JP2013530160A - 赤血球増加症治療用ａｎｔｉｍｉＲ−４５１ - Google Patents

赤血球増加症治療用ａｎｔｉｍｉＲ−４５１ Download PDF

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JP2013530160A
JP2013530160A JP2013512611A JP2013512611A JP2013530160A JP 2013530160 A JP2013530160 A JP 2013530160A JP 2013512611 A JP2013512611 A JP 2013512611A JP 2013512611 A JP2013512611 A JP 2013512611A JP 2013530160 A JP2013530160 A JP 2013530160A
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mir
seq
sequence
antisense oligonucleotide
modification
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JP2013530160A5 (OSRAM
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エヌ． オルソン，エリック
エム． パトリック，デイヴィッド
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2013512611A 2010-01-20 2011-01-20 赤血球増加症治療用ａｎｔｉｍｉＲ−４５１ Pending JP2013530160A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29678310P 2010-01-20 2010-01-20
US61/296,783 2010-01-20
US28254610P 2010-02-26 2010-02-26
US61/282,546 2010-02-26
PCT/US2011/021886 WO2012148373A1 (en) 2010-01-20 2011-01-20 Antimir-451 for the treatment of polycythemias

Publications (2)

Publication Number Publication Date
JP2013530160A true JP2013530160A (ja) 2013-07-25
JP2013530160A5 JP2013530160A5 (OSRAM) 2014-03-06

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JP2013512611A Pending JP2013530160A (ja) 2010-01-20 2011-01-20 赤血球増加症治療用ａｎｔｉｍｉＲ−４５１

Country Status (5)

Country Link
US (1) US9340782B2 (OSRAM)
EP (1) EP2536436A4 (OSRAM)
JP (1) JP2013530160A (OSRAM)
CN (1) CN102869386A (OSRAM)
WO (1) WO2012148373A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150131365A (ko) 2013-03-15 2015-11-24 미라젠 세러퓨틱스 인코포레이티드 브리지드 바이사이클릭 뉴클레오시드
US10517888B2 (en) 2014-12-08 2019-12-31 Thomas Jefferson University Treatment and prevention of thrombosis using an anti-miR
US10306081B2 (en) * 2015-07-09 2019-05-28 Turner Broadcasting System, Inc. Technologies for generating a point-of-view video
ES2659845B1 (es) 2016-09-19 2019-01-04 Univ Valencia Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello
CN113332434B (zh) * 2021-05-25 2023-09-05 大连医科大学 miR-451a调节剂在制备调控血压制剂中的应用
US20260071214A1 (en) 2022-04-06 2026-03-12 Universitat De València Antagonists of human micro rna mir-100, mir-20, mir-222, mir-181 and mir-92 and uses of same
CN115920054A (zh) * 2022-12-23 2023-04-07 扬州大学 miR-144/451作为靶点在治疗精神分裂症中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539699A (ja) * 2005-04-29 2008-11-20 ザ ロックフェラー ユニバーシティ マイクロｒｎａ及びそれを阻害する方法
US20090326051A1 (en) * 2008-06-04 2009-12-31 The Board Of Regents Of The University Of Texas System Modulation of gene expression through endogenous small RNA targeting of gene promoters

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2666859T3 (en) 2006-04-03 2019-04-08 Roche Innovation Ct Copenhagen As PHARMACEUTICAL COMPOSITION CONTAINING ANTI-miRNA ANTISENSE OLIGONUCLEOTIDES
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008539699A (ja) * 2005-04-29 2008-11-20 ザ ロックフェラー ユニバーシティ マイクロｒｎａ及びそれを阻害する方法
US20090326051A1 (en) * 2008-06-04 2009-12-31 The Board Of Regents Of The University Of Texas System Modulation of gene expression through endogenous small RNA targeting of gene promoters

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6015000530; ＰＡＳＥ，　Ｌ　ｅｔ　ａｌ，　ＢＬＯＯＤ，　２００９，　ｖｏｌ．１１３，　ｎｏ．８，　ｐ．１７９４-８０４ *
JPN6015000532; ＬＯＩＳ，　ＣＤ　ｅｔ　ａｌ，　ＰＮＡＳ，　２００８，　ｖｏｌ．１０５，　ｎｏ．９，　ｐ．３３３３-８ *
JPN6015000537; ＺＨＡＮ，　Ｍ　ｅｔ　ａｌ，　Ｅｘｐ　Ｈｅｍａｔｏｌ，　２００７，　ｖｏｌ．３５，　ｎｏ．７，　ｐ．１０１５-２５ *
JPN6015000540; ＢＲＵＣＨＯＶＡ，　Ｈ　ｅｔ　ａｌ，　Ｅｘｐ　Ｈｅｍａｔｏｌ，　２００７，　ｖｏｌ．３５，　ｎｏ．１１，　ｐ．１６５７-６７ *
JPN6015000542; ＢＲＵＣＨＯＶＡ，　Ｈ　ｅｔ　ａｌ，　ＢＬＯＯＤ，　２００６，　ｖｏｌ．１０８，　ｎｏ．１１，　Ａｂｓｔｒａｃｔ　３６１３ *
JPN6015000544; 福島雅典監修，　メルクマニュアル第１８版日本語版，　２００６，　ｐ．１１６２-６ *

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Publication number Publication date
EP2536436A4 (en) 2015-01-14
EP2536436A1 (en) 2012-12-26
US20140011859A1 (en) 2014-01-09
CN102869386A (zh) 2013-01-09
US9340782B2 (en) 2016-05-17
WO2012148373A1 (en) 2012-11-01

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