JP2013504577A5 - - Google Patents
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- Publication number
- JP2013504577A5 JP2013504577A5 JP2012528860A JP2012528860A JP2013504577A5 JP 2013504577 A5 JP2013504577 A5 JP 2013504577A5 JP 2012528860 A JP2012528860 A JP 2012528860A JP 2012528860 A JP2012528860 A JP 2012528860A JP 2013504577 A5 JP2013504577 A5 JP 2013504577A5
- Authority
- JP
- Japan
- Prior art keywords
- par
- antigen
- binding fragment
- human
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24078309P | 2009-09-09 | 2009-09-09 | |
| US61/240,783 | 2009-09-09 | ||
| US24282109P | 2009-09-16 | 2009-09-16 | |
| US61/242,821 | 2009-09-16 | ||
| US31783910P | 2010-03-26 | 2010-03-26 | |
| US61/317,839 | 2010-03-26 | ||
| PCT/US2010/048034 WO2011031695A1 (en) | 2009-09-09 | 2010-09-08 | High affinity human antibodies to human protease-activated receptor-2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015177339A Division JP6055055B2 (ja) | 2009-09-09 | 2015-09-09 | ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504577A JP2013504577A (ja) | 2013-02-07 |
| JP2013504577A5 true JP2013504577A5 (cg-RX-API-DMAC10.html) | 2013-09-05 |
| JP5832435B2 JP5832435B2 (ja) | 2015-12-16 |
Family
ID=43063654
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528860A Expired - Fee Related JP5832435B2 (ja) | 2009-09-09 | 2010-09-08 | ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体 |
| JP2015177339A Expired - Fee Related JP6055055B2 (ja) | 2009-09-09 | 2015-09-09 | ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015177339A Expired - Fee Related JP6055055B2 (ja) | 2009-09-09 | 2015-09-09 | ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体 |
Country Status (29)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3246B1 (ar) * | 2009-09-09 | 2018-03-08 | Regeneron Pharma | اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| AP2014007588A0 (en) * | 2011-09-22 | 2014-04-30 | Amgen Inc | CD27L antigen binding proteins |
| HK1223096A1 (zh) | 2013-09-25 | 2017-07-21 | Vertex Pharmaceuticals Incorporated | 用作par-2信號通路抑制劑的咪唑並噠嗪 |
| WO2015128846A1 (en) * | 2014-02-28 | 2015-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing monoclonal antibodies against hiv-1 v1v2 env region |
| WO2017023780A1 (en) | 2015-07-31 | 2017-02-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-drug conjugates for targeting cd56-positive tumors |
| EP3184547A1 (en) * | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use |
| ES2984663T3 (es) | 2015-11-13 | 2024-10-30 | Oasis Pharmaceuticals Llc | Moduladores del receptor 2 activados por proteasa |
| JP2019534044A (ja) | 2016-11-08 | 2019-11-28 | クイル ピュージェット サウンド バイオセラピューティクス コーポレーション | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
| MA49886A (fr) | 2017-03-16 | 2020-06-24 | Medimmune Ltd | Anticorps anti-par2 et leurs utilisations |
| US12077592B2 (en) * | 2019-01-18 | 2024-09-03 | Janssen Biotech, Inc. | GPRC5D chimeric antigen receptors and cells expressing the same |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
| BR112021023897A2 (pt) | 2019-05-30 | 2022-01-25 | Shandong Boan Biotechnology Co Ltd | Anticorpo ou receptor de antígeno quimérico que visa claudina18.2 |
| WO2021084760A1 (ja) * | 2019-11-01 | 2021-05-06 | 株式会社 資生堂 | 皮膚での活性型ｐａｒ－２を指標とした皮膚状態評価方法、ｐａｒ－２活性化促進剤又は抑制剤のスクリーニング方法及びｐａｒ－２活性化抑制剤 |
| CN113248611B (zh) * | 2020-02-13 | 2026-02-06 | 上海泰槿生物技术有限公司 | 抗bcma抗体、其药物组合物及应用 |
| EP4126248A4 (en) | 2020-03-31 | 2024-07-10 | Fred Hutchinson Cancer Center | HUMAN ANTI-CD33 ANTIBODIES AND THEIR USES |
| AU2021328375A1 (en) * | 2020-08-18 | 2023-04-13 | Cephalon Llc | Anti-PAR-2 antibodies and methods of use thereof |
| JP2024535740A (ja) * | 2021-09-02 | 2024-10-02 | メモリアル スローン ケタリング キャンサー センター | Ｃｄ３３を標的とする抗原認識受容体及びその使用 |
| EP4396235A4 (en) * | 2021-09-02 | 2025-07-02 | Memorial Sloan Kettering Cancer Center | ANTI-CD33 ANTIBODIES AND THEIR USES |
| CN114181311B (zh) * | 2021-12-20 | 2023-06-20 | 华东师范大学 | 一种全人源抗DLL3 scFv及其在CART细胞治疗中的应用 |
| GB202204159D0 (en) * | 2022-03-24 | 2022-05-11 | Heptares Therapeutics Ltd | Antibodies |
| WO2024059336A1 (en) * | 2022-09-18 | 2024-03-21 | Memorial Sloan Kettering Cancer Center | Inhibition of protease-activated receptor 2 (par2) pathway for treatment and prevention of lymphedema |
| CN118290572B (zh) * | 2023-09-19 | 2026-04-07 | 军事科学院军事医学研究院军事兽医研究所 | 抗狂犬病病毒全人源抗体及其组合物与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297026B1 (en) | 1993-07-26 | 2001-10-02 | Cor Therapeutics Inc. | Nucleic acids encoding the C140 receptor |
| EP1972194A1 (en) * | 1996-12-03 | 2008-09-24 | Amgen Fremont Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| US7888482B2 (en) * | 2006-02-10 | 2011-02-15 | Amgen Inc. | Antibodies that bind PAR-2 |
| WO2008086069A1 (en) * | 2007-01-03 | 2008-07-17 | The General Hospital Corporation | Methods of treating itch |
| CL2008001887A1 (es) * | 2007-06-29 | 2008-10-03 | Amgen Inc | Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende. |
| KR20090082619A (ko) | 2008-01-28 | 2009-07-31 | 주식회사 알파크립텍 | 다프네틴을 함유하는 가려움증 또는 염증 개선용 화장료조성물 |
| AR070911A1 (es) | 2008-03-19 | 2010-05-12 | Regeneron Pharma | Uso de antagonistas del receptor par2 activado con proteasa |
| WO2010017086A1 (en) | 2008-08-05 | 2010-02-11 | Boehringer Ingelheim International Gmbh | Effectors of par-2 activation and their use in the modulation of inflammation |
| CN102458356A (zh) | 2009-06-18 | 2012-05-16 | 株式会社爱茉莉太平洋 | 含有栗子皮提取物的化妆料组合物 |
| WO2010147440A2 (ko) | 2009-06-18 | 2010-12-23 | (주)아모레퍼시픽 | 밤껍질 추출물을 포함하는 건강 식품 또는 약학 조성물 |
| FR2947452B1 (fr) | 2009-07-01 | 2012-04-20 | Fabre Pierre Dermo Cosmetique | L-serine et/ou l-asparagine et/ou l-valine pour prevenir et/ou au traiter des reactions inflammatoires de la peau. |
| JO3246B1 (ar) * | 2009-09-09 | 2018-03-08 | Regeneron Pharma | اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري |
-
2010
- 2010-08-23 JO JOP/2010/0293A patent/JO3246B1/ar active
- 2010-09-07 AR ARP100103275A patent/AR078346A1/es unknown
- 2010-09-08 WO PCT/US2010/048034 patent/WO2011031695A1/en not_active Ceased
- 2010-09-08 US US12/877,133 patent/US8101724B2/en active Active
- 2010-09-08 NZ NZ599204A patent/NZ599204A/en not_active IP Right Cessation
- 2010-09-08 CA CA2773541A patent/CA2773541A1/en not_active Abandoned
- 2010-09-08 SI SI201031386A patent/SI2475684T1/sl unknown
- 2010-09-08 SG SG2012015228A patent/SG178976A1/en unknown
- 2010-09-08 PT PT107543878T patent/PT2475684T/pt unknown
- 2010-09-08 EP EP10754387.8A patent/EP2475684B1/en active Active
- 2010-09-08 HR HRP20170324TT patent/HRP20170324T1/hr unknown
- 2010-09-08 TW TW099130262A patent/TWI492757B/zh not_active IP Right Cessation
- 2010-09-08 MX MX2012002927A patent/MX2012002927A/es active IP Right Grant
- 2010-09-08 BR BR112012005338A patent/BR112012005338A2/pt not_active IP Right Cessation
- 2010-09-08 JP JP2012528860A patent/JP5832435B2/ja not_active Expired - Fee Related
- 2010-09-08 ES ES10754387.8T patent/ES2609780T3/es active Active
- 2010-09-08 SM SM20170102T patent/SMT201700102T1/it unknown
- 2010-09-08 AU AU2010292342A patent/AU2010292342C1/en not_active Ceased
- 2010-09-08 MY MYPI2012001005A patent/MY159551A/en unknown
- 2010-09-08 CN CN201080047991.9A patent/CN102574923B/zh not_active Expired - Fee Related
- 2010-09-08 HU HUE10754387A patent/HUE031725T2/en unknown
- 2010-09-08 PL PL10754387T patent/PL2475684T3/pl unknown
- 2010-09-08 DK DK10754387.8T patent/DK2475684T3/en active
- 2010-09-08 LT LTEP10754387.8T patent/LT2475684T/lt unknown
- 2010-09-08 KR KR1020127008692A patent/KR101766701B1/ko not_active Expired - Fee Related
- 2010-09-09 UY UY0001032883A patent/UY32883A/es not_active Application Discontinuation
-
2011
- 2011-12-14 US US13/325,098 patent/US8425907B2/en active Active
-
2012
- 2012-03-06 IL IL218501A patent/IL218501A/en not_active IP Right Cessation
- 2012-03-09 ZA ZA2012/01730A patent/ZA201201730B/en unknown
-
2013
- 2013-03-26 US US13/850,644 patent/US9028819B2/en active Active
-
2015
- 2015-09-09 JP JP2015177339A patent/JP6055055B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-01 CY CY20171100144T patent/CY1118714T1/el unknown
- 2017-02-15 SM SM201700102T patent/SMT201700102B/it unknown
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