JP2013519685A - ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法 - Google Patents

ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法 Download PDF

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JP2013519685A
JP2013519685A JP2012553052A JP2012553052A JP2013519685A JP 2013519685 A JP2013519685 A JP 2013519685A JP 2012553052 A JP2012553052 A JP 2012553052A JP 2012553052 A JP2012553052 A JP 2012553052A JP 2013519685 A JP2013519685 A JP 2013519685A
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alkyl
cycloalkyl
membered ring
optionally substituted
halogen
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JP2013519685A5 (enExample
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コン，ピー．，ジェフリー
ダブリュ． リンズリー，クレイグ
アール． ホプキンス，コーリー
デイヴィッド ウェイバー，チャールズ
エム． ニスウェンダー，コリーン
ダブリュ． エンガース，ダレン
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Vanderbilt University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A—HUMAN NECESSITIES
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
JP2012553052A 2010-02-11 2011-02-11 ｍＧｌｕＲ４アロステリック増強剤としてのベンズイソオキサゾール類およびアザベンズイソオキサゾール類、組成物、および神経機能不全を治療する方法 Pending JP2013519685A (ja)

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US30348110P 2010-02-11 2010-02-11
US61/303,481 2010-02-11
PCT/US2011/024627 WO2011100614A1 (en) 2010-02-11 2011-02-11 BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

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JP2013519685A5 JP2013519685A5 (enExample) 2014-04-03

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EP (1) EP2533642A4 (enExample)
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KR (1) KR20120120416A (enExample)
CN (1) CN102834009A (enExample)
AU (1) AU2011215645A1 (enExample)
BR (1) BR112012020271A2 (enExample)
CA (1) CA2789434A1 (enExample)
IL (1) IL221389A0 (enExample)
MX (1) MX2012009377A (enExample)
RU (1) RU2012139491A (enExample)
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JP2016531869A (ja) * 2013-09-25 2016-10-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ エチニル誘導体
JP2017527548A (ja) * 2014-08-13 2017-09-21 オークランド ユニサービシーズ リミティド トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用

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US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
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KR101532211B1 (ko) * 2014-04-30 2015-06-30 세종대학교산학협력단 Ampk 억제기능에 기반한 뇌졸중 치료용 약학적 조성물 및 방법
US10221172B2 (en) 2015-01-13 2019-03-05 Vanderbilt University Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US9980945B2 (en) 2015-01-13 2018-05-29 Vanderbilt University Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2016123629A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10227343B2 (en) 2015-01-30 2019-03-12 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US9987242B2 (en) 2015-05-05 2018-06-05 Northwestern University Treatment of Levodopa-induced Dyskinesias
CN104926745A (zh) * 2015-07-14 2015-09-23 佛山市赛维斯医药科技有限公司 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途
CN104974103A (zh) * 2015-07-14 2015-10-14 佛山市赛维斯医药科技有限公司 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途
WO2017034420A1 (en) 2015-08-27 2017-03-02 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
US10294222B2 (en) 2016-09-01 2019-05-21 Vanderbilt University Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10710997B2 (en) 2016-09-01 2020-07-14 Vanderbilt University Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11242342B2 (en) 2016-11-08 2022-02-08 Vanderbilt University Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2018089546A1 (en) 2016-11-08 2018-05-17 Vanderbilt University Isoquinoline ether compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11319304B2 (en) 2017-06-28 2022-05-03 Vanderbilt University Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
PE20200756A1 (es) 2017-08-16 2020-07-27 Univ Vanderbilt Compuestos de indazol como potenciadores alostericos mglur4, composiciones y metodos de tratamiento de la disfuncion neurologica
TW202039481A (zh) 2018-12-21 2020-11-01 美商西建公司 Ripk2之噻吩并吡啶抑制劑
CA3140170A1 (en) 2019-06-04 2020-12-10 Belew Mekonnen Imidazolo derivatives, compositions and methods as orexin antagonists

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JPN6014052033; Ｒｏｘａｎｎｅ　Ｋ．　Ｋｕｎｚ，　ｅｔ　ａｌ．，: 'Ｄｉｓｃｏｖｅｒｙ　ｏｆ　ａｍｉｄｏ-ｂｅｎｚｉｓｏｘａｚｏｌｅｓ　ａｓ　ｐｏｔｅｎｔ　ｃ-Ｋｉｔ　ｉｎｈｉｂｉｔｏｒｓ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．１８，　Ｎｏ．１８, 2008, ｐｐ．５１１５-５１１７ *
JPN6014052035; Ｌｉｎａ　Ｌｉ，　ｅｔ　ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｅｖａｌｕａｔｉｏｎ　ｏｆ　ｂｅｎｚｏ［ｂ］ｔｈｉｏｐｈｅｎｅ　ｄｅｒｉｖａｔｉｖｅｓ　ａｓ　ｉｎｈｉｂｉｔｏｒｓ　ｏｆ　ａｌｋａｌｉｎｅ　ｐｈｏｓｐｈａｔａｓｅｓ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７，　Ｎｏ．２０, 2009, ｐｐ．７２９０-７３００ *
JPN6014052036; Ｊｏｈｎ　Ｔ．　Ｓｈｅｅｈａｎ，　ｅｔ　ａｌ．: 'Ｔｈｉｅｎｏ［３，２-ｂ］ｐｙｒｉｄｉｎｅ．　ＩＩ．　Ｔｈｅ　ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｓｏｍｅ　ｄｉａｌｋｙｌａｍｉｎｏａｌｋｙｌ　ｄｅｒｉｖａｔｉｖｅｓ　ｏｆ　ａｎ　Ｓ-ｉｓｏｓｔｅｒｉｃ　８' Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．７４, 1952, ｐｐ．５５０４-５５０５ *
JPN6014052037; Ｍａｒｉａ-Ｊｏａｏ　Ｒ．　Ｐ．　Ｑｕｅｉｒｏｚ，: 'Ｐａｌｌａｄｉｕｍ-ｃａｔａｌｙｓｅｄ　ａｍｉｎａｔｉｏｎ　ｏｆ　ｅｌｅｃｔｒｏｎ-ｄｅｆｉｃｉｅｎｔ　ｏｒ　ｒｅｌａｔｉｖｅｌｙ　ｅｌｅｃｔｒｏｎ-ｒｉｃｈ　ｂｅｎｚｏ［ｂ］ｔｈｉｅｎｙｌ　ｂｒｏｍ' Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７, 2004, ｐｐ．３６７９-３６８５ *
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JPN6014052041; Ｅｍｉｌｉｅ　Ｄａｖｉｄ，　ｅｔ　ａｌ．: 'Ｅｆｆｉｃｉｅｎｔ　Ａｃｃｅｓｓ　ｔｏ　２-Ａｒｙｌ-３-Ｓｕｂｓｔｉｔｕｔｅｄ　Ｂｅｎｚｏ［ｂ］ｔｈｉｏｐｈｅｎｅｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７０，　Ｎｏ．９, 2005, ｐ．３５６９-３５７３ *
JPN6014052043; Ｉｓａｂｅｌ　Ｃ．　Ｆ．　Ｒ．　Ｆｅｒｒｅｉｒａ，　ｅｔ　ａｌ．: 'Ｐａｌｌａｄｉｕｍ-ｃａｔａｌｙｚｅｄ　ａｍｉｎａｔｉｏｎ　ａｎｄ　ｃｙｃｌｉｚａｔｉｏｎ　ｔｏ　ｈｅｔｅｒｏａｎｎｅｌａｔｅｄ　ｉｎｄｏｌｅｓ　ａｎｄ　ｃａｒｂａｚｏｌｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５９，　Ｎｏ．２１, 2003, ｐｐ．３７３７-３７４３ *
JPN6014052045; Ｆｕｙａｏ　Ｚｈａｎｇ，　ｅｔ　ａｌ．: 'Ｅｆｆｉｃｉｅｎｔ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　３-ｏｘｙｇｅｎａｔｅｄ　ｂｅｎｚｏｔｈｉｏｐｈｅｎｅ　ｄｅｒｉｖａｔｉｖｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ Ｖｏｌ．４８，　Ｎｏ．１３, 2007, ｐｐ．２３４９-２３５２ *
JPN6014052047; Ｍａｒｋ　Ｄ．　Ｃｈａｒｌｅｓ，　ｅｔ　ａｌ．: 'Ｅｆｆｉｃｉｅｎｔ　Ｐｄ-Ｃａｔａｌｙｚｅｄ　Ａｍｉｎａｔｉｏｎ　ｏｆ　Ｈｅｔｅｒｏａｒｙｌ　Ｈａｌｉｄｅｓ' Ｏｒｇａｎｉｃ　Ｌｅｔｔｅｒｓ Ｖｏｌ．７，　Ｎｏ．１８, 2005, ｐｐ．３９６５-３９６８ *

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JP2016531869A (ja) * 2013-09-25 2016-10-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ エチニル誘導体
JP2017527548A (ja) * 2014-08-13 2017-09-21 オークランド ユニサービシーズ リミティド トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用
JP2021006579A (ja) * 2014-08-13 2021-01-21 オークランド ユニサービシーズ リミティド トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用
JP7323985B2 (ja) 2014-08-13 2023-08-09 オークランド ユニサービシーズ リミティド トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用

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