JP2013521287A5 - - Google Patents
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- Publication number
- JP2013521287A5 JP2013521287A5 JP2012556123A JP2012556123A JP2013521287A5 JP 2013521287 A5 JP2013521287 A5 JP 2013521287A5 JP 2012556123 A JP2012556123 A JP 2012556123A JP 2012556123 A JP2012556123 A JP 2012556123A JP 2013521287 A5 JP2013521287 A5 JP 2013521287A5
- Authority
- JP
- Japan
- Prior art keywords
- imaging
- calcium channel
- type calcium
- channel inhibitor
- imaging marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000003384 imaging method Methods 0.000 claims description 59
- 239000003550 marker Substances 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 27
- 241000124008 Mammalia Species 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- HBNPJJILLOYFJU-VMPREFPWSA-N Mibefradil Chemical group C1CC2=CC(F)=CC=C2[C@H](C(C)C)[C@@]1(OC(=O)COC)CCN(C)CCCC1=NC2=CC=CC=C2N1 HBNPJJILLOYFJU-VMPREFPWSA-N 0.000 claims description 7
- 229960004438 mibefradil Drugs 0.000 claims description 7
- 206010010904 Convulsion Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 238000002600 positron emission tomography Methods 0.000 claims description 4
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 claims description 3
- 208000006994 Precancerous Conditions Diseases 0.000 claims description 3
- 230000018199 S phase Effects 0.000 claims description 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 3
- 206010002388 Angina unstable Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000007814 Unstable Angina Diseases 0.000 claims description 2
- 230000003187 abdominal effect Effects 0.000 claims description 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 2
- FFEARJCKVFRZRR-JJZBXVGDSA-N methionine c-11 Chemical compound [11CH3]SCC[C@H](N)C(O)=O FFEARJCKVFRZRR-JJZBXVGDSA-N 0.000 claims description 2
- 208000004296 neuralgia Diseases 0.000 claims description 2
- 208000021722 neuropathic pain Diseases 0.000 claims description 2
- 229960005311 telbivudine Drugs 0.000 claims description 2
- DKNDOKIVCXTFHJ-HNNXBMFYSA-N 3,5-dichloro-n-[[1-[[(4s)-2,2-dimethyloxan-4-yl]methyl]-4-fluoropiperidin-4-yl]methyl]benzamide Chemical compound C1COC(C)(C)C[C@H]1CN1CCC(F)(CNC(=O)C=2C=C(Cl)C=C(Cl)C=2)CC1 DKNDOKIVCXTFHJ-HNNXBMFYSA-N 0.000 claims 31
- IJPVCOQVFLNLAP-SQOUGZDYSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoyl fluoride Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(F)=O IJPVCOQVFLNLAP-SQOUGZDYSA-N 0.000 claims 2
- 230000006369 cell cycle progression Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims 1
- 230000008051 G1/S transition checkpoint Effects 0.000 claims 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Natural products O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 229940104230 thymidine Drugs 0.000 claims 1
- 229940123587 Cell cycle inhibitor Drugs 0.000 description 11
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- NSVFSAJIGAJDMR-UHFFFAOYSA-N 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 NSVFSAJIGAJDMR-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- -1 TTL-1177 Chemical compound 0.000 description 1
- 230000012820 cell cycle checkpoint Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 229950003102 efonidipine Drugs 0.000 description 1
- HAPOVYFOVVWLRS-UHFFFAOYSA-N ethosuximide Chemical compound CCC1(C)CC(=O)NC1=O HAPOVYFOVVWLRS-UHFFFAOYSA-N 0.000 description 1
- 229960002767 ethosuximide Drugs 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30903010P | 2010-03-01 | 2010-03-01 | |
| US61/309,030 | 2010-03-01 | ||
| PCT/US2011/026416 WO2011109262A2 (en) | 2010-03-01 | 2011-02-28 | Cancer diagnosis and imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521287A JP2013521287A (ja) | 2013-06-10 |
| JP2013521287A5 true JP2013521287A5 (cg-RX-API-DMAC7.html) | 2014-07-31 |
| JP6017964B2 JP6017964B2 (ja) | 2016-11-02 |
Family
ID=44542787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556123A Expired - Fee Related JP6017964B2 (ja) | 2010-03-01 | 2011-02-28 | 癌診断および撮像 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9427429B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2542155B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6017964B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101821343B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102781316B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011223883B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2787673A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2557407T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL221035A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX360640B (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201501496TA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011109262A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201205377B (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4927735B2 (ja) * | 2004-08-20 | 2012-05-09 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | Ｔ型カルシウムチャネル阻害剤 |
| AU2011223883B2 (en) | 2010-03-01 | 2015-10-08 | Cavion, Inc. | Cancer diagnosis and imaging |
| EA039877B1 (ru) * | 2016-07-19 | 2022-03-23 | Бристол-Майерс Сквибб Компани | Радиолиганды для визуализации фермента ido1 |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| KR102642063B1 (ko) | 2017-02-15 | 2024-03-04 | 카비온, 인코포레이티드 | 칼슘 채널 억제제 |
| AU2020231916B2 (en) | 2019-03-01 | 2025-08-28 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1219609A (en) | 1968-07-19 | 1971-01-20 | Koninklijke Pharma Fab Nv | Diphenylmethoxyethylamino derivatives |
| US3732247A (en) | 1970-08-14 | 1973-05-08 | Robins Co Inc A H | 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms |
| US4091103A (en) | 1976-06-23 | 1978-05-23 | Ciba-Geigy Corporation | Quinolyl or isoquinolyl-lower-alkoxy-phenylene-amino derivatives |
| JPS59161392A (ja) | 1983-03-04 | 1984-09-12 | Nippon Shinyaku Co Ltd | ジヒドロピリジン誘導体及びその製法 |
| US4906646A (en) | 1983-03-31 | 1990-03-06 | Board Of Governors Of Wayne State University | Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class |
| US4885284A (en) | 1986-01-22 | 1989-12-05 | Nissan Chemical Industries Ltd. | Dihydropyridine-5-phosphonic acid cyclic propylene ester |
| FR2601366B1 (fr) | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
| JP2850376B2 (ja) | 1988-08-02 | 1999-01-27 | 日産化学工業株式会社 | 抗癌剤薬効増強剤 |
| DE68924456T2 (de) | 1988-08-02 | 1996-05-30 | Nissan Chemical Ind Ltd | Mittel zur Verbesserung von Arzneimitteleffekten für Antitumormittel. |
| FR2636946B1 (fr) | 1988-09-23 | 1990-11-02 | Lipha | ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0467435A3 (en) | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
| US5919816A (en) | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| US6413967B1 (en) | 1995-03-30 | 2002-07-02 | The University Of Virginia Patents Foundation | Inhibition of novel calcium entry pathway in electrically non-excitable cells acting as an anti-proliferative therapy |
| ATE324114T1 (de) | 1995-09-08 | 2006-05-15 | Beth Israel Hospital | Isolierung der mikrodomänen von kaveolae und gpi verankerten proteinen |
| EP0853615B1 (en) | 1995-09-15 | 2003-12-10 | Neurosearch A/S | Piperidine compounds as calcium channel blockers |
| CN1214688A (zh) | 1996-02-14 | 1999-04-21 | 伊希斯药物有限公司 | 糖修饰的缺口寡核苷酸 |
| CA2204082A1 (en) | 1996-05-03 | 1997-11-03 | Michael William John Urquhart | Pharmaceutical compounds |
| US6191156B1 (en) | 1997-04-11 | 2001-02-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating bladder dysfunction |
| US6703374B1 (en) | 1997-10-30 | 2004-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleosides for imaging and treatment applications |
| CA2312195A1 (en) | 1997-12-03 | 1999-06-10 | Merck & Co., Inc. | Low-voltage activated calcium channel compositions and methods |
| WO1999029847A1 (en) | 1997-12-05 | 1999-06-17 | Loyola University Of Chicago | T-type voltage-gated calcium channels and method of using same |
| JPH11246417A (ja) | 1998-03-04 | 1999-09-14 | Nissan Chem Ind Ltd | 糖尿病性腎症治療用医薬組成物 |
| US6372719B1 (en) | 1998-03-04 | 2002-04-16 | Jay Cunningham | ανβ3 integrin antagonists in combination with chemotherapeutic agents |
| JP2002525077A (ja) | 1998-08-26 | 2002-08-13 | サウス、アラバマ、メディカル、サイエンス、ファウンデーション | Ｔ型カルシウムチャンネル |
| US6251886B1 (en) | 1998-12-07 | 2001-06-26 | Schering Corporation | Methods of using temozolomide in the treatment of cancers |
| EP1165508B1 (en) | 1999-04-07 | 2004-06-23 | The University of Virginia Patent Foundation | Anticancer calcium channel blockers |
| US6946475B1 (en) | 1999-04-07 | 2005-09-20 | University Of Virginia Patent Foundation | Anticancer calcium channel blockers |
| US7195783B2 (en) | 1999-07-09 | 2007-03-27 | Fx Life Sciences International Gmbh | Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics |
| AU2001235363A1 (en) | 2000-02-25 | 2001-09-03 | Novo-Nordisk A/S | Mibefradil analogues and their use |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| DE60127410T2 (de) | 2000-07-27 | 2007-12-13 | Pharmacia Corp. | Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen |
| ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| CA2446806A1 (en) | 2001-05-11 | 2002-11-21 | Board Of Regents, The University Of Texas System | Anti-cd26 monoclonal antibodies as therapy for diseases associated with cells expressing cd26 |
| EP1408975A2 (en) | 2001-07-23 | 2004-04-21 | Epidauros Biotechnologie AG | Methods for the treatment of cancer with irinotecan based on cyp3a5 |
| KR101265180B1 (ko) | 2002-01-17 | 2013-05-29 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아이지에프비피-2 및 아이지에프비피-5를 억제하는 양특이성 안티센스 올리고뉴클레오티드, 이를 이용하여 약학적 조성물을 제조하는 방법 및 그 약학적 조성물 |
| CA2486622A1 (en) | 2002-05-20 | 2003-12-04 | Research Development Foundation | Aerosol drug inhibition of lung metastases |
| GB0211578D0 (en) | 2002-05-21 | 2002-06-26 | Univ Belfast | Medicaments |
| DE10227511A1 (de) | 2002-06-19 | 2004-01-08 | Max-Delbrück-Centrum für Molekulare Medizin | Mittel zur medikamentösen Behandlung von akuten und chronischen Schmerzen |
| US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| JP2006502188A (ja) | 2002-09-17 | 2006-01-19 | ニューヨーク ユニバーシティ | 年齢関連記憶欠陥（ａａｍｉ）、中程度認識欠陥（ｍｃｉ）、および痴呆を細胞周期インヒビターで処置する方法 |
| RU2326886C2 (ru) | 2003-03-28 | 2008-06-20 | Ниссан Кемикал Индастриз, Лтд. | Блокатор кальциевых каналов т-типа |
| TW200528107A (en) | 2003-11-25 | 2005-09-01 | Nissan Chemical Ind Ltd | T-type calcium channel inhibitor |
| AU2011203315B8 (en) | 2004-02-11 | 2012-02-16 | University Of Virginia Patent Foundation | Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer |
| EP2319536A1 (en) | 2004-02-11 | 2011-05-11 | University Of Virginia Patent Foundation | Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer |
| CA2555208A1 (en) | 2004-02-18 | 2005-09-01 | Merck & Co., Inc. | Nucleic acid molecules encoding novel murine low-voltage activated calcium channel proteins, designated-alpha 1h, encoded proteins and methods of use thereof |
| US20060003020A1 (en) * | 2004-03-11 | 2006-01-05 | The Regents Of The University Of Michigan | Anti-metastatic ability of mibefradil and gadolinium |
| TW200538149A (en) | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| WO2006003020A1 (en) | 2004-07-02 | 2006-01-12 | L'oreal | Compositions containing a triazine derivative, an arylalkyl benzoate derivative and a eutectic n-butylphthalimide/isopropylphthalimide mixture; cosmetic uses thereof |
| JP4927735B2 (ja) | 2004-08-20 | 2012-05-09 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | Ｔ型カルシウムチャネル阻害剤 |
| JP2008510730A (ja) | 2004-08-20 | 2008-04-10 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | Ｔ型カルシウムチャネルブロッカーおよび疾患の治療 |
| US20100222406A1 (en) | 2007-09-11 | 2010-09-02 | University Of Virginia Patent Foundation | T Type Calcium Channel Blockers and the Treatment of Diseases |
| US20120264804A1 (en) | 2004-08-20 | 2012-10-18 | University Of Virginia Patent Foundation | T type calcium channel blockers and the treatment of diseases |
| US7851431B2 (en) | 2005-07-27 | 2010-12-14 | Prescription Dispensing Laboratories | Treatment of actinic keratoses with calcium channel blockers |
| KR100743255B1 (ko) | 2006-05-04 | 2007-07-27 | 한국과학기술연구원 | Ｔ-형 칼슘 채널에 활성을 지닌 신규1,3-다이옥소아이소인돌 유도체 |
| CA2660438A1 (en) * | 2006-08-10 | 2008-02-14 | Oncotherapy Science, Inc. | Genes and polypeptides relating to breast cancers |
| CN101528768A (zh) * | 2006-08-10 | 2009-09-09 | 肿瘤疗法科学股份有限公司 | 与乳腺癌相关的基因和多肽 |
| KR20140148491A (ko) | 2006-12-19 | 2014-12-31 | 제넨테크, 인크. | 조기 종양의 치료 및 아주반트 및 네오아주반트 요법을 위한 ｖｅｇｆ－특이적 길항제 |
| CA2684938A1 (en) | 2007-05-02 | 2008-11-13 | Tau Therapeutics Llc | Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions |
| WO2008141189A1 (en) | 2007-05-09 | 2008-11-20 | Elixir Pharmaceuticals, Inc. | Ghrelin modulating compounds and combinations thereof |
| EP2190429B1 (en) | 2007-09-10 | 2016-04-20 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| JP5029328B2 (ja) | 2007-12-05 | 2012-09-19 | マツダ株式会社 | 自動車の前部車体構造 |
| MX2010012064A (es) | 2008-05-05 | 2010-12-06 | Schering Corp | Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer. |
| MX2011000233A (es) | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
| KR101905050B1 (ko) | 2009-06-05 | 2018-10-08 | 타우 쎄라퓨틱스 엘엘씨 | 암 또는 전암성 질환을 치료하기 위한 인터레이스 방법 |
| AU2011223883B2 (en) | 2010-03-01 | 2015-10-08 | Cavion, Inc. | Cancer diagnosis and imaging |
| EP2755674A4 (en) | 2011-09-12 | 2015-04-08 | Tau Therapeutics Llc | ANTAGONISTS OF PRODUCTS OF THE HS-459642-UNIGEN CLUSTER TO AVOID PROLIFERATION, DEVELOPMENT, OR DIFFERENTIATION OF STEM CELLS WITH CANCER STEM CELLS |
-
2011
- 2011-02-28 AU AU2011223883A patent/AU2011223883B2/en not_active Ceased
- 2011-02-28 ES ES11751125.3T patent/ES2557407T3/es active Active
- 2011-02-28 JP JP2012556123A patent/JP6017964B2/ja not_active Expired - Fee Related
- 2011-02-28 CA CA2787673A patent/CA2787673A1/en not_active Abandoned
- 2011-02-28 WO PCT/US2011/026416 patent/WO2011109262A2/en not_active Ceased
- 2011-02-28 US US13/581,390 patent/US9427429B2/en not_active Expired - Fee Related
- 2011-02-28 EP EP11751125.3A patent/EP2542155B1/en not_active Not-in-force
- 2011-02-28 CN CN201180011495.2A patent/CN102781316B/zh not_active Expired - Fee Related
- 2011-02-28 SG SG10201501496TA patent/SG10201501496TA/en unknown
- 2011-02-28 KR KR1020127022975A patent/KR101821343B1/ko not_active Expired - Fee Related
- 2011-02-28 SG SG2012055232A patent/SG183114A1/en unknown
- 2011-02-28 MX MX2012010119A patent/MX360640B/es active IP Right Grant
-
2012
- 2012-07-18 ZA ZA2012/05377A patent/ZA201205377B/en unknown
- 2012-07-19 IL IL221035A patent/IL221035A0/en not_active IP Right Cessation
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