JP2013520509A5 - - Google Patents
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- JP2013520509A5 JP2013520509A5 JP2012555095A JP2012555095A JP2013520509A5 JP 2013520509 A5 JP2013520509 A5 JP 2013520509A5 JP 2012555095 A JP2012555095 A JP 2012555095A JP 2012555095 A JP2012555095 A JP 2012555095A JP 2013520509 A5 JP2013520509 A5 JP 2013520509A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- expression
- oct4
- endoderm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 36
- 210000004602 germ cell Anatomy 0.000 claims description 19
- 239000002870 angiogenesis inducing agent Substances 0.000 claims description 17
- 230000001023 pro-angiogenic effect Effects 0.000 claims description 16
- 101710150336 Protein Rex Proteins 0.000 claims description 15
- 108010017842 Telomerase Proteins 0.000 claims description 15
- 210000001900 endoderm Anatomy 0.000 claims description 15
- 230000028327 secretion Effects 0.000 claims description 14
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims description 13
- 210000003981 ectoderm Anatomy 0.000 claims description 13
- 210000003716 mesoderm Anatomy 0.000 claims description 13
- DZUXGQBLFALXCR-UHFFFAOYSA-N (+)-(9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprost-13-en-1-oic acid Natural products CCCCCC(O)C=CC1C(O)CC(O)C1CCCCCCC(O)=O DZUXGQBLFALXCR-UHFFFAOYSA-N 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 238000007876 drug discovery Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims description 2
- 229960001160 latanoprost Drugs 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 206010063897 Renal ischaemia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30810310P | 2010-02-25 | 2010-02-25 | |
| US61/308,103 | 2010-02-25 | ||
| PCT/US2011/025846 WO2011106365A1 (en) | 2010-02-25 | 2011-02-23 | Modulation of angiogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044246A Division JP6312326B2 (ja) | 2010-02-25 | 2015-03-06 | 血管形成の調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520509A JP2013520509A (ja) | 2013-06-06 |
| JP2013520509A5 true JP2013520509A5 (enExample) | 2014-02-13 |
Family
ID=44507175
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555095A Pending JP2013520509A (ja) | 2010-02-25 | 2011-02-23 | 血管形成の調節 |
| JP2015044246A Active JP6312326B2 (ja) | 2010-02-25 | 2015-03-06 | 血管形成の調節 |
| JP2015163449A Pending JP2015214585A (ja) | 2010-02-25 | 2015-08-21 | 血管形成の調節 |
| JP2017097945A Withdrawn JP2017137355A (ja) | 2010-02-25 | 2017-05-17 | 血管形成の調節 |
| JP2019036165A Withdrawn JP2019089846A (ja) | 2010-02-25 | 2019-02-28 | 血管形成の調節 |
| JP2021002029A Withdrawn JP2021058218A (ja) | 2010-02-25 | 2021-01-08 | 血管形成の調節 |
| JP2023001052A Pending JP2023026662A (ja) | 2010-02-25 | 2023-01-06 | 血管形成の調節 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044246A Active JP6312326B2 (ja) | 2010-02-25 | 2015-03-06 | 血管形成の調節 |
| JP2015163449A Pending JP2015214585A (ja) | 2010-02-25 | 2015-08-21 | 血管形成の調節 |
| JP2017097945A Withdrawn JP2017137355A (ja) | 2010-02-25 | 2017-05-17 | 血管形成の調節 |
| JP2019036165A Withdrawn JP2019089846A (ja) | 2010-02-25 | 2019-02-28 | 血管形成の調節 |
| JP2021002029A Withdrawn JP2021058218A (ja) | 2010-02-25 | 2021-01-08 | 血管形成の調節 |
| JP2023001052A Pending JP2023026662A (ja) | 2010-02-25 | 2023-01-06 | 血管形成の調節 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2539439B1 (enExample) |
| JP (7) | JP2013520509A (enExample) |
| KR (1) | KR101900507B1 (enExample) |
| CN (1) | CN102858956B (enExample) |
| AU (1) | AU2011220940C1 (enExample) |
| BR (1) | BR112012021451B8 (enExample) |
| CA (1) | CA2791331A1 (enExample) |
| DK (1) | DK2539439T3 (enExample) |
| ES (1) | ES2703428T3 (enExample) |
| IL (3) | IL221575A (enExample) |
| SG (4) | SG10201501353YA (enExample) |
| WO (1) | WO2011106365A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| EP3533465A4 (en) * | 2016-09-26 | 2020-07-01 | MPO, Inc. | Egg, fertilized egg, or embryo quality improving agent |
| KR102656200B1 (ko) * | 2017-06-16 | 2024-04-12 | 아이엠비에이 - 인스티튜트 퓌어 몰레쿨라레 바이오테크놀로지 게엠베하 | 혈관 오가노이드, 상기 오가노이드의 제조 및 사용 방법 |
| DE102017116204B4 (de) * | 2017-07-18 | 2024-06-27 | Universität Rostock | Verfahren zur Vorhersage der Antwort auf die kardiovaskuläre Regeneration |
| KR102498202B1 (ko) * | 2019-01-24 | 2023-02-10 | 가톨릭대학교 산학협력단 | 줄기세포의 혈관 재생 유효성 평가 방법 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4304907A (en) * | 1972-05-10 | 1981-12-08 | The Upjohn Company | Bicyclo lactone intermediates for prostaglandin analogs |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4744933A (en) | 1984-02-15 | 1988-05-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system |
| US4749620A (en) | 1984-02-15 | 1988-06-07 | Massachusetts Institute Of Technology | Encapsulated active material system |
| JPH0628570B2 (ja) | 1986-02-13 | 1994-04-20 | 雪印乳業株式会社 | カプセル体の製造方法及び装置 |
| EP0301777A1 (en) | 1987-07-28 | 1989-02-01 | Queen's University At Kingston | Multiple membrane microencapsulation |
| EP0435928A1 (en) | 1988-09-21 | 1991-07-10 | Animal Biotechnology Cambridge Limited | Derivation of pluripotential embryonic cell lines from domestic animals |
| US5089272A (en) | 1989-03-29 | 1992-02-18 | Snow Brand Milk Products Co., Ltd. | Process for producing capsules having a permeability-controllable membrane |
| US7037721B1 (en) | 1990-01-29 | 2006-05-02 | Hy-Gene Biomedical, Inc. | Protein-free defined media for the growth of normal human keratinocytes |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| AU2882992A (en) | 1991-11-06 | 1993-06-07 | Arthur A. Axelrad | Cell culture medium |
| US5578442A (en) | 1992-03-23 | 1996-11-26 | Vivorx, Inc. | Graft copolymers of polycationic species and water-soluble polymers, and use therefor |
| US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US7153684B1 (en) | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5766951A (en) | 1992-11-12 | 1998-06-16 | Quality Biological, Inc. | Serum-free medium supporting growth and proliferation of normal bone marrow cells |
| CA2169292C (en) | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US6037174A (en) | 1993-08-23 | 2000-03-14 | Nexell Therapeutics, Inc. | Preparation of serum-free suspensions of human hematopoietic cells or precursor cells |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6432711B1 (en) | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
| FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US6190910B1 (en) | 1996-05-21 | 2001-02-20 | The Institute Of Physical And Chemical Research | Mouse embryonic stem cell lines |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
| EP1129176A4 (en) | 1998-11-09 | 2002-10-30 | Es Cell Int Pte Ltd | EMBRYONIC STEM CELLS |
| CA2348687A1 (en) | 1998-11-09 | 2000-05-18 | Consorzio Per La Gestione Del Centro Di Biotecnologie Avanzate | Serum free medium for chondrocyte-like cells |
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| DK1226233T3 (da) * | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US20060003323A1 (en) * | 2000-03-01 | 2006-01-05 | John Alsobrook | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| JP4795616B2 (ja) | 2000-06-20 | 2011-10-19 | イーエス・セル・インターナショナル・プライヴェート・リミテッド | Ｂｍｐ−２経路アンタゴニストの存在下においてｅｓ細胞を培養することによって胚性幹細胞の分化をコントロールする方法 |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
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| CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| EP1421181A1 (en) | 2001-08-23 | 2004-05-26 | Reliance Life Sciences Pvt., Ltd. | ISOLATION OF INNER CELL MASS FOR THE ESTABLISHMENT OF HUMAN EMBRYONIC STEM CELL (hESC) LINES |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
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| US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| GB0221481D0 (en) | 2002-09-16 | 2002-10-23 | Richards John M | Grip for hand held instruments |
| WO2004039248A2 (en) * | 2002-10-31 | 2004-05-13 | The General Hospital Corporation | Repairing or replacing tissues or organs |
| JP2005065661A (ja) * | 2003-08-20 | 2005-03-17 | Akihiro Yamaguchi | ヒト血管内皮細胞のＶＥＧＦ誘導性活性化及び血管新生におけるＩｄの役割 |
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| US11992507B2 (en) * | 2006-01-23 | 2024-05-28 | Abt Holding Company | MAPC therapeutics without adjunctive immunosuppressive treatment |
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| US20100239535A1 (en) * | 2006-05-17 | 2010-09-23 | University Of Basel | Method for isolating homogeneous populations of transduced progenitors stably expressing specific levels of a transgene |
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-
2011
- 2011-02-23 BR BR112012021451A patent/BR112012021451B8/pt active IP Right Grant
- 2011-02-23 EP EP11747958.4A patent/EP2539439B1/en active Active
- 2011-02-23 SG SG10201501353YA patent/SG10201501353YA/en unknown
- 2011-02-23 KR KR1020127024595A patent/KR101900507B1/ko not_active Expired - Fee Related
- 2011-02-23 CN CN201180020289.8A patent/CN102858956B/zh not_active Expired - Fee Related
- 2011-02-23 WO PCT/US2011/025846 patent/WO2011106365A1/en not_active Ceased
- 2011-02-23 SG SG10201913904PA patent/SG10201913904PA/en unknown
- 2011-02-23 ES ES11747958T patent/ES2703428T3/es active Active
- 2011-02-23 JP JP2012555095A patent/JP2013520509A/ja active Pending
- 2011-02-23 DK DK11747958.4T patent/DK2539439T3/en active
- 2011-02-23 SG SG2012063194A patent/SG183498A1/en unknown
- 2011-02-23 CA CA2791331A patent/CA2791331A1/en not_active Abandoned
- 2011-02-23 AU AU2011220940A patent/AU2011220940C1/en active Active
- 2011-02-23 SG SG10202102952YA patent/SG10202102952YA/en unknown
-
2012
- 2012-08-22 IL IL221575A patent/IL221575A/en active IP Right Grant
-
2015
- 2015-03-06 JP JP2015044246A patent/JP6312326B2/ja active Active
- 2015-08-21 JP JP2015163449A patent/JP2015214585A/ja active Pending
-
2017
- 2017-05-17 JP JP2017097945A patent/JP2017137355A/ja not_active Withdrawn
- 2017-11-26 IL IL255914A patent/IL255914B/en active IP Right Grant
-
2019
- 2019-02-28 JP JP2019036165A patent/JP2019089846A/ja not_active Withdrawn
- 2019-11-26 IL IL270957A patent/IL270957B2/en unknown
-
2021
- 2021-01-08 JP JP2021002029A patent/JP2021058218A/ja not_active Withdrawn
-
2023
- 2023-01-06 JP JP2023001052A patent/JP2023026662A/ja active Pending
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