JP2013531784A5 - - Google Patents
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- Publication number
- JP2013531784A5 JP2013531784A5 JP2013510677A JP2013510677A JP2013531784A5 JP 2013531784 A5 JP2013531784 A5 JP 2013531784A5 JP 2013510677 A JP2013510677 A JP 2013510677A JP 2013510677 A JP2013510677 A JP 2013510677A JP 2013531784 A5 JP2013531784 A5 JP 2013531784A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- panel
- concentration
- brain injury
- comprises assaying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims 46
- 229920001184 polypeptide Polymers 0.000 claims 39
- 238000000034 method Methods 0.000 claims 26
- 208000029028 brain injury Diseases 0.000 claims 13
- 238000003556 assay Methods 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 9
- 238000003745 diagnosis Methods 0.000 claims 8
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 claims 7
- 102100029139 Peroxiredoxin-1 Human genes 0.000 claims 7
- 102100030943 Glutathione S-transferase P Human genes 0.000 claims 6
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 6
- 101000619805 Homo sapiens Peroxiredoxin-5, mitochondrial Proteins 0.000 claims 6
- 101000619708 Homo sapiens Peroxiredoxin-6 Proteins 0.000 claims 6
- 108700021154 Metallothionein 3 Proteins 0.000 claims 6
- 102100028708 Metallothionein-3 Human genes 0.000 claims 6
- 102100022078 Peroxiredoxin-5, mitochondrial Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 102100035785 Acyl-CoA-binding protein Human genes 0.000 claims 4
- 208000006011 Stroke Diseases 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 108010061635 Cystatin B Proteins 0.000 claims 3
- 102100026891 Cystatin-B Human genes 0.000 claims 3
- 108010039287 Diazepam Binding Inhibitor Proteins 0.000 claims 3
- 101710115777 Glycine-rich cell wall structural protein 2 Proteins 0.000 claims 3
- 101710168683 Glycine-rich protein 1 Proteins 0.000 claims 3
- ZUKPVRWZDMRIEO-VKHMYHEASA-N L-cysteinylglycine Chemical compound SC[C@H]([NH3+])C(=O)NCC([O-])=O ZUKPVRWZDMRIEO-VKHMYHEASA-N 0.000 claims 3
- 102000016501 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Human genes 0.000 claims 3
- 108050006009 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Proteins 0.000 claims 3
- 102100028489 Phosphatidylethanolamine-binding protein 1 Human genes 0.000 claims 3
- 101710204191 Phosphatidylethanolamine-binding protein 1 Proteins 0.000 claims 3
- 230000036542 oxidative stress Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 108010061642 Cystatin C Proteins 0.000 claims 2
- 102100026897 Cystatin-C Human genes 0.000 claims 2
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 2
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 2
- 102100031347 Metallothionein-2 Human genes 0.000 claims 2
- 101710094505 Metallothionein-2 Proteins 0.000 claims 2
- 102100023055 Neurofilament medium polypeptide Human genes 0.000 claims 2
- 101710109612 Neurofilament medium polypeptide Proteins 0.000 claims 2
- 102100029494 Neutrophil defensin 1 Human genes 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 2
- 230000012743 protein tagging Effects 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 1
- 101710106492 Acyl-CoA-binding protein Proteins 0.000 claims 1
- 101710169323 Acyl-CoA-binding protein homolog Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 101710167917 Carbonic anhydrase 2 Proteins 0.000 claims 1
- 102100024633 Carbonic anhydrase 2 Human genes 0.000 claims 1
- 108010075016 Ceruloplasmin Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 102100031552 Coactosin-like protein Human genes 0.000 claims 1
- 101710105549 Coactosin-like protein Proteins 0.000 claims 1
- 108010072220 Cyclophilin A Proteins 0.000 claims 1
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 1
- 102100025287 Cytochrome b Human genes 0.000 claims 1
- 102000002140 Fatty Acid-Binding Protein 7 Human genes 0.000 claims 1
- 108010001387 Fatty Acid-Binding Protein 7 Proteins 0.000 claims 1
- 102100037733 Fatty acid-binding protein, brain Human genes 0.000 claims 1
- 101710098548 Fatty acid-binding protein, brain Proteins 0.000 claims 1
- 101000922020 Homo sapiens Cysteine and glycine-rich protein 1 Proteins 0.000 claims 1
- 101000858267 Homo sapiens Cytochrome b Proteins 0.000 claims 1
- 101000873851 Homo sapiens N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Proteins 0.000 claims 1
- 101000918983 Homo sapiens Neutrophil defensin 1 Proteins 0.000 claims 1
- 101000632561 Homo sapiens SH3 domain-binding glutamic acid-rich protein Proteins 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 102100029698 Metallothionein-1A Human genes 0.000 claims 1
- 101710196493 Metallothionein-1E Proteins 0.000 claims 1
- 102100035854 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Human genes 0.000 claims 1
- 101710117081 Neutrophil defensin 1 Proteins 0.000 claims 1
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 claims 1
- 108050001408 Profilin Proteins 0.000 claims 1
- 102100028857 Profilin-1 Human genes 0.000 claims 1
- 101710113369 Putative acyl-CoA-binding protein Proteins 0.000 claims 1
- 102100028400 SH3 domain-binding glutamic acid-rich protein Human genes 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 101710094130 Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims 1
- 102100035000 Thymosin beta-4 Human genes 0.000 claims 1
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 1
- 108700015934 Triose-phosphate isomerases Proteins 0.000 claims 1
- 102000044159 Ubiquitin Human genes 0.000 claims 1
- 108090000848 Ubiquitin Proteins 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 108010079996 thymosin beta(4) Proteins 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
- KRJOFJHOZZPBKI-KSWODRSDSA-N α-defensin-1 Chemical compound C([C@H]1C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=4C=CC(O)=CC=4)NC(=O)[C@H](CSSC[C@H](NC2=O)C(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C)C(=O)N3)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](C)C(=O)N1)[C@@H](C)CC)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 KRJOFJHOZZPBKI-KSWODRSDSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1008541.3 | 2010-05-21 | ||
| GBGB1008541.3A GB201008541D0 (en) | 2010-05-21 | 2010-05-21 | Diagnostic methods |
| PCT/GB2011/000784 WO2011144914A2 (en) | 2010-05-21 | 2011-05-23 | Diagnostic methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531784A JP2013531784A (ja) | 2013-08-08 |
| JP2013531784A5 true JP2013531784A5 (https=) | 2014-05-08 |
| JP5775568B2 JP5775568B2 (ja) | 2015-09-09 |
Family
ID=42341144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510677A Expired - Fee Related JP5775568B2 (ja) | 2010-05-21 | 2011-05-23 | 診断方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130252834A1 (https=) |
| EP (1) | EP2572202A2 (https=) |
| JP (1) | JP5775568B2 (https=) |
| AU (1) | AU2011254386B2 (https=) |
| CA (1) | CA2800038A1 (https=) |
| GB (1) | GB201008541D0 (https=) |
| WO (1) | WO2011144914A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2628013B1 (en) * | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| JP2014518624A (ja) | 2011-05-12 | 2014-08-07 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ニューログラニン診断キットのためのアッセイ試薬 |
| EP2802879B1 (en) * | 2012-01-12 | 2016-04-06 | Fundació Hospital Universitari Vall d' Hebron - Institut de Recerca | Use of ccl23 as brain damage marker |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| EP3022322A4 (en) | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| CN103432574B (zh) * | 2013-08-25 | 2015-04-08 | 浙江大学 | 一种过氧化物酶在制备防治脑血管疾病药物中的应用 |
| US10041949B2 (en) * | 2013-09-13 | 2018-08-07 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry |
| WO2016055148A2 (en) * | 2014-10-06 | 2016-04-14 | Université De Genève | Markers and their use in brain injury |
| WO2017174557A2 (en) | 2016-04-04 | 2017-10-12 | Brains Online Holding B.V. | Use of push pull microdialysis in combination with shotgun proteomics for analyzing the proteome in extracellular space of brain |
| WO2018148294A2 (en) * | 2017-02-07 | 2018-08-16 | Bioregency, Inc. | S100β AND ISOFORMS FOR DETECTION OF NEUROLOGICAL CONDITIONS |
| CN107748263A (zh) * | 2017-08-31 | 2018-03-02 | 北京臻惠康生物科技有限公司 | 一种纤维蛋白溶酶原的新用途及试剂盒 |
| CN109536469B (zh) * | 2018-11-23 | 2021-02-09 | 北华大学 | 突变改造Prx6蛋白及其表达基因、制备方法和应用 |
| WO2021163608A2 (en) * | 2020-02-14 | 2021-08-19 | Galaxy Ccro, Inc. | Devices and methods for treating ischaemia and acute respiratory distress syndromes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2263063C (en) * | 1999-02-26 | 2004-08-10 | Skye Pharmatech Incorporated | Method for diagnosing and distinguishing stroke and diagnostic devices for use therein |
| DK2357477T3 (en) * | 2003-09-20 | 2018-02-05 | Electrophoretics Ltd | Diagnostic approach for brain injury-related disorders based on detection of NDKA |
| US20080307537A1 (en) * | 2005-03-31 | 2008-12-11 | Dana-Farber Cancer Institute, Inc. | Compositions and Methods for the Identification, Assessment, Prevention, and Therapy of Neurological Diseases, Disorders and Conditions |
| JP4521512B2 (ja) * | 2005-06-15 | 2010-08-11 | 独立行政法人産業技術総合研究所 | 痴呆症の診断方法及び診断キット |
| GB2428240A (en) * | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| EP2520935A3 (en) * | 2006-08-09 | 2013-02-13 | Homestead Clinical Corporation | Organ-specific proteins and methods of their use |
-
2010
- 2010-05-21 GB GBGB1008541.3A patent/GB201008541D0/en not_active Ceased
-
2011
- 2011-05-23 CA CA2800038A patent/CA2800038A1/en not_active Abandoned
- 2011-05-23 WO PCT/GB2011/000784 patent/WO2011144914A2/en not_active Ceased
- 2011-05-23 US US13/699,444 patent/US20130252834A1/en not_active Abandoned
- 2011-05-23 JP JP2013510677A patent/JP5775568B2/ja not_active Expired - Fee Related
- 2011-05-23 AU AU2011254386A patent/AU2011254386B2/en not_active Ceased
- 2011-05-23 EP EP11731457A patent/EP2572202A2/en not_active Withdrawn
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