JP2013518051A - 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト - Google Patents
長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト Download PDFInfo
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- JP2013518051A JP2013518051A JP2012550140A JP2012550140A JP2013518051A JP 2013518051 A JP2013518051 A JP 2013518051A JP 2012550140 A JP2012550140 A JP 2012550140A JP 2012550140 A JP2012550140 A JP 2012550140A JP 2013518051 A JP2013518051 A JP 2013518051A
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- benzimidazole
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US29691210P | 2010-01-21 | 2010-01-21 | |
| US61/296,912 | 2010-01-21 | ||
| PCT/US2011/022001 WO2011091225A2 (en) | 2010-01-21 | 2011-01-21 | Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect |
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| JP2015211447A Pending JP2016026206A (ja) | 2010-01-21 | 2015-10-28 | 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト |
| JP2017086952A Expired - Fee Related JP6466504B2 (ja) | 2010-01-21 | 2017-04-26 | 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト |
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| JP2017086952A Expired - Fee Related JP6466504B2 (ja) | 2010-01-21 | 2017-04-26 | 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト |
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| US (1) | US9889088B2 (https=) |
| EP (1) | EP2525793B1 (https=) |
| JP (3) | JP2013518051A (https=) |
| KR (1) | KR20120125305A (https=) |
| CN (1) | CN102770135A (https=) |
| AU (1) | AU2011207301A1 (https=) |
| BR (1) | BR112012018154A2 (https=) |
| CA (1) | CA2787573A1 (https=) |
| CL (1) | CL2012002038A1 (https=) |
| CO (1) | CO6592108A2 (https=) |
| IL (1) | IL221030A0 (https=) |
| MX (1) | MX2012008516A (https=) |
| RU (1) | RU2012134065A (https=) |
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| TW (1) | TW201141477A (https=) |
| WO (1) | WO2011091225A2 (https=) |
| ZA (1) | ZA201205470B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013016072A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
| CA2842866A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| US20130046003A1 (en) * | 2011-07-22 | 2013-02-21 | Mohammed I. Dibas | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating retinal diseases |
| WO2014159576A1 (en) * | 2013-03-14 | 2014-10-02 | Allergan, Inc. | Alpha-2 adrenergic agonist for treating intraocular pressure and ocular diseases through intravitreal and intracameral routes |
| TWI699205B (zh) * | 2014-12-12 | 2020-07-21 | 日商興和股份有限公司 | 用於預防或治療青光眼之藥物療法 |
| EP3647420B1 (en) | 2017-06-27 | 2023-08-23 | The University Of Tokyo | Probe and method for detecting transcript resulting from fusion gene and/or exon skipping |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
| PT4236932T (pt) * | 2020-11-02 | 2026-02-23 | Visus Therapeutics Inc | Composto degradante num medicamento |
| WO2023086878A1 (en) * | 2021-11-10 | 2023-05-19 | Visus Therapeutics, Inc. | Carbachol formulations to enhance anti-presbyopia effects |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004270A1 (en) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
| JPH09507216A (ja) * | 1993-12-17 | 1997-07-22 | ザ、プロクター、エンド、ギャンブル、カンパニー | ５−（２−イミダゾリニルアミノ）ベンゾイミダゾール誘導体、それらの製法及びα−２−アドレノセプター作動剤としてのそれらの用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495583B1 (en) * | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| JP2009500409A (ja) * | 2005-06-29 | 2009-01-08 | アラーガン、インコーポレイテッド | 痛みを処置するためのα２アドレナリン作動剤 |
| JP2009525970A (ja) * | 2006-02-06 | 2009-07-16 | ニコックス エス エイ | α２−アドレナリン受容体アゴニストとしてのアプラクロニジンおよびブリモドニジンのニトロオキシ含有誘導体 |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
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2011
- 2011-01-21 BR BR112012018154A patent/BR112012018154A2/pt not_active IP Right Cessation
- 2011-01-21 AU AU2011207301A patent/AU2011207301A1/en not_active Abandoned
- 2011-01-21 SG SG2012053815A patent/SG182637A1/en unknown
- 2011-01-21 US US13/010,958 patent/US9889088B2/en not_active Expired - Fee Related
- 2011-01-21 MX MX2012008516A patent/MX2012008516A/es unknown
- 2011-01-21 TW TW100102411A patent/TW201141477A/zh unknown
- 2011-01-21 RU RU2012134065/15A patent/RU2012134065A/ru unknown
- 2011-01-21 JP JP2012550140A patent/JP2013518051A/ja active Pending
- 2011-01-21 CA CA2787573A patent/CA2787573A1/en not_active Abandoned
- 2011-01-21 WO PCT/US2011/022001 patent/WO2011091225A2/en not_active Ceased
- 2011-01-21 KR KR1020127021719A patent/KR20120125305A/ko not_active Withdrawn
- 2011-01-21 EP EP11702342.4A patent/EP2525793B1/en not_active Not-in-force
- 2011-01-21 CN CN2011800111530A patent/CN102770135A/zh active Pending
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2012
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- 2012-07-20 CL CL2012002038A patent/CL2012002038A1/es unknown
- 2012-07-20 ZA ZA2012/05470A patent/ZA201205470B/en unknown
- 2012-08-17 CO CO12140238A patent/CO6592108A2/es not_active Application Discontinuation
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2015
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2017
- 2017-04-26 JP JP2017086952A patent/JP6466504B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09507216A (ja) * | 1993-12-17 | 1997-07-22 | ザ、プロクター、エンド、ギャンブル、カンパニー | ５−（２−イミダゾリニルアミノ）ベンゾイミダゾール誘導体、それらの製法及びα−２−アドレノセプター作動剤としてのそれらの用途 |
| WO1996004270A1 (en) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012008516A (es) | 2012-10-15 |
| JP2017125074A (ja) | 2017-07-20 |
| EP2525793B1 (en) | 2018-09-05 |
| US9889088B2 (en) | 2018-02-13 |
| ZA201205470B (en) | 2013-05-29 |
| CO6592108A2 (es) | 2013-01-02 |
| RU2012134065A (ru) | 2014-02-27 |
| CN102770135A (zh) | 2012-11-07 |
| BR112012018154A2 (pt) | 2016-04-05 |
| CL2012002038A1 (es) | 2012-11-16 |
| AU2011207301A1 (en) | 2012-08-09 |
| SG182637A1 (en) | 2012-08-30 |
| IL221030A0 (en) | 2012-09-24 |
| CA2787573A1 (en) | 2011-07-28 |
| TW201141477A (en) | 2011-12-01 |
| JP6466504B2 (ja) | 2019-02-06 |
| US20110178145A1 (en) | 2011-07-21 |
| WO2011091225A3 (en) | 2012-05-18 |
| EP2525793A2 (en) | 2012-11-28 |
| JP2016026206A (ja) | 2016-02-12 |
| KR20120125305A (ko) | 2012-11-14 |
| WO2011091225A2 (en) | 2011-07-28 |
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