JP2013539860A5 - - Google Patents
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- Publication number
- JP2013539860A5 JP2013539860A5 JP2013530331A JP2013530331A JP2013539860A5 JP 2013539860 A5 JP2013539860 A5 JP 2013539860A5 JP 2013530331 A JP2013530331 A JP 2013530331A JP 2013530331 A JP2013530331 A JP 2013530331A JP 2013539860 A5 JP2013539860 A5 JP 2013539860A5
- Authority
- JP
- Japan
- Prior art keywords
- dextran
- reagent
- detectable
- binding
- binding moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002307 Dextran Polymers 0.000 claims description 77
- 239000003153 chemical reaction reagent Substances 0.000 claims description 49
- 238000001514 detection method Methods 0.000 claims description 8
- 108090001008 Avidin Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 108010090804 Streptavidin Proteins 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- 238000000295 emission spectrum Methods 0.000 claims description 4
- 230000005284 excitation Effects 0.000 claims description 4
- 238000000695 excitation spectrum Methods 0.000 claims description 4
- 230000001268 conjugating effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 claims description 2
- 101710120037 Toxin CcdB Proteins 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims description 2
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims description 2
- 230000001900 immune effect Effects 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38593710P | 2010-09-23 | 2010-09-23 | |
| US61/385,937 | 2010-09-23 | ||
| PCT/US2011/052837 WO2012040514A2 (en) | 2010-09-23 | 2011-09-22 | Methods and reagents for signal amplification |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015183025A Division JP2015227895A (ja) | 2010-09-23 | 2015-09-16 | シグナル増幅のための方法と試薬 |
| JP2017169450A Division JP2017205132A (ja) | 2010-09-23 | 2017-09-04 | シグナル増幅のための方法と試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539860A JP2013539860A (ja) | 2013-10-28 |
| JP2013539860A5 true JP2013539860A5 (https=) | 2014-11-13 |
| JP6234817B2 JP6234817B2 (ja) | 2017-11-22 |
Family
ID=45874393
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530331A Active JP6234817B2 (ja) | 2010-09-23 | 2011-09-22 | シグナル増幅のための方法と試薬 |
| JP2015183025A Pending JP2015227895A (ja) | 2010-09-23 | 2015-09-16 | シグナル増幅のための方法と試薬 |
| JP2017169450A Withdrawn JP2017205132A (ja) | 2010-09-23 | 2017-09-04 | シグナル増幅のための方法と試薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015183025A Pending JP2015227895A (ja) | 2010-09-23 | 2015-09-16 | シグナル増幅のための方法と試薬 |
| JP2017169450A Withdrawn JP2017205132A (ja) | 2010-09-23 | 2017-09-04 | シグナル増幅のための方法と試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9347946B2 (https=) |
| EP (1) | EP2619588B1 (https=) |
| JP (3) | JP6234817B2 (https=) |
| CN (1) | CN103229057B (https=) |
| CA (1) | CA2812291C (https=) |
| WO (1) | WO2012040514A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023235B2 (en) | 2012-09-07 | 2015-05-05 | Prestone Products Corporation | Heat transfer fluid additive composition |
| US10955379B2 (en) | 2018-09-27 | 2021-03-23 | Taiwan Semiconductor Manufacturing Co., Ltd. | Differential sensing with BioFET sensors |
| US10984211B1 (en) | 2019-10-18 | 2021-04-20 | Taiwan Semiconductor Manufacturing Co., Ltd. | Semiconductor device with bioFET and biometric sensors |
| CN111830250A (zh) * | 2020-08-04 | 2020-10-27 | 珠海市丽拓生物科技有限公司 | 一种信号放大的酶标二抗的制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE427505B (sv) * | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
| US4576912A (en) * | 1978-11-30 | 1986-03-18 | Technicon Instruments Corporation | Fluoroimmunoassaying |
| US4615986A (en) * | 1979-03-05 | 1986-10-07 | Syntex (U.S.A.) Inc. | Method for competitive protein binding assays inhibiting non-specific interference |
| US4256834A (en) * | 1979-04-09 | 1981-03-17 | Syva Company | Fluorescent scavenger particle immunoassay |
| US4719182A (en) * | 1985-03-18 | 1988-01-12 | Eastman Kodak Company | Fluorescent labels and labeled species and their use in analytical elements and determinations |
| US6881536B1 (en) * | 1986-04-30 | 2005-04-19 | Bioveris Corporation | Particle based electrochemiluminescent assays |
| DE4140142A1 (de) * | 1991-12-05 | 1993-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim, De | Multivalentes dextranreagenz zum einsatz in praezipitationstests |
| US5846741A (en) | 1992-08-21 | 1998-12-08 | Immunomedics, Inc. | Boron neutron capture therapy using pre-targeting methods |
| US5798276A (en) * | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
| US5650334A (en) * | 1995-08-31 | 1997-07-22 | First Medical, Inc. | Fluorescent labelling compositions and methods for their use |
| US7288636B2 (en) * | 1997-04-30 | 2007-10-30 | Hybritech Incorporated | Forms of prostate specific antigens and methods for their detection |
| US7659073B2 (en) * | 1997-04-30 | 2010-02-09 | Hybritech Incorporated | Forms of prostate specific antigens and methods for their detection |
| US5994089A (en) * | 1997-05-16 | 1999-11-30 | Coulter International Corp. | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
| US5891741A (en) * | 1997-05-16 | 1999-04-06 | Coulter International Corp. | Antibody-aminodextran-phycobiliprotein conjugates |
| WO1999040438A1 (en) | 1998-02-03 | 1999-08-12 | Synbiotics Corporation | Device and method to detect immunoprotective antibody titers |
| ATE268905T1 (de) * | 1998-07-30 | 2004-06-15 | Oakville Trading Hong Kong Ltd | Verfahren zur herstellung von wasserlöslichen vernetzten conjugate |
| US6284873B1 (en) * | 1999-03-12 | 2001-09-04 | Hybritech Incorporated | Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex |
| DE60238928D1 (de) * | 2001-09-19 | 2011-02-24 | Masaaki Kai | Lumineszierendes polymer und seine verwendung im bioassay |
| CN100425991C (zh) * | 2004-02-25 | 2008-10-15 | 中国科学院动物研究所 | 一种用于检测sars抗体的免疫微球及其制备方法和用途 |
| JP2007531801A (ja) * | 2004-03-17 | 2007-11-08 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | 光架橋されたハイドロゲルブレンドの表面コーティング |
| US20060046310A1 (en) | 2004-08-25 | 2006-03-02 | Zong-Li Xia | Amplification method for solid phase immunoassays |
| SE0402476D0 (sv) * | 2004-10-13 | 2004-10-13 | Biacore Ab | Preparation and use of a reactive solid support surface |
| US20070037174A1 (en) * | 2005-08-12 | 2007-02-15 | Rampal Jang B | Chemiluminescent generated fluorescent labeling |
| WO2007049269A1 (en) * | 2005-10-27 | 2007-05-03 | Bio-Rad Haifa Ltd. | Binding layer and method for its preparation and uses thereof |
| DE112006003813T5 (de) * | 2006-03-20 | 2009-01-22 | Inverness Medical Switzerland Gmbh | Wasserlösliche Konjugate zur elektrochemischen Detektion |
| GB0711560D0 (en) * | 2007-06-14 | 2007-07-25 | Innova Biosciences Ltd | Improvements in or relating to production of conjugates |
| EP2225561A4 (en) | 2007-11-28 | 2011-09-14 | Great Basin Scient | METHODS AND COMPOSITIONS FOR REINFORCING SIGNALS USING MULTIVALENT INTERACTIONS |
| CN101750483B (zh) * | 2008-12-02 | 2013-12-25 | 浙江我武生物科技股份有限公司 | 一种光纤生物传感器探头及其制备方法和应用 |
| AU2010229924B2 (en) * | 2009-03-24 | 2016-07-21 | Plus Therapeutics Inc. | Devices and methods of cell capture and analysis |
| US20120100538A1 (en) * | 2009-03-24 | 2012-04-26 | Biocept, Inc. | Devices and methods of cell capture and analysis |
| TWI484186B (zh) * | 2009-05-26 | 2015-05-11 | 財團法人工業技術研究院 | 使用生物感測器的方法及偵測待測樣本中葡萄糖濃度的套組 |
-
2011
- 2011-09-22 CN CN201180056340.0A patent/CN103229057B/zh active Active
- 2011-09-22 US US13/241,083 patent/US9347946B2/en active Active
- 2011-09-22 JP JP2013530331A patent/JP6234817B2/ja active Active
- 2011-09-22 CA CA2812291A patent/CA2812291C/en active Active
- 2011-09-22 EP EP11827572.6A patent/EP2619588B1/en active Active
- 2011-09-22 WO PCT/US2011/052837 patent/WO2012040514A2/en not_active Ceased
-
2015
- 2015-09-16 JP JP2015183025A patent/JP2015227895A/ja active Pending
-
2017
- 2017-09-04 JP JP2017169450A patent/JP2017205132A/ja not_active Withdrawn
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