JP2013508293A - ５−ｆｕ又はそのプロドラッグと、ｄｐｄ阻害剤との組合せに付随した神経毒性の処置 - Google Patents
５−ｆｕ又はそのプロドラッグと、ｄｐｄ阻害剤との組合せに付随した神経毒性の処置 Download PDFInfo
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- JP2013508293A JP2013508293A JP2012534373A JP2012534373A JP2013508293A JP 2013508293 A JP2013508293 A JP 2013508293A JP 2012534373 A JP2012534373 A JP 2012534373A JP 2012534373 A JP2012534373 A JP 2012534373A JP 2013508293 A JP2013508293 A JP 2013508293A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| JP2015190757A Pending JP2016014051A (ja) | 2009-10-14 | 2015-09-29 | ５−ｆｕ又はそのプロドラッグと、ｄｐｄ阻害剤との組合せに付随した神経毒性の処置 |
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| WO2014089004A1 (en) * | 2012-12-04 | 2014-06-12 | Adherex Technologies, Inc. | Methods for treating 5-fluorouracil prodrug non-responsive cancer patients |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| EP4629999A1 (en) * | 2022-12-06 | 2025-10-15 | Elion Oncology, Inc. | Combined use of eniluracil and capecitabine for treating cancer |
| US20250017931A1 (en) * | 2023-07-13 | 2025-01-16 | Processa Pharmaceuticals, Inc., | Methods of personalizing cancer treatment |
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| JP2008521930A (ja) * | 2004-12-03 | 2008-06-26 | アドヘレックス テクノロジーズ， インコーポレイテッド | ５−ｆｕおよび５−ｆｕプロドラッグと併用してｄｐｄ阻害物質を投与するための方法 |
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| JPS5687599A (en) | 1979-12-19 | 1981-07-16 | Yamasa Shoyu Co Ltd | E 55 22halogenovinyl arabinofuranosyluracil and its preparation |
| GB8629892D0 (en) | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| US5157114A (en) | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
| ATE161722T1 (de) | 1990-07-19 | 1998-01-15 | Wellcome Found | Enzyminaktivatoren |
| GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
| US5476855A (en) | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| NZ330360A (en) | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20040028687A1 (en) | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
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- 2010-10-14 KR KR1020127012289A patent/KR20120127709A/ko not_active Withdrawn
- 2010-10-14 MX MX2012004383A patent/MX2012004383A/es not_active Application Discontinuation
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008521930A (ja) * | 2004-12-03 | 2008-06-26 | アドヘレックス テクノロジーズ， インコーポレイテッド | ５−ｆｕおよび５−ｆｕプロドラッグと併用してｄｐｄ阻害物質を投与するための方法 |
Non-Patent Citations (1)
| Title |
|---|
| SCHILSKY R L: "Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced c", JOURNAL OF CLINICAL ONCOLOGY, vol. V16 N4, JPN5007022016, April 1998 (1998-04-01), pages 1450 - 1457, ISSN: 0002926501 * |
Also Published As
| Publication number | Publication date |
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| ES2644237T3 (es) | 2017-11-28 |
| MX2012004383A (es) | 2012-08-23 |
| JP2016014051A (ja) | 2016-01-28 |
| BR112012008951A2 (pt) | 2019-09-24 |
| KR20120127709A (ko) | 2012-11-23 |
| AU2010306698B2 (en) | 2016-05-26 |
| AU2010306698A1 (en) | 2012-05-17 |
| CA2777546A1 (en) | 2011-04-21 |
| EA201270551A1 (ru) | 2012-12-28 |
| IL219179A0 (en) | 2012-06-28 |
| CO6541596A2 (es) | 2012-10-16 |
| CN102811721A (zh) | 2012-12-05 |
| US8658618B2 (en) | 2014-02-25 |
| CA2777546C (en) | 2019-11-05 |
| US20110130359A1 (en) | 2011-06-02 |
| WO2011047195A1 (en) | 2011-04-21 |
| EP2488182B1 (en) | 2017-07-19 |
| EP2488182A1 (en) | 2012-08-22 |
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