JP2013508349A5 - - Google Patents
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- Publication number
- JP2013508349A5 JP2013508349A5 JP2012534798A JP2012534798A JP2013508349A5 JP 2013508349 A5 JP2013508349 A5 JP 2013508349A5 JP 2012534798 A JP2012534798 A JP 2012534798A JP 2012534798 A JP2012534798 A JP 2012534798A JP 2013508349 A5 JP2013508349 A5 JP 2013508349A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- administered
- inhibitor
- compound according
- antiretroviral agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 229940124522 antiretrovirals Drugs 0.000 claims 4
- 239000003903 antiretrovirus agent Substances 0.000 claims 4
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- MGWQOOSAUWCOOU-UHFFFAOYSA-N 1-(3-fluorophenyl)pyrrole-2-carbaldehyde Chemical compound FC1=CC=CC(N2C(=CC=C2)C=O)=C1 MGWQOOSAUWCOOU-UHFFFAOYSA-N 0.000 claims 1
- NUBQKPWHXMGDLP-UHFFFAOYSA-N 1-[4-benzyl-2-hydroxy-5-[(2-hydroxy-2,3-dihydro-1h-inden-1-yl)amino]-5-oxopentyl]-n-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide;sulfuric acid Chemical compound OS(O)(=O)=O.C1CN(CC(O)CC(CC=2C=CC=CC=2)C(=O)NC2C3=CC=CC=C3CC2O)C(C(=O)NC(C)(C)C)CN1CC1=CC=CN=C1 NUBQKPWHXMGDLP-UHFFFAOYSA-N 0.000 claims 1
- NJQGRWPAQLGORO-DEOSSOPVSA-N 4-[[(2s)-2-benzamido-3-naphthalen-2-ylpropanoyl]amino]-n-hydroxybenzamide Chemical compound C1=CC(C(=O)NO)=CC=C1NC(=O)[C@@H](NC(=O)C=1C=CC=CC=1)CC1=CC=C(C=CC=C2)C2=C1 NJQGRWPAQLGORO-DEOSSOPVSA-N 0.000 claims 1
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 claims 1
- 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims 1
- 229960003804 efavirenz Drugs 0.000 claims 1
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 claims 1
- 229940125777 fusion inhibitor Drugs 0.000 claims 1
- -1 hydroxycarbamoyl-phenylcarbamoyl Chemical group 0.000 claims 1
- 229960004243 indinavir sulfate Drugs 0.000 claims 1
- 229940124524 integrase inhibitor Drugs 0.000 claims 1
- 239000002850 integrase inhibitor Substances 0.000 claims 1
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- VDVJGIYXDVPQLP-UHFFFAOYSA-N piperonylic acid Chemical compound OC(=O)C1=CC=C2OCOC2=C1 VDVJGIYXDVPQLP-UHFFFAOYSA-N 0.000 claims 1
- 229960003490 raltegravir potassium Drugs 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A001837A IT1396915B1 (it) | 2009-10-23 | 2009-10-23 | Dietil-[6-(4-idrossicarbamoil-fenil-carbamoilossimetil)-naftalen-2-il-metil]-ammonio cloruro ed altri derivati della n-idrossi-benzammide per l'uso nel trattamento di infezioni da hiv. |
| ITMI2009A001837 | 2009-10-23 | ||
| PCT/IB2010/054139 WO2011048514A1 (en) | 2009-10-23 | 2010-09-14 | Derivatives of n-hydroxybenzamide for treating hiv infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508349A JP2013508349A (ja) | 2013-03-07 |
| JP2013508349A5 true JP2013508349A5 (https=) | 2013-05-09 |
| JP5746196B2 JP5746196B2 (ja) | 2015-07-08 |
Family
ID=42153811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534798A Expired - Fee Related JP5746196B2 (ja) | 2009-10-23 | 2010-09-14 | Ｈｉｖ感染症を治療するためのｎ−ヒドロキシベンズアミドの誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8637702B2 (https=) |
| EP (1) | EP2490682A1 (https=) |
| JP (1) | JP5746196B2 (https=) |
| KR (1) | KR101687644B1 (https=) |
| CN (1) | CN102548551A (https=) |
| BR (1) | BR112012008780A2 (https=) |
| CA (1) | CA2773210C (https=) |
| IN (1) | IN2012DN03387A (https=) |
| IT (1) | IT1396915B1 (https=) |
| WO (1) | WO2011048514A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6272773B2 (ja) * | 2011-11-29 | 2018-01-31 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | Ｈｄａｃ６阻害剤・抗腫瘍剤用複素環アミド化合物 |
| CN107007580A (zh) | 2012-02-03 | 2017-08-04 | 意大发马克股份公司 | 用于治疗肌肉萎缩症的化合物 |
| IT201600074606A1 (it) * | 2016-07-18 | 2018-01-18 | Italfarmaco Spa | New benzo-N-hydroxy amide compounds having antitumor activity |
| US11149082B2 (en) | 2016-10-17 | 2021-10-19 | University Of Maryland, College Park | Multispecific antibodies targeting human immunodeficiency virus and methods of using the same |
| IT201900003281A1 (it) * | 2019-03-06 | 2020-09-06 | Chemi Spa | Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza |
| WO2022088047A1 (zh) * | 2020-10-30 | 2022-05-05 | 中国科学院深圳先进技术研究院 | Itf2357在制备预防和治疗冠状病毒的药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1283637B1 (it) | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| ITMI20030063A1 (it) | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. |
| JP2007529548A (ja) * | 2004-03-18 | 2007-10-25 | サマリタン，ファーマスーティカルス，インク． | 抗ｈｉｖベンズアミド化合物およびベンゾアート化合物 |
| ITMI20041347A1 (it) * | 2004-07-05 | 2004-10-05 | Italfarmaco Spa | Derivati di alfa-amminoacidi ad attivita'antiinfiammatoria |
| US20100324034A1 (en) | 2007-02-08 | 2010-12-23 | Hazuda Daria J | Methods of Using SAHA for Treating HIV Infection |
-
2009
- 2009-10-23 IT ITMI2009A001837A patent/IT1396915B1/it active
-
2010
- 2010-09-14 EP EP10771187A patent/EP2490682A1/en not_active Withdrawn
- 2010-09-14 JP JP2012534798A patent/JP5746196B2/ja not_active Expired - Fee Related
- 2010-09-14 WO PCT/IB2010/054139 patent/WO2011048514A1/en not_active Ceased
- 2010-09-14 US US13/393,863 patent/US8637702B2/en not_active Expired - Fee Related
- 2010-09-14 KR KR1020127007623A patent/KR101687644B1/ko not_active Expired - Fee Related
- 2010-09-14 IN IN3387DEN2012 patent/IN2012DN03387A/en unknown
- 2010-09-14 CA CA2773210A patent/CA2773210C/en not_active Expired - Fee Related
- 2010-09-14 CN CN2010800454818A patent/CN102548551A/zh active Pending
- 2010-09-14 BR BR112012008780-0A patent/BR112012008780A2/pt not_active Application Discontinuation
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