JP2013518574A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013518574A5 JP2013518574A5 JP2012551627A JP2012551627A JP2013518574A5 JP 2013518574 A5 JP2013518574 A5 JP 2013518574A5 JP 2012551627 A JP2012551627 A JP 2012551627A JP 2012551627 A JP2012551627 A JP 2012551627A JP 2013518574 A5 JP2013518574 A5 JP 2013518574A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- cancer
- relative amount
- condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 29
- 238000000034 method Methods 0.000 claims 21
- 108010077544 Chromatin Proteins 0.000 claims 6
- 210000003483 chromatin Anatomy 0.000 claims 6
- 210000004962 mammalian cell Anatomy 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
- 102100024263 CD160 antigen Human genes 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 101710094296 CD160 antigen Proteins 0.000 claims 2
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 2
- 208000036626 Mental retardation Diseases 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 102100021494 Protein S100-P Human genes 0.000 claims 2
- 102100034906 Transmembrane 4 L6 family member 19 Human genes 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000007698 birth defect Effects 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 2
- 210000002449 bone cell Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002487 chromatin immunoprecipitation Methods 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 210000003292 kidney cell Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 108700039887 Essential Genes Proteins 0.000 claims 1
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 102100021186 Granulysin Human genes 0.000 claims 1
- 102300051372 Homeodomain-interacting protein kinase 3 isoform 1 Human genes 0.000 claims 1
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 1
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 1
- 101001040751 Homo sapiens Granulysin Proteins 0.000 claims 1
- 101600085189 Homo sapiens Homeodomain-interacting protein kinase 3 (isoform 1) Proteins 0.000 claims 1
- 101001022948 Homo sapiens LIM domain-binding protein 2 Proteins 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 101000821881 Homo sapiens Protein S100-P Proteins 0.000 claims 1
- 101000658571 Homo sapiens Transmembrane 4 L6 family member 19 Proteins 0.000 claims 1
- 102100035113 LIM domain-binding protein 2 Human genes 0.000 claims 1
- 101710109756 Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102000023159 Platelet Glycoprotein GPIb-IX Complex Human genes 0.000 claims 1
- 108010045766 Platelet Glycoprotein GPIb-IX Complex Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 101710122257 Protein S100-P Proteins 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 101710087263 Transmembrane 4 L6 family member 19 Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000002550 fecal effect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000004104 gestational diabetes Diseases 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 210000001138 tear Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10001121.2 | 2010-02-03 | ||
| EP10001121A EP2354242A1 (en) | 2010-02-03 | 2010-02-03 | Assay for determining the type and/or status of a cell based on the epigenetic pattern and the chromatin structure |
| PCT/EP2011/051601 WO2011095564A1 (en) | 2010-02-03 | 2011-02-03 | Assay for determining the type and/or status of a cell based on the epigenetic pattern and the chromatin structure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518574A JP2013518574A (ja) | 2013-05-23 |
| JP2013518574A5 true JP2013518574A5 (https=) | 2014-03-06 |
| JP5992338B2 JP5992338B2 (ja) | 2016-09-14 |
Family
ID=42154213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551627A Expired - Fee Related JP5992338B2 (ja) | 2010-02-03 | 2011-02-03 | エピジェネティックパターン及びクロマチン構造に基づいて細胞の型及び／又は状況を決定するアッセイ |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9840736B2 (https=) |
| EP (1) | EP2354242A1 (https=) |
| JP (1) | JP5992338B2 (https=) |
| WO (1) | WO2011095564A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170233807A1 (en) | 2008-12-16 | 2017-08-17 | Epiontis Gmbh | Epigenetic Markers for the Identification of Blood Sub-cells of Type 1 |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| HRP20151294T1 (hr) | 2010-04-05 | 2016-03-11 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| WO2014060483A1 (en) | 2012-10-17 | 2014-04-24 | Spatial Transcriptomics Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| JP6590790B2 (ja) * | 2013-04-19 | 2019-10-16 | エピオンティス ゲーエムベーハー | 生体サンプルにおける定量的細胞組成を特定する方法 |
| EP3013983B1 (en) | 2013-06-25 | 2023-02-15 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| DE202015000425U1 (de) * | 2015-01-23 | 2016-04-26 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Parabolrinnenkollektormodul, Parabolrinnenkollektormoduleinheit sowie solarthermisches Kraftwerk |
| US10774374B2 (en) | 2015-04-10 | 2020-09-15 | Spatial Transcriptomics AB and Illumina, Inc. | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| KR101781200B1 (ko) * | 2015-06-26 | 2017-09-22 | 차의과학대학교 산학협력단 | 비만 진단용 마커 tm4sf19 및 이를 이용한 방법 |
| EP3844304B1 (en) * | 2018-08-28 | 2024-10-02 | 10X Genomics, Inc. | Methods for generating spatially barcoded arrays |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| EP3894590B1 (en) | 2018-12-10 | 2025-10-22 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| WO2021133849A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| EP4081656A1 (en) | 2019-12-23 | 2022-11-02 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| CN115135984B (zh) | 2019-12-23 | 2025-12-23 | 10X基因组学有限公司 | 可逆固定试剂及其使用方法 |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
| EP4153775B1 (en) | 2020-05-22 | 2024-07-24 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| EP4553168A3 (en) | 2020-05-22 | 2025-08-27 | 10x Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| EP4165207B1 (en) | 2020-06-10 | 2024-09-25 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| EP4172362B1 (en) | 2020-06-25 | 2024-09-18 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| CN116057182A (zh) * | 2020-09-04 | 2023-05-02 | 10X基因组学有限公司 | 用于鉴定来自单细胞分区的多基因组特征数据中的细胞相关条形码的系统和方法 |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| CN112415198B (zh) * | 2020-11-20 | 2022-11-11 | 四川大学华西医院 | Gp1bb检测试剂在制备肺癌筛查试剂盒中的用途 |
| EP4729631A2 (en) | 2020-12-21 | 2026-04-22 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4428246B1 (en) | 2021-04-14 | 2025-12-24 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| EP4320271B1 (en) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4582555A3 (en) | 2021-06-03 | 2025-10-22 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| ES3011462T3 (en) | 2021-09-01 | 2025-04-07 | 10X Genomics Inc | Methods for blocking a capture probe on a spatial array |
| WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| WO2024102809A1 (en) | 2022-11-09 | 2024-05-16 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of multiple analytes in a biological sample |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US5849482A (en) | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US6090947A (en) | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
| US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| US6610489B2 (en) * | 2000-04-28 | 2003-08-26 | Sangamo Biosciences, Inc. | Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions |
| EP1824993A1 (en) | 2004-11-11 | 2007-08-29 | Garvan Institute Of Medical Research | Method of diagnosing cancer and reagents therefor |
| EP1748080A3 (en) * | 2005-03-11 | 2007-04-11 | Epiontis GmbH | Specific DNAs for epigenetic characterisation of cells and tissues |
| WO2006094836A2 (en) * | 2005-03-11 | 2006-09-14 | Epiontis Gmbh | Specific dnas for epigenetic characterisation of cells and tissues |
| CA2633544A1 (en) | 2005-12-13 | 2007-06-21 | Nimblegen Systems, Inc. | Method for identification and monitoring of epigenetic modifications |
| GB0700374D0 (en) * | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| EP2141245A1 (en) * | 2008-07-03 | 2010-01-06 | Ivana Türbachova | DNA methylation analysis of regulatory T cells through DNA-methylation analysis of the TSDR region of the gene foxP3 |
| WO2010074924A1 (en) * | 2008-12-23 | 2010-07-01 | University Of Utah Research Foundation | Identification and regulation of a novel dna demethylase system |
| PL2248913T3 (pl) * | 2009-04-28 | 2017-04-28 | Epiontis Gmbh | GNLY jako marker epigenetyczny do identyfikacji komórek naturalnej cytotoksyczności ekspresjonujących CD56 |
-
2010
- 2010-02-03 EP EP10001121A patent/EP2354242A1/en not_active Ceased
-
2011
- 2011-02-03 US US13/575,819 patent/US9840736B2/en active Active
- 2011-02-03 JP JP2012551627A patent/JP5992338B2/ja not_active Expired - Fee Related
- 2011-02-03 WO PCT/EP2011/051601 patent/WO2011095564A1/en not_active Ceased
-
2017
- 2017-07-27 US US15/661,585 patent/US20170327889A1/en not_active Abandoned
-
2022
- 2022-01-26 US US17/584,812 patent/US20220145390A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013518574A5 (https=) | ||
| Eggermann et al. | Imprinting disorders | |
| Santos et al. | A human autoimmune organoid model reveals IL-7 function in coeliac disease | |
| ES2615733T3 (es) | Métodos para el análisis masivo paralelo de ácidos nucleicos en células individuales | |
| Hou et al. | Risk factors for pregnancy-associated breast cancer: a report from the Nigerian Breast Cancer Study | |
| Mak et al. | MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis | |
| JP2017501694A5 (https=) | ||
| JP2013178260A5 (https=) | ||
| JP2010504530A5 (https=) | ||
| US20140370505A1 (en) | Saliva-derived measures of telomere abundance and sample collection device | |
| CN109462996A (zh) | 通过rnaset2诊断炎性肠病的方法 | |
| AU2012318734A1 (en) | Methods and devices for assessing risk to a putative offspring of developing a condition | |
| Sadras et al. | Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions | |
| Wang et al. | MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis | |
| Svensson et al. | MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients | |
| Li et al. | Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling | |
| Wedderburn et al. | Paediatric idiopathic inflammatory muscle disease | |
| Vinsland et al. | Cell atlas of the developing human meninges reveals a dura origin of meningioma | |
| ES2932803T3 (es) | Biomarcadores para el diagnóstico y/o pronóstico de fragilidad | |
| Ohkawa et al. | PAX3/7-FOXO1 fusion-negative alveolar rhabdomyosarcoma in Schuurs-Hoeijmakers syndrome | |
| KR20130031464A (ko) | 알츠하이머 치매의 조기 진단용 조성물 | |
| CN105039577B (zh) | Cyp2f1基因在骨关节炎诊治中的应用 | |
| Liu et al. | Reversing Immunosenescence with Senolytics to Enhance Tumor Immunotherapy | |
| ITPD20110324A1 (it) | Metodo per la rilevazione di galfa15 come marcatore tumorale nel carcinoma pancreatico | |
| Zoon et al. | Expansion of melanoma-specific lymphocytes in alternate gamma chain cytokines: gene expression variances between T cells and T-cell subsets exposed to IL-2 versus IL-7/15 |