JP2013544349A5 - - Google Patents
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- Publication number
- JP2013544349A5 JP2013544349A5 JP2013523401A JP2013523401A JP2013544349A5 JP 2013544349 A5 JP2013544349 A5 JP 2013544349A5 JP 2013523401 A JP2013523401 A JP 2013523401A JP 2013523401 A JP2013523401 A JP 2013523401A JP 2013544349 A5 JP2013544349 A5 JP 2013544349A5
- Authority
- JP
- Japan
- Prior art keywords
- macrophages
- derived
- nlrp3
- test substance
- lps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002540 macrophage Anatomy 0.000 claims 40
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 28
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 claims 27
- 239000000126 substance Substances 0.000 claims 24
- 238000000034 method Methods 0.000 claims 23
- 108010034143 Inflammasomes Proteins 0.000 claims 17
- 230000000694 effects Effects 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 16
- 229940079593 drug Drugs 0.000 claims 15
- 238000012216 screening Methods 0.000 claims 12
- 230000028327 secretion Effects 0.000 claims 12
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 102000004890 Interleukin-8 Human genes 0.000 claims 3
- 108090001007 Interleukin-8 Proteins 0.000 claims 3
- 101150061038 NLRP3 gene Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000033116 Asbestos intoxication Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 101710126825 NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 206010003441 asbestosis Diseases 0.000 claims 1
- 208000025487 periodic fever syndrome Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41510210P | 2010-11-18 | 2010-11-18 | |
| US61/415,102 | 2010-11-18 | ||
| PCT/JP2011/077265 WO2012067265A1 (en) | 2010-11-18 | 2011-11-17 | Method for screening drugs for suppressing inflammasome activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544349A JP2013544349A (ja) | 2013-12-12 |
| JP2013544349A5 true JP2013544349A5 (enExample) | 2015-01-08 |
| JP5924742B2 JP5924742B2 (ja) | 2016-05-25 |
Family
ID=46084180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523401A Expired - Fee Related JP5924742B2 (ja) | 2010-11-18 | 2011-11-17 | インフラマソームの活性を抑える薬剤をスクリーニングする方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9557321B2 (enExample) |
| EP (1) | EP2641086B9 (enExample) |
| JP (1) | JP5924742B2 (enExample) |
| WO (1) | WO2012067265A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103667195B (zh) * | 2013-12-17 | 2016-04-27 | 南京大学 | 以nlrp3为靶点的药物筛选细胞模型及其应用 |
| WO2015131076A1 (en) * | 2014-02-27 | 2015-09-03 | Yale University | Nlrp6 inflammasome intestinal epithelium mucus secretion |
| JP6445802B2 (ja) * | 2014-07-16 | 2018-12-26 | 学校法人慶應義塾 | インフラマソーム活性化制御物質のスクリーニング方法 |
| PE20221627A1 (es) * | 2015-02-16 | 2022-10-19 | Univ Queensland | Sulfonilureas y compuestos relacionados y uso de estos |
| KR101731303B1 (ko) * | 2015-06-11 | 2017-05-02 | 가톨릭대학교 산학협력단 | 인터루킨―1베타 억제제의 스크리닝 방법 |
| PT3661925T (pt) | 2017-07-07 | 2022-01-31 | Inflazome Ltd | Novos compostos de sulfonamida-carboxamida |
| CN108588209A (zh) * | 2018-04-10 | 2018-09-28 | 广州中医药大学(广州中医药研究院) | 一种用于诊断心血管疾病的分子标志物Nlrp3及其应用 |
| EP3859331A1 (en) | 2020-01-31 | 2021-08-04 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Methods for assigning a phenotypic signature for diagnostic and therapeutic applications |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080008652A1 (en) * | 2006-01-10 | 2008-01-10 | The Regents Of The University Of Michigan | Methods and compositions for mediation of immune responses and adjuvant activity |
| US20110262956A1 (en) | 2008-10-07 | 2011-10-27 | Guillermo Munoz Elias | Co-culture compositions and methods |
| JP2011121949A (ja) * | 2009-12-14 | 2011-06-23 | Kyoto Univ | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
-
2011
- 2011-11-17 EP EP11842110.6A patent/EP2641086B9/en not_active Not-in-force
- 2011-11-17 JP JP2013523401A patent/JP5924742B2/ja not_active Expired - Fee Related
- 2011-11-17 WO PCT/JP2011/077265 patent/WO2012067265A1/en not_active Ceased
- 2011-11-17 US US13/885,950 patent/US9557321B2/en not_active Expired - Fee Related
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