JP2013520488A - ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法 - Google Patents
ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法 Download PDFInfo
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- perphenazine
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30748110P | 2010-02-24 | 2010-02-24 | |
| US30748210P | 2010-02-24 | 2010-02-24 | |
| US61/307,482 | 2010-02-24 | ||
| US61/307,481 | 2010-02-24 | ||
| PCT/IB2011/000915 WO2011104637A2 (en) | 2010-02-24 | 2011-02-24 | Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520488A true JP2013520488A (ja) | 2013-06-06 |
| JP2013520488A5 JP2013520488A5 (enExample) | 2014-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2012554446A Pending JP2013520488A (ja) | 2010-02-24 | 2011-02-24 | ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法 |
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| Country | Link |
|---|---|
| US (2) | US8377929B2 (enExample) |
| EP (1) | EP2539857A4 (enExample) |
| JP (1) | JP2013520488A (enExample) |
| CN (1) | CN102858345A (enExample) |
| AU (1) | AU2011219529A1 (enExample) |
| CA (1) | CA2789654A1 (enExample) |
| IL (1) | IL221461A0 (enExample) |
| MX (1) | MX2012009821A (enExample) |
| WO (1) | WO2011104637A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7544681B2 (en) * | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| JP5284779B2 (ja) * | 2005-06-07 | 2013-09-11 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | コンジュゲート化された向精神薬の新規な塩およびその調製方法 |
| WO2008010223A2 (en) * | 2006-07-17 | 2008-01-24 | Ramot At Tel Aviv University Ltd. | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use in treating pain and other cns disorders |
| US8207369B2 (en) * | 2008-02-11 | 2012-06-26 | Ramot At Tel-Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
| CN102762211A (zh) | 2009-12-09 | 2012-10-31 | 拜欧利纳斯有限公司 | 改善认知功能的方法 |
| MX2012009821A (es) | 2010-02-24 | 2012-10-09 | Univ Ramot | Formas cristalinas de la sal de tri-mesilato de perfenazina-gaba y proceso para producirlas. |
| US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
| US10562930B1 (en) * | 2018-08-31 | 2020-02-18 | Praxis Precision Medicines, Inc. | Salts and crystal forms of GABAA positive allosteric modulator |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008545777A (ja) * | 2005-06-07 | 2008-12-18 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | コンジュゲート化された向精神薬の新規な塩およびその調製方法 |
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| GB1460713A (en) | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
| US5525727A (en) | 1982-05-18 | 1996-06-11 | University Of Florida | Brain-specific drug delivery |
| GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5780590A (en) | 1993-10-15 | 1998-07-14 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
| US5534522A (en) | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| AU6636996A (en) | 1995-07-13 | 1997-02-10 | Anormed Inc. | 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate |
| DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| US6130221A (en) | 1997-03-05 | 2000-10-10 | Nymox Corporation | Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions |
| TWI238062B (en) | 1999-12-01 | 2005-08-21 | Ucb Sa | A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorders |
| JP2005097120A (ja) | 2000-10-06 | 2005-04-14 | Mochida Pharmaceut Co Ltd | ４−ヒドロキシピペリジン誘導体の非潮解性塩 |
| US7544681B2 (en) * | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| KR100996239B1 (ko) | 2001-09-27 | 2010-11-23 | 바-일란 유니버시티 | 접합된 항-정신병 약물 및 그의 용도 |
| US7005138B2 (en) | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| US20040092504A1 (en) | 2002-11-12 | 2004-05-13 | Anuthep Benja-Athon | Definitive medications for treating fibromyalgia |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| CN101247837B (zh) * | 2005-06-07 | 2013-03-20 | 特拉维夫大学拉莫特有限公司 | 新的轭合精神活性药物的盐及其制备方法 |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7872046B2 (en) * | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| MX2012009821A (es) | 2010-02-24 | 2012-10-09 | Univ Ramot | Formas cristalinas de la sal de tri-mesilato de perfenazina-gaba y proceso para producirlas. |
| US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
-
2011
- 2011-02-24 MX MX2012009821A patent/MX2012009821A/es not_active Application Discontinuation
- 2011-02-24 AU AU2011219529A patent/AU2011219529A1/en not_active Abandoned
- 2011-02-24 CN CN2011800207232A patent/CN102858345A/zh active Pending
- 2011-02-24 EP EP11746937.9A patent/EP2539857A4/en not_active Withdrawn
- 2011-02-24 US US13/034,453 patent/US8377929B2/en not_active Expired - Fee Related
- 2011-02-24 CA CA2789654A patent/CA2789654A1/en not_active Abandoned
- 2011-02-24 JP JP2012554446A patent/JP2013520488A/ja active Pending
- 2011-02-24 WO PCT/IB2011/000915 patent/WO2011104637A2/en not_active Ceased
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2012
- 2012-08-14 IL IL221461A patent/IL221461A0/en unknown
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2013
- 2013-02-11 US US13/763,815 patent/US20130150352A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008545777A (ja) * | 2005-06-07 | 2008-12-18 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | コンジュゲート化された向精神薬の新規な塩およびその調製方法 |
Non-Patent Citations (1)
| Title |
|---|
| ABRAHAM NUDELMAN ET AL: "A Mutual Prodrug Ester of GABA and Perphenazine Exhibits Antischizophrenic Efficacy with Diminished", J. MED. CHEM, vol. 51, JPN6014042815, 2008, pages 2858 - 2862, ISSN: 0002914741 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011104637A2 (en) | 2011-09-01 |
| US8377929B2 (en) | 2013-02-19 |
| WO2011104637A3 (en) | 2012-02-23 |
| CA2789654A1 (en) | 2011-09-01 |
| US20110312948A1 (en) | 2011-12-22 |
| WO2011104637A9 (en) | 2012-01-05 |
| US20130150352A1 (en) | 2013-06-13 |
| MX2012009821A (es) | 2012-10-09 |
| EP2539857A4 (en) | 2013-07-24 |
| CN102858345A (zh) | 2013-01-02 |
| AU2011219529A1 (en) | 2012-08-30 |
| EP2539857A2 (en) | 2013-01-02 |
| IL221461A0 (en) | 2012-10-31 |
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