JP2013511559A - 上皮成長因子受容体リガンドのモジュレーション - Google Patents

上皮成長因子受容体リガンドのモジュレーション Download PDF

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JP2013511559A
JP2013511559A JP2012540228A JP2012540228A JP2013511559A JP 2013511559 A JP2013511559 A JP 2013511559A JP 2012540228 A JP2012540228 A JP 2012540228A JP 2012540228 A JP2012540228 A JP 2012540228A JP 2013511559 A JP2013511559 A JP 2013511559A
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mirna
mir
expression
activity
egfr ligand
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JP2012540228A
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Japanese (ja)
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JP2013511559A5 (OSRAM
Inventor
ジェフリー リードマン,ピーター
マイケル ジャイルズ,キース
カリス カリノウスキ,フェリシティー
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University of Western Australia
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University of Western Australia
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Priority claimed from AU2009905758A external-priority patent/AU2009905758A0/en
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Publication of JP2013511559A publication Critical patent/JP2013511559A/ja
Publication of JP2013511559A5 publication Critical patent/JP2013511559A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012540228A 2009-11-24 2010-11-24 上皮成長因子受容体リガンドのモジュレーション Pending JP2013511559A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009905758 2009-11-24
AU2009905758A AU2009905758A0 (en) 2009-11-24 Method of Modulating Epidermal Growth Factor (EGF) Ligands
PCT/AU2010/001577 WO2011063455A1 (en) 2009-11-24 2010-11-24 Modulation of epidermal growth factor receptor ligands

Publications (2)

Publication Number Publication Date
JP2013511559A true JP2013511559A (ja) 2013-04-04
JP2013511559A5 JP2013511559A5 (OSRAM) 2014-01-16

Family

ID=44065735

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012540229A Pending JP2013511560A (ja) 2009-11-24 2010-11-24 チロシンキナーゼインヒビターに対する感受性を増加する方法と組成物
JP2012540228A Pending JP2013511559A (ja) 2009-11-24 2010-11-24 上皮成長因子受容体リガンドのモジュレーション

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2012540229A Pending JP2013511560A (ja) 2009-11-24 2010-11-24 チロシンキナーゼインヒビターに対する感受性を増加する方法と組成物

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Country Link
US (2) US9051551B2 (OSRAM)
EP (2) EP2521555B1 (OSRAM)
JP (2) JP2013511560A (OSRAM)
CN (2) CN102762214A (OSRAM)
AU (2) AU2010324529A1 (OSRAM)
CA (2) CA2781572A1 (OSRAM)
DK (1) DK2521555T3 (OSRAM)
ES (1) ES2608923T3 (OSRAM)
WO (2) WO2011063456A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2534302T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
EP2591106A1 (en) * 2010-07-06 2013-05-15 InteRNA Technologies B.V. Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CN104160038B (zh) * 2011-11-25 2018-06-12 国家健康科学研究所 一种用于预测对采用egfr抑制剂的治疗的响应性的方法
FR2984168B1 (fr) * 2011-12-19 2019-07-05 Chanel Parfums Beaute Micro-rna pour leur utilisation dans la pigmentation
US20150126621A1 (en) * 2012-05-15 2015-05-07 New York University METHOD FOR PREDICTING RECURRENCE OF MELANOMA USING miRNA ALTERATIONS
US9795626B2 (en) 2012-10-18 2017-10-24 The University Of Western Australia Cancer therapy using miRNAs
BR112015023439A2 (pt) * 2013-03-15 2017-07-18 Mirna Therapeutics Inc combinação de tratamentos de câncer utilizando micrornas e inibidores egfr-tki
US20140308274A1 (en) * 2013-03-15 2014-10-16 Mirna Therapeutics, Inc. Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors
CA2919477A1 (en) 2013-07-31 2015-02-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules
CN108537001B (zh) * 2018-04-12 2021-06-01 华中科技大学鄂州工业技术研究院 一种预测用于治疗肝癌的特异性治疗药物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025073A1 (en) * 2006-08-28 2008-03-06 The University Of Western Australia Method of modulation of expression of epidermal growth factor receptor (egfr) involving mirna

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008511678A (ja) * 2004-09-02 2008-04-17 イェール ユニバーシティ マイクロrnaによるオンコジーンの調節
ES2534302T3 (es) * 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
AU2007333109A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro RNAs
US20100173954A1 (en) * 2007-01-19 2010-07-08 Bayer Healthcare Llc Treatment of cancers having resistance to chemotherapeutic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025073A1 (en) * 2006-08-28 2008-03-06 The University Of Western Australia Method of modulation of expression of epidermal growth factor receptor (egfr) involving mirna

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6014049516; J.BIOL.CHEM. VOL.284, NO.9, 20090227, P.5731-5741 *
JPN6014049519; CANCER RES. VOL.68, NO.10, 2008, P.3566-3572 *

Also Published As

Publication number Publication date
EP2521555A1 (en) 2012-11-14
EP2521555A4 (en) 2013-08-07
ES2608923T3 (es) 2017-04-17
US20130116299A1 (en) 2013-05-09
AU2010324530A1 (en) 2012-07-19
DK2521555T3 (en) 2017-01-09
JP2013511560A (ja) 2013-04-04
AU2010324530B2 (en) 2016-12-15
EP2504014A1 (en) 2012-10-03
EP2521555B1 (en) 2016-09-28
CA2781572A1 (en) 2011-06-03
CN102762213A (zh) 2012-10-31
AU2010324529A1 (en) 2012-07-19
WO2011063455A1 (en) 2011-06-03
EP2504014A4 (en) 2013-04-17
US9051551B2 (en) 2015-06-09
CA2781571A1 (en) 2011-06-03
CN102762214A (zh) 2012-10-31
US20130090366A1 (en) 2013-04-11
WO2011063456A1 (en) 2011-06-03

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