.e. with the container 3 opened.

  In the second embodiment of the nebulizer 1, the housing part 18 is preferably of a nested structure and can be pushed together or shortened in the axial direction. Specifically, the housing part 18 of the second embodiment comprises two axially insertable nesting parts 32 and 33 and an axially insertable base part 34.

  FIG. 5 shows the nebulizer 1 or the housing part 18 in a non-actuated state with the telescopic extension. In this state, the two nesting parts 32, 33 and the base part 34 are preferably secured to prevent undesired axial insertion in a latching engagement and / or frictional locking manner. Specifically, the forces required or must be overcome to perform the axial insertion are consistent with each other, so that when axial pressure is applied to the base part 34, first the first The nesting part 32 is pushed into the housing part 18, then the second nesting part 33 is pushed into the first nesting part 32 and finally the base part 34 is second in the axial direction. It is pushed into the nested part 33.

  FIG. 7 shows an axial push-in operating state. In this state, the nesting parts 32, 33 and the base part 34 are fixed axially in their axial position, preferably by latching engagement, friction lock, or more specifically by interlocking engagement. Is done.

  For example, in order to fix the nesting parts 32, 33 in the axial direction with respect to the housing part 18, the corresponding latching projections 29 fit into the latching recesses 30, 31. The aim is to obtain the desired fixed state on the one hand in the axially extended position and on the other hand in the axial push-in position.

  The enlarged description of the details of FIG. 5 shown in FIG. 6 shows the transport lock 36 of the nebulizer 1 for axially securing or preventing the container 3 from moving in the delivery state of the nebulizer 1. In the illustrated embodiment, the transport lock 36 has an encircling retaining bead or at least one retaining arm 37. The holding bead or holding arm 37 cooperates with the container base 21, which is somewhat wider in the radial direction, in the manner in which the container 3 in the delivered state is defined in the axial direction, or an annular shoulder or an annular flange 38. Alternatively, it is fixedly held by some other contact portion.

  In the delivered state, the base part 34 of the illustrated embodiment is telescoped by engaging at least one radial protrusion or surrounding bead 35 with a radially-backward complementary structure provided on the nesting part 33. Or it fixes to the position extended in the direction of an axis. These fixing forces can only be overcome if, for example, a sufficiently strong axial force is applied as a result of plastic or elastic deformation and / or radial deflection of the protrusion / bead 35. is there. During the subsequent axial push-in of the base part 34 relative to the nesting part 33, the piercing element 22 provided in the base part 34 preferably pierces and opens the vent opening 26. In addition, the base part 34 contacts the container base 21 and pushes the container 3 axially out of the transport lock 36 and presses it against the holder 6 in the nebulizer 1 together with the container head (nebulizer). With 1 being pulled). Thus, the axial holding force of the transport lock 36 is overcome by the base part 34. Specifically, the holding bead or holding arm 37 is configured to be sufficiently elastically or plastically deformable in the radial direction for this purpose.

  After the base part 34 has been fully pushed into the second nesting part 33, the base part 34 is preferably again, again by radial engagement with the nesting part 33 and / or by frictional engagement. It is fixed so that it cannot perform axial displacement or outward movement.

  FIGS. 8-11 has shown 3rd Embodiment of the nebulizer 1 of this invention. FIG. 8 shows the nebulizer 1 in a delivered state, and the container 3 is sealed. FIG. 9 is a partially enlarged view of FIG. FIG. 10 shows the nebulizer 1 in the actuated state, i.e. with the container 3 opened. FIG. 11 shows the nebulizer 1 in the operating state as shown in FIG. 10, but the operating member 39 is not provided.

  In the second embodiment, the nebulizer 1 has an actuating member 39 in addition to the housing part 18 which is preferably in the form of a cap, quiver or cup. The actuating member 39 is only partially mounted or pushed on to the housing part 18 in the delivered state, such actuating member being located from the transport tube 9 in the nebulizer 1 as shown in FIG. Hold axially at a distance. Accordingly, the housing part 18 is configured to open at its base.

  A guide sleeve 40 for guiding the container 3 in the radial direction is arranged in the housing part 18 near the base opening, but this is optional. The guide sleeve 40 protrudes beyond the end of the housing part 18 in the axial direction, particularly in the delivered state, and the guide member is pushed into the housing part 18 during operation by pushing the actuating member 18 axially (fully). Push in in the axial direction. Depending on the form of the housing part 18, the guide sleeve 40 may be omitted, in particular according to the degree of radial play with the container 3.

  The base part 34 and the insertion part 41 with the piercing element 22 as in the second embodiment are preferably provided in the actuating member 39.

  The insertion part 41 is configured in a manner similar to the second nesting part 33 of the second embodiment. As can be seen from the enlarged detail view of FIG. 9, the base part 34 and the insertion member 41 are arranged in a radial direction relative to each other as already described with reference to FIG. 2 with respect to the relationship between the second nesting part 33 and the base part 34. Therefore, please refer to the description on that point.

  The insert member 41 also forms a transport lock 36, as already described in connection with the second embodiment, and therefore reference is made to the description made there.

  In the delivered state, the base part 34 is held axially by the actuating member 39, preferably in a radial engagement and / or friction lock manner. The base part 34 holds the insertion member 41 in the axial direction, and the insertion member fixes the container 3 in the axial direction via a transport lock 36.

  In order to actuate the actuating member 39, the actuating member is pushed completely on the housing part 18 in the axial direction and finally the actuating member 39 is preferably like a cap or a cap, as shown in FIG. The nebulizer 1, in particular the housing part 18, is received or enclosed.

  When the actuating member 39 is pushed on in the axial direction, the container 3 is first pushed on the conveying tube 9, ie the container 3 is opened by the conveying tube 9.

  By further pushing on the actuating member 39 to the housing part 18, the insertion member 41 engages the housing part 18, in particular the latching arm 28, and the latching protrusion 29 is in the corresponding latching recess 31 of the housing part 18. The insertion member 41 is thereby fixed in the axial direction with respect to the housing part 18.

  During the last part of the axial movement, the base part 34 is finally pushed axially into the insertion part 41 so that the piercing element 22 pierces or opens the vent opening 26 and the base part 34 The container 3 is released from the transport lock 36 in the axial direction, and the container 3 is moved toward the holder 6 in the state where the nebulizer 1 or the pressure generator 5 is pulled, or the container 3 is moved into the holder 6. The holder 6 is engaged with the container 3 by pushing in the axial direction. This position is shown in FIG.

  As shown in FIG. 10, the nebulizer 1 can be used by the actuating member 39 in the complete push-on state. Specifically, the nebulizer 1 or its pressure generator 5 can be pulled in a normal manner by rotating the actuating member 39 accordingly.

  However, the actuating member 39 is not necessary for the use (separate use) of the nebulizer 1. On the contrary, depending on the design of the nebulizer 1, the actuating member 39 can be taken out again after actuating (fully inserted), or must be done in particular and must be pulled apart in the axial direction. Preferably, the nebulizer 1 is configured such that it only occurs after the axial disengagement or removal of the actuating member 39 has been fully pushed on the housing part 18 first, or only after actuation of the nebulizer 1. It is configured as follows. A suitable lock or release mechanism may be provided for this purpose, but is not shown here.

  FIG. 12 shows a fourth embodiment of the nebulizer 1 of the present invention in a schematic exploded view. In this variant embodiment, which is substantially the same as this third embodiment, the nebulizer 1 can be fixed using an actuating member 39, and for this purpose a clip-like elastic retaining bar or retaining A clip 42 and the like are provided. The actuating member 39, and therefore the nebulizer 1, may be attached to a belt, waistband, pocket, etc. by a retaining bar or clip 42 if necessary.

  As in the case of the third embodiment, once the nebulizer 1 is actuated or the container 3 is opened, the actuating member 39 can be removed from the nebulizer 1 as necessary. Specifically, if the actuating member 39 of the fourth embodiment is used as necessary, the nebulizer 1 can be fixed as desired. In order to obtain an optimally fixed state of the nebulizer 1, the actuating member 39 is preferably releasably connectable to the nebulizer 1 by clamping and / or latching. Can be inserted into the actuating member 39, preferably within at least a substantially hollow cylindrical portion.

  Also, the configuration and usage of the actuating member 39 as a holder of the nebulizer 1 can be designed independently of the pre-container 3, that is, for any type of nebulizer 1 in general. In this case, other configurations are possible, in particular simply by clamping the actuating member 39 to the nebulizer 1, for example.

  13 and 14 are schematic cross-sectional views showing a fifth embodiment of the nebulizer 1 of the present invention. FIG. 13 shows the nebulizer 1 in its delivery state (a state in which the preliminary storage sealed container 3 is provided). FIG. 14 shows the nebulizer 1 in the activated state, i.e. with the container 3 open.

  The fifth embodiment is substantially the same as the third embodiment. Preferably, the nebulizer 1 can be operated by pushing on a cap-shaped, quiver-shaped, or cup-shaped operating member 39. Only the essential differences between this embodiment and the third embodiment are described below.

  The insertion member 41 does not include the latching arm 28, but for attachment to the housing part 18, the insertion member is preferably in the form of a cap, quiver, cup or cap. In the actuated state, the insertion member 41 is formed in the vicinity of the free end of the housing part 18 and in particular surrounds or constitutes a through-opening that allows axial insertion of the container 3. Sit around 43 or fit into the annular portion 43. Specifically, the insertion member 41 is axially coupled to the housing component 18 in a frictional engagement manner or in an interlock engagement manner in the activated state.

  Preferably, the insertion member 41 is pleasant to the nebulizer 1 even when the operation member 39 is removed from the nebulizer 1 when in the activated state or when connected to the housing part 18 as in the case of the third embodiment. The smoothest outer contour is formed as much as possible to give surface feel and ease of handling. According to the third embodiment, the actuating member 39 of the fourth embodiment can be completely removed even after the actual operation, or can be pulled off in the axial direction.

  In the fifth embodiment, the nebulizer 1 is arranged in the radial direction with the container 3 delivered, in order to be able to prevent unwanted detachment from the transport lock 36, in particular by tilting the container 3 to one side. The guide sleeve 40 of the third embodiment for centering, fixing, or supporting may be provided. However, in the illustrated embodiment, the guide sleeve 40 is not provided. Instead, a through opening for the container 3 is formed at the free axial end of the housing part 18 or, for example, a slight radial play with respect to the container 3 in the vicinity of the annular part 43. It is provided that a locking part, for example a guide sleeve 40, is not necessary.

  Another structural difference between the third embodiment and the fourth embodiment is that in the fifth embodiment, the base part 34 has a radial clamp in the delivered state as shown in FIG. As an alternative or in addition, it is held axially by the actuating member 39. Preferably, for this purpose, the actuating member 39 preferably has a shaft with a nipple-like, pin-like or bolt-like projection 44 fitted in a correspondingly provided recess in the base of the base part 34. Thus, the base part 34 is axially fixed to the actuating member 39.

  In the activated state, the actuating member 39 can be released from the base part 34 so that the actuating member 39 can be removed axially if necessary. Preferably, the interlock or frictional engagement and material forces are designed so that the base part 34 is held by the insertion member 41 in the pushed or retracted puncture position even when the actuating member 39 is pulled axially apart. Yes. For example, when the actuating member 39 is pulled apart in the axial direction, the protrusion 44 tears off and remains attached to the base part 34 or remains in the base part 34.

  The construction of the transport lock 36 and the release of the container 3 from the transport lock 36 during operation is preferably consistent with the third embodiment. Preferably, the actuation occurs even when the nebulizer 1 or the pressure generator 5 is in the tensioned state, and when the actuating member 39 is fully pushed on in the axial direction, the container 3 is moved to its bottom by insertion of the transport tube 9. Is opened or penetrated, and the head side end is engaged with the holder 6.

  15 and 16 are schematic cross-sectional views of a sixth embodiment of the nebulizer 1 of the present invention. FIG. 15 shows the nebulizer 1 in the delivered state. FIG. 16 shows the nebulizer 1 in the activated position, i.e. ready for use with the container 3 open.

  In the sixth embodiment, as in the third embodiment, an insertion member 41 and a base part 34 are provided, which are operatively associated with each other and inserted into the housing part 18 opened in the axial direction. it can. In contrast to the third embodiment, a separate or actuated additional actuating member 39 is not necessary. Instead, the insert member 41 is configured as a sleeve, which insert member is not in the housing part 18, particularly in the delivered state and when inserted axially into the nebulizer 1 or the housing part 18. Formed or, in particular, guided or held by a hollow cylindrical portion 45 molded and attached thereto. In the push-in or actuated state, the insert part 41, together with the base part 34, terminates in a hollow cylindrical part 45, thus forming an at least substantially smooth outer contour for the nebulizer 1.

  In a sixth embodiment, the base part 34 is defined by an axial position, preferably by radial engagement, where the piercing element 22 is axially spaced from the base seal, ie the vent opening 26 of the container 3. Held by the insertion member 41 in such a manner.

  In order to actuate the base part 34, pressure is applied to the base member. As a result, the base member 34 is inserted into the insertion part 41 or pushed axially (and further) so that the piercing element 22 punctures or opens the vent opening 26. At the same time, before or after that, the insertion member 41 in which the container 3 is essentially housed is pushed into the nebulizer 1 or the housing part 18 so that the transport tube 9 is axially inserted into the container 3. Inserted and thus the container 3 is opened. In the state where the nebulizer 1 or the pressure generator 5 is pulled, the head side end of the container 3 is finally engaged with the holder 6. In the push-in operating position shown in FIG. 16, the insertion member 41 and the base part 34 are preferably axially latched and / or clamped to the housing part 18 or the hollow cylindrical part 45. Is done.

  In order to prevent undesired removal of the insertion member 41 during insertion, for example from a semi-insertion position or a full insertion position, the nebulizer 1 of the sixth embodiment is preferably progressively moved between the housing part 18 and the insertion member 41. The insertion member 41 can be inserted only in the axial direction, but cannot be taken out in the opposite direction in the axial direction. It is like that. In the illustrated embodiment, the latching means 46 is formed on the sleeve portion of the insertion member 41 and externally in the longitudinal direction along the sleeve portion. In this case, at least one latching arm 28 provided on the nebulizer 1, in particular the housing part 18 in the hollow cylindrical part 45, engages with the latching member 46. FIGS. 15 and 16 show two axially extending latching arms 29 that are elastically biased radially toward the insertion member 41.

  In order to form a transport lock that prevents accidental push-in of the insertion member 41 in the delivered state of the nebulizer 1, according to the sixth embodiment, the fixing member 27 is preferably as shown in FIG. Are provided in the form of or consisting of a safety tag. The safety tag is, for example, provided or fitted radially outwardly between at least one latching arm 28 and the wall of the hollow cylindrical portion 45. The purpose is to prevent at least one latching arm 28, or some or all of the latching arms 28 from spreading radially outwardly by spring action, so that the inner side of the insertion member 41 It is to prevent the axial movement to. Once the safety tag has been removed, in particular after it has been removed in the axial direction, one latching arm or a plurality of latching arms 28 and hence the latching member 46 is released and inserted. The member 41 can be pushed in in the axial direction, whereby the nebulizer 1 is actuated.

  17 and 18 are schematic cross-sectional views of a seventh embodiment of the nebulizer 1 of the present invention. FIG. 17 shows the nebulizer 1 in the delivered state. FIG. 18 shows the nebulizer 1 in the activated state.

  The seventh embodiment is very similar to the sixth embodiment. However, in the sixth embodiment, the insertion member 41 is not provided. Instead, in the delivered state, the housing part 18 is only pushed in the axial direction only to the nebulizer 1, in particular to the inner part 17 or to the holding part 47 provided on it. The holding portion 47 is provided on, for example, the lower portion 17b of the inner part 17. The holding portion 47 extends in the axial direction beyond the end of the inner part 17, and can sufficiently hold the housing part 18 in the axially displaced position in the delivered state, so that the container 3 stored in the housing part 18 in advance can be held. The carrier tube 9 is still positioned at an axial distance. Preferably, when the housing part 18 is pushed axially (partially) onto the retaining part 47 by means of suitable engagement, latching or the like, the housing part 18 can no longer be removed axially. Cannot be removed or removed.

  The housing part 18 of the seventh embodiment places the base part 34 in a manner consistent with or similar to the manner in which the insertion member 41 holds the base part 34 in the sixth embodiment. Hold. For operation, the nebulizer 1 or the pressure generator 5 is preferably pushed in the axial direction again in the tensioned state. As a result, the housing part 18 is pushed on (completely) axially to the nebulizer 1 or the inner part 17. The container 3 is opened by axial insertion of the transport tube 9. In particular, as a result of pushing the base part 34 axially into the housing part 18 until the base part 34 is just flush with the axial end of the housing part 18, the base of the container 3 is finally punctured, In the seventh embodiment, the base of the base 3 is released from the axial transport lock 36 formed by the housing part 18, and the container 3 is inserted into the holder 6 in the axial direction.

  Preferably, a device (not shown) such as a latching member 46 between the housing part 18 and the nebulizer 1 or the inner part 17 in the sixth embodiment, for example having at least one associated latching arm 28 or the like. So that the housing part 18 can only be pushed on to the nebulizer 1 and can prevent reverse axial removal or movement. According to the sixth embodiment, a fixed tube 27 (not shown) in the form of or consisting of a safety tag or the like is also pushed in with the housing part 18 in the delivered state when the fixed member 27 is not removed. It may be provided to prevent it from being done.

  19 to 22 are schematic cross-sectional views of the eighth embodiment of the nebulizer 1 of the present invention. FIG. 19 shows the nebulizer 1 in its delivered state. FIG. 20 shows the nebulizer 1 in the actuated state, i.e. the container 3 has already been opened, but the nebulizer 1 or the pressure generator 5 has not yet been pulled. FIG. 21 shows the nebulizer 1 in the activated and tensioned state. FIG. 22 shows a part of FIG. 21 in an enlarged detail view and shows a transport lock 36 of the eighth embodiment.

  In the eighth embodiment, as in the seventh embodiment, the housing part 18 is only partially pushed on in the axial direction in the delivered state. In contrast to the seventh embodiment, the housing part 18 in the eighth embodiment is closed at its base, ie no separate base part 34 is provided. Instead, a piercing element 22 is provided inside the base of the housing part 18, and in the delivered state, the container 3 is held axially spaced from a correspondingly configured transport lock 36. Opening or puncturing of the bottom of the vent opening 26 is prevented.

  In the example shown, the transport lock 36 is preferably held axially movable in or by the housing part 18 so that the base of the container 3 can be punctured in operation.

  In the illustrated embodiment, the transport lock 36 has at least one gripping arm or gripper arm 48, preferably a plurality of gripping arms or gripper arms 48, which grip arms are axially in the delivered state. Prior to holding, as shown in FIG. 19 for one gripping arm or gripper arm 48, the container 3 is preferably engaged around a radially expanded base end.

  As in the case of the seventh embodiment, the eighth embodiment preferably allows the housing part 18 and the nebulizer 1 or the inner part to be pushed on in the axial direction but not in the axial direction. 17 with a device such as a latching element 46 having at least one associated latching arm 28 between them. The latching element 46 is formed inside the housing part 18 as indicated in FIGS. A latching arm 28 with a latching lug 29 engages with the latching element 46. In contrast to the sixth embodiment, in this case a coarse latching element 46 is provided. In addition, the axial push-on motion is restrained by restraining the latching arm 28 using a fixing member 27 (not shown), specifically in the form of a safety tag or the like or consisting of a safety tag or the like. Is also possible.

  In the eighth embodiment, the actuation is preferably performed in a non-tensioned operating state of the nebulizer 1. After removal of an optional safety tag or the like, the housing part 18 is pushed along the nebulizer 1, in particular the inner part 17. At the same time, the transport tube 9 is inserted into the container 3 in the axial direction, thus opening the container 3.

  In the fully pushed-on state, the container 3 is pushed axially or further into the housing part 18 and the piercing element 22 pierces the vent opening 26 or opens the vent opening 26 and the transport lock 36 is released. To be.

  In particular, the transport lock 36 is opened by means of the inner part 17 or, preferably, at least one axial arm or projection 49 formed in the holding part 47. In the illustrated embodiment, a plurality of axial arms 49 are provided corresponding to the gripper arms 48, which are fully pushed on the housing part 18 so that they are shown in FIGS. Thus, particularly when the transport lock 36 is opened, as shown in FIG. 22, the gripper arm 48 is fully rotated or swung.

  In order to open the transport lock 36 or the gripper arm 48, preferably a force is required to first move the transport lock 36 axially towards the base of the housing part 18 and consequently open the base of the container 3. It is. This is achieved by correspondingly matching the ratio of the axial locking force of the transport lock 36 inside or outside the housing part 18 and the opening force required to pivot the gripper arm 48. Only after reaching the axial end position of the transport lock 36 in the housing part 18, the gripper arm 18 and hence the transport lock 36 is opened and the container 3 is released axially.

  During the next first pulling operation, the transport tube 9 is moved further into the container 3 and the holder 6 is engaged with the container 3. FIG. 21 shows this position. During the next release of the nebulizer 1, the container can be moved axially by the holder 6 in the usual manner during the atomization process. This is because the transport lock 36 remains open and the container 3 can be moved freely in the axial direction.

  23 to 31 show a ninth embodiment of the nebulizer 1 of the present invention. FIG. 23 shows the nebulizer 1 in the delivered state. FIG. 24 shows the nebulizer 1 being activated but not yet being pulled. FIG. 25 shows the nebulizer 1 in the activated and tensioned state. FIG. 26 shows the transport lock 36 in a detailed perspective view, with the securing element attached to the container 3, for example, the cartridge element 50 and the base element 51 formed on or attached to the housing part 18. . FIG. 27 shows the cartridge element in a side view with the cartridge element 50 lifted axially from the base element 51, the base element being shown partially in section for clarity. . FIG. 28 shows the cartridge element 50 in a lowered state in a state corresponding to FIG. FIG. 29 is a schematic axial view of the transport lock 36 in the opened state. FIG. 30 shows the inner part 17 of the nebulizer 1 in a perspective view. FIG. 31 shows the housing part 18 in a schematic perspective view.

  The ninth embodiment is basically the same in configuration and design as the eighth embodiment. The following description relates only to essential differences. The descriptions made with respect to the eighth embodiment and other embodiments are also complementary to each other.

  In the ninth embodiment, the housing part 18 is in the delivered state and is not fully pushed on. In the delivered state, the transport lock 36 fixes the container 3 to the base of the housing part 18.

  In the ninth embodiment, the axial motion is preferably converted into rotational motion upon actuation. The purpose is to open the transport lock 36 or to free the container 3 in the axial direction. Specifically, liberating or releasing is performed on an inclined plane. By releasing the axial push-on movement due to the rotational movement and the release movement of the transfer lock 36, the optimum axial fixation of the container 3 in the fixed state and the relatively easy opening of the transport lock 36 are possible. The container 3 is released in the axial direction. This will be described below with reference to the illustrated embodiment.

  The cartridge element 50 is rotatably connected to the container 3. Specifically, the cartridge element 50 is formed on the container 3, is attached to the container 3, or is injection-molded on the container 3, and has a radially wide width. Surrounds the rim or edge of the bottom 21. In the delivery state, as shown in FIGS. 23, 26 and 27, the cartridge element 50 with the container 3 is spaced from the base element 51, more specifically, from the base element 51 in the axial direction. It is fixed axially and non-rotatably, so that the piercing element 22 of the base element 51 does not open or pierce the base of the container 3.

  Rigid gripper arms 48 are attached to the base element 51 and are specifically formed on the base element 51, which engage and engage the radial protrusions 52 of the cartridge element 50 at specified rotational positions. , Thereby fixing the cartridge element 50 so as not to move away from the base element 51 in the axial direction. A lock arm 53 provided on the base element 51 stops the radial stop 54 of the cartridge element 50, thereby preventing rotation of the cartridge element 50 (clockwise direction in the illustrated embodiment). The reverse rotation is stopped by the appropriate design of the gripper element 48 and / or the cooperation of the sliding ramp provided on the cartridge element 50 and the inclined surface 56 provided on the base element 51.

  The sliding slope 55 and the inclined face 56 extend in the circumferential direction and are inclined in the circumferential direction, and the base element 51 in the delivered state, as can be seen from FIG. Are held together axially spaced from each other so that they can be lifted from each other.

  In order to actuate the nebulizer 1 and open the container 3, the housing part 18 is fully pushed on in the axial direction. The inner part 17 has an axial arm or protrusion 49 as shown in FIG. 30 that rotates the stop arm 53 in the actuated state or when the housing part 18 is fully pushed on. Move, thereby opening the transport lock 36 or at least loosening or unlatching it. The stop arm 53 or the portion of the stop arm 53 that stops the radial abutment 54 can be pivoted radially outward so that the cartridge element 50 can be rotated relative to the base element 51.

  24, 25, 28 and 29 show the cartridge element 51 which has already been rotated clockwise. This rotation is effected by sliding the sliding slope 55 on the inclined surface 56 along this, in particular during the pulling operation of the pressure generator or when the container 3 is pushed down by the holder 6. During this sliding movement, the cartridge element 50 is moved axially relative to the base element 51, and the base of the container 3 is punctured by the puncture element 22 of the base element 51. Furthermore, this rotation frees the cartridge element 50 in the container 3 in the axial direction. This is because the radial protrusion 52 is retracted from below the gripper arm 48, thereby freeing in the axial direction. The rotation of the cartridge element 50 for puncturing the container 3 as an option and releasing it axially is preferably between 5 ° and 10 °.

  Of course, the transport lock 36 may be of different construction, but it should have an equivalent function, in particular the cartridge element 50 being rotated relative to the base element 51 in a counterclockwise direction. This should allow the transport lock 36 to be opened or at least loosened or released.

  The principle described above or the specific configuration of the transport lock 36 of the ninth embodiment can be embodied in other embodiments, in particular the eighth embodiment, if necessary.

  The base element 51 preferably has a holding arm 57 that fits into a corresponding pouch 58 provided on the housing part 18 so as to be attachable to the housing part 18. In particular, during assembly, the base element 51 is preferably clipped into the housing part 18 together with the container 3 and the cartridge element 50. Thereby, an easy assembly becomes possible. However, the base element 51 may be attached to the housing part 18 in some other way and / or may be formed thereby.

  In the illustrated embodiment, the inner part 17 has several, specifically three, latching arms 28 distributed along the circumference. However, the housing part 18 illustrated by way of example in FIG. 31 preferably comprises only one latching member 46 on the inside, so that only one associated latching arm 28 has its latching projection. At 29, the latching member 46 is fitted. This mating function has already been described with particular reference to the sixth and eighth embodiments, and therefore will not need to be described again at this point.

  The other latching arm 28 engages with latching recesses 30, 31 provided in the housing part 18, the recess 30 corresponds to the axial direction 1 in the delivered state, and the recess 31 is the axial direction of the housing part 18. Corresponds to the complete insertion position. This results in a particularly durable fixation of the housing part 18 in both positions so that the housing part 18 can be removed from the nebulizer 1 by the user or the housing part 18 has a full push-on force. There is no risk of partial axial removal that is not permitted.

  In the ninth embodiment, the housing part 18 is attached to the nebulizer 1 or the inner part 17 in a preferably non-rotatable manner, as in the other embodiments.

  In the ninth embodiment, the operation is performed by the nebulizer 1 or the pressure generator 5 in the non-tensioning operation state. Thus, after actuation by axial insertion of the housing part 18, an initial pulling operation is still necessary to engage the holder 6 with the container 3 as indicated in FIG.

  However, the nebulizer 1 or the pressure generator 5 may already be pulled even in the delivered state. This is especially true in the first embodiment, the second embodiment, the third embodiment, the fifth embodiment, the sixth embodiment, and the seventh embodiment.

  According to a particularly preferred variant embodiment, the cartridge element 50 and the container 3 are mounted such that they cannot be separated from one another. Preferably, the cartridge element 50 serves to encode the container 3 or the fluid 2 or medicament contained therein. The encoding may vary depending on, for example, the particular active substance and / or dose. The encoding by the cartridge element 50 allows the container 3 with the cartridge element 50 to be used only in connection with a specific nebulizer 1, in particular only in connection with a specific or matched housing part 18 or base element 51. . This is a technique that ensures that only the correct container or the correct fluid 2 is used in the appropriate nebulizer 1.

  The coding, in particular, in order to be able to insert the container 3 in question with the cartridge element 50 into the nebulizer 1 only if the coding is matched, i.e. if the parts are fit. Corresponding adaptation measures such as recesses, undercuts, arm structures and numbers, or complementary structures.

  With respect to the cartridge element 50, it should also be pointed out that, in general, in connection with the ninth embodiment, the cartridge element does not necessarily have to be of a continuous surrounding structure. On the contrary, this may only extend over a part of the circumference of the container 3, especially along the container base 21 if necessary. However, the container 3 replaces the cartridge element 50 with some other fixed element which only cooperates mechanically with the base element 51 in particular, for example by means of a corresponding suitable design such as a container rim in the vicinity of the container base 21 (see FIG. (Not shown) or may be formed.

  Next, a tenth embodiment of the nebulizer 1 or the transport lock 36 will be described in detail with reference to FIGS. 32 and 33. FIG. 32 corresponds to the diagram of FIG. FIG. 33 corresponds to the diagram of FIG.

  The tenth embodiment essentially differs from the ninth embodiment only in that the configuration of the transport lock 36 is somewhat simpler. Compared to the ninth embodiment, the gripper arm 48 is omitted from the tenth embodiment. Instead, the restraining arm 53 further serves to fix the cartridge element 50 in the axial direction relative to the base element 51 or the housing part 18 or to prevent it from moving in the fixed state. Specifically, the restraining arm 53 covers and engages the cartridge element 50 or a suitable protrusion of the cartridge element 50, for example, the radial protrusion 52, in a corresponding, preferably inclined portion. Then, the cartridge element 50 is fixed so as not to be lifted in the radial direction from the position shown in FIG.

  FIG. 33 shows the transport lock or device 36 already unlocked or already opened. The restraining arm 53 is bent and pivots in particular radially outwardly in order to release the cartridge element 50 and hence the container 3 in the axial direction. Furthermore, in the position shown in FIG. 33, the cartridge element 50 has already been placed on the base element 51 together with the container 3, which is during the pulling operation of the nebulizer 1 with the transport lock 36 open. This is performed by the action of the holder 6. Thus, the base of the container 3 is punctured in this state.

  Other explanations and features associated with the ninth embodiment also basically apply equally to the tenth embodiment, or at least complementarily to the tenth embodiment.

  34 to 40 show an eleventh embodiment of the nebulizer 1 of the present invention.

  FIG. 34 shows the nebulizer 1 or, more precisely, the lower part of the nebulizer 1 in an intermediate state in a partially imagined schematic side view. The container 3 provided in the nebulizer 1 is not shown. The housing part 18 is in the lower position or the first position, in which the housing part 18 is held axially spaced from the inner part 17 by the upper housing part 16 and thus the housing part 18. The container 3 contained therein is still located at a distance from the conveying element or conveying tube 9, i.e. not yet opened or punctured.

  FIG. 35 shows an axial sectional view of the relative rotational position of the housing part 18 from the inner part 17 in the delivered state. FIG. 36 shows the rotational position of the housing part 18 relative to the inner part 17 in the intermediate state shown in FIG. In this case, the housing part 18 is rotating with respect to the inner part 17 or the delivered state. FIG. 37 shows the housing part 18 without the inner part 17 but with the container 3 in a partial cross-sectional side view, with the transport lock 36 holding the container 3 in the housing part 18. 38 to 40 are partial sectional side views showing the housing component 18 in various states.

  The eleventh embodiment is basically very similar to the seventh embodiment, the eighth embodiment, the ninth embodiment, and / or the tenth embodiment. Reference should be made to the notes and explanations given and the illustrations given in connection therewith, which apply equally or complementarily. Only essential differences or novel features of the eleventh embodiment will be described in detail below.

  In the delivery position shown in FIG. 35, the housing part 18 is pushed axially (further) along the inner part 17 or moved close to the upper housing part 16, preferably in an interlocking manner. Be blocked. As already described in other embodiments, the axis of the nebulizer 1 is only after rotation of the housing part 18 relative to the inner part 17 to the intermediate position shown in FIGS. 34 and 36, preferably about 10 ° to about 20 °. Insertion or actuation of the nebulizer 1 can only occur after direction (more axial) insertion or actuation, and the container 3 can be opened and fluidly coupled I can't.

  The aforementioned rotational movement of the housing part 18 relative to the inner part 17 from the delivery position to the intermediate position is essential in order to be able to push on the housing part 18 axially rearward or to activate the nebulizer 1. . Thus, axial restraining of the housing part 18 in the delivery position provides a protective measure that prevents accidental operation of the nebulizer 1. For example, this prevents the nebulizer 1 from being accidentally activated when dropped.

  During assembly, the housing part 18 is first pushed along the inner part 17 or the lower part 17b of the inner part 17 while being held by the transport lock 36 together with the container 3 housed therein. In the end, only the housing part 18 is attached to the inner part 17 in a separable manner, in particular only to be latched and secured thereto. Particularly preferably, in the delivery state, the latching arm 28 engages with the first latching recess 30 at the latching projection 29 so that the housing part 18 can no longer be detached from the inner part 17 or Make sure you ca n’t pull away. In this delivery state, the housing part 18 is in this case at least initially prevented from being pushed further in the axial direction by means of an interlocking engagement.

  The locking action, which prevents further axial pushing in the delivery state, preferably in the illustrated embodiment causes at least one axial abutment 59, in particular at least two axial abutments 59, to be connected to each other in the housing. This is achieved by providing on the opposite side, these axial abutments abutting at least one preferably radial projection 60 provided on the inner part 17 in the delivered state. The abutment 59 is most clearly shown in the end view of FIG. In this case, the housing part 13 has already been rotated to an intermediate position, so that the projection 60 no longer overlaps the abutment 59 in the axial direction and is fitted in the adjacent axial recess 61. .

  Rotation of the housing part 18 with respect to the inner part 17 from the delivery position to the intermediate position is possible, inter alia, because the latching recess 30 has a corresponding circumferential extension, so that the latching protrusion 29 is more precisely speaking In the intermediate position shown in FIG. 34, it can be slid or moved along the circumference of the inner wall of the housing part 18.

  The locking action that prevents further axial pushing of the housing part 18 in the delivered state can also be achieved by other structural means.

  When rotating the housing part 18 from the delivery position to the intermediate position, a certain resistance must preferably be overcome. The rotating motion should be not smooth for this purpose. In the illustrated embodiment, the housing part 18 moves to a delivery position and an intermediate position in a substantially latched state (in the delivery position, the radial protrusion 59 fits into the radial recess 62 and in the intermediate position these radii The directional protrusion fits into the adjacent axial recess 61 of the housing part 18) and therefore must overcome some latching resistance when moving from the delivery position to the intermediate position, while the housing part 18 18, and / or the inner part 17 is preferably elastically deformed in the radial direction or the corresponding part is elastically deflected accordingly.

  Preferably, a locking device is also provided to prevent the housing part 18 from being rotated from the intermediate position back to the delivery position. In the illustrated embodiment, the inner part 17 is provided with at least one preferably radially acting lock latch 63, which is initially in the delivery position a first shaft provided on the housing part 18. It is fitted with a latching notch 64 extending in the direction, and is fitted with a latching notch 65 extending in the second axial direction at the intermediate position. During the transition from the delivery position to the intermediate position, i.e., from the first latching notch 64 to the second latching notch 65, the lock latch 63 bends radially inward. Can do. In the illustrated embodiment, two locking latches 63 are provided on opposite sides of each other with associated latching notches 64 and 65. Reverse rotation from the intermediate position to the delivery position can also be prevented by other structural means.

  In the eleventh embodiment, in order to operate the nebulizer 1, a combination of rotational motion and average motion is required. As a result of this combined movement, a particularly good blocking means against accidental actuation of the nebulizer 1 is obtained.

  Preferably, in a non-actuated state, i.e. when the housing part 18 has not been fully pushed on, the nebulizer prevents the pressure generator from being pulled, i.e. in particular the rotation of the inner part 17 relative to the upper housing part 16. Locked to prevent This is particularly important when the nebulizer 1 is supplied in a delivery state in which the pressure generator 5 is not pulled. Thus, the inhaler 1 has a barrier that allows the inner part 17 to rotate only relative to the upper housing part 16 when the housing part 18 is fully pushed on. This rotation barrier is particularly effective in the delivery state, and such a rotation barrier can be used in other embodiments in which the nebulizer 1 is delivered in a non-tensioning operation state regardless of the eleventh embodiment.

  The direction of rotation when moving the housing part 18 from the delivery position to the intermediate position is preferably opposite to the direction of rotation when pulling the pressure generator 5 or the nebulizer 1 by rotating the housing part 18 in the operating state. Pull in the direction. However, in order to pull the nebulizer 1 or the pressure generator 5 simultaneously if desired, as a modification, the rotation from the delivery position to the intermediate position may be performed in the pulling operation direction.

  In the illustrated embodiment, one of the radial protrusions 60 preferably forms the bearing of the counting or monitoring device 23 shown in FIG. 34, in particular the threaded spindle 66 of the device 23. The spindle 66 is preferably a slider (not shown) that indicates the number of doses that have already been dispensed or can still be dispensed. By rotating the spindle 66, the slider can be moved along the spindle 66. Preferably, a window 67 (see FIG. 35 and FIG. 36) is formed in the housing part 18 to see the axial position of the slider even if the housing part 18 is not transparent in construction. It can be done.

  The eleventh embodiment has a transport lock 36 that is significantly different in structure from the transport lock of the previous embodiment. However, the function of the transport lock 36 is consistent with the above description, and therefore only the essential differences of the transport lock 36 are described below.

  FIG. 37 shows a preferred structure of the transport lock 36. A base element 51 is inserted into the housing part 18 and held by a holding arm 57. The transport lock 36 or the base element 51 has a gripper arm 48 for fixing the container 3 in the illustrated transport state. Specifically, the gripper arm 48 engages the container 3 or, in this state, its transition to the base 21 in the radial direction and / or engages in the axial direction. The purpose is to fix the container 3 by frictional engagement, more specifically by interlock engagement. The gripper arms 48 are distributed along the periphery of the container 3.

  The transport lock 36 preferably further comprises an annular anchoring element 68, which in particular comprises a radially extending locking element 69, which is secured to the gripper arm 48 in the illustrated state or transport. In the state, it is prevented from bouncing radially outward. Specifically, for this purpose, the locking element 69 engages a circumferential or lateral (hammer-like) protrusion provided on the gripper arm 48 radially from the outside.

  Preferably, the locking element 69 is supported radially on the inner wall of the housing part 18 by means of an interlocking engagement in the transport position in which the exterior holds the container 3 by means of the interlocking engagement. And the locking element is preferably secured against the locking or locking of the gripper arm 48), and these locking elements are preferably arranged on the housing part as indicated in FIG. 18 is held axially by a circumferential groove 71 and associated circumferential bead 72 in 18 or in some other manner. Thus, the fixing element 68 is fixed or held axially in the transport state. However, the securing element 68 may be held axially directly or in some other manner.

  The locking element 69 is preferably connected to the fixing element 68 by an axial bar 73 and forms a space between them when the gripper arm 48 opens the transport lock 36. It can be deflected outwards and is large enough to be able to bend in the axial direction, especially when the fixing element 68 is pushed towards the base of the housing part 18, as will be described below.

  FIG. 38 shows the housing part 18 with the inner part 17 already partially inserted, so that the axial arm or protrusion 49 of the inner part 17 is already in contact with the end face of the locking element 69. Yes. Starting from the intermediate position, the container 18 has not yet been pushed completely along the inner part 17 or the nebulizer 1.

  FIG. 39 shows the position with the housing part 18 fully pushed on. The inner part 17 has pushed the fixing element 68 axially from the fixing or transport position shown in FIGS. 37 and 38 towards the base of the housing part 18, so that the locking element 69 no longer holds the gripper arm 48. It is not fixed to stop axial deflection. During axial displacement, the inner part 17 preferably overcomes or negates the interlocking engagement obtained between the housing part 18 and the locking element 69.

  Furthermore, when the inner part 17 reaches the position shown in FIG. 39, the gripper arm 48 is deflected radially by corresponding axial engagement, thereby opening the transport lock 36. In this position, the container 3 is already held at the head end by the holder 6 even if the container 3 may not yet be completely fitted into the holder 6.

  During the next pulling operation of the nebulizer 1 or the pressure generator 5, the holder 6 is moved further axially in the direction of the housing part 18, so that, even if this has not already occurred, The container 3 is latched at its head end to the holder 6 in the desired manner and the container 3 is moved to its lower axial end position so that the container 3 is indicated in FIG. The base is opened or punctured by the piercing element 22.

  The nebulizer 1 preferably has an indicator device that indicates the operational state or the open state of the transport lock 36. In the illustrated embodiment, this is accomplished by the housing part 18 having a side inspection window 74 in its base region. Peripheral, preferably differently colored parts of the fixing element 68, in particular the locking element 69, are visible through the inspection window 74 only when the transport lock 36 is opened or the inner part 17 is fully fitted.

  The transport lock 36 allows easy assembly of the container 3 into the housing part 18, in particular easy insertion, very secure holding of the container 3 in the transport position, easy and reliable opening by the inner part 17, etc. .

  The transport lock 36 of the eleventh embodiment can be used in other embodiments.

  41 and 42 are schematic cross-sectional views of the twelfth embodiment of the nebulizer 1 of the present invention. FIG. 41 shows a delivery state. FIG. 42 shows an operating state in which the container 3 is opened.

  In contrast to the other embodiments, in the twelfth embodiment, the nebulizer 1 is completely closed, specifically pushing elements, components etc. in order to actuate or open the container 3. There is no need to push on or to act mechanically (additionally) in a different way. Instead, activation of the nebulizer 1 or opening of the container 3 occurs when the nebulizer 1 or the pressure generator 5 is initially pulled.

  In the twelfth embodiment, the container 3 and the conveying device for the fluid 2 in the nebulizer 1 preferably have the conveying tube 9 or some other conveying element not yet hold the container 3 in the non-tensioning and delivery state of the nebulizer 1. They are put together so as not to puncture. Only during the pulling operation is the transport tube 9 inserted axially into the container 3, thereby opening the container 3 and engaging the holder 6 with the container 3. An advantage for the user is that no special action is required for the user to operate the device. On the contrary, the nebulizer 1 is activated automatically during normal use, i.e. when it is first pulled. Thus, as a result of the provision of the pre-container 3, a particularly simple and hence reliable operating means for the user is obtained.

  Preferably, in the twelfth embodiment, the housing part 18 cannot be detached from the nebulizer 1 as in most of the other embodiments. Specifically, the housing part 18 is latched in place and is held in a non-removable manner by the latching arm 28 shown in FIGS. 41 and 42, for example in the push-on position.

  In general, it should be pointed out that the container 3 can preferably be inserted into the nebulizer 1 of the invention, i.e. incorporated into the nebulizer 1. As a result, the container 3 is preferably a separate component. However, the container 3 may theoretically be formed directly by the nebulizer 1 or may be part of the nebulizer, or may be incorporated in the nebulizer 1 in a different manner.

  As mentioned above, the individual features, aspects, and / or principles of the described embodiments can be combined with each other as desired, and not only the known nebulizers of FIGS. It can be used for similar or different nebulizers.

  Unlike self-supporting devices or the like, the nebulizer 1 of the present invention is preferably designed to be portable, and in particular is a portable manually operated instrument.

  However, the solution of the present invention can be applied not only to the nebulizer 1 specifically described herein, but also to other nebulizers or inhalers, such as powder inhalers or so-called metered dose inhalers.

  Preferably, fluid 2 is a liquid as described above, in particular an aqueous pharmaceutical formulation. However, this may be some other pharmaceutical formulation, suspension or the like.

  According to an alternative embodiment, the fluid 2 may further comprise particles or powder. In this case, instead of the discharge nozzle 12, some other type of supply device, in particular a discharge opening (not shown) or a supply channel (not shown) for supplying fluid or powder or the like into the mouthpiece 13 is provided. It is good to provide. In this case, an optional air supply opening 15 supplies ambient air, preferably in parallel, preferably in parallel, or enables air flow with sufficient inspiration or inhalation through the mouthpiece 13. To help.

  If necessary, the fluid 2 may be atomized with a propellant gas.

  The preferred components and / or preparations of the medical fluid 2 are preferably listed below. As noted above, these may be aqueous or non-aqueous solutions, mixtures, formulations, etc. that contain ethanol or no solvent. The fluid 2 particularly preferably contains the following.

  All inhalable compounds are used as pharmaceutically active substances, substance formulations or substance mixtures, for example the inhalable macromolecules disclosed in EP 1,003,478. Preferably, substances, substance preparations or substance mixtures that treat respiratory complications and are administered by inhalation are used.

  Particularly preferred pharmaceutical formulations in the context of the present invention are anticholinergics, betamimetic (s), steroids, phosphodiesterase (PDE) IV inhibitors, LTD4 antagonists and EGFR kinase inhibitors, anti Selected from among allergic drugs, derivatives of bacqua alkaloids, triptans, CGRP antagonists, phosphodiesterase V inhibitors and combinations of such active substances, eg beta mimetics + anticholinergics or beta mimetics + antiallergic drugs Is. In the case of a combination, preferably at least one of the active substances comprises chemically bound water. Preferably, the antiallergic agent-containing active substance is used in the form of a monopreparation agent or a combination preparation agent.

  The following are specifically described as active ingredients or examples of their use.

  Anticholinergic agents that can be used are preferably tiotropium bromide, oxitropium bromide, furtropium bromide, ipratropium bromide, glycopyrronium salt, trospium chloride, tolterodine, tropenol 2,2-diphenylpropionate methobromide Scopine 2,2-diphenylpropionate methobromide scopine 2-fluoro-2,2-diphenylacetate methobromide, tropenotol 2-fluoro-2,2-diphenylacetate methobromide, tropenol 3,3 ', 4 4'-tetrafluorobenzylate methobromide, scopine 3,3 ', 4,4'-tetrafluorobenzylate methobromide, tropenol 4,4'-difluorobenzylate methobromide, scopine 4,4'-difluorobenzile Tomethobromide, tropenol 3,3'-difluorobenzylate methobromide, scopine 3,3'-difluorobenzylate methobromide, tropenol 9-hydroxy-fluorene-9-carboxylate methobromide, tropenol 9-fluoro-fluorene-9-carboxy Rate Metobromide, Scopine 9-Hydroxy-Fluorene-9-Carboxylate Metobromide, Scopine 9-Fluoro-Fluorene-9-Carboxylate Metobromide, Tropenol 9-Methyl-Fluorene-9-Carboxylate Metobromide, Scopine 9-Methyl -Fluorene-9-carboxylate methobromide, cyclopropyltropine benzylate methobromide, cyclopropyltropin 2,2-diphenylpropionate methobromide, cyclopro Pyrtropine 9-hydroxy-cyanothene-9-carboxylate methobromide, cyclopropyl tropine 9-methyl-fluorene-9-carboxylate methobromide, cyclopropyl tropine 9-methyl-xanthene-9-carboxylate methobromide, cyclopropyl tropine 9 -Hydroxy-fluorene-9-carboxylate methobromide, cyclopropyltropine methyl 4,4'-difluorobenzylate methobromide, tropenol 9-hydroxy-xanthene-9-carboxylate methobromide, scopine 9-hydroxy-xanthene-9- Carboxylate metobromide, tropenol 9-methyl-xanthene-9-carboxylate metobromide, scopine 9-methyl-xanthene-9-carboxylate metobromide Tropenol 9-ethyl-xanthene-9-carboxylate methobromide, tropenol 9-difluoromethyl-xanthene-9-carboxylate metrobromide and scopine 9-hydroxymethyl-xanthene-9-carboxylate methobromide and optionally their racemates Compounds, enantiomers or diastereoisomers and optionally these solvates and / or hydrates are selected.

  The beta mimetics that can be used are preferably albuterol, bambuterol, vitorterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenalin, ibuterol, indacaterol, isoetarine, isoprenaline, levosalbutamol, mabuterol, prodote, Renol, Ortiprenaline, Pyrbuterol, Procaterol, Reproterol, Limiterol, Ritodrine, Salmeterol, Salmefamol, Soternote, Sulfonterol, Thiaramid, Terbutaline, Tolubuterol, CHF-1035, HOKU-81, KUL-1248, 3- (4- {6- [ 2-Hydroxy-2- (4-hydroxy-3-hydroxymethyl-phenyl) -ethyla No] -hexyloxy} -butyl) -benzolsulfonamide, 5- [2- (5,6-diethyl-indan-2-iramino) -1-hydroxy-ethyl] -8-hydroxy-1H-quinoline-2- ON, 4-hydroxy-7- [2-{[2-{[3- (2-phenyletoxy) propyl] sulfonyl} ethyl] -amino} ethyl] -2 (3H) -benzothiazolone, 1- (2-fluoro- 4-hydroxyphenyl) -2- [4- (1-benzimidazolyl) 2-methyl-2-butyramino] ethanol, 1- [3- (4-methoxybenzyl-amino) -4-hydroxyphenyl] -2- [4 -(1-Benzimidazolyl) -2-methyl-2-butyramino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazine-8-i ] -2- [3- (4-N, N-dimethylaminophenyl) -2-methyl-2-propyramino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1.4-benzoxazine -8-yl] -2- [3- (4-methoxyphenyl) -2-methyl-2-propyramino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1.4-benzoxazine-8 -Yl] -2- [3- (4-n-Butyloxyphenyl) -2-methyl-2-propyramino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1.4-benzoxazine 8 -Yl] -2- {4- [3- (4-methoxyphenyl) -1.2.4-triazol-3-yl] -2-methyl-2-butyramino} ethanol, 5-hydroxy-8- (1 -Hydroxy-2-isop (Ropyraminobutyl) -2H-1.4-benzoxazin-3- (4H) -one, 1- (4-amino-3-chloro-5-trifluoromethylphenyl) -2-ter-butyramino) ethanol and 1- (4 -Ethoxycarbonyl-amino-3-cyano-5-fluorophenyl) -2- (ter-butyramino) ethanol and optionally their racemic, enantiomeric or diastereomeric forms and optionally their pharmacological The acid addition salts, solvates, and / or hydrates are acceptable.

  The steroids that can be used are preferably prednisolone, prednisone, butyxocortopropionate, RPR-106541, flunisolide, benclomethasone, trianthinolone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide, ST-126, dexamethasone, (S ) -Fluoromethyl 6α, 9α-difluoro-17α-[(2-furanylcarbonyl) oxy] -11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothionate, (S)-(2-oxo-tetrahydro-furan-3S-yl) 6α, 9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionioxy-androst-1,4-diene- 17β-carbothionate and Ethipredonol-dichloroacetate (BNP-166) and optionally their racemic, enantiomeric or diastereomeric forms and optionally their salts, derivatives of such salts, solvates and / or hydrate forms Selected from.

Usable phosphodiesterase (PDE) IV inhibitors are preferably enprofylline, theophylline, roflumilast, ariflo (tylomilast), CP-325,366, BY343, D-4396 (Sch-355191), AWD- 12-281 (GW-842470), N- (3,5-dichloro-1-oxo-pyridin-4-yl) -4-difluoromethoxy-3-cyclopropylmethoxybenzamide, NCS-613, pumafentin, (- ) P-[(4aR ^* , 10bS ^* ])-9-ethoxy-1,2,3,4,4a, 10b-hexahydro-8-methoxy-2-methylbenzo [s] [1,6] naphthyridine-6 Yl] -N, N-diisopropylbenzamide, (R)-(+)-1-1 (4-bromobenzyl) -4- [ -Cyclopentyloxy] -4-methoxyphenyl] -2-pyrroloridone, 3- (cyclopentyloxy-4-methoxyphenyl) -1- (4-N '-[N-2-cyano-S-methyl-isothioureido] Benzyl) -2-pyrrolidone, cis [4-cyano-4- (3-cyclopentyloxy-4-methoxyphenyl) cyclohexane-carboxylic acid], 2-carbomethoxy-4-cyano-4- (3-cyclopropylmethoxy) -4-difluoromethoxyphenyl) cyclohexane-1-one, cis [4-cyano-4- (3-cyclopropyl-methoxy-4-difluoromethoxyphenyl) cyclohexane-1-ol], (R)-(+)- Ethyl [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine-2-ylidone] acetate, S)-(−)-Ethyl [4- (3-cyclopentyloxy] -4-methoxyphenyl) pyrrolidine-2-ylidone] acetate, CDP840, Bay-198004, D-4418, PD-168787, T-440, T2585, allophylline, atizolane, V-11294A, C1-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370, 9-cyclopentyl-5,6-dihydro-7-ethyl-3 ( 2-thienyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4,3-a] pyridine and 9-cyclopentyl-5,6-dihydro-7-ethyl-3- (ter -Butyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4,3-a] pyridine, and optionally Of these racemates, enantiomers or diastereomers, and optionally these pharmaceutically acceptable acid addition salts, solvates, and / or hydrates. Selected.

  The LTD4 antagonist that can be used is preferably montelukast, 1-(((R)-(3- (2- (6,7-difluoro-2-quinolinyl) ethenyl) phenyl) -3- (2- (2 -Hydroxy-2-propyl) phenyl) thio) methylcyclopropane-acetic acid, 1 ((((1 (R) -3 (3- (2- (2,3-dichlorothieno [3,2-b] pyridine-5) -Yl)-(E) ethenyl) phenyl) -3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropane-acetic acid, pranlukast, zafirlukast, [2-[[ 2- (4-ter-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl] phenyl] acetic acid, MCC-847 (ZD-3523), MN-001, MEN-90507 (LM-150 ), VUF-5078, VUF-K-8707 and L-733321 and optionally their racemic, enantiomeric or diastereomeric forms and optionally their pharmacologically acceptable acid addition salts, solvates And / or selected from hydrate forms.

  The EGFR kinase inhibitor that can be used is preferably cetuximab, trastuzumab, ABX-EGF, Mab ICR-62, 4-[(3-chloro-4-fluorophenyl) amino]- 6-{[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxy-quinazoline, 4-[(R)-(1-phenyl-ethyl) ) Amino] -6-{[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopentyloxy-quinazoline, 4-[(3-chloro- 4-fluoro-phenyl) amino] -6-{[4-((R) -6-methyl-2-oxo-morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-[(S) (Tetrahydrofuran-3-yl) oxy] -quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- [2-((S) -6-methyl-2-methyl-2-morpho Lin-4-yl) -ethoxy] -7-methoxy-quinazoline, 4-[(3-chloro-4-fluorophenyl) amino] -6-({4- [N- (2-methoxy-ethyl) -N -Methyl-amino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxy-quinazoline, 4-[(R)-(1-phenyl-ethyl) amino] -6-({ 4- [N- (tetrahydropyran-4-yl) -N-methyl-amino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxy-quinazoline, 4-[(3- Chloro-4-fluoropheny L) amino] -6-({4- [N- (2-methoxy-ethyl) -N-methyl-amino] -1-oxo-2-buten-1-yl} amino) -7-cyclopentyloxy- Quinazoline, 4-[(3-chloro-4-fluorophenyl) amino] -6-{[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7- [(R)-(tetrahydrofuran-2-yl) methoxy] -quinazoline, 4-[(3-ethynyl-phenyl) amino] -6,7-bis- (2-methoxy-ethoxy) -quinazoline, 4-[( R)-(1-Phenyl-ethyl) amino] -6- (4-hydroxy-phenyl) -7H-pyrrolo [2,3-d] pyrimidine, 3-cyano-4-[(3-chloro-4-fluoro Phenyl) amino] -6-{[4- (N, -Dimethylamino) -1-oxo-2-buten-1-yl] amino} -7-ethoxy-quinoline, 4-[(R)-(1-phenyl-ethyl) amino] -6-{[4- ( (R) -6-methyl-2-oxo-morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-methoxy-quinazoline, 4-[(3-chloro-4 -Fluorophenyl) amino] -6-{[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-[(tetrahydrofuran-2-yl) methoxy]- Quinazoline, 4-[(3-ethynyl-phenyl) amino] -6-{[4- (5,5-dimethyl-2-oxo-morpholin-4-yl) -1-oxo-2-butene-1- Yl] amino} -quinazoline, 4-[(3-chloro- -Fluoro-phenyl) amino] -6- {2- [4- (2-oxo-morpholin-4-yl) -piperidin-1-yl] -ethoxy} -7-methoxy-quinazoline, 4-[(3 -Chloro-4-fluoro-phenyl) amino] -6- (trans-4-amino-cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (trans-4-metanesulphoniramino-cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (tetrahydropyran- 3-Iroxy] -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- {1-[(morpholin-4-yl) carbo Nyl] -piperidine-4-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (piperidine-3-yloxy) -7-methoxy-quinazoline, 4 -[(3-Chloro-4-fluoro-phenyl) amino] -6- [1- (2-acetylamino-ethyl) -piperidine-4-yloxy] -7-methoxy-quinazoline, 4-[(3-chloro- 4-fluoro-phenyl) amino] -6- (tetrahydropyran-4-yloxy) -7-ethoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- {trans-4- [(Morpholin-4-yl) carbonylamino] -cyclohexane-1-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl Amino] -6- {1-[(piperidin-1-yl) carbonyl] -piperidine-4-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6 -(Cis-4- {N-[(morpholin-4-yl) carbonyl] -N-methyl-amino} -cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4 -Fluoro-phenyl) amino] -6- (trans-4-ethanesulfoniramino-cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino]- 6- (1-Methanesulfonyl-piperidine-4-yloxy) -7- (2-methoxy-ethoxy) -quinazoline, 4-[(3-chloro-4-fluoro-phenyl Amino] -6- {1- (2-methoxy-acetyl) -piperidine-4-yloxy] -7- (2-methoxy-ethoxy) -quinazoline, 4-[(3-ethynyl-phenyl) amino] -6 (Tetrahydropyran-4-yloxy] -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (cis-4- {N-[(piperidin-1-yl) Carbonyl] -N-methyl-amino} -cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- {cis-4-[(morpho Phosphorin-4-yl) carbonilamino] -cyclohexane-1-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- {1- [ 2- (2-oxopyrrolidine-1-yl) ethyl] -piperidine-4-yloxy} -7-methoxy-quinazoline, 4-[(3-ethynyl-phenyl) amino] -6- (1-acetyl-piperidine -4-Iroxy) -7-methoxy-quinazoline, 4-[(3-ethynyl-phenyl) amino] -6- (1-methyl-piperidine-4-iroxy) -7-methoxy-quinazoline, 4-[(3 -Ethynyl-phenyl) amino] -6- (1-methanesulfonyl-piperidine-4-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- ( 1-methyl-piperidine-4-yloxy) -7 (2-methoxy-ethoxy) -quinazoline, 4-[(3-ethynyl-phenyl) amino] -6- {1-[(morpho N-4-yl) carbonyl] -piperidine-4-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) -amino] -6- {1- [N-methyl- N-2-methoxyethyl-amino] carbonyl] -piperidine-4-yloxy} -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (1-ethyl-piperidine -4-Iroxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- [cis-4- (N-methanesulfonyl-N-methyl-amino)- Cyclohexane-1-yloxy] -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- [cis-4- (N-acetyl-N-methyl-a) F) -cyclohexane-1-yloxy] -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (trans-4-methylamino-cyclohexane-1-yloxy) -7 -Methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- [trans-4- (N-methanesulfonyl-N-methyl-amino) -cyclohexane-1-yloxy]- 7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (trans-4-dimethylamino-cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3 -Chloro-4-fluoro-phenyl) amino] -6- (trans-4- {N-[(morpholin-4-yl) carbonyl] -N-methyl -Amino} -cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- [2- (2,2-dimethyl-6-oxo- Morpholin-4-yl) -iroxy] -7-[(S)-(tetrahydrofuran-2-yl) methoxy] -quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- ( 1-Methanesulfonyl-piperidine-4-yloxy) -7-methoxy-quinazoline, 4-[(3-chloro-4-fluoro-phenyl) amino] -6- (1-cyano-piperidine-4-iroxy)- 7-methoxy-quinazoline and 4-[(3-chloro-4-fluoro-phenyl) amino] -6- {1-[(2-methoxyethyl) carbonyl] -piperidine-4-ethoxy -7-methoxy-quinazoline and optionally their racemates, enantiomers, or diastereomeric forms and optionally their pharmacologically acceptable acid addition salts, solvates and / or water, It is selected from Japanese forms.

  Acid addition salts, i.e. salts containing pharmacologically acceptable acids that the compound may form, are for example hydrochloride (hydrochloride), hydrobromide (hydrobromide), hydriodide (hydrogen iodide). Acid), hydrosulfate (bisulfate), hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrobenzoate, hydrocitrate, hydrofumarate, hydrotartrate, hydrooxalate, hydro Succinate, hydrobenzoate and hydro-p-toluenesulfonate, preferably hydrochloride (hydrochloride), hydrobromide (hydrobromide), hydrosulfate (bisulfate), hydrophosphate, hydrofumarate and Hydromethanesulfonate, hydronitrate, Is Romareato.

  Examples of antiallergic drugs are disodium cromoglycate, nedolromil.

  Examples of the derivatives of the buckthorn alkaloid are dihydroergotamine and ergotamine.

  For inhalation, it is possible to use pharmaceutical preparations, pharmaceutical preparations and mixtures, as well as salts, esters and combinations of these active substances, salts and esters comprising the active substances mentioned above.

DESCRIPTION OF SYMBOLS 1 Nebulizer 2 Fluid 3 Container 4 Bag 5 Pressure generator 6 Holder 7 Drive spring 8 Locking element 9 Transport pipe 10 Check valve 11 Pressure chamber 12 Discharge nozzle 13 Mouthpiece 14 Aerosol 15 Air supply opening 16 Upper housing part 17 Inner part Part 17a Upper part of inner part 17a Upper part of inner part 18 Housing part (lower part)
19 Holding element 20 Spring (spring of the lower housing part)
DESCRIPTION OF SYMBOLS 21 Container base 22 Puncture element 23 Monitor apparatus 24 Seal 25 Diaphragm 26 Venting opening 27 Fixing member 28 Latch stop arm 29 Latch stop protrusion 30 Latch stop recess 31 Latch stop recess 32 First nesting component 33 Second nesting component 34 Base Parts 35 Beads 36 Transport locks 37 Holding beads / holding arms 38 Annular shoulders 39 Actuating members 40 Guide sleeves 41 Inserting members 42 Holding bars / holding clips 43 Annular parts 44 Protrusions 45 Hollow cylindrical parts 46 Latching elements 47 Holding parts 48 Gripper Arm 49 Axial arm / protruding portion 50 Cartridge element 51 Base element 52 Radial protruding portion 53 Lock arm 54 Radial abutting portion 55 Sliding inclined surface 56 Inclined surface 57 Holding arm 58 Pouch 59 Axial abutting portion 60 Radial protruding Portion 61 Axial recess 62 Radial recess 63 Lock latch 64 First latch stop notch 65 Second latch stop notch 66 Spindle 67 Window 68 Fixed element 69 Lock element 70 Circumferential protrusion 71 Circumferential groove 72 Circumferential direction Bead 73 Axial bar 74 Viewing window

Claims (30)

In a nebulizer (1) for a fluid (2), which contains said fluid (2) and is closed in the delivered state, in particular a sealed, preferably insertable container (3) ,
The sealed container (3) is already stored in the nebulizer (1) in the delivery state of the nebulizer (1), and the nebulizer (1) is used before the first use of the nebulizer (1), or The container (3) is configured to be opened inside the nebulizer (1) during use of the nebulizer (1), and / or
The nebulizer (1) is configured such that the container (3) cannot be replaced, and in particular cannot be removed.
Nebulizer characterized by that.   2. Nebulizer according to claim 1, characterized in that the nebulizer (1) has a transport element, in particular a transport tube (9), for transporting the fluid (2) from the container (3).   The nebulizer (1) in particular comprises a pressure generator (5) with a conveying element, for example a conveying tube (9), which carries the fluid (2) and / or atomizes the fluid (2). The nebulizer according to claim 1 or 2, characterized by comprising:   4. Nebulizer according to claim 2 or 3, characterized in that the container (3) can be opened by the conveying element, in particular by puncture or insertion.   Any of the preceding claims, characterized in that the container (3) can be moved, preferably by stroke action, during transport of the fluid, during pressure generation and / or during atomization. The nebulizer according to one item.   Nebulizer according to any one of claims 2 to 5, characterized in that the container (3) can be moved together with the transport element.   The nebulizer according to claim 5 or 6, depending on claim 4, characterized in that the puncture or the insertion is performed in the direction of movement of the container (3).   Nebulizer according to any one of the preceding claims, characterized in that the container (3) can be opened at the head end.   The container can be vented at the base, preferably before or during the first use of the nebulizer (1) inside the nebulizer (1), in particular puncturing the container to vent the container In particular, the ventilation or the puncture is performed before the container (3) is opened, while the container (3) is opened, or after the container (3) is opened. The nebulizer according to any one of claims 1 to 8.   Before opening the container (3) or during opening of the container (3), manually opening the fixing member (27), in particular the original seal, banderol and / or safety tag. A nebulizer according to any one of the preceding claims, characterized in that it must be removed.   11. The container (3), preferably open only by mechanical action and / or can only be opened manually. The nebulizer according to item.   12. The container (3) can be opened in particular by pushing in the nebulizer (1), preferably a housing part (18) of the nebulizer (1) in a telescoping manner. Nebulizer as described in any one of these.   Push on the housing part (18), the actuating member (39), or preferably the insertion member (41) in the form of a cap, quiver or cup, or push in the insertion member (41) The nebulizer according to any one of claims 1 to 12, characterized in that the container (3) can be opened by this.   The housing part (18) can be rotated from a transport position to an intermediate position, from which the housing part can only be pushed on, or the housing part can only be pushed in, 14. Nebulizer according to claim 12 or 13, characterized in that the housing part can only be pushed on or pushed in.   Said container (3), in particular of the housing part (18), preferably in combination movement, in particular rotational movement, and / or translational movement, and / or two continuous movements in different directions, in particular Nebulizer according to any one of the preceding claims, characterized in that it can be opened by two successive movements in a vertical direction.   In the use position, the nebulizer (1), in particular the container (3) is opened and / or the housing part (18) is pushed on, or the housing part (18 16. The device according to claim 12, characterized in that it can be tensioned by turning the housing part (18), preferably by turning the housing part (18), in the pushed-in state. The nebulizer according to claim 1.   14. Nebulizer according to claim 13, characterized in that, after opening the container (3), the actuating member (39) can be removed, in particular can be pulled off.   The actuating member (39) is designed to hold the nebulizer (1), in particular in the delivered state and / or in the open state of the container (3). The nebulizer according to claim 13 or 14.   In order to carry the fluid (2) and / or to atomize the fluid (2), an initial pull of the nebulizer (1), in particular the pressure generator (5) of the nebulizer (1). Nebulizer according to any one of the preceding claims, characterized in that the container (3) can be opened by operation.   The container (3) occupies a first position in the closed delivery state and in the open state in the nebulizer (1) or at least an opening device in the nebulizer (1), for example a conveying element, in particular Nebulizer according to any one of the preceding claims, characterized in that it occupies a second position different from the first position with respect to the transport tube (9).   The container (3) is positioned at a distance from the holder (6) of the container (3) in the first position, or is removed from the holder and / or the container (3) 21. Nebulizer according to claim 20, characterized in that the head side end is preferably held by the holder (6) in a second position.   The container (3) is fixed in the first position, in particular the container (3) is moved from the first position to the second position after rotating the housing part (18). 22. A nebulizer according to claim 20 or 21, characterized in that it can only be moved or moved.   The nebulizer (1) has a transport lock (36) for the container (3), which preferably acts on the base of the container (3) in hermetically delivered state. The nebulizer according to any one of claims 1 to 22.   24. Nebulizer according to claim 20 or 23, characterized in that the transport lock (36) holds the container (3) in the first position.   Before the container (3) is opened or during the opening of the container (3), the transportation lock (36) is released, or the transportation lock (36) is opened, or the transportation lock (36) is opened. 25. Nebulizer according to claim 23 or 24, characterized in that it can be unlocked.   The transport lock (36) is freed of the container (3) after unlocking and can perform the next stroke operation during the atomization of the fluid (2) and / or the container (3) 26. Nebulizer according to claim 25, characterized in that it translates linear motion into rotational motion in order to allow the opening of 3) and / or the ventilation of the container (3).   27. The transport lock (36) according to any of claims 23 to 26, characterized in that it preferably comprises a fixing element, in particular a cartridge ring (50), mounted non-rotatably on the container (3). The nebulizer according to one item.   28. Nebulizer according to any one of claims 23 to 27, characterized in that the transport lock (36) is provided in a housing part (18) of the nebulizer (1).   29. Nebulizer according to any one of claims 1 to 28, characterized in that the atomization is carried out purely mechanically, in particular without a propellant gas, preferably by means of a spring force.   30. Nebulizer according to any one of claims 1 to 29, characterized in that the nebulizer (1) is configured in particular as an inhaler for medical aerosol therapeutics.

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