JP2013544502A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013544502A5 JP2013544502A5 JP2013532230A JP2013532230A JP2013544502A5 JP 2013544502 A5 JP2013544502 A5 JP 2013544502A5 JP 2013532230 A JP2013532230 A JP 2013532230A JP 2013532230 A JP2013532230 A JP 2013532230A JP 2013544502 A5 JP2013544502 A5 JP 2013544502A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- otl
- sample
- methylation
- survival
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 9
- 230000011987 methylation Effects 0.000 claims 8
- 238000007069 methylation reaction Methods 0.000 claims 8
- 230000004083 survival effect Effects 0.000 claims 8
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 7
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 5
- 208000026310 Breast neoplasm Diseases 0.000 claims 5
- 238000004458 analytical method Methods 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- -1 CD45RA Proteins 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108091029523 CpG island Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 108700039887 Essential Genes Proteins 0.000 claims 1
- 101150027879 FOXP3 gene Proteins 0.000 claims 1
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 102100039844 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Human genes 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 1
- 101000887521 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Proteins 0.000 claims 1
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001055145 Homo sapiens Interleukin-2 receptor subunit beta Proteins 0.000 claims 1
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims 1
- 101000620662 Homo sapiens Serine/threonine-protein phosphatase 6 catalytic subunit Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000818605 Homo sapiens Zinc finger and BTB domain-containing protein 32 Proteins 0.000 claims 1
- 102100022341 Integrin alpha-E Human genes 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 claims 1
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 238000011529 RT qPCR Methods 0.000 claims 1
- 102100022345 Serine/threonine-protein phosphatase 6 catalytic subunit Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 108700009124 Transcription Initiation Site Proteins 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100021135 Zinc finger and BTB domain-containing protein 32 Human genes 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 1
- 230000017858 demethylation Effects 0.000 claims 1
- 238000010520 demethylation reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10187046 | 2010-10-08 | ||
| EP10187046.7 | 2010-10-08 | ||
| PCT/EP2011/067660 WO2012045888A1 (en) | 2010-10-08 | 2011-10-10 | Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544502A JP2013544502A (ja) | 2013-12-19 |
| JP2013544502A5 true JP2013544502A5 (enExample) | 2014-11-27 |
| JP6010037B2 JP6010037B2 (ja) | 2016-10-19 |
Family
ID=44802051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532230A Expired - Fee Related JP6010037B2 (ja) | 2010-10-08 | 2011-10-10 | 腫瘍浸潤全ｔリンパ球の分析に基づいて、がん患者の生存指標を測定する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20130260378A1 (enExample) |
| EP (1) | EP2625288B1 (enExample) |
| JP (1) | JP6010037B2 (enExample) |
| CA (1) | CA2814150A1 (enExample) |
| WO (1) | WO2012045888A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201221133D0 (en) | 2012-11-23 | 2013-01-09 | Epiontis Gmbh | Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes |
| GB201516971D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells |
| GB201516972D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells |
| DE102016005947B3 (de) * | 2016-05-16 | 2017-06-08 | Dimo Dietrich | Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen |
| US11685955B2 (en) | 2016-05-16 | 2023-06-27 | Dimo Dietrich | Method for predicting response of patients with malignant diseases to immunotherapy |
| JP7061342B2 (ja) * | 2018-03-14 | 2022-04-28 | 学校法人 愛知医科大学 | エフェクター制御性ｔ細胞の検出及び調製 |
| DE102018116353B4 (de) * | 2018-07-05 | 2020-06-10 | Epiontis Gmbh | Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening |
| WO2021077063A1 (en) * | 2019-10-18 | 2021-04-22 | Washington University | Methods and systems for measuring cell states |
| WO2024254366A1 (en) | 2023-06-09 | 2024-12-12 | Dow Global Technologies Llc | Method for producing corrugated laminated panels |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002171973A (ja) | 2000-12-07 | 2002-06-18 | Univ Tokyo | Ｄｎａメチル化パターンによる細胞の同定法 |
| AU2003285586A1 (en) | 2002-12-03 | 2004-06-23 | Medical Research Council | Regulatory t-cells |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| DK1826279T3 (da) | 2006-02-28 | 2011-09-05 | Charite Universitaetsmedizin | Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet |
| EP2141245A1 (en) * | 2008-07-03 | 2010-01-06 | Ivana Türbachova | DNA methylation analysis of regulatory T cells through DNA-methylation analysis of the TSDR region of the gene foxP3 |
| DK2199411T3 (en) * | 2008-12-16 | 2015-08-03 | Epiontis Gmbh | Epigenetic markers for the identification of CD3-positive T lymphocytes |
-
2011
- 2011-10-10 CA CA2814150A patent/CA2814150A1/en not_active Abandoned
- 2011-10-10 WO PCT/EP2011/067660 patent/WO2012045888A1/en not_active Ceased
- 2011-10-10 EP EP11770415.5A patent/EP2625288B1/en active Active
- 2011-10-10 JP JP2013532230A patent/JP6010037B2/ja not_active Expired - Fee Related
- 2011-10-10 US US13/825,691 patent/US20130260378A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013544502A5 (enExample) | ||
| Peng et al. | Gastric microbiome alterations are associated with decreased CD8+ tissue-resident memory T cells in the tumor microenvironment of gastric cancer | |
| Hurst et al. | Microbiomes of urine and the prostate are linked to human prostate cancer risk groups | |
| Mehra et al. | A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer | |
| Wang et al. | Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor | |
| WO2011056489A3 (en) | Diagnostic methods for determining prognosis of non-small cell lung cancer | |
| Abdelrahman et al. | Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma | |
| EP3524689A1 (en) | Method for predicting the prognosis of breast cancer patient | |
| EP2007874A2 (en) | Propagation of primary cells | |
| JP2012511917A5 (enExample) | ||
| Gimondi et al. | Circulating miRNA panel for prediction of acute graft-versus-host disease in lymphoma patients undergoing matched unrelated hematopoietic stem cell transplantation | |
| JP6010037B2 (ja) | 腫瘍浸潤全ｔリンパ球の分析に基づいて、がん患者の生存指標を測定する方法 | |
| CN105018638A (zh) | 胃癌发生相关分子标志物lncRNA HOTTIP的检测及应用 | |
| WO2013135454A1 (en) | Epigenetic marker for the identification of cd3cd4 positive t lymphocytes | |
| Leng et al. | A direct plasma miRNA assay for early detection and histological classification of lung cancer | |
| Kamies et al. | Advances of single-cell genomics and epigenomics in human disease: where are we now? | |
| Xu et al. | Urinary cell-free DNA IQGAP3/BMP4 ratio as a prognostic marker for non–muscle-invasive bladder cancer | |
| Türbachova et al. | The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns | |
| Giebel et al. | Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer | |
| Peng et al. | Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer | |
| EP3473729A1 (en) | Mmp1 gene transcript for use as marker for diagnosis of ovarian cancer prognosis, and test method | |
| AU2017254347B2 (en) | Marker genes for colorectal cancer classification, method for judging lymph node metastasis for prognosis of colorectal cancer and kit therefor | |
| Zhang et al. | Identification of novel molecular therapeutic targets and their potential prognostic biomarkers based on cytolytic activity in skin cutaneous melanoma | |
| JP6156621B2 (ja) | Ａｔｌｌの診断のためのデータ取得方法、ａｔｌｌ診断用キットおよびａｔｌｌ診断システム | |
| Hu et al. | Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer |