JP2013545472A5 - - Google Patents
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- Publication number
- JP2013545472A5 JP2013545472A5 JP2013541336A JP2013541336A JP2013545472A5 JP 2013545472 A5 JP2013545472 A5 JP 2013545472A5 JP 2013541336 A JP2013541336 A JP 2013541336A JP 2013541336 A JP2013541336 A JP 2013541336A JP 2013545472 A5 JP2013545472 A5 JP 2013545472A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- derivative
- pcr
- cells
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 16
- 239000002245 particle Substances 0.000 claims 4
- 238000003757 reverse transcription PCR Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000007790 solid phase Substances 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 238000001712 DNA sequencing Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000010382 chemical cross-linking Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41842310P | 2010-12-01 | 2010-12-01 | |
| US61/418,423 | 2010-12-01 | ||
| EP10193291.1 | 2010-12-01 | ||
| EP10193291 | 2010-12-01 | ||
| PCT/EP2011/071433 WO2012072705A1 (en) | 2010-12-01 | 2011-11-30 | Simultaneous detection of biomolecules in single cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013545472A JP2013545472A (ja) | 2013-12-26 |
| JP2013545472A5 true JP2013545472A5 (https=) | 2014-12-25 |
Family
ID=43638742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541336A Pending JP2013545472A (ja) | 2010-12-01 | 2011-11-30 | 単一細胞内の生体分子の同時検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20140011698A1 (https=) |
| EP (1) | EP2646573A1 (https=) |
| JP (1) | JP2013545472A (https=) |
| KR (1) | KR20140027915A (https=) |
| WO (1) | WO2012072705A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708654B2 (en) | 2012-06-15 | 2017-07-18 | Board Of Regents, The University Of Texas System | High throughput sequencing of multiple transcripts |
| CN105008895B (zh) | 2012-10-15 | 2019-02-15 | 纳诺赛莱克特生物医药股份有限公司 | 颗粒分选的系统、设备和方法 |
| US10119134B2 (en) | 2013-03-15 | 2018-11-06 | Abvitro Llc | Single cell bar-coding for antibody discovery |
| US10457088B2 (en) * | 2013-05-13 | 2019-10-29 | Ridgefield Acquisition | Template for self assembly and method of making a self assembled pattern |
| US11952622B2 (en) * | 2013-07-18 | 2024-04-09 | The Johns Hopkins University | Analysis of DNA-containing samples and resolution of mixed contributor DNA samples |
| ES2895750T3 (es) | 2014-09-15 | 2022-02-22 | Abvitro Llc | Secuenciación de alto rendimiento de colecciones de nucleótidos |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US7674632B1 (en) | 2001-12-10 | 2010-03-09 | Zeus Scientific, Inc | Method and composition for homogeneous multiplexed microparticle-based assay |
| WO2005003375A2 (en) | 2003-01-29 | 2005-01-13 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| CA2553833C (en) | 2004-01-28 | 2012-10-02 | 454 Corporation | Nucleic acid amplification with continuous flow emulsion |
| JP2007526772A (ja) | 2004-02-27 | 2007-09-20 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | インサイチュー配列決定用ポロニー蛍光ビーズ |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| US7601499B2 (en) | 2005-06-06 | 2009-10-13 | 454 Life Sciences Corporation | Paired end sequencing |
| DK1966393T3 (da) | 2005-12-22 | 2012-10-08 | Keygene Nv | Fremgangsmåde til AFLP-baseret påvisning af polymorfisme med høj omsætning |
| JP2009536313A (ja) | 2006-01-11 | 2009-10-08 | レインダンス テクノロジーズ， インコーポレイテッド | ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法 |
| WO2010111656A2 (en) * | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Systems and methods for assessing images |
-
2011
- 2011-11-30 EP EP11790968.9A patent/EP2646573A1/en not_active Withdrawn
- 2011-11-30 WO PCT/EP2011/071433 patent/WO2012072705A1/en not_active Ceased
- 2011-11-30 KR KR1020137017037A patent/KR20140027915A/ko not_active Ceased
- 2011-11-30 US US13/989,814 patent/US20140011698A1/en not_active Abandoned
- 2011-11-30 JP JP2013541336A patent/JP2013545472A/ja active Pending
-
2017
- 2017-07-26 US US15/660,396 patent/US20170322204A1/en not_active Abandoned
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