JP2013528174A5 - - Google Patents
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- Publication number
- JP2013528174A5 JP2013528174A5 JP2013512048A JP2013512048A JP2013528174A5 JP 2013528174 A5 JP2013528174 A5 JP 2013528174A5 JP 2013512048 A JP2013512048 A JP 2013512048A JP 2013512048 A JP2013512048 A JP 2013512048A JP 2013528174 A5 JP2013528174 A5 JP 2013528174A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- arylalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 88
- 125000000304 alkynyl group Chemical group 0.000 claims description 84
- 125000006725 C1-C10 alkenyl group Chemical group 0.000 claims description 81
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 27
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 16
- 210000004881 tumor cell Anatomy 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 102000001307 androgen receptors Human genes 0.000 claims description 10
- 108010080146 androgen receptors Proteins 0.000 claims description 10
- 238000011394 anticancer treatment Methods 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000014509 gene expression Effects 0.000 claims description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 238000000315 cryotherapy Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000001794 hormone therapy Methods 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 238000001361 intraarterial administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- -1 n- butyl Chemical group 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000007792 addition Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008521 reorganization Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34955510P | 2010-05-28 | 2010-05-28 | |
| US61/349,555 | 2010-05-28 | ||
| PCT/US2011/038395 WO2011150360A1 (en) | 2010-05-28 | 2011-05-27 | Oligo-benzamide compounds and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016122278A Division JP6385986B2 (ja) | 2010-05-28 | 2016-06-21 | オリゴベンズアミド化合物およびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013528174A JP2013528174A (ja) | 2013-07-08 |
| JP2013528174A5 true JP2013528174A5 (https=) | 2014-07-10 |
Family
ID=45004429
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512048A Pending JP2013528174A (ja) | 2010-05-28 | 2011-05-27 | オリゴベンズアミド化合物およびそれらの使用 |
| JP2016122278A Active JP6385986B2 (ja) | 2010-05-28 | 2016-06-21 | オリゴベンズアミド化合物およびそれらの使用 |
| JP2018097720A Pending JP2018131459A (ja) | 2010-05-28 | 2018-05-22 | オリゴベンズアミド化合物およびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016122278A Active JP6385986B2 (ja) | 2010-05-28 | 2016-06-21 | オリゴベンズアミド化合物およびそれらの使用 |
| JP2018097720A Pending JP2018131459A (ja) | 2010-05-28 | 2018-05-22 | オリゴベンズアミド化合物およびそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20130231385A1 (https=) |
| EP (1) | EP2575453B1 (https=) |
| JP (3) | JP2013528174A (https=) |
| KR (1) | KR20130115108A (https=) |
| CN (1) | CN102958364A (https=) |
| AU (1) | AU2011258009B2 (https=) |
| BR (1) | BR112012030298A2 (https=) |
| CA (1) | CA2800811C (https=) |
| CL (1) | CL2012003322A1 (https=) |
| CO (1) | CO6640301A2 (https=) |
| EA (1) | EA201291460A1 (https=) |
| MX (1) | MX2012013855A (https=) |
| SG (1) | SG186076A1 (https=) |
| WO (1) | WO2011150360A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201291460A1 (ru) | 2010-05-28 | 2013-11-29 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Олигобензамидные соединения и их применение |
| WO2012177624A2 (en) * | 2011-06-21 | 2012-12-27 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
| US8835493B2 (en) | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
| WO2013078277A1 (en) | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| SMT201900719T1 (it) * | 2015-05-18 | 2020-01-14 | Nerre Therapeutics Ltd | Antagonista del recettore nk-1/nk-3 per il trattamento delle vampate di calore |
| CN113384390B (zh) | 2015-09-15 | 2023-08-22 | 萨维奇医疗股份有限公司 | 用于在组织腔中锚定护套的装置和方法 |
| USD874674S1 (en) * | 2016-10-17 | 2020-02-04 | Brandcore Limited | Vibrator |
| WO2020117715A1 (en) | 2018-12-03 | 2020-06-11 | Board Of Regents, The University Of Texas System | Oligo-benzamide analogs and their use in cancer treatment |
| WO2023154856A1 (en) * | 2022-02-11 | 2023-08-17 | Board Of Regents, The University Of Texas System | Oligo-benzamide analogs and their use in cancer treatment |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1903899A (en) | 1933-04-18 | Cabboxylic acid abylides oe the benzene sebies and process oe making | ||
| US3951914A (en) | 1974-07-30 | 1976-04-20 | E. I. Du Pont De Nemours And Company | Process for preparing poly(1,4-benzamide) in cyclic sulfone media |
| US5212203A (en) | 1986-01-21 | 1993-05-18 | Centre International De Recherches Dermatogologiques (C.I.R.D.) | Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations |
| US5734081A (en) | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US7355081B2 (en) * | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| EP1670483A4 (en) * | 2003-09-10 | 2010-02-17 | Merck & Co Inc | 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules |
| EP1718323B1 (en) | 2004-02-20 | 2011-12-07 | The Trustees of The University of Pennsylvania | Binding peptidomimetics and uses of the same |
| US20070248535A1 (en) | 2005-02-07 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity |
| WO2007056593A2 (en) | 2005-11-08 | 2007-05-18 | Choongwae Pharma Corporation | α-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS |
| US7816324B2 (en) | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
| US8236983B2 (en) | 2008-03-13 | 2012-08-07 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by apoptosis |
| EP2620432A3 (en) * | 2007-10-26 | 2013-12-18 | The Regents Of the University of California | Diarylhydantoin compounds |
| DE112009000300T5 (de) | 2008-02-08 | 2011-01-20 | Aileron Therapeutics, Inc., Cambridge | Therapeutische Peptidomimetische Makrocyclen |
| CA2716320C (en) * | 2008-02-22 | 2014-01-28 | Radius Health, Inc. | Selective androgen receptor modulators |
| US8188098B2 (en) | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| CN101643451B (zh) * | 2008-08-07 | 2013-03-06 | 浙江海正药业股份有限公司 | 过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法 |
| US8524669B2 (en) | 2008-10-17 | 2013-09-03 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
| WO2010088498A1 (en) | 2009-01-30 | 2010-08-05 | Bayer Healthcare Llc | Methods for treating estrogen receptor positive cancer by x-box binding protein 1 inhibition |
| AP2012006277A0 (en) | 2009-10-23 | 2012-06-30 | Health Research Inc | Method for treating androgen receptor positive cancers. |
| EA201291460A1 (ru) | 2010-05-28 | 2013-11-29 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Олигобензамидные соединения и их применение |
| WO2013078277A1 (en) | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| US8835493B2 (en) * | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
-
2011
- 2011-05-27 EA EA201291460A patent/EA201291460A1/ru unknown
- 2011-05-27 US US13/700,500 patent/US20130231385A1/en not_active Abandoned
- 2011-05-27 SG SG2012087235A patent/SG186076A1/en unknown
- 2011-05-27 KR KR1020127033981A patent/KR20130115108A/ko not_active Withdrawn
- 2011-05-27 AU AU2011258009A patent/AU2011258009B2/en active Active
- 2011-05-27 MX MX2012013855A patent/MX2012013855A/es not_active Application Discontinuation
- 2011-05-27 CN CN2011800323958A patent/CN102958364A/zh active Pending
- 2011-05-27 WO PCT/US2011/038395 patent/WO2011150360A1/en not_active Ceased
- 2011-05-27 JP JP2013512048A patent/JP2013528174A/ja active Pending
- 2011-05-27 BR BR112012030298A patent/BR112012030298A2/pt not_active IP Right Cessation
- 2011-05-27 CA CA2800811A patent/CA2800811C/en active Active
- 2011-05-27 EP EP11787517.9A patent/EP2575453B1/en active Active
-
2012
- 2012-11-27 CL CL2012003322A patent/CL2012003322A1/es unknown
- 2012-12-04 CO CO12219956A patent/CO6640301A2/es not_active Application Discontinuation
-
2015
- 2015-11-04 US US14/932,480 patent/US9856206B2/en active Active
-
2016
- 2016-06-21 JP JP2016122278A patent/JP6385986B2/ja active Active
-
2018
- 2018-01-02 US US15/860,095 patent/US10618869B2/en active Active
- 2018-05-22 JP JP2018097720A patent/JP2018131459A/ja active Pending
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