JP2013500342A5 - - Google Patents
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- Publication number
- JP2013500342A5 JP2013500342A5 JP2012522939A JP2012522939A JP2013500342A5 JP 2013500342 A5 JP2013500342 A5 JP 2013500342A5 JP 2012522939 A JP2012522939 A JP 2012522939A JP 2012522939 A JP2012522939 A JP 2012522939A JP 2013500342 A5 JP2013500342 A5 JP 2013500342A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkyl
- aralkyl
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 125000003710 aryl alkyl group Chemical group 0.000 claims 19
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 claims 2
- 229910052768 actinide Inorganic materials 0.000 claims 2
- 150000001255 actinides Chemical class 0.000 claims 2
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical class 0.000 claims 2
- 206010065973 Iron Overload Diseases 0.000 claims 1
- PLIUCYCUYQIBDZ-RMWYGNQTSA-N all-trans-4-oxoretinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C PLIUCYCUYQIBDZ-RMWYGNQTSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22869009P | 2009-07-27 | 2009-07-27 | |
| US61/228,690 | 2009-07-27 | ||
| PCT/US2010/043241 WO2011017054A2 (en) | 2009-07-27 | 2010-07-26 | Prodrugs of desazadesferrothiocin polyether analogues as metal chelation agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013500342A JP2013500342A (ja) | 2013-01-07 |
| JP2013500342A5 true JP2013500342A5 (cg-RX-API-DMAC7.html) | 2013-09-12 |
Family
ID=43544849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012522939A Pending JP2013500342A (ja) | 2009-07-27 | 2010-07-26 | 金属キレート化剤としてのデサザデスフェロチオシンポリエーテルアナログのプロドラッグ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110053993A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2459544A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013500342A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102648189A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010281452A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012001761A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2768041A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011017054A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003270473A1 (en) | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| MX2007012226A (es) | 2005-04-04 | 2007-12-10 | Univ Florida | Analogos de polieter de desferritiocina. |
| EP2137170B1 (en) | 2007-03-15 | 2016-03-09 | University of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
| MY163516A (en) * | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| WO2011140232A2 (en) * | 2010-05-04 | 2011-11-10 | Ferrokin Biosciences, Inc | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| ES2571128T3 (es) * | 2010-07-26 | 2016-05-24 | Lg Electronics Inc | Realimentación aperiódica de información de estado de canal en un sistema de acceso inalámbrico que soporta agregación de múltiples portadoras |
| EP2787994A4 (en) | 2011-12-09 | 2015-08-26 | Ferrokin Biosciences Inc | ORAL FORMULATIONS FOR TREATING METAL OVERLOAD |
| JP6539046B2 (ja) | 2011-12-16 | 2019-07-03 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ４’−デスフェリチオシン類似体の使用 |
| TW201427962A (zh) * | 2012-12-07 | 2014-07-16 | Ferrokin Biosciences Inc | 脫氮雜去鐵硫辛（ｄｅｓａｚａｄｅｓｆｅｒｒｉｔｈｉｏｃｉｎ）類似物之多晶型形式 |
| US9512095B2 (en) | 2013-03-15 | 2016-12-06 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
| CA2930966A1 (en) | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| JP2018515475A (ja) | 2015-04-27 | 2018-06-14 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | 代謝的にプログラムされた金属キレーターおよびその使用 |
| EP3575359A4 (en) | 2017-01-24 | 2020-01-01 | Sumitomo Rubber Industries, Ltd. | TIRES |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0214101A3 (de) * | 1985-09-03 | 1989-05-31 | Ciba-Geigy Ag | Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria |
| US5840739A (en) * | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
| AT500490A1 (de) * | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| US20060069134A1 (en) * | 2002-10-01 | 2006-03-30 | Kaneka Corporation | Process for producing optically active alpha-substituted cysteine or salt thereof, intermediate therefor, and process for producing the same |
| AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| MX2007012226A (es) * | 2005-04-04 | 2007-12-10 | Univ Florida | Analogos de polieter de desferritiocina. |
| CA2684837A1 (en) * | 2006-12-12 | 2008-10-30 | Raymond J. Bergeron, Jr. | Desferrithiocin analogue actinide decorporation agents |
| EP2137170B1 (en) * | 2007-03-15 | 2016-03-09 | University of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
| MY163516A (en) * | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| US20120184586A1 (en) * | 2009-08-25 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof |
| WO2011140232A2 (en) * | 2010-05-04 | 2011-11-10 | Ferrokin Biosciences, Inc | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
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2010
- 2010-07-26 US US12/843,483 patent/US20110053993A1/en not_active Abandoned
- 2010-07-26 CA CA2768041A patent/CA2768041A1/en not_active Abandoned
- 2010-07-26 EP EP10806863A patent/EP2459544A4/en not_active Withdrawn
- 2010-07-26 AU AU2010281452A patent/AU2010281452A1/en not_active Abandoned
- 2010-07-26 CN CN2010800395082A patent/CN102648189A/zh active Pending
- 2010-07-26 BR BR112012001761A patent/BR112012001761A2/pt not_active IP Right Cessation
- 2010-07-26 WO PCT/US2010/043241 patent/WO2011017054A2/en not_active Ceased
- 2010-07-26 JP JP2012522939A patent/JP2013500342A/ja active Pending
-
2012
- 2012-09-05 US US13/604,025 patent/US20130005781A1/en not_active Abandoned