JP2013508417A5 - - Google Patents
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- JP2013508417A5 JP2013508417A5 JP2012535441A JP2012535441A JP2013508417A5 JP 2013508417 A5 JP2013508417 A5 JP 2013508417A5 JP 2012535441 A JP2012535441 A JP 2012535441A JP 2012535441 A JP2012535441 A JP 2012535441A JP 2013508417 A5 JP2013508417 A5 JP 2013508417A5
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- JP
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- Prior art keywords
- carbons
- composition
- alkyl
- compound
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- Prior art date
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- 239000000203 mixture Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 150000002366 halogen compounds Chemical class 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 102000001307 androgen receptors Human genes 0.000 claims 5
- 108010080146 androgen receptors Proteins 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 125000005011 alkyl ether group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atoms Chemical group 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000005017 Glioblastoma Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 0 *[n]1c2ccccc2c2ccccc12 Chemical compound *[n]1c2ccccc2c2ccccc12 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 5
- DRELUPFLXXDYEO-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1C(Nc(cc1)ccc1NC(c(cc1)cc2c1OCCO2)=O)=O Chemical compound CC(C)(C)c(cc1)ccc1C(Nc(cc1)ccc1NC(c(cc1)cc2c1OCCO2)=O)=O DRELUPFLXXDYEO-UHFFFAOYSA-N 0.000 description 1
- JSICPNDQWXVALY-UHFFFAOYSA-N CCC[n]1c(ccc(C(C)=O)c2)c2c2ccccc12 Chemical compound CCC[n]1c(ccc(C(C)=O)c2)c2c2ccccc12 JSICPNDQWXVALY-UHFFFAOYSA-N 0.000 description 1
- AYTGARGOCPEHGL-UHFFFAOYSA-N Cc(cc1)cc2c1OCCO2 Chemical compound Cc(cc1)cc2c1OCCO2 AYTGARGOCPEHGL-UHFFFAOYSA-N 0.000 description 1
- VFCSCFYJARCXSF-UHFFFAOYSA-N Clc1c(C(N2)Nc3cccc4cccc2c34)cccc1 Chemical compound Clc1c(C(N2)Nc3cccc4cccc2c34)cccc1 VFCSCFYJARCXSF-UHFFFAOYSA-N 0.000 description 1
- BHQRPHQIVPXTCQ-XFFZJAGNSA-N O=C1N=C(Nc(cccc2Cl)c2Cl)S/C1=C\c1ccc[o]1 Chemical compound O=C1N=C(Nc(cccc2Cl)c2Cl)S/C1=C\c1ccc[o]1 BHQRPHQIVPXTCQ-XFFZJAGNSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25439509P | 2009-10-23 | 2009-10-23 | |
| US61/254,395 | 2009-10-23 | ||
| PCT/US2010/053916 WO2011050353A1 (en) | 2009-10-23 | 2010-10-25 | Method for treating androgen receptor positive cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508417A JP2013508417A (ja) | 2013-03-07 |
| JP2013508417A5 true JP2013508417A5 (US20080242721A1-20081002-C00053.png) | 2013-12-05 |
Family
ID=43900720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535441A Pending JP2013508417A (ja) | 2009-10-23 | 2010-10-25 | アンドロゲン受容体陽性癌を処置する方法 |
Country Status (15)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201291460A1 (ru) | 2010-05-28 | 2013-11-29 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Олигобензамидные соединения и их применение |
| WO2013023300A1 (en) * | 2011-08-15 | 2013-02-21 | The University Of British Columbia | Inhibitors of androgen receptor activation function-2 (af2) as therapeutics and methods for their use |
| US9708276B2 (en) | 2011-10-12 | 2017-07-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
| US8835493B2 (en) | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
| US8754124B2 (en) | 2011-11-23 | 2014-06-17 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| JP6138928B2 (ja) | 2012-06-01 | 2017-05-31 | ライプニッツ−インスティテュート フュア アルテルスフォルシュング−フリッツ−リップマン−インスティテュート エー．ファウ．（エフエルイー） | 医薬に使用されるｎｏｔｃｈシグナル伝達経路及び分泌の阻害物質 |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| EP3733170A1 (en) * | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| CN110845626A (zh) * | 2012-07-27 | 2020-02-28 | 阿拉贡药品公司 | 用于确定抵抗雄激素受体疗法的方法和组合物 |
| US20160024083A1 (en) * | 2013-03-14 | 2016-01-28 | Health Research, Inc. | Compounds and methods for treating cancers |
| WO2015042297A1 (en) * | 2013-09-20 | 2015-03-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compounds for treating prostate can cancer |
| US20160257657A1 (en) | 2013-09-20 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| US10980806B2 (en) | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
| ES2900149T3 (es) * | 2016-07-21 | 2022-03-16 | Hadasit Med Res Service | Combinaciones que comprenden antagonistas o inhibidores de AR para su uso en el tratamiento del glioblastoma |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224326A (en) * | 1978-09-21 | 1980-09-23 | Eli Lilly And Company | Immunosuppressive agents |
| AU626881B2 (en) | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| AU3846395A (en) | 1994-11-07 | 1996-05-31 | Janssen Pharmaceutica N.V. | Compositions comprising carbazoles and cyclodextrins |
| WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| KR20060130781A (ko) * | 2004-04-08 | 2006-12-19 | 토포타겟 에이/에스 | 다이페닐 인돌-2-온 화합물 및 암 치료에 있어서의 그의용도 |
| US20060003966A1 (en) * | 2004-06-16 | 2006-01-05 | Jack Arbiser | Carbazole formulations for the treatment of psoriasis and angiogenesis |
| GB0513702D0 (en) * | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| JP2009528383A (ja) * | 2006-03-02 | 2009-08-06 | スミスクライン・ビーチャム・コーポレイション | Ｐｉ３キナーゼ阻害剤として用いるためのチアゾロン |
| WO2008051523A2 (en) * | 2006-10-23 | 2008-05-02 | Georgetown University | Carbazole derivatives useful as medicaments in cancer therapy |
-
2010
- 2010-10-25 EA EA201290208A patent/EA201290208A1/ru unknown
- 2010-10-25 US US13/501,566 patent/US8835447B2/en not_active Expired - Fee Related
- 2010-10-25 CN CN2010800474879A patent/CN102573472A/zh active Pending
- 2010-10-25 AU AU2010310477A patent/AU2010310477A1/en not_active Abandoned
- 2010-10-25 WO PCT/US2010/053916 patent/WO2011050353A1/en active Application Filing
- 2010-10-25 AP AP2012006277A patent/AP2012006277A0/xx unknown
- 2010-10-25 CA CA2779309A patent/CA2779309A1/en not_active Abandoned
- 2010-10-25 MX MX2012004624A patent/MX2012004624A/es not_active Application Discontinuation
- 2010-10-25 GE GEAP201012711A patent/GEP20146138B/en unknown
- 2010-10-25 JP JP2012535441A patent/JP2013508417A/ja active Pending
- 2010-10-25 EP EP10825802.1A patent/EP2490531A4/en not_active Withdrawn
- 2010-10-25 KR KR1020127013113A patent/KR20120095402A/ko not_active Application Discontinuation
- 2010-10-25 BR BR112012009262A patent/BR112012009262A2/pt not_active IP Right Cessation
-
2012
- 2012-04-10 ZA ZA2012/02557A patent/ZA201202557B/en unknown
- 2012-04-22 IL IL219331A patent/IL219331A0/en unknown
