JP2013512866A - アピコンプレクサFerlin、Ferlin様タンパク質、及び他のC2ドメイン含有タンパク質に基づくマラリアワクチン - Google Patents

アピコンプレクサFerlin、Ferlin様タンパク質、及び他のC2ドメイン含有タンパク質に基づくマラリアワクチン Download PDF

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Publication number
JP2013512866A
JP2013512866A JP2012541362A JP2012541362A JP2013512866A JP 2013512866 A JP2013512866 A JP 2013512866A JP 2012541362 A JP2012541362 A JP 2012541362A JP 2012541362 A JP2012541362 A JP 2012541362A JP 2013512866 A JP2013512866 A JP 2013512866A
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Prior art keywords
ferlin
protein
epitope
apicomplexer
peptide
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Japanese (ja)
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JP2013512866A5 (cg-RX-API-DMAC7.html
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ミュラー,アン−クリスティン
モラート,エーファ
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Universitaet Heidelberg
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Universitaet Heidelberg
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/002Protozoa antigens
    • A61K39/015Hemosporidia antigens, e.g. Plasmodium antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6075Viral proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012541362A 2009-12-05 2010-12-06 アピコンプレクサFerlin、Ferlin様タンパク質、及び他のC2ドメイン含有タンパク質に基づくマラリアワクチン Pending JP2013512866A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26702609P 2009-12-05 2009-12-05
US61/267,026 2009-12-05
PCT/EP2010/007399 WO2011066995A1 (en) 2009-12-05 2010-12-06 Malaria vaccines based on apicomplexan ferlins, ferlin-like proteins and other c2-domain containing proteins

Publications (2)

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JP2013512866A true JP2013512866A (ja) 2013-04-18
JP2013512866A5 JP2013512866A5 (cg-RX-API-DMAC7.html) 2017-01-26

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JP2012541362A Pending JP2013512866A (ja) 2009-12-05 2010-12-06 アピコンプレクサFerlin、Ferlin様タンパク質、及び他のC2ドメイン含有タンパク質に基づくマラリアワクチン

Country Status (8)

Country Link
US (1) US8968750B2 (cg-RX-API-DMAC7.html)
EP (1) EP2507259B1 (cg-RX-API-DMAC7.html)
JP (1) JP2013512866A (cg-RX-API-DMAC7.html)
CN (1) CN102781958B (cg-RX-API-DMAC7.html)
BR (1) BR112012013581A8 (cg-RX-API-DMAC7.html)
CA (1) CA2783107C (cg-RX-API-DMAC7.html)
MX (1) MX2012006458A (cg-RX-API-DMAC7.html)
WO (1) WO2011066995A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017210441A (ja) * 2016-05-26 2017-11-30 国立大学法人大阪大学 マラリアワクチン

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076157A2 (en) 2010-12-06 2012-06-14 Ruprecht-Karls-Universität Heidelberg Malaria vaccines based on pre-erythrocytic antigens from p. falciparum
ES2847930T3 (es) 2013-01-07 2021-08-04 Mucosal Vaccine Tech Llc Vacunas terapéuticas para el tratamiento de las infecciones por el virus del herpes simple de tipo 2
TWI790593B (zh) 2014-08-19 2023-01-21 美商默沙東有限責任公司 抗tigit抗體
CN108290936B (zh) * 2015-08-14 2022-07-12 默沙东公司 抗tigit抗体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09510877A (ja) * 1994-03-31 1997-11-04 アイシス・イノベーション・リミテッド マラリアペプチド
WO2004037856A2 (en) * 2002-10-25 2004-05-06 Institut Pasteur Plasmodium falciparum virulence factor var o
WO2004078099A2 (en) * 2003-03-03 2004-09-16 Pevion Biotech Ltd. Compositions and methods for the generation of protective immune response against malaria
WO2005063804A1 (en) * 2003-12-30 2005-07-14 Københavns Universitet Panum Compounds useful in the diagnosis and treatment of malaria
WO2009082440A2 (en) * 2007-12-18 2009-07-02 Vaxinnate Corporation Compositions of toll-like receptor agonists and malaria antigens and methods of use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US5198334A (en) * 1989-07-21 1993-03-30 Terumo Corporation Protection of natural killer cell cytolytic activity in peripheral blood mononuclear cells
JP2001509813A (ja) * 1997-01-21 2001-07-24 ニューヨーク ユニヴァーシティ 抗マラリアワクチン用ユニバーサルt細胞エピトープ
US20030077653A1 (en) * 2000-04-20 2003-04-24 The University Of Georgia Research Foundation, Inc. Method for the identification of active site protease inactivators
US7811575B2 (en) * 2001-04-10 2010-10-12 Agensys, Inc. Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer
GB0210128D0 (en) * 2002-05-02 2002-06-12 Chiron Spa Nucleic acids and proteins from streptococcus groups A & B
CA2536819A1 (en) * 2003-08-26 2005-03-03 The Council Of The Queensland Institute Of Medical Research Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens including plasmodium spp
US7951782B2 (en) * 2005-09-29 2011-05-31 Maruha Nichiro Seafoods, Inc Composition effective to prevent or treat adult disease
GB0601059D0 (en) * 2006-01-19 2006-03-01 Univ Durham Target
US8343498B2 (en) * 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
WO2011085070A2 (en) * 2010-01-06 2011-07-14 Virginia Tech Intellectual Properties, Inc. Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts
WO2012076157A2 (en) * 2010-12-06 2012-06-14 Ruprecht-Karls-Universität Heidelberg Malaria vaccines based on pre-erythrocytic antigens from p. falciparum

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09510877A (ja) * 1994-03-31 1997-11-04 アイシス・イノベーション・リミテッド マラリアペプチド
WO2004037856A2 (en) * 2002-10-25 2004-05-06 Institut Pasteur Plasmodium falciparum virulence factor var o
WO2004078099A2 (en) * 2003-03-03 2004-09-16 Pevion Biotech Ltd. Compositions and methods for the generation of protective immune response against malaria
WO2005063804A1 (en) * 2003-12-30 2005-07-14 Københavns Universitet Panum Compounds useful in the diagnosis and treatment of malaria
WO2009082440A2 (en) * 2007-12-18 2009-07-02 Vaxinnate Corporation Compositions of toll-like receptor agonists and malaria antigens and methods of use

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
JPN6015004114; Trends in Parasitology 24, 2, 2007, p.74-84 *
JPN6015004117; Infection and Immunity 75, 12, 2007, p.5947-5955 *
JPN6015004120; Phil. Trans. R. Soc. Lond. B 357, 2002, p.25-33 *
JPN6015004124; Science 307, 2005, p.82-86 *
JPN6015004127; Nature 419, 2002, p.498-511 *
JPN6015004130; Nature 419, 2002, p.512-519 *
JPN6015004136; Journal of the Neurological Sciences 260, 2007, p.114-123 *
JPN6015004138; Trends in Cell Biology 14, 4, 2004, p.206-213 *
JPN6015053142; NCBI[online], Accession No. XM_001348668, <URL: http://www.ncbi.nlm.nih.gov/nuccore/124809863?sat=13 *
JPN7015000319; EMBL/GenBank/DDBJ databases , 200803 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017210441A (ja) * 2016-05-26 2017-11-30 国立大学法人大阪大学 マラリアワクチン

Also Published As

Publication number Publication date
EP2507259B1 (en) 2016-08-24
BR112012013581A8 (pt) 2017-12-26
CN102781958B (zh) 2017-07-11
US8968750B2 (en) 2015-03-03
MX2012006458A (es) 2012-09-07
CA2783107C (en) 2018-08-07
WO2011066995A1 (en) 2011-06-09
BR112012013581A2 (pt) 2017-01-10
CN102781958A (zh) 2012-11-14
CA2783107A1 (en) 2011-06-09
US20120308598A1 (en) 2012-12-06
EP2507259A1 (en) 2012-10-10

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