JP2013510899A - 癌治療のための大環状ラクトン誘導体 - Google Patents
癌治療のための大環状ラクトン誘導体 Download PDFInfo
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- JP2013510899A JP2013510899A JP2012539450A JP2012539450A JP2013510899A JP 2013510899 A JP2013510899 A JP 2013510899A JP 2012539450 A JP2012539450 A JP 2012539450A JP 2012539450 A JP2012539450 A JP 2012539450A JP 2013510899 A JP2013510899 A JP 2013510899A
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
- MPMSZXWCZKCHLQ-UHFFFAOYSA-N trihydridoiodine Chemical compound [H]I([H])[H] MPMSZXWCZKCHLQ-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26185609P | 2009-11-17 | 2009-11-17 | |
| US61/261,856 | 2009-11-17 | ||
| PCT/IB2010/055161 WO2011061666A1 (en) | 2009-11-17 | 2010-11-15 | Macrocyclic lactone derivatives for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013510899A true JP2013510899A (ja) | 2013-03-28 |
| JP2013510899A5 JP2013510899A5 (enExample) | 2014-01-30 |
Family
ID=43566625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539450A Pending JP2013510899A (ja) | 2009-11-17 | 2010-11-15 | 癌治療のための大環状ラクトン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8637683B2 (enExample) |
| EP (1) | EP2501689A1 (enExample) |
| JP (1) | JP2013510899A (enExample) |
| KR (1) | KR20120092677A (enExample) |
| CN (1) | CN102666523A (enExample) |
| AU (1) | AU2010320557A1 (enExample) |
| CA (1) | CA2792198A1 (enExample) |
| IL (1) | IL219807A0 (enExample) |
| MX (1) | MX2012005618A (enExample) |
| NZ (1) | NZ600660A (enExample) |
| RU (1) | RU2012124817A (enExample) |
| WO (1) | WO2011061666A1 (enExample) |
| ZA (1) | ZA201204488B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013510900A (ja) * | 2009-11-17 | 2013-03-28 | ピラマル・ライフ・サイエンシーズ・リミテッド | 炎症性疾患治療のための大環状ラクトン誘導体の使用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014118740A1 (en) * | 2013-02-04 | 2014-08-07 | Piramal Enterprises Limited | Macrocyclic lactone derivatives and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997023475A1 (en) * | 1995-12-22 | 1997-07-03 | Astra Aktiebolag | Active compounds ii |
| JP2013510900A (ja) * | 2009-11-17 | 2013-03-28 | ピラマル・ライフ・サイエンシーズ・リミテッド | 炎症性疾患治療のための大環状ラクトン誘導体の使用 |
-
2010
- 2010-11-15 KR KR1020127015787A patent/KR20120092677A/ko not_active Withdrawn
- 2010-11-15 JP JP2012539450A patent/JP2013510899A/ja active Pending
- 2010-11-15 CA CA2792198A patent/CA2792198A1/en not_active Abandoned
- 2010-11-15 WO PCT/IB2010/055161 patent/WO2011061666A1/en not_active Ceased
- 2010-11-15 EP EP10798188A patent/EP2501689A1/en not_active Withdrawn
- 2010-11-15 CN CN201080057594XA patent/CN102666523A/zh active Pending
- 2010-11-15 RU RU2012124817/04A patent/RU2012124817A/ru not_active Application Discontinuation
- 2010-11-15 US US13/510,458 patent/US8637683B2/en not_active Expired - Fee Related
- 2010-11-15 AU AU2010320557A patent/AU2010320557A1/en not_active Abandoned
- 2010-11-15 MX MX2012005618A patent/MX2012005618A/es not_active Application Discontinuation
- 2010-11-15 NZ NZ600660A patent/NZ600660A/en not_active IP Right Cessation
-
2012
- 2012-05-15 IL IL219807A patent/IL219807A0/en unknown
- 2012-06-18 ZA ZA2012/04488A patent/ZA201204488B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997023475A1 (en) * | 1995-12-22 | 1997-07-03 | Astra Aktiebolag | Active compounds ii |
| JP2013510900A (ja) * | 2009-11-17 | 2013-03-28 | ピラマル・ライフ・サイエンシーズ・リミテッド | 炎症性疾患治療のための大環状ラクトン誘導体の使用 |
Non-Patent Citations (2)
| Title |
|---|
| JPN5013000497; ＨＡＲＵＹＡＳＵ ＫＩＮＡＳＨＩ: 'ＡＬＫＡＬＩＮＥ ＤＥＧＲＡＤＡＴＩＯＮ ＰＲＯＤＵＣＴＳ ＯＦ ＣＯＮＣＡＮＡＭＹＣＩＮ Ａ' ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ２２ Ｎ３９, 1981, Ｐ３８５７-３８６０ * |
| JPN5013000498; ＨＵＳＳ Ｍ．: 'ＩＮＨＩＢＩＴＯＲＳ ＯＦ Ｖ-ＡＴＰＡＳＥＳ： ＯＬＤ ＡＮＤ ＮＥＷ ＰＬＡＹＥＲＳ' ＪＯＵＲＮＡＬ ＯＦ ＥＸＰＥＲＩＭＥＮＴＡＬ ＢＩＯＬＯＧＹ Ｖ２１２ Ｎ３, 20090201, Ｐ３４１-３４６, ＣＯＭＰＡＮＹ ＯＦ ＢＩＯＬＯＧＩＳＴＳ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013510900A (ja) * | 2009-11-17 | 2013-03-28 | ピラマル・ライフ・サイエンシーズ・リミテッド | 炎症性疾患治療のための大環状ラクトン誘導体の使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8637683B2 (en) | 2014-01-28 |
| ZA201204488B (en) | 2014-08-27 |
| EP2501689A1 (en) | 2012-09-26 |
| RU2012124817A (ru) | 2013-12-27 |
| MX2012005618A (es) | 2012-08-15 |
| US20120245183A1 (en) | 2012-09-27 |
| IL219807A0 (en) | 2012-07-31 |
| AU2010320557A1 (en) | 2012-07-05 |
| KR20120092677A (ko) | 2012-08-21 |
| CA2792198A1 (en) | 2011-05-26 |
| NZ600660A (en) | 2014-02-28 |
| CN102666523A (zh) | 2012-09-12 |
| WO2011061666A1 (en) | 2011-05-26 |
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