JP2013510899A5 - - Google Patents
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- Publication number
- JP2013510899A5 JP2013510899A5 JP2012539450A JP2012539450A JP2013510899A5 JP 2013510899 A5 JP2013510899 A5 JP 2013510899A5 JP 2012539450 A JP2012539450 A JP 2012539450A JP 2012539450 A JP2012539450 A JP 2012539450A JP 2013510899 A5 JP2013510899 A5 JP 2013510899A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- cancer
- alkyl
- alkoxy
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 6
- -1 hydroxy, amino Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006143 Brain stem glioma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000007641 Pinealoma Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 230000001886 ciliary effect Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000024724 pineal body neoplasm Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 206010060971 Astrocytoma malignant Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 201000007335 cerebellar astrocytoma Diseases 0.000 claims 1
- 208000030239 cerebral astrocytoma Diseases 0.000 claims 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000003115 germ cell cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000002267 hypothalamic effect Effects 0.000 claims 1
- 208000030883 malignant astrocytoma Diseases 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000008205 supratentorial primitive neuroectodermal tumor Diseases 0.000 claims 1
- 210000000239 visual pathway Anatomy 0.000 claims 1
- 230000004400 visual pathway Effects 0.000 claims 1
- 0 C=*(CC1)C*1=C Chemical compound C=*(CC1)C*1=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26185609P | 2009-11-17 | 2009-11-17 | |
| US61/261,856 | 2009-11-17 | ||
| PCT/IB2010/055161 WO2011061666A1 (en) | 2009-11-17 | 2010-11-15 | Macrocyclic lactone derivatives for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013510899A JP2013510899A (ja) | 2013-03-28 |
| JP2013510899A5 true JP2013510899A5 (OSRAM) | 2014-01-30 |
Family
ID=43566625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539450A Pending JP2013510899A (ja) | 2009-11-17 | 2010-11-15 | 癌治療のための大環状ラクトン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8637683B2 (OSRAM) |
| EP (1) | EP2501689A1 (OSRAM) |
| JP (1) | JP2013510899A (OSRAM) |
| KR (1) | KR20120092677A (OSRAM) |
| CN (1) | CN102666523A (OSRAM) |
| AU (1) | AU2010320557A1 (OSRAM) |
| CA (1) | CA2792198A1 (OSRAM) |
| IL (1) | IL219807A0 (OSRAM) |
| MX (1) | MX2012005618A (OSRAM) |
| NZ (1) | NZ600660A (OSRAM) |
| RU (1) | RU2012124817A (OSRAM) |
| WO (1) | WO2011061666A1 (OSRAM) |
| ZA (1) | ZA201204488B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2501378A1 (en) * | 2009-11-17 | 2012-09-26 | Veera, Swati | Use of macrocyclic lactone derivatives for the treatment of inflammatory disorders |
| WO2014118740A1 (en) * | 2013-02-04 | 2014-08-07 | Piramal Enterprises Limited | Macrocyclic lactone derivatives and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9504617D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Ab | Active compounds II |
| EP2501378A1 (en) * | 2009-11-17 | 2012-09-26 | Veera, Swati | Use of macrocyclic lactone derivatives for the treatment of inflammatory disorders |
-
2010
- 2010-11-15 CA CA2792198A patent/CA2792198A1/en not_active Abandoned
- 2010-11-15 CN CN201080057594XA patent/CN102666523A/zh active Pending
- 2010-11-15 EP EP10798188A patent/EP2501689A1/en not_active Withdrawn
- 2010-11-15 RU RU2012124817/04A patent/RU2012124817A/ru not_active Application Discontinuation
- 2010-11-15 KR KR1020127015787A patent/KR20120092677A/ko not_active Withdrawn
- 2010-11-15 NZ NZ600660A patent/NZ600660A/en not_active IP Right Cessation
- 2010-11-15 MX MX2012005618A patent/MX2012005618A/es not_active Application Discontinuation
- 2010-11-15 US US13/510,458 patent/US8637683B2/en not_active Expired - Fee Related
- 2010-11-15 AU AU2010320557A patent/AU2010320557A1/en not_active Abandoned
- 2010-11-15 WO PCT/IB2010/055161 patent/WO2011061666A1/en not_active Ceased
- 2010-11-15 JP JP2012539450A patent/JP2013510899A/ja active Pending
-
2012
- 2012-05-15 IL IL219807A patent/IL219807A0/en unknown
- 2012-06-18 ZA ZA2012/04488A patent/ZA201204488B/en unknown
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