JP2013523841A5 - - Google Patents
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- Publication number
- JP2013523841A5 JP2013523841A5 JP2013504018A JP2013504018A JP2013523841A5 JP 2013523841 A5 JP2013523841 A5 JP 2013523841A5 JP 2013504018 A JP2013504018 A JP 2013504018A JP 2013504018 A JP2013504018 A JP 2013504018A JP 2013523841 A5 JP2013523841 A5 JP 2013523841A5
- Authority
- JP
- Japan
- Prior art keywords
- cord blood
- umbilical cord
- stem cell
- human umbilical
- blood stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004700 fetal blood Anatomy 0.000 claims 101
- 210000000130 stem cell Anatomy 0.000 claims 97
- 239000000523 sample Substances 0.000 claims 72
- 238000000034 method Methods 0.000 claims 51
- 230000002062 proliferating effect Effects 0.000 claims 37
- 230000003394 haemopoietic effect Effects 0.000 claims 27
- 210000004369 blood Anatomy 0.000 claims 20
- 239000008280 blood Substances 0.000 claims 20
- 230000003169 placental effect Effects 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 13
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 12
- 239000012520 frozen sample Substances 0.000 claims 10
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 9
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 9
- 230000035755 proliferation Effects 0.000 claims 8
- 238000004590 computer program Methods 0.000 claims 6
- 241000282412 Homo Species 0.000 claims 4
- 206010033661 Pancytopenia Diseases 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 208000004235 neutropenia Diseases 0.000 claims 4
- 238000010257 thawing Methods 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 230000005865 ionizing radiation Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 210000003954 umbilical cord Anatomy 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32254410P | 2010-04-09 | 2010-04-09 | |
| US61/322,544 | 2010-04-09 | ||
| PCT/US2011/031953 WO2011127470A1 (en) | 2010-04-09 | 2011-04-11 | Compositions and methods for providing hematopoietic function without hla matching |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017056141A Division JP6853081B2 (ja) | 2010-04-09 | 2017-03-22 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523841A JP2013523841A (ja) | 2013-06-17 |
| JP2013523841A5 true JP2013523841A5 (https=) | 2015-05-21 |
| JP6165627B2 JP6165627B2 (ja) | 2017-07-19 |
Family
ID=44120970
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504018A Active JP6165627B2 (ja) | 2010-04-09 | 2011-04-11 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
| JP2017056141A Active JP6853081B2 (ja) | 2010-04-09 | 2017-03-22 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
| JP2019051186A Active JP6998911B2 (ja) | 2010-04-09 | 2019-03-19 | Ｈｌａの適合なしに造血機能を提供するための組成物 |
| JP2021066078A Pending JP2021105045A (ja) | 2010-04-09 | 2021-04-08 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017056141A Active JP6853081B2 (ja) | 2010-04-09 | 2017-03-22 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
| JP2019051186A Active JP6998911B2 (ja) | 2010-04-09 | 2019-03-19 | Ｈｌａの適合なしに造血機能を提供するための組成物 |
| JP2021066078A Pending JP2021105045A (ja) | 2010-04-09 | 2021-04-08 | Ｈｌａの適合なしに造血機能を提供するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20130095079A1 (https=) |
| EP (3) | EP2555782A1 (https=) |
| JP (4) | JP6165627B2 (https=) |
| CA (1) | CA2795627C (https=) |
| WO (1) | WO2011127470A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2943566A1 (en) | 2013-01-08 | 2015-11-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for expansion of embryonic hematopoietic stem cells |
| CN105873952A (zh) | 2013-10-31 | 2016-08-17 | 弗莱德哈钦森癌症研究中心 | 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途 |
| WO2015120197A1 (en) * | 2014-02-05 | 2015-08-13 | Regents Of The University Of California | Rna editing biomarkers for diagnosis, pharmacological screening and prognostication in cancer |
| FR3026744B1 (fr) | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
| CN115777690A (zh) * | 2014-11-14 | 2023-03-14 | 日本赤十字社 | 脐带血以及末梢血的冻结保存方法以及冻结保存用溶液 |
| JP2016104711A (ja) * | 2014-11-21 | 2016-06-09 | 国立大学法人 東京大学 | 造血幹細胞移植を補助することに用いるための医薬組成物およびその製造方法 |
| WO2016118780A1 (en) | 2015-01-21 | 2016-07-28 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
| US20180015125A1 (en) * | 2015-03-23 | 2018-01-18 | Pluristem Ltd. | Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| RU2747728C2 (ru) * | 2015-12-04 | 2021-05-13 | Фред Хатчинсон Кэнсер Рисерч Сентер | Применение размноженных популяций гематопоэтических стволовых клеток/клеток-предшественников |
| ES2931530T3 (es) | 2017-02-13 | 2022-12-30 | Hopitaux Paris Assist Publique | Método para generar progenitores de células T |
| EP4417210A1 (en) * | 2017-03-15 | 2024-08-21 | Orca Biosystems, Inc. | Compositions and methods for hematopoietic stem cell transplants |
| WO2020056170A1 (en) | 2018-09-12 | 2020-03-19 | Fred Hutchinson Cancer Research Center | Reducing cd33 expression to selectively protect therapeutic cells |
| EP3741842A4 (en) * | 2018-09-27 | 2021-04-21 | TERUMO Kabushiki Kaisha | CELL CRYOPRESERVATION METHOD |
| MX2021014039A (es) * | 2019-05-17 | 2022-02-11 | Deverra Therapeutics Inc | Composiciones y métodos para mejorar resultados de tratamiento para pacientes que tienen neoplasias malignas hematológicas usando un producto de células madre expandidas. |
| JP2022542321A (ja) * | 2019-07-29 | 2022-09-30 | デヴェラ セラピューティクス インコーポレイテッド | 免疫療法のためのｎｋ細胞組成物および調製物ならびにそれらの製造のための方法 |
| WO2021108769A1 (en) * | 2019-11-27 | 2021-06-03 | Deverra Therapeutics Inc. | Compositions and methods for culturing hematopoietic stem and progenitor cells |
| AU2021245671A1 (en) * | 2020-03-31 | 2022-10-20 | Cell Exosome Therapeutics Inc. | Cell preservation method |
| WO2022005462A1 (en) * | 2020-06-30 | 2022-01-06 | Tr1X, Inc. | Poly-donor cd4+ t cells expressing il-10 and uses thereof |
| CN114187965A (zh) * | 2021-12-09 | 2022-03-15 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种人骨髓造血干/祖细胞的单细胞转录组图谱及构建方法 |
| US20250135039A1 (en) | 2022-02-07 | 2025-05-01 | Ensoma, Inc. | Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| DE69638023D1 (de) | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| WO2002059285A1 (en) * | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| AU2003219966A1 (en) * | 2002-03-05 | 2003-09-22 | Daniel D. Richard | Dual blood donation plus method |
| WO2004071283A2 (en) * | 2003-02-13 | 2004-08-26 | Anthrogenesis Corporation | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| JP2005102656A (ja) * | 2003-10-02 | 2005-04-21 | Toray Ind Inc | 細胞培養器具およびそれを用いた細胞製剤の製造方法 |
| CN1961283A (zh) * | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| ZA200704252B (en) | 2004-10-25 | 2009-09-30 | Cellerant Therapeutics Inc | Methods of expanding myeloid cell populations and uses thereof |
| EP1906729B1 (en) * | 2005-06-02 | 2012-03-28 | Stemcyte, Inc. | Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use |
| CN101421393B (zh) | 2006-02-14 | 2013-08-14 | 塞勒兰特治疗公司 | 提高造血干细胞植入的方法和组合物 |
-
2011
- 2011-04-11 CA CA2795627A patent/CA2795627C/en active Active
- 2011-04-11 EP EP11717379A patent/EP2555782A1/en not_active Withdrawn
- 2011-04-11 EP EP16166225.9A patent/EP3097917B1/en active Active
- 2011-04-11 EP EP19191594.1A patent/EP3590520B1/en active Active
- 2011-04-11 WO PCT/US2011/031953 patent/WO2011127470A1/en not_active Ceased
- 2011-04-11 JP JP2013504018A patent/JP6165627B2/ja active Active
- 2011-04-11 US US13/640,297 patent/US20130095079A1/en not_active Abandoned
-
2017
- 2017-03-22 JP JP2017056141A patent/JP6853081B2/ja active Active
- 2017-11-10 US US15/809,699 patent/US20180085406A1/en not_active Abandoned
-
2019
- 2019-03-19 JP JP2019051186A patent/JP6998911B2/ja active Active
- 2019-04-08 US US16/378,206 patent/US20190298777A1/en not_active Abandoned
- 2019-04-08 US US16/378,229 patent/US20190298778A1/en active Pending
-
2021
- 2021-04-08 JP JP2021066078A patent/JP2021105045A/ja active Pending
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