JP2013545461A - 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 - Google Patents

高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 Download PDF

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JP2013545461A
JP2013545461A JP2013538190A JP2013538190A JP2013545461A JP 2013545461 A JP2013545461 A JP 2013545461A JP 2013538190 A JP2013538190 A JP 2013538190A JP 2013538190 A JP2013538190 A JP 2013538190A JP 2013545461 A JP2013545461 A JP 2013545461A
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glycerin
population
strain
locus
propanediol
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JP2013545461A5 (enExample
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ライナー、フィゲ
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メタボリック エクスプローラー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/32—Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013538190A 2010-11-10 2011-11-10 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 Pending JP2013545461A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41216210P 2010-11-10 2010-11-10
US61/412,162 2010-11-10
EP10306234 2010-11-10
EP10306234.5 2010-11-10
PCT/EP2011/069789 WO2012062832A1 (en) 2010-11-10 2011-11-10 Microorganisms for 1,3-propanediol production using high glycerine concentration

Publications (2)

Publication Number Publication Date
JP2013545461A true JP2013545461A (ja) 2013-12-26
JP2013545461A5 JP2013545461A5 (enExample) 2016-05-12

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Family Applications (1)

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JP2013538190A Pending JP2013545461A (ja) 2010-11-10 2011-11-10 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物

Country Status (10)

Country Link
US (1) US20130177956A1 (enExample)
EP (2) EP3012325A1 (enExample)
JP (1) JP2013545461A (enExample)
KR (1) KR20140005170A (enExample)
CN (1) CN103298945A (enExample)
AR (1) AR083799A1 (enExample)
BR (1) BR112013011417A2 (enExample)
CA (1) CA2814441A1 (enExample)
TW (1) TWI542685B (enExample)
WO (1) WO2012062832A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020529849A (ja) * 2017-08-04 2020-10-15 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3−プロパンジオールの改良された生産を行うための微生物および方法
JP2021533764A (ja) * 2018-08-10 2021-12-09 メタボリック エクスプローラー 1,3−プロパンジオールおよび酪酸の生産が改善された微生物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328360B2 (en) 2013-09-06 2016-05-03 The Curators Of The University Of Missouri Conversion of glycerol to 1,3-propanediol under haloalkaline conditions
EP3481850A1 (en) 2016-07-08 2019-05-15 Evonik Degussa GmbH Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)
CN106190901B (zh) 2016-07-15 2020-06-26 上海交通大学 一种菌及其获取方法和应用
CN106978380A (zh) * 2016-12-14 2017-07-25 天津科技大学 一株高木糖耐性肺炎克雷伯氏菌株及其构建方法
PT3583221T (pt) * 2017-02-20 2021-09-24 Metabolic Explorer Sa Consórcio microbiano compreendendo clostridia para a produção de 1,3-propanodiol a partir de glicerol
US11293039B2 (en) 2017-10-02 2022-04-05 Metabolic Explorer Method for producing organic acid salts from fermentation broth
CN112358986B (zh) * 2020-11-09 2022-10-21 华南理工大学 一种丁酸梭菌及其在固定化发酵生产1,3-丙二醇的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796081B1 (fr) * 1999-07-09 2003-09-26 Agronomique Inst Nat Rech Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs
CN1327001C (zh) 2005-06-03 2007-07-18 清华大学 利用生物柴油副产物甘油生产1,3-丙二醇的方法
US7858790B2 (en) * 2006-06-29 2010-12-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
MX2009003605A (es) 2006-10-03 2009-04-22 Metabolic Explorer Sa Procedimiento para integracion cromosomica y reemplazo de secuencia de adn en clostridia.
JP2010508013A (ja) 2006-10-31 2010-03-18 メタボリック エクスプローラー グリセロールから1,3−プロパンジオールを高収量で生物学的に製造する方法
KR101543485B1 (ko) 2007-11-30 2015-08-10 메타볼릭 익스플로러 발효 브로쓰로부터 알콜을 정제하는 방법
CA2738452C (en) 2008-10-03 2016-06-21 Metabolic Explorer Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator
EP2248904A1 (en) * 2009-05-05 2010-11-10 Metabolic Explorer Continuous culture for 1,3-propanediol production using high glycerine concentration

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6015046535; GONZALEZ-PAJUELO, M., et al.: Metabolic Engineering 7, 2005, pp.329-336 *
JPN6015046537; GONZALEZ-PAJUELO, M., et al.: APPLIED AND ENVIRONMENTAL MICROBIOLOGY 72(1), 2006, pp.96-101 *
JPN6015046539; CELINSKA, E.: Biotechnology Advances 28, 20100331, pp.519-530 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020529849A (ja) * 2017-08-04 2020-10-15 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3−プロパンジオールの改良された生産を行うための微生物および方法
JP7175961B2 (ja) 2017-08-04 2022-11-21 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3-プロパンジオールの改良された生産を行うための微生物および方法
JP2021533764A (ja) * 2018-08-10 2021-12-09 メタボリック エクスプローラー 1,3−プロパンジオールおよび酪酸の生産が改善された微生物
JP7569783B2 (ja) 2018-08-10 2024-10-18 メタボリック エクスプローラー 1,3-プロパンジオールおよび酪酸の生産が改善された微生物

Also Published As

Publication number Publication date
BR112013011417A2 (pt) 2017-04-04
EP2638172A1 (en) 2013-09-18
TW201226563A (en) 2012-07-01
TWI542685B (zh) 2016-07-21
US20130177956A1 (en) 2013-07-11
EP3012325A1 (en) 2016-04-27
CN103298945A (zh) 2013-09-11
CA2814441A1 (en) 2012-05-18
WO2012062832A1 (en) 2012-05-18
KR20140005170A (ko) 2014-01-14
AR083799A1 (es) 2013-03-20

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